LOCUS       NM_178717               4252 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus relaxin family peptide receptor 3 (Rxfp3), mRNA.
ACCESSION   NM_178717
VERSION     NM_178717.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4252)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4252)
  AUTHORS   Farris,M.H., Texter,P.A., Mora,A.A., Wiles,M.V., Mac Garrigle,E.F.,
            Klaus,S.A. and Rosfjord,K.
  TITLE     Detection of CRISPR-mediated genome modifications through altered
            methylation patterns of CpG islands
  JOURNAL   BMC Genomics 21 (1), 856 (2020)
   PUBMED   33267773
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4252)
  AUTHORS   Kothandapani,A., Lewis,S.R., Noel,J.L., Zacharski,A., Krellwitz,K.,
            Baines,A., Winske,S., Vezina,C.M., Kaftanovskaya,E.M.,
            Agoulnik,A.I., Merton,E.M., Cohn,M.J. and Jorgensen,J.S.
  TITLE     GLI3 resides at the intersection of hedgehog and androgen action to
            promote male sex differentiation
  JOURNAL   PLoS Genet 16 (6), e1008810 (2020)
   PUBMED   32497091
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4252)
  AUTHORS   van Gastel,J., Leysen,H., Santos-Otte,P., Hendrickx,J.O., Azmi,A.,
            Martin,B. and Maudsley,S.
  TITLE     The RXFP3 receptor is functionally associated with cellular
            responses to oxidative stress and DNA damage
  JOURNAL   Aging (Albany NY) 11 (23), 11268-11313 (2019)
   PUBMED   31794429
REFERENCE   5  (bases 1 to 4252)
  AUTHORS   Park,J.C., Bae,J.W., Kim,J. and Jung,M.W.
  TITLE     Dynamically changing neuronal activity supporting working memory
            for predictable and unpredictable durations
  JOURNAL   Sci Rep 9 (1), 15512 (2019)
   PUBMED   31664169
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4252)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (bases 1 to 4252)
  AUTHORS   Smith,C.M., Shen,P.J., Banerjee,A., Bonaventure,P., Ma,S.,
            Bathgate,R.A., Sutton,S.W. and Gundlach,A.L.
  TITLE     Distribution of relaxin-3 and RXFP3 within arousal, stress,
            affective, and cognitive circuits of mouse brain
  JOURNAL   J Comp Neurol 518 (19), 4016-4045 (2010)
   PUBMED   20737598
  REMARK    GeneRIF: Data provide evidence for the conserved nature of
            RLN3/RXFP3 systems in mammalian brain and the ability of RLN3/RXFP3
            signaling to modulate 'behavioral state' and an array of circuits
            involved in arousal, stress, affect, and cognition.
REFERENCE   8  (bases 1 to 4252)
  AUTHORS   Susens,U., Hermans-Borgmeyer,I., Urny,J. and Schaller,H.C.
  TITLE     Characterisation and differential expression of two very closely
            related G-protein-coupled receptors, GPR139 and GPR142, in mouse
            tissue and during mouse development
  JOURNAL   Neuropharmacology 50 (4), 512-520 (2006)
   PUBMED   16378626
REFERENCE   9  (bases 1 to 4252)
  AUTHORS   Chen,J., Kuei,C., Sutton,S.W., Bonaventure,P., Nepomuceno,D.,
            Eriste,E., Sillard,R., Lovenberg,T.W. and Liu,C.
  TITLE     Pharmacological characterization of relaxin-3/INSL7 receptors
            GPCR135 and GPCR142 from different mammalian species
  JOURNAL   J Pharmacol Exp Ther 312 (1), 83-95 (2005)
   PUBMED   15367576
REFERENCE   10 (bases 1 to 4252)
  AUTHORS   Boels,K., Hermans-Borgmeyer,I. and Schaller,H.C.
  TITLE     Identification of a mouse orthologue of the G-protein-coupled
            receptor SALPR and its expression in adult mouse brain and during
            development
  JOURNAL   Brain Res Dev Brain Res 152 (2), 265-268 (2004)
   PUBMED   15351514
  REMARK    GeneRIF: A distinct pattern of expression in brain, spinal cord,
            and dorsal root ganglia during development and in the mature brain
            hint at important functions of SALPR for differentiation and
            maintenance of the nervous system.(SALPR PROTEIN, MOUSE)
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK084001.1.
            
            On Apr 6, 2007 this sequence version replaced NM_178717.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK084001.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4252              AK084001.1         3-4254
FEATURES             Location/Qualifiers
     source          1..4252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.42 cM"
     gene            1..4252
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; Rln3r1; Salpr"
                     /note="relaxin family peptide receptor 3"
                     /db_xref="GeneID:239336"
                     /db_xref="MGI:MGI:2441827"
     exon            1..4252
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; Rln3r1; Salpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             685..2103
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; Rln3r1; Salpr"
                     /note="G-protein coupled receptor SALPR; somatostatin and
                     angiotensin-like peptide receptor; relaxin-3/INSL7
                     receptor 1; RLN3 receptor 1; g protein-coupled receptor
                     SALPR homolog"
                     /codon_start=1
                     /product="relaxin-3 receptor 1"
                     /protein_id="NP_848832.1"
                     /db_xref="CCDS:CCDS27383.1"
                     /db_xref="GeneID:239336"
                     /db_xref="MGI:MGI:2441827"
                     /translation="MQVASATPAATVRKAAAGDELSEFFALTPDLLEVANASGNASLQ
                     LQDLWWELGLELPDGAAPGHPPGGGGAESTDTEARVRILISAVYWVVCALGLAGNLLV
                     LYLMKSKQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM
                     VTSMNMYASVFFLTAMSVARYHSVASALKSHRTRGRGRGDCCGQSLRESCCFSAKVLC
                     GLIWASAALASLPNAIFSTTIRVLGEELCLMHFPDKLLGWDRQFWLGLYHLQKVLLGF
                     LLPLSIISLCYLLLVRFISDRRVVGTTDAVGAAAAPGGGLSTASARRRSKVTKSVTIV
                     VLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFQCQVYAFPVSVCLAHSNSCLNPILY
                     CLVRREFRKALKNLLWRIASPSLTNMRPFTATTKPEPEDHGLQALAPLNAAAEPDLIY
                     YPPGVVVYSGGRYDLLPSSSAY"
     regulatory      3669..3674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; Rln3r1; Salpr"
                     /note="hexamer: AATAAA"
     regulatory      3673..3678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; Rln3r1; Salpr"
                     /note="hexamer: AATAAA"
     polyA_site      3687
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; Rln3r1; Salpr"
                     /note="major polyA site"
     polyA_site      3691
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; Rln3r1; Salpr"
                     /note="major polyA site"
ORIGIN      
        1 agtagactct gcctctccct gcgtggcgcg cggggttcag cacttcggaa agcaccccca
       61 tcttctcgca cggagattat gcaagctctt cggggctctc agcagaggtg ggtgccaatg
      121 taactcatca aacgctggca actcactggg ggttgacaat atcggacaca cagaaaacac
      181 caacggagct ccaggaagtg atggcgtgaa tcagccttca ggcagtcaga gcgagacaca
      241 gatgtccacg atctgttttc ctctagaagg agagaaactc ctccgggcaa cctcagaagc
      301 caacaaaggt actgggagag ccgtgctcct gagtagggga ctgcatctaa gtgacagcag
      361 gaaagcagag gggtatgact cagtcttaga gtaggtagct ggagactcag ttctcaccag
      421 gaggaacctt gatccccagc cacttgccta gaactatcct ctcttctaaa cccaccaaga
      481 actgatgctg agtgcagcca acccctgcgc ccaaggcggt tctgggcgcc aacgcggctc
      541 agcatccagt ttccaggagc ccttttgagc gtctacatag aaagctcagg cacctgcttt
      601 gcgcgcccgc ctgggtacca cacccggagc aagcgctgac tctcggtagt cggcttgcag
      661 aacgtgacta aggcgcacct gagcatgcag gtggcttctg caacccccgc ggccaccgtg
      721 aggaaagcag ctgcgggtga tgagctctca gaattcttcg ctctgacccc agacttgctg
      781 gaagtggcca acgccagcgg caatgcgtcg ctgcagcttc aggatctgtg gtgggagctg
      841 gggctagagt tgccagacgg tgcggcgcct gggcatcctc cgggtggcgg cggggcagag
      901 agcacagaca ctgaggccag ggtacggatc ctcatcagcg cggtttactg ggtggtttgt
      961 gccctgggac tggccggcaa cctgctggtt ctctacctga tgaagagcaa gcaaggctgg
     1021 cgcaaatcct ccatcaacct ctttgtcact aacctggcac tgactgactt tcagttcgtg
     1081 ctcactctgc ccttttgggc tgtggagaac gcactagact tcaagtggcc cttcggcaag
     1141 gccatgtgta agatcgtgtc catggtgaca tccatgaaca tgtacgccag cgtcttcttc
     1201 ctcactgcta tgagcgtggc gcgctaccac tcggtggcct cggctctcaa gagccatcgg
     1261 acccgagggc gtggccgtgg cgactgctgc ggccagagct tgagggagag ctgctgtttt
     1321 tcagccaagg tgctgtgtgg gttgatctgg gcttcggctg cgctggcctc gctgcccaat
     1381 gccatttttt ccaccaccat cagggtgttg ggtgaggagc tctgcctcat gcactttcca
     1441 gacaagctac tgggctggga caggcagttc tggctgggtt tgtaccacct gcagaaggtg
     1501 ctgctgggct tcctgctgcc gctgagcatc atcagtctgt gttacctgtt gcttgtgcgc
     1561 ttcatctccg accgtcgcgt agttgggaca acagatgcag taggagcagc agcagcgcct
     1621 gggggaggcc tgagtacagc cagcgctagg agacgctcca aggtcaccaa gtcggtgacc
     1681 atcgtcgtcc tctccttctt cctgtgttgg ctgcccaacc aggcgcttac cacctggagc
     1741 atcctcatca agttcaacgc cgtgcccttc agccaggagt actttcagtg ccaagtgtac
     1801 gcgttcccag tcagcgtgtg cctggcgcac tccaacagct gcctcaaccc gatcctctac
     1861 tgcttagtgc gccgcgagtt ccgcaaggcg ctcaagaacc tgctgtggcg gatagcctcg
     1921 ccttcgctca ccaacatgcg ccctttcacc gccaccacca agccagaacc tgaagatcac
     1981 gggctgcagg ccctggcgcc gcttaatgct gctgccgaac ctgacctgat ctactatcca
     2041 cccggtgtgg tggtctacag cgggggtcgc tacgacctgc tccctagtag ctctgcctac
     2101 tgagacctgc caaggctcaa ggtctttcaa ggaaaaggag agggaaggga gaacagtttg
     2161 gaggctgaag gggtgagaat ggagaaattc ctgggaaagg gatgtgggga agagcactgt
     2221 gacggcgcca gaggaggact gtccctgcag aaatcacatt aaggaaggaa tacctgggac
     2281 cagatagagc aagcagcctt gcctcctagt tcccactcca tgccttctat cccaagcccc
     2341 atttctgcac gtgcgcgctg aacactggga cacccagaag ctggggaagg atcagagaag
     2401 cagagggatt gagttgtgta ggagttggtg ctcatatagc ctttcctaag ctctttgacc
     2461 tgggagtgtc ccaagcaagc atctaacttg ctgtaaccat ctgggaaaga atgagaagtt
     2521 aaaccccggt atcctttatc accctcgaca gggctaatgt gcacgagctg agactgatct
     2581 cctcctcgcc ataccacgca tctgagcaga gatgtcaccg ggagtcttta ggcagtggca
     2641 tgaggtgcca aagagagcac tgtgattaga gggtacgaaa cagagagacc ctgaaggaac
     2701 agggggactg cataagtgtc tccggaagcc tagttatccg gaatgtcttg agggcagtct
     2761 ggagacctgg cgctctggtc tattgttgga ggtgaaccag caagcatccg gaaaagctct
     2821 gctgggggtg tgggaacatt aggagccccc cctccttact ctttgggaac cgagctgact
     2881 gggatgataa actggattgg cagatagaga gatggttcaa tgatgttaga agcgcaggag
     2941 atgctgtcta gttgttctct agaagccgaa gattgctctt tcaaagtggg aaggaggatt
     3001 taagtcaaat ctctcctaag gggaagattt ctgttctcaa gggcatcgcc agaatcttat
     3061 gagtaaaggt attgctcctg taactaacaa aagaaggtga gagtcagaac ttgagtagac
     3121 taccctaacc aagttccagg ggcttgaata ttttactcat ctgaatatgc aggacagctg
     3181 cagggctgtc tctgcagagt gaggccactc ctcgtgacag ctcagttcta ggaacagtct
     3241 gagatcttaa gatcttctca gagtctcttc ttgagactgt tctgaggaca gagatcaata
     3301 ttaacctcac cattcctcaa taattgagaa aataattgag aataataata ttgatcattc
     3361 aggatcaata gagagactac agttctattt ggcttagtct ggggtaaaga ggctggtgaa
     3421 gtaggtacct ccaattgcag tgtggtcact ttaataccat aagggaccat tagagaagcc
     3481 ttgctgctca aatgaccttc tgaactatgg gattggttga taattttgtc aaaattgcac
     3541 tgttacatat gagagttaaa gcttgggata tggagtctac acgcctgcca tcaaagccat
     3601 gctttctgcc atatagtagt tacactcaga taccttccca caaaaagcaa ataataaata
     3661 aataaataaa taaataaata aatcaaagca agtcctgagg tattgtttta aagtagcaac
     3721 attagtcctc ccattgccct atggtgatat tggtattggt attggctagc aaccagaaca
     3781 acaaagggtg gactgtgagc ccctaatgct catagttgga tagttgtatg tcactatgac
     3841 aaaagctaaa agttatctgg aagggggaga tctcaattga gaaaatacct ccataaaacc
     3901 cagctgtagg gcatttttta aattagggat tgactggaga agacccaagc aggtgggggg
     3961 gttcccctgt ctagtggtcc taggttctat agcaaagcaa gctgagaaac ccatggggga
     4021 gcaagccagt aagcaccact cttccatggc ttctacatca gctcctacct tcacgtttct
     4081 tccctgttcc cattctggct cccttcagtg atgaactata atgtagacgt gcaagccaaa
     4141 taagcccttt cttcatgaac ttgccttttg gctctagtgt tttgtcacag gaaaagaaac
     4201 cctaactagg acatgctcca atatacaaaa taaataaaag ggtcaacata ag
//
