LOCUS       NM_019685               1684 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RuvB-like AAA ATPase 1 (Ruvbl1), mRNA.
ACCESSION   NM_019685
VERSION     NM_019685.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1684)
  AUTHORS   Tian,J., Wen,M., Gao,P., Feng,M. and Wei,G.
  TITLE     RUVBL1 ubiquitination by DTL promotes
            RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ
            pathway and enhances radiation resistance in breast cancer
  JOURNAL   Cell Death Dis 15 (4), 259 (2024)
   PUBMED   38609375
  REMARK    GeneRIF: RUVBL1 ubiquitination by DTL promotes
            RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ
            pathway and enhances radiation resistance in breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1684)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1684)
  AUTHORS   Hattori,A., Takamatsu-Ichihara,E., Yamamoto,Y., Fujita,S.,
            Yamagata,K., Katsumoto,T., Machida,Y., Shinohara,H., Murakami,R.
            and Kitabayashi,I.
  TITLE     Genetic and chemical targeting of the ATPase complex TIP48 and 49
            impairs acute myeloid leukemia
  JOURNAL   Leukemia 37 (9), 1812-1829 (2023)
   PUBMED   37491463
REFERENCE   4  (bases 1 to 1684)
  AUTHORS   Chen,T., Yuan,Z., Lei,Z., Duan,J., Xue,J., Lu,T., Yan,G., Zhang,L.,
            Liu,Y., Li,Q. and Zhang,Y.
  TITLE     Hippocalcin-Like 1 blunts liver lipid metabolism to suppress
            tumorigenesis via directly targeting RUVBL1-mTOR signaling
  JOURNAL   Theranostics 12 (17), 7450-7464 (2022)
   PUBMED   36438486
  REMARK    GeneRIF: Hippocalcin-Like 1 blunts liver lipid metabolism to
            suppress tumorigenesis via directly targeting RUVBL1-mTOR
            signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1684)
  AUTHORS   Xu,Z., Qiao,S., Qian,W., Zhu,Y., Yan,W., Shen,S. and Wang,T.
  TITLE     Card9 protects fungal peritonitis through regulating Malt1-mediated
            activation of autophagy in macrophage
  JOURNAL   Int Immunopharmacol 110, 108941 (2022)
   PUBMED   35850054
REFERENCE   6  (bases 1 to 1684)
  AUTHORS   Muzio,L., Soria,J.M., Pannese,M., Piccolo,S. and Mallamaci,A.
  TITLE     A mutually stimulating loop involving emx2 and canonical wnt
            signalling specifically promotes expansion of occipital cortex and
            hippocampus
  JOURNAL   Cereb Cortex 15 (12), 2021-2028 (2005)
   PUBMED   15800025
REFERENCE   7  (bases 1 to 1684)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   8  (bases 1 to 1684)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1684)
  AUTHORS   Hawley,S.B., Tamura,T. and Miles,L.A.
  TITLE     Purification, cloning, and characterization of a profibrinolytic
            plasminogen-binding protein, TIP49a
  JOURNAL   J Biol Chem 276 (1), 179-186 (2001)
   PUBMED   11027681
REFERENCE   10 (bases 1 to 1684)
  AUTHORS   Bauer,A., Huber,O. and Kemler,R.
  TITLE     Pontin52, an interaction partner of beta-catenin, binds to the TATA
            box binding protein
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14787-14792 (1998)
   PUBMED   9843967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153694.1, AK132783.1 and AF100694.2.
            
            On Dec 30, 2016 this sequence version replaced NM_019685.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004718.1, AF100694.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC153694.1         2287-2319           c
            34-1666             AK132783.1         2-1634
            1667-1684           AF100694.2         1611-1628
FEATURES             Location/Qualifiers
     source          1..1684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.51 cM"
     gene            1..1684
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /note="RuvB-like AAA ATPase 1"
                     /db_xref="GeneID:56505"
                     /db_xref="MGI:MGI:1928760"
     exon            1..260
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1490
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /EC_number="3.6.4.12"
                     /note="Pontin 52; DNA helicase p50; 49 kDa TBP-interacting
                     protein; 49 kDa TATA box-binding protein-interacting
                     protein; RuvB-like protein 1"
                     /codon_start=1
                     /product="ruvB-like 1"
                     /protein_id="NP_062659.1"
                     /db_xref="CCDS:CCDS20336.1"
                     /db_xref="GeneID:56505"
                     /db_xref="MGI:MGI:1928760"
                     /translation="MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQEN
                     AREACGVIVELIKSKKMAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVY
                     STEIKKTEVLMENFRRAIGLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIG
                     LKTAKGTKQLKLDPSIFESLQKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAE
                     EYVPLPKGDVHKKKEIIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLR
                     GEINKVVNKYIDQGVAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFASNRG
                     NCVIRGTEDITSPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQTEGINISEEALN
                     HLGEIGTKTTLRYSVQLLTPANLLAKINGKDSIEKEHVEEISELFYDAKSSAKILADQ
                     QDKYMK"
     exon            261..347
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     exon            348..480
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     exon            481..632
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     exon            633..722
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     exon            723..872
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     exon            873..936
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1135
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1238
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1330
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1669
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1640..1645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /note="hexamer: AATAAA"
     polyA_site      1664
                     /gene="Ruvbl1"
                     /gene_synonym="2510009G06Rik; Pontin52; Tip49a"
                     /note="major polyA site"
ORIGIN      
        1 atattgatag gggcgggtcc aggagagcgg cctagtaacg gccgcgtggt aacccaggcg
       61 cctggcgtgc ggtagttcct accactccac gcaggttgtg ttcctagaca ctcggcaaaa
      121 tgaagattga ggaggtgaag agcaccacga agacgcagcg catcgcctcc cacagccacg
      181 tgaagggtct ggggctggac gagagcggcc tagccaagca ggcggcttcg ggtctcgtgg
      241 gccaggagaa cgcgagagag gcatgtggcg tcattgtaga attaatcaaa agcaagaaaa
      301 tggctggaag agctgtcttg ttggcggggc ctcctggaac tggcaagaca gccttggccc
      361 ttgctattgc tcaggagctg ggcagtaaag tccctttctg cccgatggtg ggtagcgagg
      421 tatactcaac tgagatcaaa aagacagagg tgctgatgga gaacttccgc agggccattg
      481 ggttgcggat aaaggagact aaggaggttt atgaagggga ggtgacagag ctcactccct
      541 gtgagacaga gaaccccatg ggtgggtacg gcaaaactat cagccatgtg atcatagggc
      601 tcaagactgc taaaggaacc aaacagctga agctggaccc cagtattttt gaaagtttgc
      661 agaaagaacg agtagaggct ggagatgtga tttacattga agcaaatagt ggagctgtga
      721 agaggcaagg caggtgtgac acctatgcca cagagtttga ccttgaagct gaagagtacg
      781 tccctttgcc aaagggagat gtgcacaaga agaaggaaat catacaggat gtgaccttgc
      841 atgacctgga tgtggctaat gcgcggcctc agggtgggca agatattctg tctatgatgg
      901 gccagttgat gaagccaaaa aagacagaga tcacagataa acttcgaggg gagatcaaca
      961 aagtggtgaa caaatacatt gaccagggtg tggccgagct ggtccctgga gtgctttttg
     1021 tcgatgaggt ccacatgctg gatatcgagt gctttaccta cctgcaccga gccctggagt
     1081 cctccatcgc ccccattgtc atctttgcat ccaaccgagg caactgtgtc atcaggggca
     1141 ctgaggacat cacttctcca cacggcatcc cgttggatct gctagacagg gtgatgatca
     1201 tcaggaccat gctatacacg ccacaggaga tgaagcagat cattaagatc cgagcccaga
     1261 cggaaggcat caacatcagc gaggaggcgc tgaaccacct cggggagatt ggcaccaaga
     1321 ccactctgag gtattcggtg cagctgctga ccccagccaa cctgctggca aagatcaatg
     1381 gcaaggacag cattgagaag gagcacgtgg aagagatcag cgagctcttc tatgacgcca
     1441 agtcctctgc caagattttg gctgaccagc aggacaagta catgaagtaa cgttgggatg
     1501 gaggcgcacc cagagacgga ccccacaccg tgcacagggg ctcgcctcaa gcatgctttg
     1561 cagtgttaca gtttctttgt aaattatcaa acctccatgg tggtttggaa ggatcccttc
     1621 cccacctagc ttgttttcta ataaaactga ataggttatt ttgatgataa aaaaaaaaaa
     1681 aaaa
//
