LOCUS       NM_001170641            2336 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus RUN and FYVE domain containing 4 (Rufy4), transcript
            variant 1, mRNA.
ACCESSION   NM_001170641
VERSION     NM_001170641.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2336)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2336)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2336)
  AUTHORS   Terawaki,S., Camosseto,V., Prete,F., Wenger,T., Papadopoulos,A.,
            Rondeau,C., Combes,A., Rodriguez Rodrigues,C., Vu Manh,T.P.,
            Fallet,M., English,L., Santamaria,R., Soares,A.R., Weil,T.,
            Hammad,H., Desjardins,M., Gorvel,J.P., Santos,M.A., Gatti,E. and
            Pierre,P.
  TITLE     RUN and FYVE domain-containing protein 4 enhances autophagy and
            lysosome tethering in response to Interleukin-4
  JOURNAL   J Cell Biol 210 (7), 1133-1152 (2015)
   PUBMED   26416964
  REMARK    GeneRIF: RUFY4 is therefore the first molecule characterized to
            date that promotes autophagy and influences endosome dynamics in a
            subset of immune cells.
REFERENCE   4  (bases 1 to 2336)
  AUTHORS   Wei,Z., Sun,M., Liu,X., Zhang,J. and Jin,Y.
  TITLE     Rufy3, a protein specifically expressed in neurons, interacts with
            actin-bundling protein Fascin to control the growth of axons
  JOURNAL   J Neurochem 130 (5), 678-692 (2014)
   PUBMED   24720729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117757.23.
            
            [WARNING] On Jul 10, 2024 this sequence was replaced by
            NM_001170641.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC117757.23        131628-131701
            75-206              AC117757.23        133679-133810
            207-313             AC117757.23        133933-134039
            314-439             AC117757.23        135035-135160
            440-546             AC117757.23        135426-135532
            547-690             AC117757.23        135785-135928
            691-760             AC117757.23        137265-137334
            761-1387            AC117757.23        138807-139433
            1388-1491           AC117757.23        140191-140294
            1492-1638           AC117757.23        147006-147152
            1639-1749           AC117757.23        152741-152851
            1750-2336           AC117757.23        153731-154317
FEATURES             Location/Qualifiers
     source          1..2336
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.38 cM"
     gene            1..2336
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /note="RUN and FYVE domain containing 4"
                     /db_xref="GeneID:435626"
                     /db_xref="MGI:MGI:3588214"
     exon            1..74
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            75..206
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            207..313
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            314..439
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            440..546
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            547..690
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            691..760
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            761..1387
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1491
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1638
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1749
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2336
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2331
                     /gene="Rufy4"
                     /gene_synonym="F930048N03Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagcccacag tcacaaggga catactcagg ctacagaatc ctgcccacat cccaaacaga
       61 caagcttttc tcagtctaaa ctctcatccc gtccatatgt aaggaaagca agcagctgaa
      121 cccagaggat cacagggaat cccatcactt ccgagtcttc atggccaaca acgggaccat
      181 cctcaagatc agcagaagcc tgaaaaatgc agtctctgcc atcctccagg gatatgggga
      241 cgggcaggag ccagtgacag aaaccagcgc tgagctacac agactctgtg gctgcctgga
      301 gctgctactg cagtttgatc agaaagagca gaggagcttc ctgggggccc ggaaggatta
      361 ctgggacttc ctattcactg cccttcgacg gcaccgggga tacacagagc agatgagctt
      421 catatgctca caggacaagc tgaagacctc actaggaaaa ggtcgtgcct ttatccgact
      481 ctgccttgcc cgaggccagc tggctgagtc gatgcagctg tgcctcctga acccacaact
      541 caccagggaa tggtatggcc ctcggagccc tctgttgtgc gctgagctcc aggaagacat
      601 cttggactct ctctatgccc tcaatggagt tgccttcaac ttggacctgc agcggccaga
      661 cctggatgaa gcctggccca tgttctcaga gtcccgctgt tccagtccca gccggaccgg
      721 gaaaagaaga cccgggaaac ccaaaggttt tccagaggag gtgagatgct ccaggggaga
      781 gcagctgcag gaaccagaca ctggaggaac cagctgtctg caggatgcaa ccagagaaga
      841 ccgcacacct gacctctgta aacccttgca gccaagccat cttcccacct ttctggaaga
      901 gaagagggag gattccagaa gcctcagttg tccccagagc acttgggaaa cagaaaggga
      961 aggatttcag ctagaccaga aggatggagg cccaaagccc aggaaattcc tggaaaactc
     1021 aacagccagc atccagcaac agaggagcag ggctaaggat gttaaaatgc agctgacagg
     1081 aaggaaagtt gaaggaaaag gaagtctgtc ggggacagaa gatcagagaa caacagaagg
     1141 gatccagaaa agggcagcag attgggacct tggccagggg ctgatggccc ccggtcttca
     1201 gggaagagaa gatgcagagt taggatacag gtgtgagtgg aatcagcctg atgttctcag
     1261 gcaatcctgg gtcctgggaa caaagaaaag ttctcccaca gagaagccac aagagtggac
     1321 aggagtgacc agtggaacca tgcaggagga tgggtcagaa gtgcccttgc agcaggaggt
     1381 gatcaaggac cctgggtatg ggctccagct ggcaaaggaa caggcccagt gccaggagca
     1441 gctgcgggca caggaagcag aacttcaggc gctccaggag cagctcagca ggtgtcaaaa
     1501 agaaagagcc ctgttgcaag tgaagctgga gcagaagcag caggaggctg agaggaggga
     1561 cgccatgtat cagacagagc ttgaagggca gagggacctg gtccaggcca tgaaaaggag
     1621 ggtgttggaa ctgatccatg agaaggacct tcagtggcag agactccagc agctgtctac
     1681 tgtggcccct ggacactgca taggctgcaa caaggtcttc aggcgtctgt ctcggcggta
     1741 tccttgcagg ctctgtggag gcctggtttg ccacgcctgc tctgtagact acaagaagag
     1801 agagcgttgc tgcccaacct gtgcccagca ggaagaaatc caggacacct gacagcacaa
     1861 ggcaactaag accagccgcc ccaccagttc actctccctg tttctcttcc caaccctgat
     1921 gtctgactac tcttttcttc tgcaagctgg ggccccagca ccgctgtgga gggccagagg
     1981 gaacagctgg cagtccacag ataggcctag ctctgcgttc ctgtggaagg gactgagggg
     2041 aacatgccaa agctctagaa gcattgtgtc tgatgaggaa gacatgccat aacctctctg
     2101 taaagtccct tgaagcacag tgagtcgtga ccatgaataa gagcagccca gggcccagat
     2161 gtttcctagc caccctcccc ctcccccatc acccataaga agcgaagtcc aaatacattg
     2221 ggctcttcag gaacctcccc tccgatctcc ttcagagatc attgccttat cttgtgtttc
     2281 gcagatttac tgagtcgttg ttgacataga ataaacattg tgtaagtgtg atgggt
//
