LOCUS       NM_212452               5476 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus relaxin/insulin-like family peptide receptor 1
            (Rxfp1), mRNA.
ACCESSION   NM_212452 XM_355441
VERSION     NM_212452.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5476)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   2  (bases 1 to 5476)
  AUTHORS   Ng,H.H., Soula,M., Rivas,B., Wilson,K.J., Marugan,J.J. and
            Agoulnik,A.I.
  TITLE     Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule
            Agonist of the Human Relaxin Receptor, ML290 in Mice With
            Unilateral Ureteral Obstruction
  JOURNAL   Front Physiol 12, 650769 (2021)
   PUBMED   34305630
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5476)
  AUTHORS   Hu,M., Wang,Y., Liu,Z., Yu,Z., Guan,K., Liu,M., Wang,M., Tan,J. and
            Huang,L.
  TITLE     Hepatic macrophages act as a central hub for relaxin-mediated
            alleviation of liver fibrosis
  JOURNAL   Nat Nanotechnol 16 (4), 466-477 (2021)
   PUBMED   33495618
  REMARK    GeneRIF: Hepatic macrophages act as a central hub for
            relaxin-mediated alleviation of liver fibrosis.
REFERENCE   4  (bases 1 to 5476)
  AUTHORS   Patil,N.A., Rosengren,K.J., Separovic,F., Wade,J.D.,
            Bathgate,R.A.D. and Hossain,M.A.
  TITLE     Relaxin family peptides: structure-activity relationship studies
  JOURNAL   Br J Pharmacol 174 (10), 950-961 (2017)
   PUBMED   27922185
  REMARK    Review article
            Erratum:[Br J Pharmacol. 2017 Dec;174(24):4836. doi:
            10.1111/bph.14111.. PMID: 29235105]
REFERENCE   5  (bases 1 to 5476)
  AUTHORS   Petrie,E.J., Lagaida,S., Sethi,A., Bathgate,R.A. and Gooley,P.R.
  TITLE     In a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the
            LGR Family
  JOURNAL   Front Endocrinol (Lausanne) 6, 137 (2015)
   PUBMED   26441827
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5476)
  AUTHORS   Ortinau,S., Lin,F., Wade,J.D., Tregear,G.W., Bathgate,R.A. and
            Gundlach,A.L.
  TITLE     Insulin-relaxin family peptide signaling and receptors in mouse
            brain membranes and neuronal cells
  JOURNAL   Ann N Y Acad Sci 1041, 211-215 (2005)
   PUBMED   15956710
  REMARK    GeneRIF: expression of lgr7 in mouse brain membranes and neurons
REFERENCE   7  (bases 1 to 5476)
  AUTHORS   Siebel,A.L., Gehring,H.M., Reytomas,I.G. and Parry,L.J.
  TITLE     Inhibition of oxytocin receptor and estrogen receptor-alpha
            expression, but not relaxin receptors (LGR7), in the myometrium of
            late pregnant relaxin gene knockout mice
  JOURNAL   Endocrinology 144 (10), 4272-4275 (2003)
   PUBMED   12959965
REFERENCE   8  (bases 1 to 5476)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   9  (bases 1 to 5476)
  AUTHORS   Hsu,S.Y., Nakabayashi,K., Nishi,S., Kumagai,J., Kudo,M.,
            Sherwood,O.D. and Hsueh,A.J.
  TITLE     Activation of orphan receptors by the hormone relaxin
  JOURNAL   Science 295 (5555), 671-674 (2002)
   PUBMED   11809971
REFERENCE   10 (bases 1 to 5476)
  AUTHORS   Hsu,S.Y., Kudo,M., Chen,T., Nakabayashi,K., Bhalla,A., van der
            Spek,P.J., van Duin,M. and Hsueh,A.J.
  TITLE     The three subfamilies of leucine-rich repeat-containing G
            protein-coupled receptors (LGR): identification of LGR6 and LGR7
            and the signaling mechanism for LGR7
  JOURNAL   Mol Endocrinol 14 (8), 1257-1271 (2000)
   PUBMED   10935549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159281.3 and AC122462.5.
            
            On Oct 4, 2022 this sequence version replaced NM_212452.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.20980.1, AY509975.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC159281.3         93889-94023         c
            136-273             AC122462.5         27778-27915
            274-372             AC122462.5         46592-46690
            373-478             AC122462.5         50944-51049
            479-550             AC122462.5         54743-54814
            551-622             AC122462.5         62572-62643
            623-694             AC122462.5         65637-65708
            695-766             AC122462.5         65796-65867
            767-841             AC122462.5         66987-67061
            842-913             AC122462.5         70122-70193
            914-985             AC122462.5         72151-72222
            986-1057            AC122462.5         73348-73419
            1058-1129           AC122462.5         76007-76078
            1130-1201           AC122462.5         77176-77247
            1202-1431           AC122462.5         81093-81322
            1432-1842           AC122462.5         82666-83076
            1843-2061           AC122462.5         85199-85417
            2062-5476           AC122462.5         88473-91887
FEATURES             Location/Qualifiers
     source          1..5476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 34.94 cM"
     gene            1..5476
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /note="relaxin/insulin-like family peptide receptor 1"
                     /db_xref="GeneID:381489"
                     /db_xref="MGI:MGI:2682211"
     exon            1..135
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2363
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /note="relaxin receptor 1; leucine-rich repeat-containing
                     7; leucine-rich repeat-containing G-protein coupled
                     receptor 7; relaxin family peptide receptor 1"
                     /codon_start=1
                     /product="relaxin receptor 1 precursor"
                     /protein_id="NP_997617.1"
                     /db_xref="CCDS:CCDS17420.1"
                     /db_xref="GeneID:381489"
                     /db_xref="MGI:MGI:2682211"
                     /translation="MTSGPFFFCIFIIGKYFTLGSAQDVSCPLGSFPCGNMSRCLPQL
                     LHCNGVDDCGNRADEDHCGDNNGWSLQLDKYFANYYKLASTNSFEAETSECLVGSVPM
                     HCLCRDLELDCDEANLRAVPSVSSNVTVMSLQRNFIRTLPPNGFRKYHELQKLCLQNN
                     RIHSVSVSAFRGLRSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPLTF
                     YGLNSLILLVLMNNALTRLPDKPLCQHMPRLHWLDFEGNRIHNLRNLTFISCNNLTVL
                     VMRKNKINYLNEHAFTHLQKLDELDLGSNKIENLPPNIFKDLKELSQLNISYNPIQKI
                     EVNQFDCLAKLKSLSLEGIEISNIQQRMFRPLINLSHIYFKKFQYCGYAPHVRSCKPN
                     TDGISSLENLLASIIQRVFVWVVSAITCFGNIFVICMRPYIRSENKLHAMSIISLCCA
                     DCLMGVYLFVIGAFDLKFRGEYNKHAQPWMESVHCQFMGSLAILSTEVSVLLLTFLTL
                     EKYICIVYPFRCLRPRKCRTITVLIFIWIIGFIVAFAPLGNKEFFKNYYGTNGVCFPL
                     HSEDTGSTGAQIYSVVIFLGINLVAFIIIVFSYGSMFYSVHQSSVTVTEIQKQVKKEV
                     VLAKRFFFIVFTDALCWIPIFILKFLSLLQVEIPDSITSWVVIFILPINSALNPIIYT
                     LTTRPFKEMIHQLWHNYRQRRSVDRKETQKAYAPSFIWVEMWPLQEMSSGFMKPGAFT
                     DPCDLSLVSQSSRLNSYS"
     exon            136..273
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            274..372
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            479..550
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            551..622
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            623..694
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            695..766
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            767..841
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            842..913
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            914..985
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1057
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1129
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1201
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1431
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1842
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2061
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..5476
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2945..2950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /note="hexamer: AATAGA"
     polyA_site      2969
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
     regulatory      5444..5449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /note="hexamer: AATAAA"
     polyA_site      5476
                     /gene="Rxfp1"
                     /gene_synonym="Gm1018; Lgr7"
                     /note="major polyA site"
ORIGIN      
        1 agcacaacca ctgtgagctg tgcgcgactc atctcatcca agaccacgtt ttatctttca
       61 ttaatcagtt gctcagaaag aaggaaatga catctggtcc attcttcttc tgcatcttca
      121 ttattggaaa atatttcact ctcggaagtg cacaggatgt cagttgtccc ctcggctcct
      181 tcccctgtgg gaacatgagc aggtgcctgc ctcagctgct tcactgcaat ggtgtggacg
      241 actgcgggaa ccgagctgat gaggaccact gcggagacaa caatgggtgg tctctgcaac
      301 tggacaaata ttttgctaat tactataaac tggcttccac taactccttt gaggcagaaa
      361 cttccgaatg cttggttggc tctgtgccca tgcattgttt gtgccgagat ctagaacttg
      421 actgtgatga agccaattta cgagctgtcc catcagtttc ttccaatgtg actgtaatgt
      481 ccctgcagag gaacttcata agaacactcc ctcccaacgg cttcaggaag taccatgagc
      541 tgcagaagct gtgcctgcaa aacaatagga ttcactccgt gagcgtctct gccttcagag
      601 gactgcgcag cctcactaaa ctgtacctca gtcataacag aataaccttc ctaaagccag
      661 gagtttttga agatctccac agactggaat ggctgataat tgaagacaat cacctcagtc
      721 gaatttcccc actcacattt tacggactaa attctcttat tctcttagtg ctgatgaata
      781 atgccctcac ccgtttgcct gacaaacccc tctgtcagca catgccccgc ctgcactggc
      841 tggactttga aggcaaccgt atccataatt taagaaattt gacttttatt tcctgcaata
      901 atttaactgt tttggtaatg aggaagaaca aaatcaatta cttaaatgaa catgcattta
      961 cacacctcca gaaactagat gaattggatt taggaagtaa taagattgaa aatcttccac
     1021 cgaacatatt taaggatctg aaggagctgt cgcaattgaa tatttcttat aacccaatcc
     1081 agaaaattga agtaaatcaa ttcgattgtc ttgccaaact caagtctctc agccttgaag
     1141 gaatagaaat ttcaaatatc caacaaagga tgtttagacc gctcataaat ctctctcaca
     1201 tctattttaa gaaatttcag tactgtggat acgcaccaca tgtgcgcagc tgtaagccca
     1261 acacggatgg gatttcatct ctagagaacc tcttggcaag catcatccag agagtctttg
     1321 tctgggttgt atctgccatt acctgctttg gaaacatttt tgttatttgt atgcgaccat
     1381 acatcagatc tgagaacaag ctgcatgcca tgtcgatcat ttctctctgc tgtgctgact
     1441 gcctaatggg ggtgtatcta tttgtgattg gtgcctttga cctcaagttt cggggagagt
     1501 acaataagca cgcacagccg tggatggaga gtgttcattg tcagttcatg gggtcgttgg
     1561 ccattctgtc cacagaagta tccgttttac ttttaacatt tctgacattg gaaaagtaca
     1621 tctgcattgt gtatcctttt cggtgtttaa ggcctcgaaa atgcagaaca atcacggttc
     1681 tgattttcat ttggattatt gggtttatag tggcttttgc tccacttggc aataaggaat
     1741 ttttcaaaaa ctactatggc accaatggag tatgctttcc tcttcattca gaagacacgg
     1801 gaagtactgg agcccagatt tattcagtgg taatttttct tggtattaac ctggtggcat
     1861 ttatcatcat tgtgttctcc tatggaagca tgttttacag tgttcatcaa agctccgtaa
     1921 cagtaaccga aatacagaag caagtgaaga aggaggtggt tctcgccaaa cgctttttct
     1981 ttatcgtttt caccgacgcg ctgtgctgga ttcccatctt catactgaaa tttctttcac
     2041 tgcttcaggt ggaaatacca gattctatta cctcttgggt ggtgattttt attctgccta
     2101 tcaacagtgc tttgaaccca attatctaca cgttgaccac tagacctttc aaggaaatga
     2161 tccatcaact ctggcacaac tacagacaaa gaaggtctgt tgacaggaaa gagactcaga
     2221 aggcatatgc tccatcattc atctgggtgg aaatgtggcc cttgcaggag atgtcctctg
     2281 ggttcatgaa gccaggcgct ttcacagacc cctgtgatct gtcgctagtt tctcagtcat
     2341 ctagactcaa ttcttattcg taactggatc ttagtctcaa gaatgctgtg aagtgcttct
     2401 agagggattt gccgatatga agggatatgc cgacatctaa gacaagttag cttagagtgg
     2461 cccaaggtag ggacaggtag ctggtgttca tacagagaga agtaattatg ctgacaatgt
     2521 gtgtgtgtgt gtgtgtgtgt gtgtattatt acatatttgc atagctgatg aagggaaatc
     2581 tatttctagc atgcatttat gcacactgca tggaagtaaa gtgctgagca cacaacatag
     2641 agccttttta atctatatat tatgttgaac tattaacagc acaaactaag ctctaaagtg
     2701 ttatgatact caaagataac ggcatcagat aaaatgtttg gggtcagcga gatgctcggt
     2761 ggagaaaggt gattactaca caagcatggt gacctgagct cagtatctgg aacccacgga
     2821 agggtagagg gagaagagac tctggaaaac tgtcctctga cctccacttg cgcaccatgg
     2881 catgtgtgtg cacacatgca catcacacac acacacacgc aattttaaat gtggttgttt
     2941 gcaaaataga aacattgctg cttaatgaat cctttgcatt cttcattgag tcaccacact
     3001 tgagagtcaa cacagcatat ttattaaagg aggctttgtt gccagatgtc atggacagac
     3061 ctgtagtcct aacatgggag aggaaaaagc agaagggtca caagtttgag gccagcctca
     3121 gccacatcga aaaatcctgg ctctcacttg gaaaagcaga tcttacgata gggttcaatt
     3181 gctaaagtac ttgttgctcg cacacaacca actgagtctg aattcctagt acgaccatta
     3241 aaaagccagc tatggtagaa catactttta atcccagtgc tgaggaggta gagactggag
     3301 gaccctgaag gcttgttgcc cagctactga ggaagacacc tactgccagc ctctgactgc
     3361 cacacacatg tattactcat gcccatacac acacacacac acacacacac acacacacac
     3421 acaggaggga ggcaagcttt gttataaacc cagaaccagc atttgttctg tcactccata
     3481 ctgagttctc cagtggcttc gctctaagtt agtgttatca tgaggaaaca gaacaggacg
     3541 gtaggtagaa tattgcaaag gggtaagcca gagaagcagg actgatggca tttagatcaa
     3601 tgaaatccaa ttcagaaata agccttcatg tttcaattga ttgtttaaaa gggttacaag
     3661 acacatgtaa cctaacaaaa ttaaatcaag aagatataaa caacttatat ccacaacctg
     3721 caaacaaaac tttaagaaaa gctaacacta gtgctactca cactgttcct cagatgaaaa
     3781 tccaaggaac acgagcaaac acactctaca aacccaacac agccctgatc aaaaccttag
     3841 ggaaaaaaaa aaacaataaa agaacaaaac tatagatcaa ttctttgatc atagatgtaa
     3901 tggttctcaa taaacatcaa tgaatcaaag tcagggacag attacagatt gggaagattg
     3961 cacaccatga ctaagtttgt tttatccagg taggtaactt tgttaatcca ttacacaaat
     4021 aaataaatct aatataatac ataggataga tatcatgtga ttatttcaac acacacacac
     4081 acacacacaa aacacctttg aaaaaatttg acaaccttca taataaaagc cccgtggaaa
     4141 ctaagaattg aaggagccaa aactagccta ataaaggtca tataaaacaa agctgtaagt
     4201 aactgaacta aatgggaaat ggcatcacct ctaacacagg gaatgagata agagagcctg
     4261 atggagacct gggcagcatc atggccagca ggtaaaccat ccacatgagg tgaagaatga
     4321 aactcaaatc agcaccaatt ttgcaggtgc tggccctaaa tttccagaac ctgaccttgg
     4381 agtttatttt tcttacacat ttaagcaccg taaaacttta ggggaaggtt tccatgtgac
     4441 agttatcacg atgaaagtcc ctatagaagt agcaaagcat gtatgatctt tacaataaga
     4501 atggattgga ttggctgata aacagtgctc aggcctaagg aggaaggatt tgtaataatg
     4561 atcgattact gatggaggat acaaaggact ttgagcctcc tttgtaagtt gggttctact
     4621 cactgagaga cagactcagg attagggcct ccgcaatgct caaggtttgg caggggtggg
     4681 aggattcagg aaggcctgct ccacagccca gcaaaaggat cactaggttg tcggacaaca
     4741 cccatcccag cttcctaggc aaccggtgtc agttattttc ttcctttgaa gaaataggct
     4801 cgcatgttta atacgtctgg ttcctcaaac actttgtcct gtgcctatgt tcctgtttct
     4861 atgcagtgcc tcctacaagt gcccacttac ataattctta ttcagtatat ctttcaaagt
     4921 ggtagcttga aataaaaaac aaaaagaaat aaaaaatggc cataaatatg atggagaagt
     4981 taatatatcc ctattgtaga caactcagag ctacatttaa aagaccctaa agattccatt
     5041 agaaagttca cggacctcaa cattttccct ataatgttac tcaaaatata atctatacac
     5101 catgtgacct agccagtcaa ctcatgggca tacacccaaa gtactcagtg ttaacataac
     5161 ccagagatac ttgtatatcc atacttattg taatgttcac caaaaatcag gaaaaaggga
     5221 acagcctaga cattcattga aagaaaagac tttacatatt gacaaaatat tcagtagcct
     5281 tcctatatat ctgtaagaaa cctcatttga agtaagttca tcatgtgtac atagaaacac
     5341 tactgatttt tgtgtttatt ttgcatccta ttttttaaca ttgaaatctc cagttacatg
     5401 aatcttcctg aaaatgtctt tttttccccc tgctcggtgg ctgaataaag tttcattatg
     5461 tatatgttaa atgaaa
//
