LOCUS       NM_080468               3389 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus relaxin/insulin-like family peptide receptor 2
            (Rxfp2), transcript variant 1, mRNA.
ACCESSION   NM_080468
VERSION     NM_080468.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Kothandapani,A., Lewis,S.R., Noel,J.L., Zacharski,A., Krellwitz,K.,
            Baines,A., Winske,S., Vezina,C.M., Kaftanovskaya,E.M.,
            Agoulnik,A.I., Merton,E.M., Cohn,M.J. and Jorgensen,J.S.
  TITLE     GLI3 resides at the intersection of hedgehog and androgen action to
            promote male sex differentiation
  JOURNAL   PLoS Genet 16 (6), e1008810 (2020)
   PUBMED   32497091
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Ceyhan,Y., Zhang,M., Guo,J., Sandoval,C.G., Vacher,J.,
            Kaftanovskaya,E.M., Agoulnik,A.I. and Agoulnik,I.U.
  TITLE     Deletion of inositol polyphosphate 4-phosphatase type-II B affects
            spermatogenesis in mice
  JOURNAL   PLoS One 15 (5), e0233163 (2020)
   PUBMED   32413098
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Livermore,C., Warr,N., Chalon,N., Siggers,P., Mianne,J., Codner,G.,
            Teboul,L., Wells,S. and Greenfield,A.
  TITLE     Male mice lacking ADAMTS-16 are fertile but exhibit testes of
            reduced weight
  JOURNAL   Sci Rep 9 (1), 17195 (2019)
   PUBMED   31748609
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Ferlin,A., De Toni,L., Agoulnik,A.I., Lunardon,G., Armani,A.,
            Bortolanza,S., Blaauw,B., Sandri,M. and Foresta,C.
  TITLE     Protective Role of Testicular Hormone INSL3 From Atrophy and
            Weakness in Skeletal Muscle
  JOURNAL   Front Endocrinol (Lausanne) 9, 562 (2018)
   PUBMED   30323788
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   Tomiyama,H., Hutson,J.M., Truong,A. and Agoulnik,A.I.
  TITLE     Transabdominal testicular descent is disrupted in mice with
            deletion of insulinlike factor 3 receptor
  JOURNAL   J Pediatr Surg 38 (12), 1793-1798 (2003)
   PUBMED   14666470
  REMARK    GeneRIF: Disruption of the Greatgene causes failure of the
            transabdominal phase of descent, identical to that seen in the
            Insl3-deficient mutants, consistent with the recent data suggesting
            that Great gene encodes the Insl3 transmembrane receptor.
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Bogatcheva,N.V., Truong,A., Feng,S., Engel,W., Adham,I.M. and
            Agoulnik,A.I.
  TITLE     GREAT/LGR8 is the only receptor for insulin-like 3 peptide
  JOURNAL   Mol Endocrinol 17 (12), 2639-2646 (2003)
   PUBMED   12933905
  REMARK    GeneRIF: Insulin-like 3 peptide or great cause cryptorchidism
            (undescended testes) in mice.
REFERENCE   8  (bases 1 to 3389)
  AUTHORS   Gorlov,I.P., Kamat,A., Bogatcheva,N.V., Jones,E., Lamb,D.J.,
            Truong,A., Bishop,C.E., McElreavey,K. and Agoulnik,A.I.
  TITLE     Mutations of the GREAT gene cause cryptorchidism
  JOURNAL   Hum Mol Genet 11 (19), 2309-2318 (2002)
   PUBMED   12217959
REFERENCE   9  (bases 1 to 3389)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 3389)
  AUTHORS   Overbeek,P.A., Gorlov,I.P., Sutherland,R.W., Houston,J.B.,
            Harrison,W.R., Boettger-Tong,H.L., Bishop,C.E. and Agoulnik,A.I.
  TITLE     A transgenic insertion causing cryptorchidism in mice
  JOURNAL   Genesis 30 (1), 26-35 (2001)
   PUBMED   11353515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF346501.1, BC120741.1, AK039086.1 and CJ243198.1.
            
            On Jul 21, 2009 this sequence version replaced NM_080468.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF346501.1, BC120741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-856               AF346501.1         1-856
            857-2531            BC120741.1         826-2500
            2532-3387           AK039086.1         452-1307
            3388-3389           CJ243198.1         433-434
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 89.23 cM"
     gene            1..3389
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /note="relaxin/insulin-like family peptide receptor 2"
                     /db_xref="GeneID:140498"
                     /db_xref="MGI:MGI:2153463"
     exon            1..236
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..2407
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; G protein-coupled receptor 106; leucine-rich
                     repeat-containing G protein-coupled receptor 8; relaxin
                     receptor 2; G protein coupled receptor affecting
                     testicular descent"
                     /codon_start=1
                     /product="relaxin receptor 2 isoform 1 precursor"
                     /protein_id="NP_536716.2"
                     /db_xref="CCDS:CCDS19886.1"
                     /db_xref="GeneID:140498"
                     /db_xref="MGI:MGI:2153463"
                     /translation="MWLLLHVILLTEVKDFALADSSMVAPLCPKGYFPCGNLTKCLPR
                     AFHCDGVDDCGNGADEDNCGDTSGWTTIFGTVHGNVNKVTLTQECFLSQYPQHCYCRE
                     NELECVKADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSRYTELRKIYLQHNCITHIS
                     RRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQLAWLILDDNPITRISQKSFMGLNSL
                     FFLSMVGNRLEALPETLCAQMPQLNWVDLANNGIKYITNSTFLTCDSLTVLFLPRNQI
                     GFVPEKTFSSLKNLGELDLSSNMITKLPVHLFSDLHLLQKLNLSSNPLLYVHKNQFGS
                     LKQLQSLDLERIEIPNISTGMFQPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSS
                     EDLLANGILRVSVWVIAFITCVGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMGVY
                     LFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIV
                     FPFSNLRLGKRQTAVALASIWVVGFLIAAVPFTREDYFGNFYGKNGVCFPLHYDQAED
                     FGSRGYSLGIFLGVNLLAFLVIVISYVTMFCSIHKTALQTAEVRSHIGKEVAVANRFF
                     FIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSFFK
                     DKLKQLLHKHRRKPIFKVKKKSLSASIVWTDESSLKLGVLSKIALGDSIMKPVSP"
     exon            237..383
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            384..461
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            462..567
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            568..639
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            640..711
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            712..783
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            784..855
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            856..927
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            928..999
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1071
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1143
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1215
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1287
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1517
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1928
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2147
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..3389
                     /gene="Rxfp2"
                     /gene_synonym="Gpr106; Great; Lgr8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggactcccc agtgacaagc gtcggtgtcc cttcgtgcca aggaggtttc agctgagcat
       61 gctcagacac atgggaggca ccagactatc aaaactcctt ctgagaagca aggacacgtc
      121 tacgaactca atgctgcaaa tctacagctc tttcctctga caccggacac ctctcgagcg
      181 cacaccggcc gcaatgtggc tcctacttca tgtcatcctt ctgacagagg tcaaagattt
      241 tgcactggct gacagcagta tggtggctcc tctgtgcccc aaagggtatt ttccctgtgg
      301 gaatctcacc aaatgcttgc cccgagcctt tcactgcgat ggtgtggatg attgcgggaa
      361 tggtgccgac gaggacaact gtggtgacac tagtggatgg acaaccatat ttggcacagt
      421 ccatgggaat gtcaataaag tgacattgac acaggagtgc tttctcagcc agtatccaca
      481 gcactgttac tgcagagaaa atgaactgga atgtgtaaag gctgacttaa aagctgtgcc
      541 aaaggtttcc agcaacgtaa cattactatc tcttaagaaa aacaaaatcc acagacttcc
      601 agtcaaggtc ttcagcagat acacagaact cagaaagata taccttcagc acaactgcat
      661 cacacacatc tccaggagag cattccttgg attacataat ctacaaatac tgtatctcag
      721 ccataactgc attacctctc tcaggcctgg gatattcaaa gacttgcatc agcttgcttg
      781 gctaatttta gatgacaacc cgatcaccag aatctcacag aagtccttta tggggttaaa
      841 ctccttgttt ttcttgtcca tggtgggtaa ccggctcgag gcccttcctg aaacattgtg
      901 tgctcagatg cctcaactca actgggtgga tctggcaaac aatggaataa agtacataac
      961 gaactccacc ttcctaacgt gcgactcgct cacggttctg tttctgccta gaaatcaaat
     1021 tggttttgtt ccagagaaga cattttcttc attaaaaaat ttaggagaac tggacctgtc
     1081 tagcaatatg ataacaaaac tcccagtcca ccttttcagc gaccttcatc ttctccagaa
     1141 gctgaacctg tcatccaacc ctcttctgta tgtccacaag aaccagtttg gaagtctcaa
     1201 acaacttcag tctctagacc tggaaaggat agagattcca aacataagca caggaatgtt
     1261 ccagccaatg aagaaccttt ctcacattta tttgaaaacc tttcgatact gctcctatgt
     1321 cccccatgtc cgaatctgta tgccgtcgac tgatggtatt tcttcgtctg aggacctctt
     1381 ggctaacggt atcctcagag tgtctgtctg ggttatagct ttcattacct gcgttgggaa
     1441 tttccttgtc atagccgtga gatctctcat taaggctgag aatacaactc acgctatgtc
     1501 catcaaaatc ctttgttgtg ccgattgcct gatgggggtg tacctgttct ccgtgggcgt
     1561 ctttgacatc aagtaccgag ggcagtatca gaagtatgcg ctgctgtgga tggagagtgt
     1621 gccctgccgc ctgctgggct tcctggccac gctgtccaca gaggtctcgg tgctgctgct
     1681 gacattcctg acgctggaga agttccttgt catagtattc cctttcagca acctgcgcct
     1741 gggcaagcgc cagactgctg tggccctcgc cagcatctgg gtggtgggat ttctcatagc
     1801 ggccgttccg ttcaccagag aggattattt cggcaacttt tatgggaaaa atggagtctg
     1861 cttcccactt cattatgacc aagcagaaga ttttggaagt agagggtact cccttgggat
     1921 tttcctaggt gtgaacttgc tggctttcct cgtcatcgtg atttcctatg tcaccatgtt
     1981 ctgctccatt cataaaacag cccttcagac tgcagaagtg aggagccaca tcgggaagga
     2041 ggtggctgtt gcaaaccggt tcttttttat cgtgttctct gatgccatct gctggatccc
     2101 tgtgtttgtc gttaagatcc tgtctctcct tcaagtggag ataccaggca caatcacttc
     2161 ctggatcgtg gtttttttcc ttccggtgaa cagcgcctta aaccccatcc tctacactct
     2221 gacgacctcc ttttttaagg acaagttgaa acagttgctg cacaaacatc ggaggaaacc
     2281 catcttcaaa gttaagaaga aaagtttatc cgcttccatt gtgtggacag acgagtcttc
     2341 acttaaactt ggagtgttga gcaaaatagc ccttggggac agtataatga agccggtctc
     2401 cccgtagagg ctttggattg ctggactttg agggtactac ctaaaacaag gtacaatttg
     2461 gggaagatgg catctgagaa ggtttccatc ttggccagca gccacccact cagcaccagg
     2521 gacacaatgg aatggctgtt ggcccctgca ttccggtggc agctctagga cctgtggacc
     2581 aagctgagaa tagcatcgca tccttgccgg ctcagacctg gcatatacaa gtgaatccat
     2641 gtagactgat acagggtgga tctccaggca gtcagtactg cctgcctagc cctggatgcc
     2701 cacatgtaga cactgccatg gcttctctta caccgagttg cactgtctgt taagtatggg
     2761 catctatgac atcttattcc agtgtgacca ccaaggcaca aaatgaacat ctttgtcatt
     2821 gctctttcag tagcgaatga aaccgtcaac atcttattga tacttttgag agcttctgca
     2881 ggctgctgga atagcaactt tgaccgcagt tcttcgcacc actttatcgt gactagcatg
     2941 accagacaag caggagacat gctgtgggag actagagtca gtcgcctctt gacctctaag
     3001 ctcagaaaag ctgagatctt agatgatttt tttctaacat cacccacaga ggaaaggaaa
     3061 ttggaaaccc aaactttccc caaagattat aattctcaaa tgctttagaa caatatttct
     3121 atttctggtc agttttttct ctctctctct catttagcac aaagagttaa agggagagtt
     3181 aaaatataac tcaggacagc gggtctgatc tggggccatt tgtttagttg cacagatctc
     3241 cccatcccca cacaaaaaca ccagaaactt tggcttcttc ttcttctttt tttttttaaa
     3301 gtgaaaaatg tttatgaaga cttggacact tttatcctga aggtttaaaa ttgtgggggg
     3361 aaaatactat gaataaattt atattttgc
//
