LOCUS       NM_011305               5267 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus retinoid X receptor alpha (Rxra), transcript variant
            1, mRNA.
ACCESSION   NM_011305 XM_914281
VERSION     NM_011305.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5267)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   2  (bases 1 to 5267)
  AUTHORS   Shao,M., Li,L., Ma,L., Song,C., Li,W., Zhang,Y., Cheng,W., Chen,Y.,
            Yang,Y., Wang,Q., Li,C., Wang,Q., Wang,W. and Wang,Y.
  TITLE     Activation of RXRalpha exerts cardioprotection through
            transcriptional upregulation of Ndufs4 in heart failure
  JOURNAL   Sci Bull (Beijing) 69 (9), 1202-1207 (2024)
   PUBMED   38310046
  REMARK    GeneRIF: Activation of RXRalpha exerts cardioprotection through
            transcriptional upregulation of Ndufs4 in heart failure.
REFERENCE   3  (bases 1 to 5267)
  AUTHORS   Zhang,T. and Wang,G.
  TITLE     Inhibition of RXRA-mediated PLA2G2A improves delirium in COPD mice
            by regulating endoplasmic reticulum stress pathway and inhibiting
            cell apoptosis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 226-232 (2024)
   PUBMED   38372090
  REMARK    GeneRIF: Inhibition of RXRA-mediated PLA2G2A improves delirium in
            COPD mice by regulating endoplasmic reticulum stress pathway and
            inhibiting cell apoptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5267)
  AUTHORS   Manoharan,I., Shanmugam,A., Ramalingam,M., Patel,N., Thangaraju,M.,
            Ande,S., Pacholczyk,R., Prasad,P.D. and Manicassamy,S.
  TITLE     The Transcription Factor RXRalpha in CD11c+ APCs Regulates
            Intestinal Immune Homeostasis and Inflammation
  JOURNAL   J Immunol 211 (5), 853-861 (2023)
   PUBMED   37477694
  REMARK    GeneRIF: The Transcription Factor RXRalpha in CD11c+ APCs Regulates
            Intestinal Immune Homeostasis and Inflammation.
REFERENCE   5  (bases 1 to 5267)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   6  (bases 1 to 5267)
  AUTHORS   Brocard,J., Kastner,P. and Chambon,P.
  TITLE     Two novel RXR alpha isoforms from mouse testis
  JOURNAL   Biochem Biophys Res Commun 229 (1), 211-218 (1996)
   PUBMED   8954108
REFERENCE   7  (bases 1 to 5267)
  AUTHORS   Dyson,E., Sucov,H.M., Kubalak,S.W., Schmid-Schonbein,G.W.,
            DeLano,F.A., Evans,R.M., Ross,J. Jr. and Chien,K.R.
  TITLE     Atrial-like phenotype is associated with embryonic ventricular
            failure in retinoid X receptor alpha -/- mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7386-7390 (1995)
   PUBMED   7638202
REFERENCE   8  (bases 1 to 5267)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   9  (bases 1 to 5267)
  AUTHORS   Mangelsdorf,D.J., Borgmeyer,U., Heyman,R.A., Zhou,J.Y., Ong,E.S.,
            Oro,A.E., Kakizuka,A. and Evans,R.M.
  TITLE     Characterization of three RXR genes that mediate the action of
            9-cis retinoic acid
  JOURNAL   Genes Dev 6 (3), 329-344 (1992)
   PUBMED   1312497
REFERENCE   10 (bases 1 to 5267)
  AUTHORS   Leid,M., Kastner,P., Lyons,R., Nakshatri,H., Saunders,M.,
            Zacharewski,T., Chen,J.Y., Staub,A., Garnier,J.M., Mader,S. et al.
  TITLE     Purification, cloning, and RXR identity of the HeLa cell factor
            with which RAR or TR heterodimerizes to bind target sequences
            efficiently
  JOURNAL   Cell 68 (2), 377-395 (1992)
   PUBMED   1310259
  REMARK    Erratum:[Cell. 1992 Nov 27;71(5):887.. PMID: 1330328]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144675.1, X66223.1 and AK029121.1.
            
            On Jan 7, 2006 this sequence version replaced NM_011305.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144675.1, AK031034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               AK144675.1         3-505
            504-1813            X66223.1           449-1758
            1814-3735           AK144675.1         1816-3737
            3736-5267           AK029121.1         1895-3426
FEATURES             Location/Qualifiers
     source          1..5267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..5267
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /note="retinoid X receptor alpha"
                     /db_xref="GeneID:20181"
                     /db_xref="MGI:MGI:98214"
     exon            1..260
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..526
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..677
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..857
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1027
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1157
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1290
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1382
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1488
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..5267
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4883..4888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /note="hexamer: AATATA"
     polyA_site      4905
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /note="major polyA site"
     regulatory      5211..5216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
                     /note="hexamer: ATTACA"
     polyA_site      5232
                     /gene="Rxra"
                     /gene_synonym="9530071D11Rik; Nr2b1; RXRalpha1"
ORIGIN      
        1 gcgcggcgga ggcgcgggcg gcgggtgcgc gcgcggggcg cgcgcaggca caagtagttt
       61 acattgttgg gcgacttttg caacaactcg ccgcgccgcg gcctccgcgc gccgccgccg
      121 ccgctgccgc cgccggctcc ccgccgcccg ggccccgggc gggccgcgcc gggggccgcc
      181 gcgctgccgc cctgctgctc cgccgccggc tgggcatgag ttagtcgcag acatggacac
      241 caaacatttc ctgccgctcg acttctctac ccaggtgaac tcttcgtccc tcaactctcc
      301 aacgggtcga ggctccatgg ctgtcccctc gctgcacccc tccttgggtc cgggaatcgg
      361 ctctccactg ggctcgcctg ggcagctgca ctctcctatc agcaccctga gctcccccat
      421 caatggcatg ggtccgccct tctctgtcat cagctccccc atgggcccgc actccatgtc
      481 ggtacccacc acacccacat tgggcttcgg gactggtagc ccccagctca attcacccat
      541 gaaccctgtg agcagcactg aggatatcaa gccgccacta ggcctcaatg gcgtcctcaa
      601 ggttcctgcc catccctcag gaaatatggc ctccttcacc aagcacatct gtgctatctg
      661 tggggaccgc tcctcaggca aacactatgg ggtatacagt tgtgagggct gcaagggctt
      721 cttcaagagg acagtacgca aagacctgac ctacacctgc cgagacaaca aggactgcct
      781 gatcgacaag agacagcgga accggtgtca gtactgccgc taccagaagt gcctggccat
      841 gggcatgaag cgggaagctg tgcaggagga gcggcagcgg ggcaaggacc ggaatgagaa
      901 cgaggtggag tccaccagca gtgccaacga ggacatgcct gtagagaaga ttctggaagc
      961 cgagcttgct gtcgagccca agactgagac atacgtggag gcaaacatgg ggctgaaccc
     1021 cagctcacca aatgaccctg ttaccaacat ctgtcaagca gcagacaagc agctcttcac
     1081 tcttgtggag tgggccaaga ggatcccaca cttttctgag ctgcccctag acgaccaggt
     1141 catcctgcta cgggcaggct ggaacgagct gctgatcgcc tccttctccc accgctccat
     1201 agctgtgaaa gatgggattc tcctggccac cggcctgcac gtacaccgga acagcgctca
     1261 cagtgctggg gtgggcgcca tctttgacag ggtgctaaca gagctggtgt ctaagatgcg
     1321 tgacatgcag atggacaaga cggagctggg ctgcctgcga gccattgtcc tgttcaaccc
     1381 tgactctaag gggctctcaa accctgctga ggtggaggcg ttgagggaga aggtgtatgc
     1441 gtcactagaa gcgtactgca aacacaagta ccctgagcag ccgggcaggt ttgccaagct
     1501 gctgctccgc ctgcctgcac tgcgttccat cgggctcaag tgcctggagc acctgttctt
     1561 cttcaagctc atcggggaca cgcccatcga caccttcctc atggagatgc tggaggcacc
     1621 acatcaagcc acctaggccc ccgccgccgt gtgccggtcc cgtgccctgc ctggacacag
     1681 ctgctcagct ccagccctgc ccctgccctt tctgatggcc cgtgtggatc tttggggtgc
     1741 agtgtcctta tgggcccaaa agatgcatca ccatcctcgc catctttact catgcttgcc
     1801 tttggcccag ggccatagca gagctggtgt gacacctggc cagctcctgc cctacatcag
     1861 gctctaaggc tatgctgctg tcaccccgag ggtcgtgggg ttcgtcatgg ggccttcagc
     1921 acctggagct gcaagagctg ggaaaagggc ttgttctggt tgctggttgc tgtcgctggt
     1981 tctcgacatc ccacatggca cctctgtttg gagtgcccca tcttggcctg ttcagagtcc
     2041 tggtacccag ttagggtggg aatccacctg ggatcaagaa ggagcaggtg gggcaggccg
     2101 tatcctcctg ggtcatagct aacctataaa gcctctttcc aaagatgccc tgagatatca
     2161 ctccaagcag gattctggga ccaccttgag gctgcgtggg ctggaggtcc tctgtcatgt
     2221 cccccagttg accagttcct ttttatgtca tcgtccctct tcatgtctca ccaatccagg
     2281 gttagccaac tatagtagcc tggcttttcc ctatcacaga tcttcctttc tggtcttcaa
     2341 gatggcacca ccaatcatcc tggagggctg ccctggctca cgtagagtgg ggtttccact
     2401 tcagtggtcc tgtgggacac tgggcatcct gaggctcagg gaggagagga gggctgttgt
     2461 ctggttttgg ggaaggtggc ctgagggact tggagctgaa ccatgaaggc atggcaggtg
     2521 gctgtcctgg tgtgactgag tcaacaggct ctgtgtggga ctctagcatg ggccctttct
     2581 cggactggcc acttctgtta gaatcctgac agacagggac tttctgggac ttcttttgga
     2641 atggtggtgt ctgtggacag tgtttgctca gaatctgacc caatggttct gtcatgcctg
     2701 ctcaggtggc tggctgcaga ctcaggcttc agccctgtcc catgtggctc ttgagtgtgc
     2761 ctctccagtt gaccagcctt gtttgcactg tggagcctcc ttgggtgtca gtcttcatga
     2821 tctagtctca gactccaggg cccaggcttg tcaggagcag gtgccttagt gggtgtggcc
     2881 atactgcctc ccctgtagct ggtctcccat gaggtaggag ggagaaggtc ctcacaaaac
     2941 agaccaccta ggggattgga cctagaggtg gtgggtggga gggtccagtt tcctgggctc
     3001 tgcggggaag gacacattgc ttttccatct tttcaaaatc ctaaaccata accggcagag
     3061 gcacccataa aagattccag aaacatcttc cctgtatccc ttctctccat gtagtggcat
     3121 gggagctgac cgtggagaca gcacggttcc caggacccgc tggctgcccc tttcctaggc
     3181 tttgctagaa aatccgtaca gcctttgggg ctagtagcat caggcggagg agcggattcc
     3241 ctagtccata cccagcaccg tgccttctgc agacccccct cttccattgt tcatgccagc
     3301 cccattccac actgtaccct gtccctctga gccacagaga atgcacagtg gctccagcag
     3361 aggaagtcct ggggctgagc catgtctggg cttggctggc tgtcaggcac tggggccttg
     3421 gccgaaagcc ccactggccc acatagcctt acctgccact gcttgtcact atagattccc
     3481 tggtgagctt cctgctcctt tggcctcatt gtcactgtca tgggggcagt gttgcttgtt
     3541 tgcaatggtg gtgtgggcgt ggtgtcacta aggagaaaat tggagcttca tttaaccaga
     3601 ccttcagtcg tgttaccaat ttggctcaat taaggtgatt gtaattatta ttgttattat
     3661 tttggtggaa caatctttaa ttttctaaag atagctctaa catcagctca ttagccaccc
     3721 tgcgcccatc cccacctcaa cctgattgga ttgttgccac caatggtcat gtgacttcca
     3781 cattgcagct tctgggccat attcctcatg tgtgtcacca ccctgcttgg agattcatct
     3841 ggggctcctg tggccgagaa acgaagatga ccacagggcc tgtggcagct gctggcctgt
     3901 gtcaccctga aacagtcact gggggaattt ggcccccacg ccctcaattt tccaaattac
     3961 agcatcccca ggatcctggg caacttggtg acagtgccaa gagacaccca gcccccctcc
     4021 cctggcatcc caggatacct ggcgaaagca ggcaaccaat ggctagtcat ctgctgtccc
     4081 cgttgtagaa ctggggcttg tgaccgggtc tccatgcaca cgtgtatggt gtgaacacat
     4141 gtgctataca gagactgccc actgacgacg ggagatgcgg cacagttact ggtgttttgt
     4201 gttcttttta atcaagactt tcccattttc ctgtacattt gcttctcgtg agcaaggacc
     4261 tgaggtcccc ttctgtgggg aagtcgggct ctggggactc tctggaggca ggggatgcat
     4321 ctattttcag atgcttcagg gctggagtgc cctgaactct agccatgcct tagctgggat
     4381 gtgcggccac catggggagg aggccgcgtc cgcagggagt aaagatagag gaatgtttaa
     4441 cgcaccggga agggtaaatg aatctatttt tgtacaaatg taattttatc cctcatgtaa
     4501 actggatggc atggtggggg acctattttg tttctgcttt gagtgtcaaa aactgttggg
     4561 acaccctgac gctgagacag cagaggaggc gcttaccagg cggctgaagg cgtgagaaca
     4621 gcacagacag acacttcctt cggtgggagg ggggccgcac gggcagggtt tccttcccct
     4681 tcttggtgat ttgaacagcc ctgctctgtc ctcggtgcct gcctgcctgc ctgcctgccg
     4741 gcctctgact gtgaactgac tccccacgga actactcact gggacattgt ggtgcagacg
     4801 ccggggggtt gatgaacagc agtctcagga ttatagaaaa gaaacaacaa catgagagga
     4861 gagacaaata tgagcgtttc aaaatatatc tccattcggt tctcatctgt cctgtgttgg
     4921 ggagtccgat ctggggggtt gcagacttct ggggcagtgg gagtgggagg tcctgtggtc
     4981 agctccagtc cccagcttcc ttgggagggt cttctcttcc atgtctgctg tgctgtgaag
     5041 ctctcccctg gggccccttt gaggcctgca cagagccatc cccaatctgt gttgctacct
     5101 gcccagccct ggctttcctg cacccagctt ctacttctgt gctagctaga gtgggcagga
     5161 ggttcacacg gagggactca gatacgtgat gtcatctaac tgcccgatta attacaggtt
     5221 aacaatgccc catctgtgcc atcttgtgat aaatgccctt tgtctcc
//
