LOCUS       NM_025614               1082 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RWD domain containing 1 (Rwdd1), mRNA.
ACCESSION   NM_025614 NM_028290
VERSION     NM_025614.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1082)
  AUTHORS   van der Weyden,L., Swiatkowska,A., Iyer,V., Speak,A.O. and
            Adams,D.J.
  TITLE     A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators
            of Pulmonary Metastatic Colonisation
  JOURNAL   G3 (Bethesda) 10 (6), 1869-1877 (2020)
   PUBMED   32245826
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1082)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1082)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1082)
  AUTHORS   Grotsch,H., Kunert,M., Mooslehner,K.A., Gao,Z., Struve,D.,
            Hughes,I.A., Hiort,O. and Werner,R.
  TITLE     RWDD1 interacts with the ligand binding domain of the androgen
            receptor and acts as a coactivator of androgen-dependent
            transactivation
  JOURNAL   Mol Cell Endocrinol 358 (1), 53-62 (2012)
   PUBMED   22406838
  REMARK    GeneRIF: data describe a new role for RWDD1 as androgen receptor
            (AR) coactivator; RWDD1 interacts with the androgen receptor in
            vitro and in vivo; AR ligand-binding dis sufficient for the
            interaction with RWDD1.
REFERENCE   6  (bases 1 to 1082)
  AUTHORS   Kang,N., Chen,D., Wang,L., Duan,L., Liu,S., Tang,L., Liu,Q., Cui,L.
            and He,W.
  TITLE     Rwdd1, a thymus aging related molecule, is a new member of the
            intrinsically unstructured protein family
  JOURNAL   Cell Mol Immunol 5 (5), 333-339 (2008)
   PUBMED   18954556
  REMARK    GeneRIF: Rwdd1 is a novel member of the IUP family.
REFERENCE   7  (bases 1 to 1082)
  AUTHORS   Kang,N., Duan,L., Tang,L., Liu,S., Li,C., Li,Y., Liu,Q., Hu,Y.,
            Cui,L. and He,W.
  TITLE     Identification and characterization of a novel thymus aging related
            protein Rwdd1
  JOURNAL   Cell Mol Immunol 5 (4), 279-285 (2008)
   PUBMED   18761815
  REMARK    GeneRIF: Rwdd1 is a thymus involution related protein that may
            indirectly affect androgen receptor signaling pathway.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC153962.3.
            
            On Apr 29, 2007 this sequence version replaced NM_025614.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011277.1, BY710578.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC153962.3         34848-35098
            252-317             AC153962.3         42327-42392
            318-448             AC153962.3         45341-45471
            449-592             AC153962.3         51897-52040
            593-725             AC153962.3         52674-52806
            726-788             AC153962.3         53265-53327
            789-1082            AC153962.3         57616-57909
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 18.85 cM"
     gene            1..1082
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /note="RWD domain containing 1"
                     /db_xref="GeneID:66521"
                     /db_xref="MGI:MGI:1913771"
     exon            1..251
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..910
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /note="DRG family-regulatory protein 2"
                     /codon_start=1
                     /product="RWD domain-containing protein 1"
                     /protein_id="NP_079890.1"
                     /db_xref="CCDS:CCDS23773.1"
                     /db_xref="GeneID:66521"
                     /db_xref="MGI:MGI:1913771"
                     /translation="MTDYGEEQRNELEALESIYPDSFTVLSESPPSFTITVTSEAGEN
                     DETVQTTLKFTYSEKYPDETPLYEIFSQENLEDNDVSDILKLLALQAEENLGMVMIFT
                     LVTAVQEKLNEIVDQIKTRREEEKKQKEKEAEEAEKKLFHGTPVTIENFLSWKAKFDA
                     ELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSDIQFLEDAGNNVEVDESLFQEM
                     DDLELEDGEDDPDYNPVAPGSDSSD"
     exon            252..317
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..448
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..592
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..725
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..788
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1082
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1055..1060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /note="hexamer: AATAAA"
     polyA_site      1081
                     /gene="Rwdd1"
                     /gene_synonym="0710001K08Rik; 2610002D06Rik;
                     2700069A07Rik; IH1"
                     /note="major polyA site"
ORIGIN      
        1 ggggatcggg cggcccgcgg agccggggct gtttctcagc aatccgtgcc aggcgtggct
       61 ccaggccttt ccactccgac tctgcgcgtg cgcccgcccg gcagccggcg gccgcggtgt
      121 ccgctgcagc ccgccgccag ggagtcgcgc cgatgcacgg gcaacaacgc gggccacgat
      181 gacagattac ggcgaggaac aacgcaacga gttggaggct ctggagtcca tctaccccga
      241 ctccttcaca gtgttatcag aaagcccgcc aagcttcacc attactgtga catcggaggc
      301 tggagaaaat gatgaaactg tccagactac tctcaagttt acatacagtg aaaagtaccc
      361 tgatgagact ccactttatg aaatattctc ccaggaaaat ctagaagaca atgatgtctc
      421 agacatttta aaattactgg cattgcaggc cgaggagaat ctcggcatgg tgatgatctt
      481 caccctcgtg acagctgttc aagaaaagtt aaatgaaata gttgatcaga tcaaaacaag
      541 aagagaggaa gaaaagaagc agaaagaaaa ggaagcagaa gaagcagaga agaaactgtt
      601 ccatggcacc cctgttacga ttgagaattt cttgagttgg aaggccaaat ttgatgcaga
      661 actcctggaa attaaaaaga aacgaatgaa agaagaggag caagcaggga aaaataaact
      721 aagtgggaaa cagttatttg aaacagatca caatcttgac acatctgata tccagttcct
      781 ggaggatgct gggaacaatg tggaggtgga tgagtcattg ttccaagaaa tggacgattt
      841 ggagctagaa gatggtgaag atgatcctga ctacaatcct gttgccccag ggagtgactc
      901 ctcagactga tggactgtcc cagtctccag agaggcgtga ccgccacagc atctgtggct
      961 atgctagagg gtttggatct tccttttgtt tttttctaag aaaaaacata tttttcagga
     1021 gaatattctt ctgataactt tcatcattga acttaataaa ctgcccataa aatttcaaat
     1081 at
//
