LOCUS       NP_001355979             409 aa            linear   ROD 31-DEC-2024
DEFINITION  runt-related transcription factor 3 isoform 2 [Mus musculus].
ACCESSION   NP_001355979
VERSION     NP_001355979.1
DBSOURCE    REFSEQ: accession NM_001369050.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 409)
  AUTHORS   Zhang,J., Gao,J., Zeng,X., Wang,Z., Chen,C., Rong,C., Li,S.,
            Cai,L., Wang,L., Zhang,L. and Tian,Z.
  TITLE     A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast
            differentiation during early enamel formation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (2), 167570 (2025)
   PUBMED   39547518
REFERENCE   2  (residues 1 to 409)
  AUTHORS   Niibori-Nambu,A., Wang,C.Q., Chin,D.W.L., Chooi,J.Y., Hosoi,H.,
            Sonoki,T., Tham,C.Y., Nah,G.S.S., Cirovic,B., Tan,D.Q.,
            Takizawa,H., Sashida,G., Goh,Y., Tng,J., Fam,W.N., Fullwood,M.J.,
            Suda,T., Yang,H., Tergaonkar,V., Taniuchi,I., Li,S., Chng,W.J. and
            Osato,M.
  TITLE     Integrin-alpha9 overexpression underlies the niche-independent
            maintenance of leukemia stem cells in acute myeloid leukemia
  JOURNAL   Gene 928, 148761 (2024)
   PUBMED   39002785
REFERENCE   3  (residues 1 to 409)
  AUTHORS   Yano-Sakamoto,K., Kitai,Y., Toriu,N., Yamamoto,S., Mizuta,K.,
            Saitou,M., Tsukiyama,T., Taniuchi,I., Osato,M. and Yanagita,M.
  TITLE     Expression pattern of Runt-related transcription factor (RUNX)
            family members and the role of RUNX1 during kidney development
  JOURNAL   Biochem Biophys Res Commun 722, 150155 (2024)
   PUBMED   38795454
REFERENCE   4  (residues 1 to 409)
  AUTHORS   Xiao,L. and Ye,G.
  TITLE     RUNX3 alleviates mitochondrial dysfunction and tubular damage by
            inhibiting TLR4/NF-kappaB signalling pathway in diabetic kidney
            disease
  JOURNAL   Nephrology (Carlton) 29 (8), 470-481 (2024)
   PUBMED   38735649
  REMARK    GeneRIF: RUNX3 alleviates mitochondrial dysfunction and tubular
            damage by inhibiting TLR4/NF-kappaB signalling pathway in diabetic
            kidney disease.
REFERENCE   5  (residues 1 to 409)
  AUTHORS   He,Y., Wasti,B., Yuan,Y., Chen,Z., Duan,W., Jia,J., Xiao,B.,
            Zhang,X., Li,J., Zeng,Q., Ma,L., Liu,S. and Xiang,X.
  TITLE     Combination of androgen and estrogen improves asthma by mediating
            Runx3 expression
  JOURNAL   Int J Med Sci 21 (6), 1003-1015 (2024)
   PUBMED   38774754
  REMARK    GeneRIF: Combination of androgen and estrogen improves asthma by
            mediating Runx3 expression.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 409)
  AUTHORS   Bae,S.C., Takahashi,E., Zhang,Y.W., Ogawa,E., Shigesada,K.,
            Namba,Y., Satake,M. and Ito,Y.
  TITLE     Cloning, mapping and expression of PEBP2 alpha C, a third gene
            encoding the mammalian Runt domain
  JOURNAL   Gene 159 (2), 245-248 (1995)
   PUBMED   7622058
REFERENCE   7  (residues 1 to 409)
  AUTHORS   Wijmenga,C., Speck,N.A., Dracopoli,N.C., Hofker,M.H., Liu,P. and
            Collins,F.S.
  TITLE     Identification of a new murine runt domain-containing gene, Cbfa3,
            and localization of the human homolog, CBFA3, to chromosome
            1p35-pter
  JOURNAL   Genomics 26 (3), 611-614 (1995)
   PUBMED   7607690
REFERENCE   8  (residues 1 to 409)
  AUTHORS   Calabi,F., Rhodes,M., Williamson,P. and Boyd,Y.
  TITLE     Identification and chromosomal mapping of a third mouse runt-like
            locus
  JOURNAL   Genomics 26 (3), 607-610 (1995)
   PUBMED   7607689
REFERENCE   9  (residues 1 to 409)
  AUTHORS   Avraham,K.B., Levanon,D., Negreanu,V., Bernstein,Y., Groner,Y.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Mapping of the mouse homolog of the human runt domain gene, AML2,
            to the distal region of mouse chromosome 4
  JOURNAL   Genomics 25 (2), 603-605 (1995)
   PUBMED   7790005
REFERENCE   10 (residues 1 to 409)
  AUTHORS   Levanon,D., Negreanu,V., Bernstein,Y., Bar-Am,I., Avivi,L. and
            Groner,Y.
  TITLE     AML1, AML2, and AML3, the human members of the runt domain
            gene-family: cDNA structure, expression, and chromosomal
            localization
  JOURNAL   Genomics 23 (2), 425-432 (1994)
   PUBMED   7835892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731718.30.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF155880.1, BY729976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.19 cM"
     Protein         1..409
                     /product="runt-related transcription factor 3 isoform 2"
                     /note="transcription factor AML2/CBFA3; CBF-alpha-3;
                     PEA2-alpha C; PEBP2-alpha C; oncogene AML-2; acute myeloid
                     leukemia 2 protein; core-binding factor subunit alpha-3;
                     SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV
                     core-binding factor alpha C subunit; polyomavirus
                     enhancer-binding protein 2 alpha C subunit; core binding
                     factor alpha 3; runt domain, alpha subunit 3"
                     /calculated_mol_wt=43387
     Region          1..51
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64131.3)"
     Region          56..184
                     /region_name="Runt"
                     /note="Runt domain; pfam00853"
                     /db_xref="CDD:459963"
     Region          177..248
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64131.3)"
     Site            241
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13761; propagated from
                     UniProtKB/Swiss-Prot (Q64131.3)"
     Region          314..409
                     /region_name="RunxI"
                     /note="Runx inhibition domain; pfam08504"
                     /db_xref="CDD:430037"
     Region          346..409
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64131.3)"
     CDS             1..409
                     /gene="Runx3"
                     /gene_synonym="AML2; Cbfa3; Pebp2a3; Rx3"
                     /coded_by="NM_001369050.1:228..1457"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS89843.1"
                     /db_xref="GeneID:12399"
                     /db_xref="MGI:MGI:102672"
ORIGIN      
        1 mripvdpsts rrftppstaf pcggggggkm gensgalsaq atagpggrtr pevrsmvdvl
       61 adhagelvrt dspnflcsvl pshwrcnktl pvafkvvalg dvpdgtvvtv magndenysa
      121 elrnasavmk nqvarfndlr fvgrsgrgks ftltitvftn ptqvatyhra ikvtvdgpre
      181 prrhrqkied qtkafpdrfg dlrmrvtpst psprgslstt shfssqaqtp iqgssdlnpf
      241 sdprqfdrsf ptlqsltesr fpdprmhypg amsaafpysa tpsgtslgsl svagmpassr
      301 fhhtylpppy pgapqsqsgp fqanpapyhl fygassgsyq fsmaaaggge rsptrmltsc
      361 psgasvsagn lmnpslgqad gveadgshsn sptalstpgr mdeavwrpy
//
