LOCUS       NM_172557               2701 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RUN and FYVE domain containing 1 (Rufy1), mRNA.
ACCESSION   NM_172557
VERSION     NM_172557.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2701)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2701)
  AUTHORS   Ruan,Q.T., Yazdani,N., Reed,E.R., Beierle,J.A., Peterson,L.P.,
            Luttik,K.P., Szumlinski,K.K., Johnson,W.E., Ash,P.E.A., Wolozin,B.
            and Bryant,C.D.
  TITLE     5' UTR variants in the quantitative trait gene Hnrnph1 support
            reduced 5' UTR usage and hnRNP H protein as a molecular mechanism
            underlying reduced methamphetamine sensitivity
  JOURNAL   FASEB J 34 (7), 9223-9244 (2020)
   PUBMED   32401417
REFERENCE   3  (bases 1 to 2701)
  AUTHORS   Yazdani,N., Parker,C.C., Shen,Y., Reed,E.R., Guido,M.A., Kole,L.A.,
            Kirkpatrick,S.L., Lim,J.E., Sokoloff,G., Cheng,R., Johnson,W.E.,
            Palmer,A.A. and Bryant,C.D.
  TITLE     Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine
            Sensitivity
  JOURNAL   PLoS Genet 11 (12), e1005713 (2015)
   PUBMED   26658939
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2701)
  AUTHORS   Wei,Z., Sun,M., Liu,X., Zhang,J. and Jin,Y.
  TITLE     Rufy3, a protein specifically expressed in neurons, interacts with
            actin-bundling protein Fascin to control the growth of axons
  JOURNAL   J Neurochem 130 (5), 678-692 (2014)
   PUBMED   24720729
REFERENCE   5  (bases 1 to 2701)
  AUTHORS   Vukmirica,J., Monzo,P., Le Marchand-Brustel,Y. and Cormont,M.
  TITLE     The Rab4A effector protein Rabip4 is involved in migration of NIH
            3T3 fibroblasts
  JOURNAL   J Biol Chem 281 (47), 36360-36368 (2006)
   PUBMED   17001082
  REMARK    GeneRIF: Rabip4s, possibly via their interaction with Rab4,
            regulate integrin trafficking and are involved in the migration of
            NIH 3T3 fibroblasts
REFERENCE   6  (bases 1 to 2701)
  AUTHORS   Mari,M., Monzo,P., Kaddai,V., Keslair,F., Gonzalez,T., Le
            Marchand-Brustel,Y. and Cormont,M.
  TITLE     The Rab4 effector Rabip4 plays a role in the endocytotic
            trafficking of Glut 4 in 3T3-L1 adipocytes
  JOURNAL   J Cell Sci 119 (Pt 7), 1297-1306 (2006)
   PUBMED   16522682
  REMARK    GeneRIF: Rabip4 plays a role in the endocytotic trafficking of
            Glut4 in 3T3-L1 adipocytes.
REFERENCE   7  (bases 1 to 2701)
  AUTHORS   Mari,M., Macia,E., Le Marchand-Brustel,Y. and Cormont,M.
  TITLE     Role of the FYVE finger and the RUN domain for the subcellular
            localization of Rabip4
  JOURNAL   J Biol Chem 276 (45), 42501-42508 (2001)
   PUBMED   11509568
REFERENCE   8  (bases 1 to 2701)
  AUTHORS   Cormont,M., Mari,M., Galmiche,A., Hofman,P. and Le
            Marchand-Brustel,Y.
  TITLE     A FYVE-finger-containing protein, Rabip4, is a Rab4 effector
            involved in early endosomal traffic
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1637-1642 (2001)
   PUBMED   11172003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046625.1, AK046633.1 and BQ176179.1.
            
            On Jul 6, 2018 this sequence version replaced NM_172557.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046633.1, SRR17784644.1226479.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK046625.1         4-17
            15-2671             AK046633.1         2-2658
            2672-2701           BQ176179.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.57 cM"
     gene            1..2701
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /note="RUN and FYVE domain containing 1"
                     /db_xref="GeneID:216724"
                     /db_xref="MGI:MGI:2429762"
     exon            1..342
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2159
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /note="Rab4a interacting protein; FYVE-finger containing
                     protein; rab4-interacting protein"
                     /codon_start=1
                     /product="RUN and FYVE domain-containing protein 1"
                     /protein_id="NP_766145.1"
                     /db_xref="CCDS:CCDS24635.1"
                     /db_xref="GeneID:216724"
                     /db_xref="MGI:MGI:2429762"
                     /translation="MAARGECRRAGQDSEPEPEREPESEPGPEPEPQAGLESGEAFEI
                     VDRSQLPSPGELRSASRPRVADSWSAPILTLARRATGNLSASCGSALRAAAGLGDGGG
                     GGERAASKGQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADYAPLQQFFVVMEHCL
                     KHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLA
                     LMQKKLADYLKVLIDNKQLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGED
                     LDSQVGVIDFSLCLKDAQDLDSGREHERITDVLDQKNYVEELNRHLSCTVGDLQTKID
                     GLEKTNSKLQEELSAATDRICSLQKEQQQLREQNEVIRERSEKSVEITKQDTKVELET
                     YKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQ
                     DTLVALRQQLEEVKAINLQMFHKVQSAESSLQQKNEAIASFEGKTTQVMSSMKQMEER
                     LQQAERARQAAEERSHKLQQELSGRGSALQLQLSQLRDQCSGLEKELKSEKEQRQALQ
                     RELQREKDTSCLLQTELQQVEGLKKELRELQDEKAELRKVCEEQEQALQEMGLHLSQS
                     KLKMEDIKEVNKALKGHTWLKDDEATHCKQCEKDFSISRRKHHCRNCGHIFCNTCSSN
                     ELALPSYPKPVRVCDSCHTLLLQRCSSTAS"
     exon            343..516
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            517..634
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            635..736
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            737..860
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            861..922
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            923..988
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1058
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1160
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1277
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1445
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1543
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1663
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1793
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1888
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1937
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2015
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2688
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2652..2657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /note="hexamer: AATAAA"
     polyA_site      2688
                     /gene="Rufy1"
                     /gene_synonym="3000002E04Rik; Rabip4; ZFYVE12"
                     /note="major polyA site"
ORIGIN      
        1 gggtcacgtg acctaacaac atggccgccc gcggagaatg ccgccgggcg gggcaggatt
       61 cggagccgga gccggagcgg gagccggagt ccgagccggg gccggagcct gagccccaag
      121 caggcctaga gtccggggaa gcgttcgaga tcgtggaccg gagccagctg ccgagtcccg
      181 gcgagctgcg gagtgcgtcg cggcctcgag tggccgacag ctggtcggcg cccatcctga
      241 cgctggcgcg cagagccacc gggaacctgt cggcgagctg cggcagcgcg ctgcgcgcgg
      301 ccgcggggct gggagacggc ggcggcggcg gggagcgcgc agcttccaaa ggccagatga
      361 tggaggagcg tgccaaccta atgcacatga tgaaactcag cattaaggtc ttactccagt
      421 ctgcccttag cctgggacgc agtctggatg cagactatgc ccccttgcag cagttctttg
      481 tagtgatgga gcattgcctc aaacatgggc tgaaagtcaa gaagagtttc attggccaaa
      541 ataagtcttt ctttggtcct ttggagctgg tggaaaaact ttgtcctgaa gcatcagata
      601 tagctaccag tgtcaggaat cttccagaac taaagacagc cgtgggaaga ggcagagcgt
      661 ggctttatct tgctctcatg caaaagaaac tggcagatta tctgaaagtc ctcatagaca
      721 acaagcagct cctaagtgag ttctatgagc ccgaggcctt aatgatggag gaggaaggaa
      781 tggtgatcgt gggtctgctg gtgggactca acgttctgga tgccaacctc tgcttaaagg
      841 gagaagactt ggattctcag gtcggggtga ttgacttctc tctctgtctg aaggacgcac
      901 aggatcttga cagcggcaga gagcatgaaa gaattaccga tgtccttgat cagaaaaatt
      961 acgtggagga acttaaccgg cacctaagct gcacagttgg ggatcttcag acgaagatag
     1021 atggcttgga aaagacgaac tcaaagcttc aagaagagct ttcagctgca acagaccgaa
     1081 tttgttccct acaaaaagaa caacagcagc tgagagaaca gaacgaagta attcgagaaa
     1141 gaagcgagaa gagcgtggag ataacaaaac aggacaccaa ggttgaactg gagacttata
     1201 agcagacccg gcagggcctg gatgaaatgt acagcgatgt gtggaaacag ctgaaggagg
     1261 agaagaaagt ccgactggaa ctggaaaagg agctggagtt gcagattgga atgaagacgg
     1321 agatggagat cgccatgaag ttgctggaga aggacaccca tgagaagcaa gacacgctcg
     1381 ttgccctccg ccagcagctg gaggaagtca aagctattaa cttacagatg tttcacaaag
     1441 ttcagagtgc agagagcagt ttacagcaga agaatgaagc catcgcatct tttgaaggaa
     1501 aaaccactca ggtgatgtcc agcatgaagc aaatggagga aaggttacag caggcggaac
     1561 gggccaggca ggcggcagaa gagcgaagcc acaagttgca gcaggagctc agcgggaggg
     1621 gcagtgccct gcagctccag ctgtcccagc tgcgggacca atgctcaggt ctagagaaag
     1681 aactgaagtc agaaaaagaa caaagacaag ctctccagag agaactacag cgtgagaaag
     1741 acacctcttg tctgctccag acggagctgc agcaagtgga aggcctgaag aaggagctgc
     1801 gggagctcca agacgagaag gcagagttac ggaaggtctg tgaggagcag gagcaagccc
     1861 tccaggaaat gggactacac cttagccagt ccaaactgaa gatggaagac ataaaggaag
     1921 taaataaggc actgaagggc cacacatggt tgaaagatga cgaggcaaca cattgtaagc
     1981 agtgtgagaa ggacttctcc atttctcgga ggaagcacca ctgccgaaac tgtggccaca
     2041 ttttctgcaa cacctgctct agcaacgagc tggccctgcc ctcctaccct aagccagtgc
     2101 gtgtgtgtga cagctgccat accctgctac tgcagcgctg ctcctccact gcctcctgaa
     2161 gccatcagcc ccacccacca gcagggacct tgacctgttg acctccatcc tcagagtgga
     2221 ggaaagcctc aggtacagtg ccaaacttgg gatctccaga gacctgtagg gacccaagag
     2281 aatcaaagga aagaatgaaa ccttcaccag gctgtcagcc tcggaagaga atgccaagtg
     2341 gcagctgagc acttttccat ggtctctatg gagtcatctc ctctagacag acacttctgt
     2401 gtcctcagtt aaatcctggc tttggtacag gtgcaacttc atgactttgc tactgtcacc
     2461 ttcacttttc aaagggttaa cctgttgtgc agcagttgca ctagagaatc ctttctcttt
     2521 cctacccacg tcccacagaa accttgattt ctgctgtgct ttgaaccttg tgggtctgtc
     2581 agtgtgcctt gtctgcttcg gcatccagca tttgccatca tgctcctgcc aacacctact
     2641 gtcagccctg caataaaatc ctttattttt cactcttgta cagacaaaaa aaaaaaaaaa
     2701 a
//
