LOCUS       NM_181817               1409 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus relaxin family peptide receptor 4 (Rxfp4), mRNA.
ACCESSION   NM_181817
VERSION     NM_181817.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1409)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1409)
  AUTHORS   Fernando,S.J.A., Wang,Q., Hay,D.L., Bathgate,R.A.D., Shepherd,P.R.
            and Lee,K.L.
  TITLE     Evidence that RXFP4 is located in enterochromaffin cells and can
            regulate production and release of serotonin
  JOURNAL   Biosci Rep 43 (4) (2023)
   PUBMED   36947541
  REMARK    GeneRIF: Evidence that RXFP4 is located in enterochromaffin cells
            and can regulate production and release of serotonin.
REFERENCE   3  (bases 1 to 1409)
  AUTHORS   Lewis,J.E., Woodward,O.R., Nuzzaci,D., Smith,C.A.,
            Adriaenssens,A.E., Billing,L., Brighton,C., Phillips,B.U.,
            Tadross,J.A., Kinston,S.J., Ciabatti,E., Gottgens,B., Tripodi,M.,
            Hornigold,D., Baker,D., Gribble,F.M. and Reimann,F.
  TITLE     Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing
            hypothalamic neurons modulate food intake and preference in mice
  JOURNAL   Mol Metab 66, 101604 (2022)
   PUBMED   36184065
  REMARK    GeneRIF: Relaxin/insulin-like family peptide receptor 4 (Rxfp4)
            expressing hypothalamic neurons modulate food intake and preference
            in mice.
REFERENCE   4  (bases 1 to 1409)
  AUTHORS   Diwakarla,S., Bathgate,R.A.D., Zhang,X., Hossain,M.A. and
            Furness,J.B.
  TITLE     Colokinetic effect of an insulin-like peptide 5-related agonist of
            the RXFP4 receptor
  JOURNAL   Neurogastroenterol Motil 32 (5), e13796 (2020)
   PUBMED   31989750
  REMARK    GeneRIF: Colokinetic effect of an insulin-like peptide 5-related
            agonist of the RXFP4 receptor.
REFERENCE   5  (bases 1 to 1409)
  AUTHORS   Grosse,J., Heffron,H., Burling,K., Akhter Hossain,M., Habib,A.M.,
            Rogers,G.J., Richards,P., Larder,R., Rimmington,D.,
            Adriaenssens,A.A., Parton,L., Powell,J., Binda,M., Colledge,W.H.,
            Doran,J., Toyoda,Y., Wade,J.D., Aparicio,S., Carlton,M.B.,
            Coll,A.P., Reimann,F., O'Rahilly,S. and Gribble,F.M.
  TITLE     Insulin-like peptide 5 is an orexigenic gastrointestinal hormone
  JOURNAL   Proc Natl Acad Sci U S A 111 (30), 11133-11138 (2014)
   PUBMED   25028498
REFERENCE   6  (bases 1 to 1409)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1409)
  AUTHORS   Chen,J., Kuei,C., Sutton,S.W., Bonaventure,P., Nepomuceno,D.,
            Eriste,E., Sillard,R., Lovenberg,T.W. and Liu,C.
  TITLE     Pharmacological characterization of relaxin-3/INSL7 receptors
            GPCR135 and GPCR142 from different mammalian species
  JOURNAL   J Pharmacol Exp Ther 312 (1), 83-95 (2005)
   PUBMED   15367576
REFERENCE   8  (bases 1 to 1409)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   9  (bases 1 to 1409)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134246.4.
            
            On Mar 11, 2022 this sequence version replaced NM_181817.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY633765.1, AY288422.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1409              AC134246.4         56864-58272         c
FEATURES             Location/Qualifiers
     source          1..1409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.92 cM"
     gene            1..1409
                     /gene="Rxfp4"
                     /gene_synonym="GPCR142; Gpr100; Rln3r2; SALPR"
                     /note="relaxin family peptide receptor 4"
                     /db_xref="GeneID:242093"
                     /db_xref="MGI:MGI:2182926"
     exon            1..1409
                     /gene="Rxfp4"
                     /gene_synonym="GPCR142; Gpr100; Rln3r2; SALPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1285
                     /gene="Rxfp4"
                     /gene_synonym="GPCR142; Gpr100; Rln3r2; SALPR"
                     /note="G protein-coupled receptor 100; relaxin-3/INSL7
                     receptor 2; RLN3 receptor 2; insulin-like peptide INSL5
                     receptor"
                     /codon_start=1
                     /product="relaxin-3 receptor 2"
                     /protein_id="NP_861538.1"
                     /db_xref="CCDS:CCDS17482.1"
                     /db_xref="GeneID:242093"
                     /db_xref="MGI:MGI:2182926"
                     /translation="MATSNSSASLPTLFWVNGSGDSVLSTDGAAMPVQFLVLRIMVAL
                     AYGLVGIIGLLGNLAVLWVLGNCGQRVPGLSSDTFVFSLALADLGLALTLPFWATESA
                     MDFHWPFGSALCKVVLTTTVLSIYASTFLITALSIARYWVVAMAVGPGSHLSVFWARV
                     VTLAVWVAAALVTVPTAIFGAEVELWGVCLCLLRFPSRYWLGAYQLQRVVLAFIVPLG
                     VITTSYLLLLAFLERQQRCRPRQWQDSRVVARSVRVLVASFALCWVPNHVVTLWEILV
                     RFDLVPWDSTFYTFHTYILPITTCLAHSNSCLNPVIYCLLRREPQQVLVSSFRALWSR
                     LWPQRKACMEQMALKEVGGRTVASTQESGSSRTHTNTMEHLDEGCSLNTLLSETYQGQ
                     SPQILGRSSCSLSQAAVSPGEV"
     regulatory      1390..1395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxfp4"
                     /gene_synonym="GPCR142; Gpr100; Rln3r2; SALPR"
                     /note="hexamer: AATAAA"
     polyA_site      1409
                     /gene="Rxfp4"
                     /gene_synonym="GPCR142; Gpr100; Rln3r2; SALPR"
                     /note="major polyA site"
ORIGIN      
        1 ctctgctctg ctgtgctcta gcaacctccg cggtcttgcg atggccacat ccaattcttc
       61 tgcctctctg cccaccctct tctgggtcaa tggctctgga gacagcgtgc tgagcactga
      121 cggtgctgcc atgcctgtcc agttccttgt tctgaggatc atggttgcac tggcctatgg
      181 acttgtaggt atcattggct tgctgggaaa tttggccgta ctgtgggttc taggtaactg
      241 tggtcagcgt gtgcccggcc tgtcttctga tacctttgtc ttcagcctgg ctctagcaga
      301 cttggggctg gcccttactc tccctttctg ggcaaccgag tcagcaatgg acttccactg
      361 gcctttcgga agtgccctct gcaaggtagt cctgaccacc accgtcctca gcatctatgc
      421 cagcaccttc ctaatcacag cactgagtat cgcgcgatac tgggtggtag ccatggctgt
      481 gggaccaggt agtcacctct cagtcttttg ggcccgtgtg gtcaccctgg cagtgtgggt
      541 ggcagctgcc ctggtgactg tgcccacagc aatctttggg gctgaagttg agttgtgggg
      601 cgtgtgcctc tgtcttctgc gtttccccag cagatactgg ctgggagctt accagctaca
      661 gagggtagtt ctggccttca tcgtgccctt gggagtcatt accaccagtt acctgctgct
      721 gttggccttt ctagagcggc agcaaagatg caggccacga caatggcagg acagccgagt
      781 ggtagcccgc tctgtccgtg tcctggtggc ttccttcgcc ctctgctggg ttcccaacca
      841 tgtagtcact ctctgggaaa ttctggtaag gtttgacctg gtgccctggg acagtacttt
      901 ctacaccttt catacttaca tccttcccat caccacctgc ttggcccaca gcaacagctg
      961 cctcaaccct gtgatctatt gtctcctgcg gcgggagccc cagcaggttc ttgtcagctc
     1021 cttcagagct ctctggtcaa gactgtggcc tcaaaggaag gcctgcatgg aacaaatggc
     1081 cctcaaggag gtaggcggga gaacggtagc cagcacccag gagagtggct cttctaggac
     1141 acacacaaac acaatggaac acctggatga aggatgcagc ctgaacactc tcctttctga
     1201 gacctatcag gggcagagcc cacagattct agggaggagc agctgctctc tcagtcaggc
     1261 tgctgtgtcc ccaggagaag tctgatcttt gatcaccaac tctgggtgtg acagaacgga
     1321 gaagctggag tccaaacagg aggtggatgt ggcaaagctt atctctggag atggcaaaga
     1381 ggaactgaga ataaaccaga tcggtcaga
//
