LOCUS       NM_016759               2046 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RUN domain containing 3A (Rundc3a), transcript variant
            1, mRNA.
ACCESSION   NM_016759
VERSION     NM_016759.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2046)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2046)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2046)
  AUTHORS   Jiang,D., Burger,C.A., Casasent,A.K., Albrecht,N.E., Li,F. and
            Samuel,M.A.
  TITLE     Spatiotemporal gene expression patterns reveal molecular
            relatedness between retinal laminae
  JOURNAL   J Comp Neurol 528 (5), 729-755 (2020)
   PUBMED   31609468
REFERENCE   4  (bases 1 to 2046)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2046)
  AUTHORS   Myagmar,B.E., Umikawa,M., Asato,T., Taira,K., Oshiro,M., Hino,A.,
            Takei,K., Uezato,H. and Kariya,K.
  TITLE     PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a
            putative Rap2 effector
  JOURNAL   Biochem Biophys Res Commun 329 (3), 1046-1052 (2005)
   PUBMED   15752761
  REMARK    GeneRIF: These results suggest that PARG1 is a putative specific
            effector of Rap2 to regulate Rho.
REFERENCE   6  (bases 1 to 2046)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   7  (bases 1 to 2046)
  AUTHORS   Janoueix-Lerosey,I., Pasheva,E., de Tand,M.F., Tavitian,A. and de
            Gunzburg,J.
  TITLE     Identification of a specific effector of the small GTP-binding
            protein Rap2
  JOURNAL   Eur J Biochem 252 (2), 290-298 (1998)
   PUBMED   9523700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY277835.1, BC046319.1, AK002856.1 and AL596258.15.
            
            On Apr 28, 2018 this sequence version replaced NM_016759.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U73941.1, SRR7652917.913044.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BY277835.1         1-100
            101-1226            BC046319.1         1-1126
            1227-2044           AK002856.1         525-1342
            2045-2046           AL596258.15        44399-44400
FEATURES             Location/Qualifiers
     source          1..2046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..2046
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /note="RUN domain containing 3A"
                     /db_xref="GeneID:51799"
                     /db_xref="MGI:MGI:1858752"
     exon            1..380
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1614
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /note="isoform 1 is encoded by transcript variant 1; Rap2
                     interacting protein 8; RUN domain-containing protein 3A;
                     rap2-interacting protein 8"
                     /codon_start=1
                     /product="RUN domain-containing protein 3A isoform 1"
                     /protein_id="NP_058039.1"
                     /db_xref="CCDS:CCDS25497.1"
                     /db_xref="GeneID:51799"
                     /db_xref="MGI:MGI:1858752"
                     /translation="MEASFVQTTMALGLPSKKASSRNVIVERRNLITVCRFSVKTLLE
                     KYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPASWFSSDGQRGFWDYIRLACS
                     KVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDNRTTRRFYDSGA
                     IMLREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEE
                     ERHSAESSTSEDNSPEHPYLPLVTDEDSWYNKWHKMEQKFRIVYAQKGYLEELVRLRE
                     SQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPGDHAPLAQGSK
                     ELTTSLVNQWPSLSTLHRPEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEAKRD
                     EEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS"
     exon            381..496
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     exon            497..645
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     exon            646..731
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     exon            732..821
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     exon            822..902
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1068
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1226
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1364
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1471
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..2046
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /note="hexamer: AATAAA"
     polyA_site      2046
                     /gene="Rundc3a"
                     /gene_synonym="Rap2ip; RPIP-8; Rpip8"
                     /note="major polyA site"
ORIGIN      
        1 ggccgaggag gggggacggg cgactggggg agggggtgac gagctccggc tcagcacctc
       61 ggagagctcc ctccccggcc ttgttttgct ccggaatcgc tgccggggga gggagcaaag
      121 gggccggcct taggcgtcga ggccgaggga tggcagtgaa gaagacgaag ggcccccggg
      181 ggcagacggc ccagccgtga tcctgcgagg cgggccgggg cgccgggtgg ggtggggggc
      241 agcgggcggc gacagcagtg gccgcacatc tggatggaag cgagctttgt ccagaccacc
      301 atggctctgg ggctgccctc caagaaagca tcttcccgca acgtgatcgt ggagcgcagg
      361 aacctgatca ccgtgtgcag gttctctgtg aaaaccctgc tagagaagta cacagcagaa
      421 cccattgatg actcttccga ggagtttgtt aatttcgcag ccattttaga gcagatcctc
      481 agccaccgat ttaaagcttg tgccccagca gggccagcga gctggttcag ctcagatgga
      541 caacggggct tctgggacta catccggctg gcctgcagca aagtgcccaa caactgtgtg
      601 agcagcattg agaacatgga gaacatcagc acagctagag ccaagggccg ggcgtggatc
      661 cgggtggccc tgatggagaa gcgtatgtcg gaatacatca ccacagctct tcgggacaac
      721 cgaactacca gacggttcta tgactccgga gccatcatgc tgcgggagga agccactgtc
      781 ctcactggga tgctgatcgg gctcagcgcc atcgacttca gcttctgtct aaagggcgaa
      841 gttctggatg ggaagacacc ggtggtcatc gattacacac cctacctaaa attcacccaa
      901 agctacgact acctgacgga tgaggaggag aggcacagtg ccgagagcag caccagcgag
      961 gacaactcac cagagcaccc ctacctgcct ctcgtcaccg atgaagacag ttggtacaac
     1021 aagtggcaca agatggaaca gaagtttcgc attgtctacg cacagaaggg atacctggag
     1081 gagctggtgc ggctgcgcga gtcgcagctg aaggacttgg aggcggagaa ccggcggctg
     1141 cagctgcagc tggaggaggc cgcggcacaa aatcagcgtg agaagcggga gctggaaggc
     1201 gtgatcctgg agctgcagga gcagctgaca ggtctgatcc ccggtgacca tgcccccctg
     1261 gcccagggtt ccaaggagct caccacatcc ctagtcaacc agtggccctc cctgagcaca
     1321 cttcataggc ccgagggtgc cagcaactcc aagctatatc ggagacacag cttcatgagc
     1381 acggagccgc tgtctgcaga ggccagcctg agctcagact cccagcgcct gggagaggcc
     1441 aagagggacg aggaaccctg gggccccatc gggaaggacc ccacgccctc catgctgggc
     1501 ctctgcggct ccctggcctc catccccagc tgcaagtccc tggcaagctt caaatccaac
     1561 gaatgcctgg tgagcgacag ccctgagggc agcccggcgc tcagccccag ctgaggagca
     1621 ccaagggcaa caccagcccc acctgccagg ggccatggac aactgccacc ttatgagtcc
     1681 cccaacccag gccacccttc aagaacacca ccaacctagc ctcgggtctc tagggaaaga
     1741 tgacccaagc ctctttcctg cttcagcttc ctgccaagga ggcaggagct gcatgggaag
     1801 tggtggggcc acgagggaca cccagattac agatcctcag tcccctgggg acagcgctcc
     1861 attctggtgg ctctgaaggc tgcctggttc cttctgattt cttccacacc tgcctcagga
     1921 gcaggtggtc cagccctggc attcctgctg ccctgcctct ggtctaaccc tgtgtaccct
     1981 ctgaagtcac ccttccttgg tacctatgtg gggagagatt aggcaaataa aaaccagagg
     2041 actgaa
//
