LOCUS       NM_172566               3230 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RUN domain containing 1 (Rundc1), mRNA.
ACCESSION   NM_172566
VERSION     NM_172566.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3230)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   5  (bases 1 to 3230)
  AUTHORS   Geyer,S.H., Reissig,L., Rose,J., Wilson,R., Prin,F., Szumska,D.,
            Ramirez-Solis,R., Tudor,C., White,J., Mohun,T.J. and Weninger,W.J.
  TITLE     A staging system for correct phenotype interpretation of mouse
            embryos harvested on embryonic day 14 (E14.5)
  JOURNAL   J Anat 230 (5), 710-719 (2017)
   PUBMED   28185240
REFERENCE   6  (bases 1 to 3230)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3230)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC119592.1, AK086362.1 and AW125546.1.
            
            On Oct 31, 2009 this sequence version replaced NM_172566.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157156.1, AK086362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2023              BC119592.1         2-2024
            2024-3008           AK086362.1         2025-3009
            3009-3230           AW125546.1         1-222               c
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.0 cM"
     gene            1..3230
                     /gene="Rundc1"
                     /gene_synonym="D930024B17"
                     /note="RUN domain containing 1"
                     /db_xref="GeneID:217201"
                     /db_xref="MGI:MGI:2144506"
     exon            1..526
                     /gene="Rundc1"
                     /gene_synonym="D930024B17"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1867
                     /gene="Rundc1"
                     /gene_synonym="D930024B17"
                     /codon_start=1
                     /product="RUN domain-containing protein 1"
                     /protein_id="NP_766154.2"
                     /db_xref="CCDS:CCDS25469.1"
                     /db_xref="GeneID:217201"
                     /db_xref="MGI:MGI:2144506"
                     /translation="MATVEVATELGTVVTAVGPKAKDEEEEEEEEESLPPCETVRWAP
                     VGAVAEAGPGAATFSEAAAAEEPGAAPGSPSDATVRTLRRLEAERRQLDSALLALSSH
                     FAQVQFRLRQVVRGAPAEQQRLLRELEDFAFRGCPHVLGYEGLADPCGGDESDVLPGD
                     RPRVRGEDQSEQEKRERLETQREKQKELILQLKTQLDDLETFAYQEGSYDSLPQSVVL
                     ERQRVIIDELIKKLDMNLNEDISSLSTEELRQRVDAAVAQIVNPVRVKEQLVEQLKTQ
                     IRDLEMFISFIQDEVGSPLQTGGHCECQASGKVGIGSTRVGGSTLPPGPGKAKAEDAK
                     RARETGLHLMRRALAVLQIFTVSQLGCATGQIPQTLWQRSQADRDYSHLLKRLEVSVD
                     RVKQLALRHQPHDHVITSANLQDLSLGGKDELTTVVRKELTVAVRDLLAHGLYASSSG
                     MSLVMAPLACLLPVFSSAPETMHPWELFVKYYHAKNGRAYVESPARKLSQSFALPIMG
                     DTAVTPKQSLLTAIHLVLTEHDPFKRSADSELKALVCMALNEQRLVSWVNLICKSGSL
                     IEPHYQPWSYMAHTGFESALNLLSRLSSLKFSLPVDLAVRQLKNIKDAF"
     exon            527..685
                     /gene="Rundc1"
                     /gene_synonym="D930024B17"
                     /inference="alignment:Splign:2.1.0"
     exon            686..884
                     /gene="Rundc1"
                     /gene_synonym="D930024B17"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1001
                     /gene="Rundc1"
                     /gene_synonym="D930024B17"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..3216
                     /gene="Rundc1"
                     /gene_synonym="D930024B17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3180..3185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rundc1"
                     /gene_synonym="D930024B17"
                     /note="hexamer: AATAAA"
     polyA_site      3203
                     /gene="Rundc1"
                     /gene_synonym="D930024B17"
                     /note="major polyA site"
ORIGIN      
        1 gggcggcgtt tccgggaaga tggcgacggt ggaagtggct acggagctag gaactgtggt
       61 gaccgctgtc gggcctaagg cgaaggacga ggaagaagaa gaagaggagg aggagtcgct
      121 gccaccatgc gagactgtgc gctgggctcc cgtgggggca gtggccgagg ccggtcctgg
      181 ggcggcgacg ttctcggagg cggcggcagc cgaagagcct ggagcggctc cgggctctcc
      241 atccgacgcg actgtccgca cgctgaggcg gctggaagcc gagcggcggc agctggattc
      301 ggccctgctc gcgctgtcct cgcacttcgc gcaggtgcag ttccgtctgc gccaggtagt
      361 gcgcggggcg ccggcggagc agcagcgtct cctgcgcgag ctcgaagact ttgccttccg
      421 cggctgtcct cacgtcctgg gttacgaggg gctggcagac ccttgtggcg gtgacgaaag
      481 cgatgtgctg ccgggggacc ggccacgggt gcggggtgag gaccagagcg aacaggaaaa
      541 acgggagcgc ctggaaaccc agagggagaa gcagaaagaa ctgattctgc agctgaagac
      601 ccagcttgat gacctggaga cgtttgccta tcaggagggt agttatgact ccctgccgca
      661 gtccgtggtc ttggaaagac agcgggtgat catcgatgag ttaataaaga aactggacat
      721 gaatctgaat gaggacatca gttccctttc cactgaggag cttcgtcaac gtgtggacgc
      781 agcagtggct cagattgtca acccagtgcg ggtgaaagag cagctggtgg agcagctgaa
      841 aacccagatc cgggaccttg agatgttcat cagcttcatc caagatgaag tgggaagccc
      901 cctgcagaca ggtggacact gtgagtgcca agccagcggg aaggtgggaa tcggctccac
      961 cagggtgggt ggcagtacac tgcccccagg acccggcaaa gcaaaggcag aagatgccaa
     1021 gagagcccgg gagacggggc tgcacctgat gcggcgagcg ctggctgtgc tccagatctt
     1081 cactgttagc cagctgggct gtgccacggg ccagatccct caaaccttgt ggcagaggag
     1141 ccaggcagac agagactact cccacttact gaaaagactg gaagtatcgg tcgacagagt
     1201 aaagcagcta gccttgagac atcagccaca tgaccacgtc atcacttcgg ccaacctcca
     1261 ggacctctct ctgggaggca aggatgagct gaccacggtt gtgcggaagg agctgacagt
     1321 ggctgtgagg gacctgctgg cccatggact gtatgcctcc tcctctggga tgagccttgt
     1381 catggccccc cttgcttgct tgttgccagt tttctcctca gcccccgaga ccatgcaccc
     1441 atgggagctc tttgtaaagt actaccatgc caagaatggc cgtgcatatg tggaatcccc
     1501 ggcccggaag ctctcacagt cctttgctct gcctataatg ggtgacactg ctgtgacccc
     1561 caaacagagc cttctgacag ccatccacct ggtgctgaca gagcatgacc ctttcaagcg
     1621 cagcgctgac tcagaactga aggcgttggt gtgcatggca ctgaatgagc agcgcctggt
     1681 gtcctgggtg aacctcatct gcaagtcagg gtccctcatc gagccccatt accagccctg
     1741 gagctacatg gcccacacag gttttgagag tgccctcaac ctgctcagcc gccttagcag
     1801 cctcaagttc agccttcctg tagacttggc cgtgcgccag ctcaagaaca tcaaagatgc
     1861 cttttgatgg gaatgcctaa ccttagcccc cacacacctt gctctaaaga cgtagatgtc
     1921 ctagaattgt agattaaaag ccagggagtc ggaggaaggg ttggagatag gttttttcca
     1981 cccttttcag gtggtcagct aatggaggca aagcctgttc ttagcgtttt agaaagacgt
     2041 gccagagcct ctcatcaaaa atagtgttgg ggctgagaga cagctcgcca ggtcaagatg
     2101 cttgccatta tacctggcag tctgaggggt acaagcagag aacagagctc tcactacctg
     2161 tcctcttacc tccacacatg aactatggca catgggaatc cctgcccaaa cacaaatcaa
     2221 tgtaatagta aaatctaaaa cagaaacagt atcaggacca gaggtgtagc tcggtggtat
     2281 ggtgcatgcg aagcgtgcac agccagtgct gtggatgtta aaagcaaaca gaaggcgctg
     2341 accctagccc accacagtgt gcccggcccg ctgttggagc ctgtggtaac aaaatcaatt
     2401 accacacagc taatgcccaa ctcaccgtgc catgtctgaa ttttagaaaa tgtgggttgt
     2461 gcccaccctt ctcttgctgt atgagggagt tctggaagac actgactgac cttgagtctc
     2521 ctgctagaca agctgggaac agtcttcctt taccagaagc agctttgaga gccctagggc
     2581 cagaactgta agtgcagttg tgagttctga ttcccctttg ttcagaggga gttttaagat
     2641 gagcctaaga tgaagtctcc ctgctgaggc gatcctcaca ctcagtcagc actcctctgg
     2701 ttataaagaa tgacagctga tctcctgggc tgtttctcga aagtcacttt cttccgtggg
     2761 cctctcagga ctgacccagt cttcagaagt gaaagcactc agaagaatcc gtcaggagca
     2821 tactgcactg gtggtgatgg gtgccacagc cccctggggt gtgactcatt ggcaccactt
     2881 gttggagaca ggagcgtgca gagcggcatg actgaaggct cgcagtgggc acttgctcca
     2941 gggctcactg aggatggaga accaactgcc gcctgtgctt tgttccctga aatgcacttt
     3001 accttgtgtc tgcagtgtgc actttgatgc atcattgact tcctgttcaa gaacacggca
     3061 gtgtttgggc ttggcgtgca gctccgtgat agagtgcttg cctgggaatc cttagcacca
     3121 accccagggg gaaaagataa ttgaaaaata tcatgaataa tgatataact gtgattgcta
     3181 ataaagtttc agtattttgc gtagcttctc tgcaaaaaaa aaaaaaaaaa
//
