LOCUS       NM_001369050            3612 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus runt related transcription factor 3 (Runx3),
            transcript variant 2, mRNA.
ACCESSION   NM_001369050
VERSION     NM_001369050.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3612)
  AUTHORS   Zhang,J., Gao,J., Zeng,X., Wang,Z., Chen,C., Rong,C., Li,S.,
            Cai,L., Wang,L., Zhang,L. and Tian,Z.
  TITLE     A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast
            differentiation during early enamel formation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (2), 167570 (2025)
   PUBMED   39547518
REFERENCE   2  (bases 1 to 3612)
  AUTHORS   Niibori-Nambu,A., Wang,C.Q., Chin,D.W.L., Chooi,J.Y., Hosoi,H.,
            Sonoki,T., Tham,C.Y., Nah,G.S.S., Cirovic,B., Tan,D.Q.,
            Takizawa,H., Sashida,G., Goh,Y., Tng,J., Fam,W.N., Fullwood,M.J.,
            Suda,T., Yang,H., Tergaonkar,V., Taniuchi,I., Li,S., Chng,W.J. and
            Osato,M.
  TITLE     Integrin-alpha9 overexpression underlies the niche-independent
            maintenance of leukemia stem cells in acute myeloid leukemia
  JOURNAL   Gene 928, 148761 (2024)
   PUBMED   39002785
REFERENCE   3  (bases 1 to 3612)
  AUTHORS   Yano-Sakamoto,K., Kitai,Y., Toriu,N., Yamamoto,S., Mizuta,K.,
            Saitou,M., Tsukiyama,T., Taniuchi,I., Osato,M. and Yanagita,M.
  TITLE     Expression pattern of Runt-related transcription factor (RUNX)
            family members and the role of RUNX1 during kidney development
  JOURNAL   Biochem Biophys Res Commun 722, 150155 (2024)
   PUBMED   38795454
REFERENCE   4  (bases 1 to 3612)
  AUTHORS   Xiao,L. and Ye,G.
  TITLE     RUNX3 alleviates mitochondrial dysfunction and tubular damage by
            inhibiting TLR4/NF-kappaB signalling pathway in diabetic kidney
            disease
  JOURNAL   Nephrology (Carlton) 29 (8), 470-481 (2024)
   PUBMED   38735649
  REMARK    GeneRIF: RUNX3 alleviates mitochondrial dysfunction and tubular
            damage by inhibiting TLR4/NF-kappaB signalling pathway in diabetic
            kidney disease.
REFERENCE   5  (bases 1 to 3612)
  AUTHORS   He,Y., Wasti,B., Yuan,Y., Chen,Z., Duan,W., Jia,J., Xiao,B.,
            Zhang,X., Li,J., Zeng,Q., Ma,L., Liu,S. and Xiang,X.
  TITLE     Combination of androgen and estrogen improves asthma by mediating
            Runx3 expression
  JOURNAL   Int J Med Sci 21 (6), 1003-1015 (2024)
   PUBMED   38774754
  REMARK    GeneRIF: Combination of androgen and estrogen improves asthma by
            mediating Runx3 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3612)
  AUTHORS   Bae,S.C., Takahashi,E., Zhang,Y.W., Ogawa,E., Shigesada,K.,
            Namba,Y., Satake,M. and Ito,Y.
  TITLE     Cloning, mapping and expression of PEBP2 alpha C, a third gene
            encoding the mammalian Runt domain
  JOURNAL   Gene 159 (2), 245-248 (1995)
   PUBMED   7622058
REFERENCE   7  (bases 1 to 3612)
  AUTHORS   Wijmenga,C., Speck,N.A., Dracopoli,N.C., Hofker,M.H., Liu,P. and
            Collins,F.S.
  TITLE     Identification of a new murine runt domain-containing gene, Cbfa3,
            and localization of the human homolog, CBFA3, to chromosome
            1p35-pter
  JOURNAL   Genomics 26 (3), 611-614 (1995)
   PUBMED   7607690
REFERENCE   8  (bases 1 to 3612)
  AUTHORS   Calabi,F., Rhodes,M., Williamson,P. and Boyd,Y.
  TITLE     Identification and chromosomal mapping of a third mouse runt-like
            locus
  JOURNAL   Genomics 26 (3), 607-610 (1995)
   PUBMED   7607689
REFERENCE   9  (bases 1 to 3612)
  AUTHORS   Avraham,K.B., Levanon,D., Negreanu,V., Bernstein,Y., Groner,Y.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Mapping of the mouse homolog of the human runt domain gene, AML2,
            to the distal region of mouse chromosome 4
  JOURNAL   Genomics 25 (2), 603-605 (1995)
   PUBMED   7790005
REFERENCE   10 (bases 1 to 3612)
  AUTHORS   Levanon,D., Negreanu,V., Bernstein,Y., Bar-Am,I., Avivi,L. and
            Groner,Y.
  TITLE     AML1, AML2, and AML3, the human members of the runt domain
            gene-family: cDNA structure, expression, and chromosomal
            localization
  JOURNAL   Genomics 23 (2), 425-432 (1994)
   PUBMED   7835892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731718.30.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF155880.1, BY729976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               AL731718.30        92913-93424
            513-669             AL731718.30        95650-95806
            670-774             AL731718.30        103599-103703
            775-924             AL731718.30        111477-111626
            925-3612            AL731718.30        115668-118355
FEATURES             Location/Qualifiers
     source          1..3612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.19 cM"
     gene            1..3612
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /note="runt related transcription factor 3"
                     /db_xref="GeneID:12399"
                     /db_xref="MGI:MGI:102672"
     exon            1..512
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1457
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription factor AML2/CBFA3; CBF-alpha-3; PEA2-alpha
                     C; PEBP2-alpha C; oncogene AML-2; acute myeloid leukemia 2
                     protein; core-binding factor subunit alpha-3; SL3-3
                     enhancer factor 1 alpha C subunit; SL3/AKV core-binding
                     factor alpha C subunit; polyomavirus enhancer-binding
                     protein 2 alpha C subunit; core binding factor alpha 3;
                     runt domain, alpha subunit 3"
                     /codon_start=1
                     /product="runt-related transcription factor 3 isoform 2"
                     /protein_id="NP_001355979.1"
                     /db_xref="CCDS:CCDS89843.1"
                     /db_xref="GeneID:12399"
                     /db_xref="MGI:MGI:102672"
                     /translation="MRIPVDPSTSRRFTPPSTAFPCGGGGGGKMGENSGALSAQATAG
                     PGGRTRPEVRSMVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDV
                     PDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTN
                     PTQVATYHRAIKVTVDGPREPRRHRQKIEDQTKAFPDRFGDLRMRVTPSTPSPRGSLS
                     TTSHFSSQAQTPIQGSSDLNPFSDPRQFDRSFPTLQSLTESRFPDPRMHYPGAMSAAF
                     PYSATPSGTSLGSLSVAGMPASSRFHHTYLPPPYPGAPQSQSGPFQANPAPYHLFYGA
                     SSGSYQFSMAAAGGGERSPTRMLTSCPSGASVSAGNLMNPSLGQADGVEADGSHSNSP
                     TALSTPGRMDEAVWRPY"
     exon            513..669
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            670..774
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            775..924
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..3612
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3588..3593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /note="hexamer: AATATA"
     polyA_site      3607
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /note="major polyA site"
ORIGIN      
        1 gccacttgat tctctaggat ccgggctggg gccgcggccg ccgagtccgt ggggcggccg
       61 cgcgcgccgg atgcgggact agcgggcgcg cggccgaccg tcggggcgca ccccctcccc
      121 cggcgccgcc cctcccccca ccccccacgc tggccgggcc ccgagccgcc gccttcccgc
      181 ctcccgcttc ccgcggctgc ggccgcccgc gccctgacgg ccgcggcatg cgtattcccg
      241 tagacccgag caccagccgc cgcttcactc ccccctccac ggccttcccc tgcggcggcg
      301 gcggcggcgg caagatgggc gagaacagcg gcgcgctaag cgcgcaggca accgcgggcc
      361 ccggcggccg cacccggccc gaagtgcgct cgatggtgga cgtgctggcc gaccacgcgg
      421 gagagctcgt gcgcaccgac agccccaact tcctctgctc cgtgctgccc tcgcactggc
      481 gctgcaacaa gacgctgccg gtcgccttca aggtggtggc cctgggggat gtgccggatg
      541 gaacggtggt gaccgtgatg gccggcaatg atgagaacta ctccgccgag ctgcgcaacg
      601 cttccgctgt catgaagaac caagtggcca ggttcaacga ccttcgattc gtgggccgca
      661 gtgggcgagg gaagagtttc acgctcacaa tcaccgtgtt caccaaccct acccaagtgg
      721 ctacctacca ccgagccatc aaggtcactg tggatggacc ccgggaaccc cgacggcacc
      781 ggcagaagat agaagaccag accaaggcct tccccgaccg ctttggagac ctgcgcatgc
      841 gtgtaacacc aagcacaccc agcccccgtg gctctctcag caccacgagc cacttcagca
      901 gccaggccca gaccccaatc caaggctcct cagacctgaa ccccttctcc gacccccgcc
      961 agtttgaccg ctccttccct acgctgcaga gcctcacaga gagccgcttc ccggacccca
     1021 ggatgcacta cccgggagcc atgtctgccg ccttccccta cagcgccaca ccatcgggca
     1081 ccagcctggg cagcctgagc gtggcgggca tgccggccag cagccgcttc caccacacct
     1141 acctccctcc gccctacccc ggggccccac agagccagag cgggcccttt caggccaacc
     1201 ccgcgcccta ccacctcttt tacggcgcct cctccggctc ctaccagttc tccatggcag
     1261 ccgcgggagg tggtgagcgc tcgcccaccc gcatgctgac ctcctgcccc agcggcgctt
     1321 cggtgtcagc aggcaacctc atgaacccca gcctgggcca ggctgatggc gtggaagccg
     1381 acggcagcca cagcaactcg cccacggccc tgagcacgcc gggccgcatg gacgaggccg
     1441 tgtggcggcc ctactaagca ccctggagac tctcgggcca gccgaatcct tccctccagc
     1501 ccgagactac aagaagaaac agactttggc ctggtcccag gggccagagc tggcagtggc
     1561 tcccagagct ctgtccagcc acaagtttga gcagaggatg tggggacctc ccacaggaca
     1621 ctgctccaac ccaaatcaat gtcctctcta gctgtgcatc ccaaacccac ctcttgtctc
     1681 cagccatgcc caggatcaat tctagaatca gaggctaccc ctgcctgtgt ggggagggcc
     1741 tttgctggca agagaagctc aggctcagag atgtctggac tttctctccc tccctctctc
     1801 tctctctctc tctctctctc tctctctctc tctctctctc tctcacacac acacacacac
     1861 acacacacac acacacacac acacactgcc ctggggacca tccatgccca tcaaaccaaa
     1921 gggaaactca aacccctggg aaggtttcac tcccctgaag agagagagga gccatatctc
     1981 tctttcacat acacacacac acacacacac acacacacac acacacacgt ccccaacttg
     2041 acttccccct ggtcccaggc cagcagcccc tgatcagtcc taacttacct gaaaacacca
     2101 ggccccagag cagactcatc cggggtggca ggtccctaaa gcaaggaagg cctcacactg
     2161 tccagcatac tccagcctga attgcctact gggttctcag ggggcagaca ggtcctggcc
     2221 gaaagtctta ccatggggat cgatagggtg gttagccctg cgcactaggt ccagccaatc
     2281 tgtgctctgg gccttgcctc ccaggccaca gtcctgctcc caacttgttt gtccctagaa
     2341 gcagacaact ttgaaccaaa agcatctcag tcaagcatct aaaacagggg gcagtctgtg
     2401 tatacaagag cccacctcct gctgtgtgat gtcatcagga cacccccacc ctcaccccac
     2461 caccagggtc ctgacttcac attcttcaca gaaggggaca agacctccag gaggccctgt
     2521 ggagtctctg gtgaggtgtg cgatggcaga gcagcatcca agcagagatc agatgtcctc
     2581 ttcagtctgt gggcgggcga ttgtcagtgg gattggttaa aaagctctta ccagagctgg
     2641 ctggcccacg gctggttttt caaactgagt gagccccgta gtgatggcct ctgccttgtg
     2701 cttggccttc cccattgcct gcacctgaaa cagccaccca catacacact ctggtaggtc
     2761 agggggtccc cgacaatcct ggacaatcct gagcagaata cctcctgtta cagtgtctct
     2821 tgtcccaccc ttactggagg aaaaaaaaaa aaaaaactct atctcttgga agtagctgag
     2881 gtaaccttcc agctccctgc acccagaggg ggccttctca cctcttctca ggaagcagct
     2941 acgacccatt gccctcctac ctgcttcgct actggtccat ggtacagact gttccagatc
     3001 accaagaaag gtactttcag gatcccagtg cctagcactg ggtaagctac cccagacaac
     3061 tagccttcct tatacccaaa cgctggtcgg tggaaataga aagtcacccc tcccccatcg
     3121 cctctttctc atccctgatt aacagtgaag tttgagtctt gtcgtgagtc ctacagtgag
     3181 cacaggcagc tggggctaat aaaaaaagaa gaagaagaag aaaaaggaga ggagagaaaa
     3241 aaaacaaaaa tgaaaggaaa agggtcctta tttgcaaggc tactttaaag tgctacttga
     3301 aagcacaggc tagacagaaa gcacaaggaa cctagggggt tgatacaatg ttactgtaat
     3361 tgtgtgggtg ggtgtcatcc tttgtgacat tgttaccctg aggtatactc cctgcagtga
     3421 gctggtcttc ctgaagtggg cctgctttgc actataggct gcttgtatgt ttggtttgtt
     3481 gtttttgttt ttttgttttt tttaatgcac aacttgcttg tacaggtcaa ctgtccatct
     3541 tgggtactat ttaactgtca aacagaggaa tctgtgtttg ttacaataat ataacagatg
     3601 ccttgaagga cc
//
