LOCUS       NM_001417243            2082 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus RuvB-like AAA ATPase 2 (Ruvbl2), transcript variant 2,
            mRNA.
ACCESSION   NM_001417243 XM_006540723
VERSION     NM_001417243.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2082)
  AUTHORS   Tian,J., Wen,M., Gao,P., Feng,M. and Wei,G.
  TITLE     RUVBL1 ubiquitination by DTL promotes
            RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ
            pathway and enhances radiation resistance in breast cancer
  JOURNAL   Cell Death Dis 15 (4), 259 (2024)
   PUBMED   38609375
  REMARK    GeneRIF: RUVBL1 ubiquitination by DTL promotes
            RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ
            pathway and enhances radiation resistance in breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2082)
  AUTHORS   Hattori,A., Takamatsu-Ichihara,E., Yamamoto,Y., Fujita,S.,
            Yamagata,K., Katsumoto,T., Machida,Y., Shinohara,H., Murakami,R.
            and Kitabayashi,I.
  TITLE     Genetic and chemical targeting of the ATPase complex TIP48 and 49
            impairs acute myeloid leukemia
  JOURNAL   Leukemia 37 (9), 1812-1829 (2023)
   PUBMED   37491463
REFERENCE   3  (bases 1 to 2082)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2082)
  AUTHORS   Zhang,R., Cheung,C.Y., Seo,S.U., Liu,H., Pardeshi,L., Wong,K.H.,
            Chow,L.M.C., Chau,M.P., Wang,Y., Lee,A.R., Kwon,W.Y., Chen,S.,
            Chan,B.K., Wong,K., Choy,R.K.W. and Ko,B.C.B.
  TITLE     RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in
            Macrophages via Regulating Histone H3K4 Trimethylation
  JOURNAL   Front Immunol 12, 679184 (2021)
   PUBMED   34276666
  REMARK    GeneRIF: RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in
            Macrophages via Regulating Histone H3K4 Trimethylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2082)
  AUTHORS   Zhu,D., Xu,L., Wei,X., Xia,B., Gong,Y., Li,Q. and Chen,X.
  TITLE     PPARgamma enhanced Adiponectin polymerization and trafficking by
            promoting RUVBL2 expression during adipogenic differentiation
  JOURNAL   Gene 764, 145100 (2021)
   PUBMED   32877748
  REMARK    GeneRIF: PPARgamma enhanced Adiponectin polymerization and
            trafficking by promoting RUVBL2 expression during adipogenic
            differentiation.
REFERENCE   6  (bases 1 to 2082)
  AUTHORS   Ruhl,D.D., Jin,J., Cai,Y., Swanson,S., Florens,L., Washburn,M.P.,
            Conaway,R.C., Conaway,J.W. and Chrivia,J.C.
  TITLE     Purification of a human SRCAP complex that remodels chromatin by
            incorporating the histone variant H2A.Z into nucleosomes
  JOURNAL   Biochemistry 45 (17), 5671-5677 (2006)
   PUBMED   16634648
REFERENCE   7  (bases 1 to 2082)
  AUTHORS   Mizuno,K., Tokumasu,A., Nakamura,A., Hayashi,Y., Kojima,Y.,
            Kohri,K. and Noce,T.
  TITLE     Genes associated with the formation of germ cells from embryonic
            stem cells in cultures containing different glucose concentrations
  JOURNAL   Mol Reprod Dev 73 (4), 437-445 (2006)
   PUBMED   16425234
  REMARK    GeneRIF: RuvBl2, which encodes an ATP-dependent DNA helicase, is
            specifically detected in the spermatocytes and spermatids of the
            adult testis as well as in primordial germ cells.
REFERENCE   8  (bases 1 to 2082)
  AUTHORS   Muzio,L., Soria,J.M., Pannese,M., Piccolo,S. and Mallamaci,A.
  TITLE     A mutually stimulating loop involving emx2 and canonical wnt
            signalling specifically promotes expansion of occipital cortex and
            hippocampus
  JOURNAL   Cereb Cortex 15 (12), 2021-2028 (2005)
   PUBMED   15800025
REFERENCE   9  (bases 1 to 2082)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   10 (bases 1 to 2082)
  AUTHORS   Gohshi,T., Shimada,M., Kawahire,S., Imai,N., Ichimura,T., Omata,S.
            and Horigome,T.
  TITLE     Molecular cloning of mouse p47, a second group mammalian RuvB DNA
            helicase-like protein: homology with those from human and
            Saccharomyces cerevisiae
  JOURNAL   J Biochem 125 (5), 939-946 (1999)
   PUBMED   10220587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151602.4.
            
            On Mar 1, 2023 this sequence version replaced XM_006540723.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.246588.1,
                                           SRR17784651.59128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC151602.4         155071-155583
            514-618             AC151602.4         156108-156212
            619-673             AC151602.4         159090-159144
            674-729             AC151602.4         160500-160555
            730-871             AC151602.4         160869-161010
            872-1001            AC151602.4         161682-161811
            1002-1068           AC151602.4         161919-161985
            1069-1175           AC151602.4         165214-165320
            1176-1269           AC151602.4         165420-165513
            1270-1393           AC151602.4         165659-165782
            1394-1488           AC151602.4         166087-166181
            1489-1607           AC151602.4         166267-166385
            1608-1727           AC151602.4         167657-167776
            1728-1857           AC151602.4         167950-168079
            1858-1972           AC151602.4         168258-168372
            1973-2082           AC151602.4         168459-168568
FEATURES             Location/Qualifiers
     source          1..2082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.3 cM"
     gene            1..2082
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /note="RuvB-like AAA ATPase 2"
                     /db_xref="GeneID:20174"
                     /db_xref="MGI:MGI:1342299"
     exon            1..513
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            514..618
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     CDS             607..1998
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /EC_number="3.6.4.12"
                     /note="isoform a is encoded by transcript variant 2;
                     ruvB-like 2; reptin; RuvB-like protein 2"
                     /codon_start=1
                     /product="ruvB-like 2 isoform a"
                     /protein_id="NP_001404172.1"
                     /db_xref="GeneID:20174"
                     /db_xref="MGI:MGI:1342299"
                     /translation="MATVAATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQ
                     GMVGQLAARRAAGVVLEMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTA
                     IAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGK
                     LTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAM
                     GSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQI
                     NAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITR
                     IRGTSYQSPHGIPIDLLDRLLIVSTSPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTR
                     IGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQDAF
                     LFNELKGETMDTS"
     exon            619..673
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            674..729
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            730..871
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1001
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1068
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1175
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1269
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1393
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1488
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1607
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1727
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1857
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1972
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2082
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /note="hexamer: TATAAA"
     polyA_site      2082
                     /gene="Ruvbl2"
                     /gene_synonym="mp47; p47"
                     /note="major polyA site"
ORIGIN      
        1 gcagaacctg aagcctcctt ccatcttaag agtagtctct tgtcccttcc ccccagggcc
       61 taggacgcct actccagccc cttcacaagg acacagaagt cacaggcgct tttcccagga
      121 cccaagactc ctccacgtaa ctcttttccc gtctgaaacg gagtttcggg gccccatcct
      181 cgcctgccct tcttggtcaa gggaccaacg ctgacgttct cacccttgtt ggccacctcc
      241 caggccacct cgaaaagcac tgcgttctcg gggtcgaatt catcctccca gtcttccaat
      301 cctggaagcg aggacacaga gagactgcgg ctgagaggca tggctactgc gggcagggga
      361 cttcgagcac caaaactgga aaccagagag atcggctggg aacgcagcag acttggtgac
      421 cggtagagtt agcgggtgtc ccaggggaag cttgcaaggc gctccgcttc ctattgcacg
      481 accgcacccc cgccccagag cgctccgact cagagatgac tggatgaccg ggagcctaga
      541 gaggataaag accgcgctcc tagccgattt ccgtttccgc tgaggcattg gcggttggtg
      601 tgcatcatgg caaccgtggc agccaccacc aaagtccctg agatccgaga tgtgacaaga
      661 atcgagcgaa tcggcgctca ctcccacatc cgggggctgg gactggatga tgccctggag
      721 ccaagacagg cttcccaggg aatggtgggg cagctagctg cccggcgtgc agctggcgtg
      781 gtgctggaga tgatccgaga agggaagatt gcagggcggg ccgtcctcat tgcaggccag
      841 ccaggcactg ggaagacagc cattgccatg ggcatggccc aggcactggg ccccgacaca
      901 ccattcacag ccatcgcagg cagtgagatc ttttctctgg agatgagcaa gactgaggct
      961 ctaacgcaag ccttccgccg ttccattggt gtccggatca aggaggagac agagatcatt
     1021 gaaggggagg tggtagagat ccagattgac cggccagcca caggcacggg atccaaggtg
     1081 ggcaaactga ccctcaagac cacggagatg gagaccatct acgacctggg taccaagatg
     1141 atcgagtccc tgaccaagga caaggtccag gccggagacg tcatcaccat tgacaaggcc
     1201 accggcaaga tctccaagct gggccgctct ttcacacgtg cacgggacta cgacgccatg
     1261 ggctcccaga ccaagtttgt gcagtgccca gacggagagc tgcagaaacg caaggaggtg
     1321 gtgcacaccg tgtccctcca tgagattgac gtcatcaact cccgtactca gggcttcctg
     1381 gccctcttct caggagacac aggggagatc aagtcagaag tccgagaaca gatcaatgca
     1441 aaggtggctg agtggagaga ggagggcaag gcagagatca ttcctggggt gctgttcatc
     1501 gacgaggtcc acatgctgga cattgagagt ttctctttcc tcaaccgggc cctggagagc
     1561 gacatggcgc ctgtcctcat catggccacc aaccgaggga tcacccggat ccgaggcacc
     1621 agctaccaga gtccccacgg catccccatc gacctgctgg accgcttgct cattgtatca
     1681 acgtcaccct acagtgagaa ggataccaag cagattctgc gcatccgctg tgaggaggaa
     1741 gatgtggaga tgagtgagga cgcctacaca gtgctgaccc gcattgggct cgagacctcc
     1801 ctgcgctatg ccatccagct catcacagcg gccagcctgg tgtgccggaa acgaaagggc
     1861 accgaggtgc aggtcgatga cattaagcgt gtatactccc tcttcctgga tgaatcccgc
     1921 tccacacagt acatgaagga gtaccaagat gccttcctct tcaatgagct caaaggcgaa
     1981 acaatggaca cctcctgagc tgacctgaca ccccagccct tcccacccca ttttctacaa
     2041 gttctaacac tgtgacttta tataaaatta ttgaaaactg ga
//
