LOCUS       NM_028188               3799 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus RUN and SH3 domain containing 1 (Rusc1), transcript
            variant 1, mRNA.
ACCESSION   NM_028188
VERSION     NM_028188.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3799)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3799)
  AUTHORS   Li,C.L., Sathyamurthy,A., Oldenborg,A., Tank,D. and Ramanan,N.
  TITLE     SRF phosphorylation by glycogen synthase kinase-3 promotes axon
            growth in hippocampal neurons
  JOURNAL   J Neurosci 34 (11), 4027-4042 (2014)
   PUBMED   24623780
REFERENCE   3  (bases 1 to 3799)
  AUTHORS   MacDonald,J.I., Dietrich,A., Gamble,S., Hryciw,T., Grant,R.I. and
            Meakin,S.O.
  TITLE     Nesca, a novel neuronal adapter protein, links the molecular motor
            kinesin with the pre-synaptic membrane protein, syntaxin-1, in
            hippocampal neurons
  JOURNAL   J Neurochem 121 (6), 861-880 (2012)
   PUBMED   22404429
  REMARK    GeneRIF: Nesca functions as an adapter involved in neuronal
            vesicular transport
REFERENCE   4  (bases 1 to 3799)
  AUTHORS   MacDonald,J.I., Kubu,C.J. and Meakin,S.O.
  TITLE     Nesca, a novel adapter, translocates to the nuclear envelope and
            regulates neurotrophin-induced neurite outgrowth
  JOURNAL   J Cell Biol 164 (6), 851-862 (2004)
   PUBMED   15024033
  REMARK    GeneRIF: Data suggest that Nesca serves a novel, nuclear-dependent
            role in neurotrophin-dependent neurite outgrowth.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB871992.1, BC056360.1 and AK039664.1.
            
            [WARNING] On Apr 10, 2024 this sequence was replaced by
            NM_028188.3.
            
            On Apr 4, 2007 this sequence version replaced NM_028188.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039664.1, SRR7652917.36731.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BB871992.1         2-63
            63-1469             BC056360.1         1-1407
            1470-3778           AK039664.1         1398-3706
            3779-3799           BC056360.1         3306-3326
FEATURES             Location/Qualifiers
     source          1..3799
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.01 cM"
     gene            1..3799
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /note="RUN and SH3 domain containing 1"
                     /db_xref="GeneID:72296"
                     /db_xref="MGI:MGI:1919546"
     exon            1..97
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            98..1521
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3278
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /note="isoform 1 is encoded by transcript variant 1; RUN
                     and SH3 domain-containing protein 1; new molecule
                     containing SH3 at the carboxy-terminus; AP-4 complex
                     accessory subunit RUSC1"
                     /codon_start=1
                     /product="AP-4 complex accessory subunit RUSC1 isoform 1"
                     /protein_id="NP_082464.2"
                     /db_xref="CCDS:CCDS38486.1"
                     /db_xref="GeneID:72296"
                     /db_xref="MGI:MGI:1919546"
                     /translation="MLSPQRALLCNLNHIHLQHVSLGLHLSRRPELREGPLSTPPPPG
                     DTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGSSIENQQDPSQEEEAVSPSDPGCS
                     SSLSSCSDLSPDESPVSVYSRDLPGNEDANPQPSTLELGSPLAPAGPSTCSPDSFCCS
                     PDSCSGISSPPGPDLDSNCNALTTCQDLPSPGLEEEEDSGEQDLATSELSETEDGRID
                     AGKAEPSWKINPIWKIDTEKTEAGWKTIEDSDSGRKTDENTNSSLKTESGKLASCLNT
                     NSGSKIDAGKTDGGWRGDVSQEPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDW
                     LIVFSPDTELPPTGSLGGSLAPPREVTTFKELRSRSRAQPPPVPPRDPPAGWALVPPR
                     PPPPPVPPRRKKNRLGLQPIAEGLSEEGRAASPRAGEEASASQEPEEPRAHAVAGPSL
                     FPRPPVFRFSADGRPLLEGGGAGAPGSLLFTPLTGWSNSRLRLLGAASPPEEQLLPVR
                     LSPVGAYSPPTRGALPCLASPELALLLSPLFPRSSTFPAAAPLPRQVPAPPLPTPPCP
                     PTAPRWTRRPPPPPRQLRSSWSFAGVPGAQRLWMAEAQSGTGQLQEQKKGLLIAVSAS
                     VDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLIT
                     GQRRSSPWSVVEASVKPGSCTHSMGSLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLE
                     LWFSSLQEDAGLLSLLYLPTGFFSLARGSCPSLATELLLLLQPLSVLTFHLDLLFEHH
                     HHLPVGLQQAPAPSCPPPALQQTMQAVLHWGERLAQSLRGTSGESTTDSSTPSARPPA
                     GSWWDQLTQASRVYASGGTEGFPLLRWGPRRHGTTAEAAQEAPPPTEQTTPGRSVWLG
                     RLFGVPGCPSETESGAFKSRRPSSWLPPTVSVLALVKRGTPPETPPEALVSSPGSVVQ
                     ADRAVRALCDHTAAGPDQLSFQRGELLRVIATVDEDWLRCGRDGVEGLVPVGYTSLVL
                     "
     exon            1522..1932
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2031
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2108
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2283
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2389
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2436
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2986
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3109
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3783
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3762..3767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rusc1"
                     /gene_synonym="2210403N08Rik; NESCA"
                     /note="putative"
ORIGIN      
        1 acagtgggtt ttgccggtgc ccctcccctc cgctctgttc cctgctgggc ggggacgcag
       61 acgagcccaa ggccggagcg attccaggag gactgcggtc tgcatctaca ctgtcaggta
      121 ggtggatgtg agacgctgga tcctcttggt tctctgaaag ccatacgtcg tcctccctcg
      181 gcaccatgct gtcccctcag cgggctttac tctgcaacct caatcacatc catctccagc
      241 atgtctccct aggcctgcac ttgtcccgcc gtcctgaact acgagagggg cctctgagca
      301 cacccccgcc cccgggagac accgggggca aggaaagcag ggggccctgc agcgggaccc
      361 ttgtggatgc caactccaac agtccagctg tgccctgtag atgctgccag gagcacgggt
      421 ccagcataga aaatcagcag gacccttccc aggaggaaga ggctgtttcc ccttcagatc
      481 caggatgctc ttcctctctc agctcctgct cagaccttag ccctgatgag tctccagtgt
      541 cagtctactc gcgagacctg cctggtaatg aggatgcaaa ccctcagcct agcaccttgg
      601 agctgggctc tcctctggct ccagcgggcc ctagcacctg ctctccagac agtttctgtt
      661 gctctcctga ttcttgctct ggaatatctt ctccacctgg acctgacctg gactcgaact
      721 gcaacgccct gaccacctgc caggacctac cttccccagg cttggaggaa gaggaagaca
      781 gtggggaaca ggatcttgct acctctgagc tctcagagac cgaagatggg agaatcgacg
      841 cagggaaagc agagcccagt tggaaaatta accccatttg gaaaattgac acagagaaaa
      901 ctgaagctgg gtggaaaacc atcgaggaca gtgactctgg tcggaaaaca gacgaaaata
      961 caaactcgag cttaaaaacg gaatctggga aattggcttc ttgtttgaac accaattctg
     1021 gttcgaaaat agatgcaggg aaaactgatg ggggatggag aggtgacgtc agccaggagc
     1081 cggtgcccca tcggacaatc acgtccttcc atgagctggc ccagaagcgc aagcggggtc
     1141 cagggctgcc ccttgtgccg caggccaaga aagatcgcag cgactggctc atagtcttct
     1201 cgcccgacac tgagctcccg ccgactgggt ccttgggagg ttctttggca cctccccgag
     1261 aagtcaccac cttcaaggaa ctccggtcga gaagccgagc ccagcctccg ccagtcccgc
     1321 cccgggaccc cccggctggg tgggctttgg tcccgcctcg accgcctccc ccacccgtcc
     1381 ctccgcggag gaagaaaaat cgacttgggc tgcagcctat tgcagagggg ctgtcggagg
     1441 agggcagggc ggccagcccc cgggctggtg aggaggcatc cgcctcgcag gagccggagg
     1501 aaccgcgcgc gcacgccgtg gccggtccct cgctattccc tcggcccccg gttttccggt
     1561 tctcggccga cgggcgcccc ctgttggagg gtgggggcgc gggcgcaccc gggtccctgc
     1621 tctttacgcc tctgaccggg tggtccaatt cccggctccg gctgctgggg gcagcgagtc
     1681 ccccggagga gcagctcctg cctgtgcgcc tatccccagt gggagcttat tctcctccca
     1741 ctcggggggc cttgccttgc ctggccagcc ccgaactggc actgctgcta tccccgctct
     1801 ttcccagaag tagcaccttc cccgccgcgg cgcccctacc ccgccaggtt cccgcccccc
     1861 cgctgccaac accaccgtgt ccgccgaccg cccctcgctg gaccagaagg ccaccacctc
     1921 cgcccaggca actgcgcagt tcctggtcgt ttgccggtgt tcccggggct cagcggctgt
     1981 ggatggcaga agcccagagt gggactggcc agctgcagga gcagaagaaa ggtctcctga
     2041 tagctgtcag cgcttcagtg gacaaaatca tctcgcattt tggggctgct aggaacttgg
     2101 ttcagaaggc tcaattgggg gatagccgac tgagcccaga tgtggggcat ctggtattga
     2161 ccaccctctg cccggccctc catgctttgg tggctgatgg gctgaagcca ttccggaagg
     2221 acctcatcac tggacagcgg aggagcagcc cttggagtgt ggtggaggca tctgtgaaac
     2281 caggttcctg cacacattcg atgggatctc tgtacagcca ggtcagccga ctggcccctc
     2341 tgagtagcag ccgcagccgc ttccacgcct tcatcctggg cctcctcaac accaaacagt
     2401 tggaactgtg gttttccagc ctccaggagg atgcaggcct actgtccctc ttgtatctgc
     2461 ccaccggatt cttctccctg gctcgtggta gctgtccatc cctggctaca gagctgctgc
     2521 ttctgctgca gccactgtcg gtgctcacct tccacctgga cctgctcttt gagcaccacc
     2581 accacctacc cgtgggcctg cagcaggctc ctgccccttc atgcccccct cccgccctcc
     2641 agcagactat gcaggctgtg ctgcactggg gggaacgttt ggctcagagt ctccgaggga
     2701 cttcagggga gagcactaca gactcttcaa ccccttcagc acgccctcca gcaggcagtt
     2761 ggtgggatca gctgacccag gcttctcggg tctatgcctc tggaggcact gagggcttcc
     2821 ctcttctccg gtggggaccc aggcgtcatg gaactacagc tgaggcggca caggaggcac
     2881 ctccgcccac ggaacaaacc acaccaggca gaagcgtgtg gttggggcgg ctatttggtg
     2941 tgcctgggtg cccctcagaa actgagagtg gcgccttcaa gtctaggaga ccatccagct
     3001 ggttgccccc aacagtaagt gtgctggctc tggtgaagag ggggacacct cctgagactc
     3061 ctcctgaggc gcttgtgagc tcaccaggca gcgtggtgca ggctgacagg gcagtccggg
     3121 ctctctgtga ccacactgct gcaggacctg accaattgag cttccagcgt ggggaattgc
     3181 ttcgagtcat tgccacagtg gatgaagact ggcttcgctg tgggcgggat ggtgtggagg
     3241 gactggtgcc cgtgggatac acttcccttg ttctgtagct cagagcctgc ctcctttccc
     3301 taggctcatg aatattgttc atgtgaactt accatgccag gggcacttgt ccttctgcaa
     3361 acccacattt cttcccatat ctatttctgt ggacagttaa aaataaactt tccttcctcc
     3421 ctcaccaccc acctgtgagg tgaaatctgc tcttgcaaat atgtagaagg gacttcctgt
     3481 ccacaggatt cctcttctct atctgcacaa gagaacactg tccttcctat ctgcaagtca
     3541 gtatctatgc cacctcctcc ttcacccaag tggactgtgc cagtatagta cacatgcctt
     3601 tgcccccaac cccgcaggac ctatggtctc ctcactctgt ctctagccct tcttgcctgt
     3661 atttaagacg tactcctgct gtgctaagtg ctggacagaa gcctggacac ccctggtggg
     3721 tgggcctgtg gtgttggtct gcctctttcc ttctttgtcc caataaaacg tgggagttga
     3781 aaaaaaaaaa aaaaaaaaa
//
