LOCUS       NM_001037709            5317 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus RUN and SH3 domain containing 2 (Rusc2), transcript
            variant 2, mRNA.
ACCESSION   NM_001037709
VERSION     NM_001037709.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5317)
  AUTHORS   Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H,
            Stuart JM and Gu W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5317)
  AUTHORS   Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F,
            Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits
            B, Panse C, Schlapbach R and Mansuy IM.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   3  (bases 1 to 5317)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY283112.1, BY283239.1, AK132170.1 and AI849772.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by
            NM_001037709.3.
            
            On Sep 27, 2013 this sequence version replaced NM_001037709.1.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166260.1, SRR10223970.6169.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                BY283112.1         2-91
            91-95               BY283239.1         19-23
            96-241              BY283112.1         96-241
            242-5295            AK132170.1         132-5185
            5296-5317           AI849772.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..5317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.03 cM"
     gene            1..5317
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /note="RUN and SH3 domain containing 2"
                     /db_xref="GeneID:100213"
                     /db_xref="MGI:MGI:2140371"
     exon            1..218
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            219..2309
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..4858
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /note="isoform a is encoded by transcript variant 2;
                     iporin; interacting protein of Rab1; RUN and SH3
                     domain-containing protein 2; AP-4 complex accessory
                     subunit RUSC2"
                     /codon_start=1
                     /product="AP-4 complex accessory subunit RUSC2 isoform a"
                     /protein_id="NP_001032798.1"
                     /db_xref="CCDS:CCDS18092.1"
                     /db_xref="GeneID:100213"
                     /db_xref="MGI:MGI:2140371"
                     /translation="MPLLELSRMDSPPKLTGETLIVHHIPLVHCQVPDRQCCGGAGGG
                     GGGTRANPFCPPELGLTQPDHDLGQADSLLYPSLHSAPGAPTGSSDSVKSRSRDGRGP
                     GAPKRHNPFLVQEGVGETGLGDLHDSSTGDSVTQQSFHLHSASQPFHLSSFQLPPSGP
                     GQGRPWGATHSRPGVVEGQEQDPATALGTQCSTSHCCRPELEAERMELDECGGHGGSG
                     SGGGTSDISGFSFEQEWKISSDESPRHPGRSGSGTQHCHCSSTSSQSEAADQSMGYVS
                     DSSCNSSDGVLVTFSTLYNKMHSSSRANLNSVPQSCSDSSFCSHADPGAFYLDLQPSP
                     AESRMSCESHHPENGDREEGCGCPHVSSPELDANCNAYHPHSEPCPAVADLTACFQSQ
                     ARLVVATQNYYKLVTCDLSSQSSPSPAGSSITSCSEEHTKISPPPGPCPDPDPNQPSE
                     YYLFQKPDIQPEEQEAVGSPAEAATAMGPTVLEGQVYTNTSPPNLNTGRQRSRSYDRS
                     LERSPPVRLGSLERMLSCPVRLSEGPAALAGPASPPRRVTSFAELAKGRKKAAGSGSP
                     PLRASVGDSSQEFSPIQEAQQDRAAPLDEGTRCSHSLPSLPLGPSLDLLGPEPWSTPV
                     CQGSQSSEMPLPSLRAAGQGPLAQLMDPGPAFSGSPATSHTQRDSRARADGGGTESRP
                     VLRYSKEQRPTTLPIQPFVFQHHFPKQLAKARALHSLSQLYSLSMPCSRAQQPAPLVI
                     STAQGPAPAPSGEPQPFTSQASGRGARNAGPEPETSRPSPLGSYSPVRSAGPFGSSTD
                     SSASTSCSPPPEQGTAADSVSPWSHTCPPTVRPATSQQPPKEDQKIPTLAEYRLHGTG
                     SLPPLGSWRSGFTRAESLVRGGGEGSMANRPNNANHLSPQALKWREYRRKNPLGPPGL
                     SGSLDRRPPEARLARRNPIFEFPGSFGTTSHLNCRLNGQISKPLSLTCPDLQDPFSLT
                     EKPPAEFCLSPDGNSEAISIDILQKKGLVKAVNTAVDLIVAHFGTSRDPGVKAKLGNS
                     SVSPNVGHLVLKYLCPAVQAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKV
                     LHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGFL
                     RAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGRQQRQHKELLRVSQDLLL
                     SAHSTLQLARSRGQEGPGDMDRVAPGERVKGVGASEGGEEDEEDAEEVAVVAGSSDHG
                     KWARGGQAGWWYQLMQSSQVYIDGTAEGSRFPRSSSSSSGSGSEKKKGVGSGGPSQAP
                     PPPPREGVVEGAEACPAPEEALGQERGWPFWMGSPPDSVLAELRRSREREGPVAPPTE
                     NEEGTAEPSPGGIKWGHLFGSRKSQREARPTNRLPSDWLSLDKSVFQLVAQTMGARRE
                     PEPRENLQESHPPAVPSKPPCEVQALCHHLATGPGQLSFHKGDILRVLGPARGDWLRC
                     SRGPDTGLVPLAYVTLTPTPSSPPGSSQN"
     exon            2310..2954
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3140
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3281
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3358
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3533
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3639
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3686
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..4518
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..4656
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
     exon            4657..5301
                     /gene="Rusc2"
                     /gene_synonym="mKIAA0375"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccgaacc aacgcgcctc gcggaggggc cgcgcgaggg ctgcccagag cggaccatcg
       61 gcaccacgcc tgcagggggc gccgggcgtt accaacgcgc ggagccgagg ggagcggagg
      121 ggagagccgg cgtgggctgc cgcgcgaccc ctggaggcgc cgggaggcgc gagacaacgc
      181 tgcccgcgcg gagagacgcg gccgaggcga gaagcaaggt gtcaagctct cctgatgaaa
      241 tgtgttgtgc cccactgggc tccaaaggca gtatctggcg ctgttgatgc ccttgttgga
      301 actttccaga atggatagcc cccctaagct gactggagag accctcatcg tccaccatat
      361 ccccttagtg cactgccaag tcccagacag gcagtgctgc gggggcgcag gcggaggcgg
      421 tgggggcaca agagccaatc ccttctgccc cccggagctg ggcctcaccc agcctgacca
      481 cgacctagga caagctgact cccttctgta ccccagcctg cactcagcgc caggggcacc
      541 tacagggtct tcagacagcg tcaaaagtag gagtcgggat ggacgaggcc ccggagctcc
      601 caagcgccat aatcccttct tggtgcagga aggtgtgggt gagacaggac tcggtgacct
      661 gcatgacagc agcactggtg acagtgtcac ccagcagtcc ttccacctgc acagcgccag
      721 ccagcccttc catctgtctt ctttccagct gccaccgtcc ggccccgggc agggcaggcc
      781 gtggggtgca actcacagtc gacctggagt ggtggagggg caggaacagg acccagcgac
      841 agccttgggg acccagtgca gcaccagcca ctgctgccgg ccagagctgg aagctgagag
      901 gatggagctg gacgagtgtg ggggacacgg ggggagtggc agtggagggg ggaccagtga
      961 tatctctggc ttttcctttg agcaagagtg gaagatcagt tccgacgaat ccccaagaca
     1021 ccctggacgc tccggctcgg gaacccagca ctgccactgc agtagtacgt ccagtcagtc
     1081 ggaggcggct gaccagtcca tgggctatgt cagcgactcc tcctgtaaca gctccgacgg
     1141 tgtgctagtc accttcagca ccctctacaa taagatgcac agcagctccc gtgccaacct
     1201 caactctgtc cctcagtcct gcagcgactc ttccttctgc agccacgcag accctggagc
     1261 cttctacctg gacctgcagc cctccccggc tgagtcgaga atgtcttgcg agtcccacca
     1321 ccctgagaac ggggacaggg aagagggctg tggctgtcct catgtctcat cccctgagct
     1381 cgatgccaac tgcaacgcct accacccaca ctctgagccc tgcccagctg tggctgacct
     1441 cacagcctgc ttccagagcc aggcccgcct tgttgtggcc acacagaatt actataaact
     1501 tgtcacctgt gacctgtcct cacagtcctc cccgagcccc gccggctcct ccatcacgag
     1561 ttgctctgaa gaacacacca agataagtcc tccaccaggc ccctgcccag acccagaccc
     1621 caaccagccc tctgagtatt acctcttcca gaagccagac atccagccag aggaacaaga
     1681 agcagtgggt tccccagcag aagcagcaac cgccatgggc cccactgtac ttgaagggca
     1741 ggtgtacacg aatacttccc cccccaacct caacactggc cggcagcgct ctcgaagcta
     1801 tgaccgtagc ctggagcgca gcccccctgt ccgcctgggc tcactagagc gcatgcttag
     1861 ttgcccagta cgattaagtg agggccctgc ggccctagct gggcctgcgt ccccacccag
     1921 aagggttacc tccttcgctg agttggccaa aggccggaag aaagctgcgg gctccggctc
     1981 cccaccactg cgggcgagcg ttggagattc ttcccaagag ttctcgccca tccaagaagc
     2041 ccagcaagac agggcagccc cacttgacga gggcactcga tgtagccata gcctgccgtc
     2101 cctgcccttg gggccaagct tggacctcct tggccccgaa ccctggtcca ccccggtttg
     2161 tcagggctcc cagtccagcg agatgccact tcctagcctc agagctgctg ggcagggacc
     2221 cttggcccag ctgatggatc ctgggcctgc tttctcgggg agcccagcca ccagccatac
     2281 ccagagggat tcgagagcta gagctgacgg gggtggcacc gaaagccgac ccgtccttcg
     2341 ctacagcaag gaacagaggc cgaccaccct accgatccag ccgttcgtgt tccaacatca
     2401 cttccccaag cagctggcca aggcccgggc cctgcacagc ctctcccagc tctacagcct
     2461 ctctatgccc tgcagccgcg cacagcagcc cgccccgctg gttatctcta ctgctcaagg
     2521 cccagcccca gctccctcag gagagccgca gccattcaca tcgcaggcct ctggcagagg
     2581 cgccagaaac gctgggcctg aaccagagac ctcgcggcca tcgcccctgg gaagctactc
     2641 cccagtccgg agtgccggcc cctttgggtc tagcaccgac tcctctgcct ctacctcctg
     2701 ctccccgcct ccagagcagg gcacagcagc cgacagtgta tcaccatgga gccatacctg
     2761 ccctcctact gtgcgccctg ccacatccca gcagccaccg aaggaggacc agaagattcc
     2821 gaccttggct gagtacaggc ttcatggcac aggaagttta ccccctctgg gctcctggag
     2881 atctggcttc acccgggcag agagtctggt tcgaggaggt ggcgagggca gcatggccaa
     2941 caggcccaac aatgccaacc acctgtcccc tcaggccctc aagtggcggg aatacaggag
     3001 gaagaaccca ttagggccac ctggtttgtc aggaagccta gatcgaaggc caccggaagc
     3061 tcggctggcc cgcaggaacc ccatctttga gttccctggt tctttcggca caaccagcca
     3121 tctgaattgc cggctgaatg gtcagatttc aaagccactg tcgctgacct gtcctgacct
     3181 gcaggacccc ttctccttaa ccgagaagcc tcccgctgag ttctgtctgt ctcccgatgg
     3241 caactcggag gccatatcca tcgacatact tcagaaaaaa gggctggtaa aagctgtcaa
     3301 caccgctgtg gaccttattg tggcccattt tggcacgagc cgggatcctg gcgtgaaggc
     3361 aaagctgggc aacagttctg tgagccccaa tgtcggccac ctggttctga agtacttgtg
     3421 ccctgcagtc caggccgtgc tcgaggacgg actcaaggcc ttcgtactgg atgtgatcat
     3481 cggccaacgt aaaaacatgc cttggagtgt ggtcgaggct tccacacagc taggcccatc
     3541 caccaaggtc ttgcatggcc tctacaacaa agtcagccag ttcccagaac tcaccagtca
     3601 caccatgcgc ttcaacgcct tcatcctcgg cctgctcaac atccggtctc tggagttctg
     3661 gtttaatcac ctgtataacc atgaagatat catccagacc cactaccagc cctggggctt
     3721 cctgcgggcc gcacacacgg tgtgcccagg cctcttcgag gagctgctgc tgttgctaca
     3781 gcccttagcc ctgctaccct tcagcctgga cttgctgttc cagcaccggc tgctgcagag
     3841 cgggcggcag cagcggcagc acaaggaact gctgcgtgtg tcccaggacc tgctgctgtc
     3901 tgcgcactca acactgcagt tggccaggtc ccgaggccag gagggccctg gagacatgga
     3961 cagggtggct cctggggaac gggtgaaggg ggtgggtgcc tcagaaggtg gagaagagga
     4021 cgaggaagac gcggaagagg tggcagtggt ggcggggagc tcggatcatg gcaagtgggc
     4081 ccgagggggt caggctggct ggtggtacca gctcatgcag agctcccagg tctacatcga
     4141 tggcaccgct gagggctcta gattccctcg cagcagcagc agcagcagtg gcagcggcag
     4201 tgagaagaag aaaggagtag gcagtggggg gccgtcccag gctccgcctc cgccgcctcg
     4261 ggaaggtgtg gtagaggggg cggaggcctg ccctgcccct gaggaggccc ttggccaaga
     4321 aaggggctgg cctttctgga tggggagccc ccctgactct gtgctagctg agctgaggcg
     4381 tagtcgagag agggaagggc ctgttgcccc accgacggaa aatgaggaag ggaccgcaga
     4441 gccttcacct gggggcatca agtggggaca tctctttggt tctcggaaat ctcagcggga
     4501 agcccggccc acgaacaggc tgccgtcgga ctggctgagc ctggacaagt ctgtgttcca
     4561 gctggtagca cagacgatgg gggcccgtcg ggagcccgag cccagggaga acctgcaaga
     4621 gtcacaccct ccagccgtgc cctccaaacc tccgtgcgag gtgcaggctc tgtgccacca
     4681 tctggccaca ggccctggac aactgagctt ccacaaagga gatatcctcc gggtgctggg
     4741 accggccaga ggagactggc tgcgctgcag ccgaggccct gacaccggct tggtacctct
     4801 ggcctatgtg acattgaccc caactccaag ttcacctcct gggagcagcc aaaactgagg
     4861 cttgtgcatg ctggtggcct cagggaccct cacatccccc gagactcaga gcctaagagt
     4921 ccttcccaag ccctcaggct tggctatgaa aagtatgctg agagctgggg ccccggatct
     4981 ctgtgctggc gcctgctccc catgctcagt attaattacc cctcctcagt gtcccagacc
     5041 tccacccggg gaaggagggg aggaacactc agtgctgggc tgcccggttt tcctggccca
     5101 gaggtcattg gtaggtccac taggccgact gataatgaag atggttaaca gtattggggc
     5161 cagagtccta agccccccat gctgtaaata gtctggtcgt cagagtaggg aggagcccgg
     5221 gcttctgttt atgtatgtat ttatttattt attatttatt tattacacct aataataaaa
     5281 aggtgctcag cctccaagcc aaaaaaaaaa aaaaaaa
//
