LOCUS       NM_175542               7280 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus rotatin (Rttn), mRNA.
ACCESSION   NM_175542
VERSION     NM_175542.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7280)
  AUTHORS   Chatterjee,B., Richards,K., Bucan,M. and Lo,C.
  TITLE     Nt mutation causing laterality defects associated with deletion of
            rotatin
  JOURNAL   Mamm Genome 18 (5), 310-315 (2007)
   PUBMED   17551791
  REMARK    GeneRIF: No turning (nt), a recessive lethal mutation causing
            left-right and axial patterning defects is likely elicited by
            deficiency of Rttn on chromosome 18.
REFERENCE   3  (bases 1 to 7280)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 7280)
  AUTHORS   Faisst,A.M., Alvarez-Bolado,G., Treichel,D. and Gruss,P.
  TITLE     Rotatin is a novel gene required for axial rotation and left-right
            specification in mouse embryos
  JOURNAL   Mech Dev 113 (1), 15-28 (2002)
   PUBMED   11900971
  REMARK    GeneRIF: cloning and characterization of rotatin
REFERENCE   5  (bases 1 to 7280)
  AUTHORS   Stoykova,A., Chowdhury,K., Bonaldo,P., Torres,M. and Gruss,P.
  TITLE     Gene trap expression and mutational analysis for genes involved in
            the development of the mammalian nervous system
  JOURNAL   Dev Dyn 212 (2), 198-213 (1998)
   PUBMED   9626495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF265232.1 and BC023916.1.
            
            On Oct 17, 2003 this sequence version replaced NM_175542.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6359              AF265232.1         1-6359
            6360-7280           BC023916.1         1882-2802
FEATURES             Location/Qualifiers
     source          1..7280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 58.93 cM"
     gene            1..7280
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /note="rotatin"
                     /db_xref="GeneID:246102"
                     /db_xref="MGI:MGI:2179288"
     exon            1..289
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..6939
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /codon_start=1
                     /product="rotatin"
                     /protein_id="NP_780751.2"
                     /db_xref="CCDS:CCDS29390.1"
                     /db_xref="GeneID:246102"
                     /db_xref="MGI:MGI:2179288"
                     /translation="MVLAGLIRKLGHQLAEIRERALKSILCKIEHNLICYADLIQERL
                     LFLHLLEWFNFPSVPMKEEVLNLLSRLVKYSPAVQHLIDLGAVEFLSKLRPNVEPVIQ
                     AEIDGILDGLFILPSEVPALCSSSYHTDQIELSQQPEVLTGYFPQDKSNFQQMEVPPG
                     PAGNQAVKWLRFSVFPWLPLTTTDRHVLSSNESSLRSSNHTLIWNTCELLKDVIMQDF
                     PAEIFLQRPKIVQGLLCLVKLAFGGDGKHRLALQSVSCLQQLCTSLRNRLNFYRDPNF
                     FSSRQDTVSQNSSLSYCHEARGPYHSPNPSPGSSSSRPSVVGRTGQRPRGDGQDWDAV
                     SSSGSSSHTHVNSRISVHSPLDVAPVDLPELEAEDTLELQFQQLSLPQFCISTLEAAA
                     PLLRTGSREMIIRVLELLAEDMLLIGQAISSEIWDDNSLFAINVKEKLLQVLGSLGET
                     MCYRKTSFSMEQAEAVLVHHRMAFVSISLFTVRLLQLLLPVEKASEFLPESMSAALFF
                     VSLDMPISLEYPEIHDTVVAYLEQLDSENYSIYKRTAEAVYSIECTCNFLSDVGKEGE
                     KNLLELVELADQALRSFSYHQHSPLIKEIICICSKIWKSAQASPLLQGESQKVFLHML
                     SHPLPQVKVETYQCCLEIVKECLGVQNVTKPVSSLCSGIHFLLHPKVLYEISAFGIQE
                     SKNEVNAAAKAILLYLLQGRLMMTALTWNKFIESLAPVIPVLQGYADTEDPLGNCILL
                     LSKVSSEAGEGALPCTARLKSVLRLLLVKKPSVRSLALKLLAFHLTSEEGADKKRPFI
                     DAGVLSRVTNLFIVKKPIDLKLDDRRELVIKLETVKKVCDIFTSDDVDLVLRKSAAEQ
                     LAVIMQDIKMHTVVKKLCLVEKIIGHLNEFVGQDGEVIECLIQPCLTLLRKVLYADPV
                     IRVSLSQQASLLTLLLRVSLIFHEDCTVVAEVGALFCLLLFDEVSRMDTWSDTLSDKP
                     SLSSVFSLPVSVFRRYHLPVHVTGHHAVSPYSIVLPLPTECLTLKPVSDMLRIAWNLA
                     WYHGSDNLLKQMTSEAKIQEFLDTLQLSTEDILALKITYTDSGLKDCLQSIIQAGGHR
                     DVRAAITRMSFYLLNDKLSLKDDIGPCGVTLKSLAWHTVLNRFLQVLPACTEDEKLLI
                     DIIHFLNKLIKEQRKNPSIELLNWILELLLRHNPSPLLDLLVLTDSHAGEETDDVRTA
                     VRQQLQKELISLLNSLLLVFMTVSDRKCLELFYVFQTQLSLKLLQCLRVTDAPHFYGL
                     PSLERTLAGMAHLTAFPGWSAHSPLSKPLEICGKYLSGLLEVITSFYVERGGNAMSFM
                     GKGVTKSTGLCLLHLSHEMIVQAPGSEWMPLWFLPLGSHSEEHAPTQQGLAWLIPLWV
                     DRDPEVRFTSLGLGSALTTIEAGCVALANSCQNISGGLWGTVVNILLDQSECSLVRRE
                     AAFILQNLLVIPMPSEIIKDYTWQGPCVHDEDSGLSLSGKPALQALLYHCRFYEHLTH
                     MVKHCYVGRYIFDFNFSAFTETSEYSDLNGLDDSFKFWRAPSGTSTQDHEPSSLSTSE
                     TMVAASVVSSEIQPLLPSTLLPETALDQFVTQGQREMRPVRPRDSLLSTSLNRQYVFV
                     TPSLLSAVCSLLDNLLAVTPRDAANAFQQAHLIELLCSTVDASLIEMCIQELKTPLPL
                     PSAVEHIQAQASFFLEYLSSLSQLLKSCLLVEPKLVTQDELLKPLITNVIRVLIVCPK
                     DVLDVQLVLAFYRTWTHLFDLLATLLRKAGAVSLVPLTSALAKHWEAVTDTLCRCVGL
                     SFKCPALTIASLQFLSVLLAEEEKRRVQDKDKTNEGQAPTVALLLDGTQGSLSSSERL
                     NETILQCYEGISPKDVLKRVAANALLSLLAVSRRAQRHALRSDLIENCMEQMKHINAQ
                     LNLDLLRPGKAVLKKKEDGFIKELSITMQLLRNCLYQNEECKVAALEARLVPVLHSLW
                     PWLLMEDSLMQIALQLLCVYTANFPAGCSSLCWSNYGQCIQTAHRGTPSSSLILCILK
                     LASQMPAENTTIQQLVFMFLSNLALSHDCKGVIQKSNFLQHFLSLTLPKGGNQHLSTV
                     AILWLKLLLNMSFGEDGQQMILRLDGCLDLLIEMSKYKHKSSPHMPLLIFHNICFSPA
                     NKPKILANEKVVTLLAACLESENQTAQRIGAASLWALTYNYQKAKATLKNPSIKRKVD
                     EAYSIAKRTLSNSEENPLNSYYLKCLENLVQLLNYS"
     exon            290..477
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            478..655
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            656..745
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            746..836
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            837..951
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1102
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1268
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1450
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1566
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1737
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1950
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2063
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2190
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2316
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2433
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2573
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2745
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2845
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2934
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3052
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3149
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3218
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3407
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3647
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3792
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3947
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4167
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..4296
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            4297..4407
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..4566
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            4567..4638
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            4639..4828
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            4829..4920
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            4921..5011
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5201
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            5202..5292
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            5293..5446
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            5447..5584
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            5585..5802
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            5803..5908
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            5909..6006
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            6007..6084
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            6085..6211
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            6212..6411
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            6412..6679
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            6680..6783
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            6784..6853
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     exon            6854..7269
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7250..7255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /note="hexamer: AATAAT"
     polyA_site      7269
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /note="major polyA site"
ORIGIN      
        1 ctcctttatt ccttaggctt tttaggatgg agattgaggt taaggaatga gccgtagaaa
       61 catagagatg tcgtaagctt gtgtggtgac ggaagcattg ggaacatttc acctaatgct
      121 ctctactcaa ggggtggata gcttaaacat cgtggaacct ctgtttgttt cggccgagtt
      181 tccggaggat attaattatg aacggattct gtggcgcgac agtttaattc tccggcggcg
      241 actgattgtg gcggagagat ggttctggcg gggctcatca ggaagctcgg ccatcagctg
      301 gcggagatca gggaacgcgc cctcaaaagt atcctgtgca agattgagca caacttgatc
      361 tgctatgctg acttgattca ggaaaggttg ctttttctcc atttgctcga atggttcaat
      421 ttcccatctg tcccaatgaa agaggaggtt ctgaacttgt taagcagatt ggttaagtat
      481 tctccagccg tccaacactt gattgacctt ggtgcagtag agtttttatc taagctccgt
      541 ccaaatgtgg agccagtaat acaggctgag attgatggca ttctcgatgg acttttcatt
      601 cttccttcag aagttcctgc actgtgttct tccagttacc acactgatca aattgaattg
      661 tcacaacaac ctgaagtctt aacaggatat tttccccaag acaaaagtaa tttccagcag
      721 atggaagtac caccagggcc agcgggaaac caggctgtga agtggctgag gttctctgtg
      781 tttccttggc tacccctgac cacaacagac agacatgttc tctcttccaa tgaaagctct
      841 ttgagaagta gtaaccacac tctgatctgg aacacctgtg agcttctgaa ggacgtgatc
      901 atgcaagact ttcctgctga gatttttctt cagaggccaa agattgttca gggccttttg
      961 tgtctggtga agctggcctt cggaggagat gggaagcatc gtctagcatt acagtcagtg
     1021 tcctgtttgc agcagctgtg cacaagctta agaaacagac tcaactttta cagagacccc
     1081 aactttttct ccagtagaca agacacagtc tcccagaatt cttctttgtc ttactgtcat
     1141 gaagcaagag gtccttacca ttccccaaac ccatccccgg gaagcagtag ctctcggcct
     1201 tctgtggttg ggcgcacagg ccagcgaccc cgaggagatg gtcaggactg ggatgcagtg
     1261 tcttccagtg gaagtagtag tcacacgcat gtgaactcta ggatatctgt gcattctcct
     1321 ttggacgtgg cacccgtgga tctgccggag ctggaagcag aggacacact ggagctgcag
     1381 ttccaacagc ttagtcttcc tcagttctgc atctccaccc tggaggcagc agctcctctg
     1441 ctgagaacag gcagcagaga aatgataata agagttctgg aactgcttgc agaggacatg
     1501 ctgctcattg gacaagcaat ttcatcagaa atctgggatg ataacagcct ttttgctatc
     1561 aatgtgaaag agaaactgct ccaagtgttg gggtcccttg gagaaaccat gtgctaccgt
     1621 aaaaccagtt ttagcatgga gcaagccgag gctgtactcg tgcaccacag aatggccttt
     1681 gtcagcatct cactgttcac agttcgactg ttgcaacttc ttctccctgt tgaaaaggcg
     1741 agtgagtttt tgccagagtc catgtcagca gcattatttt ttgtctcctt ggacatgcct
     1801 atttctttgg aatatccaga gattcatgac acagttgtgg cttatttgga acagctggat
     1861 tctgaaaatt acagcattta taagcgaact gcagaggctg tttattcaat tgaatgcacc
     1921 tgtaacttcc tatctgatgt ggggaaagag ggagaaaaga atcttctaga attagtggag
     1981 ctggcagacc aagccttgcg tagcttttcc tatcatcagc attctcccct aataaaggaa
     2041 atcatctgca tctgttcaaa gatctggaaa tctgcacagg ctagtccatt actccaggga
     2101 gagagtcaga aggtgtttct ccatatgctg tctcacccat tgccacaggt gaaggtggag
     2161 acttaccagt gctgcctgga gattgtaaag gaatgtttag gtgtccaaaa tgtcactaaa
     2221 cctgtgtctt cactttgtag tggaattcat tttctgcttc atccaaaagt tctgtatgaa
     2281 atctctgcat ttggtattca agaatccaaa aatgaggtga atgctgctgc caaggccatt
     2341 ctgctgtatc tgcttcaggg acgattgatg atgacagctc tgacctggaa caagtttatc
     2401 gaatctctcg ctcctgtcat tccagtgcta cagggctacg ctgatacaga agatccctta
     2461 ggcaactgca ttctccttct aagcaaagtg agctctgagg caggagaagg cgctctcccc
     2521 tgcactgccc ggctgaagtc tgtgctacgg cttttgctag taaaaaaacc ttcggttcgt
     2581 tcactagcat taaaactttt agcatttcat cttaccagtg aagaaggggc tgataaaaag
     2641 cgcccgttca tagatgctgg cgttctctcc agagttacta atctgtttat tgtgaaaaaa
     2701 cctattgacc ttaagttgga tgacagaaga gaactagtta ttaagttgga gactgttaaa
     2761 aaggtgtgtg acatattcac ctcagacgat gttgatcttg ttttaagaaa gtcagctgca
     2821 gagcaactag ctgtgataat gcaagatatt aaaatgcata cagtggtgaa aaagttatgc
     2881 ttagttgaga agattattgg acatttaaat gaatttgtgg gtcaagatgg tgaggttata
     2941 gaatgcttga ttcagccatg cctcacactc ctgaggaagg ttttgtacgc tgacccggtt
     3001 atccgtgttt ccttgtcaca gcaggcctct ctcttgaccc tattactcag agtttccttg
     3061 atatttcatg aagattgtac tgtggtggct gaagtcgggg cattgttttg tcttctattg
     3121 ttcgatgaag tatcaagaat ggatacatgg tctgatactc tttctgataa gccttctttg
     3181 tcatcagtct tcagtttgcc ggtttcagtc tttagaaggt atcatctacc agttcatgtg
     3241 actggccacc atgctgtgag tccttactca atagttttgc cattacctac tgaatgtttg
     3301 accctgaagc cggtgtcaga tatgctgaga atagcttgga acctggcatg gtatcatggg
     3361 agtgataatc tattgaaaca aatgacctct gaagctaaaa ttcaggaatt tttagataca
     3421 ctgcagctgt ccacagaaga tatccttgca ctgaagatca catacacgga tagtgggttg
     3481 aaggactgcc ttcagtccat cattcaggct ggaggccaca gggatgtgag ggctgctatc
     3541 accaggatga gtttttatct tttgaatgac aaactgtctt tgaaggatga tattggtcca
     3601 tgtggcgtta ctttaaaatc cttggcttgg cacactgtgc tgaacaggtt tttacaagta
     3661 cttcctgctt gcactgaaga tgagaaactg ctaatagata tcatacattt tttgaataag
     3721 ttaataaagg aacaaagaaa aaacccatca attgaacttt taaactggat tctggaatta
     3781 cttcttaggc ataatccaag tccactacta gacctgctgg ttctgacaga ttcacatgca
     3841 ggagaagaaa cagatgacgt ccggactgct gtcagacagc aactccagaa agaactgatc
     3901 agtcttctca attccttgtt actggttttt atgacagtct ctgacaggaa atgcttggaa
     3961 ctgttttacg ttttccaaac acagctgtct ctgaagctac tccagtgcct cagagtcaca
     4021 gatgctcccc atttctatgg cttaccttca ttggagagga ccttagcagg gatggctcac
     4081 ctcactgcct tccctgggtg gagtgcacac tctcctcttt caaagccact tgagatttgt
     4141 gggaagtact tgtccggtct cctggaggtc attacttcct tttatgttga acggggagga
     4201 aatgctatgt ccttcatggg gaaaggcgtt acaaagagca caggtctttg cttacttcac
     4261 ttatcccatg agatgatagt ccaggcacca ggctcggagt ggatgccgct ttggttcttg
     4321 cctttgggta gtcacagtga agaacatgcc cctactcagc aaggattggc ctggctaatt
     4381 cccttatggg ttgatagaga cccagaggtg agattcactt cactggggtt gggatcagca
     4441 ctgactacta ttgaagctgg ctgtgtggcc ttggcaaaca gttgtcagaa tatttctggt
     4501 gggctctggg gaaccgtggt gaacattctt ctggatcaat cagaatgcag tctggtgcgc
     4561 cgggaggctg catttattct tcagaatctc cttgtaattc caatgccttc agaaattata
     4621 aaggattata cttggcaggg cccctgtgtc catgatgagg attctggcct gtcactttca
     4681 ggaaaacctg cccttcaggc tcttttatat cactgtcgtt tctatgaaca tttgactcac
     4741 atggtgaaac attgttatgt aggaagatat atctttgatt ttaatttttc tgcttttact
     4801 gaaacttcag aatacagtga tttaaatggt ttagacgact cattcaagtt ttggagggcc
     4861 ccttctggga catctactca ggatcatgag ccaagctctc tttccacctc agaaacaatg
     4921 gtggctgcct cggtggtcag ttctgagatt cagcccctgc tgccgtcaac acttcttcct
     4981 gaaactgccc ttgaccagtt tgtgacgcaa ggtcaacgtg aaatgagacc agtgcgacct
     5041 cgtgactcat tgctgtctac ttccctgaac aggcagtatg tgtttgttac tccgtctctg
     5101 ctgtcagcag tctgtagcct tttagacaac ctcttggcag ttactccaag agatgctgca
     5161 aatgcttttc aacaagctca tctcatagaa ctcctctgta gcacggtgga tgcttccctc
     5221 atagaaatgt gcatccaaga actcaagacc ccactgcctt taccatctgc tgttgaacat
     5281 attcaggctc aggcttcctt tttcttggaa tacctatcct ctttgtccca gctcttgaag
     5341 tcctgtctgt tggtagagcc taaacttgtg acacaagatg agctcttgaa acctcttatc
     5401 actaatgtca tccgagttct cattgtgtgt cccaaagatg tattagatgt acagttagtg
     5461 ttggcttttt accgcacatg gacgcattta tttgaccttc tggccacact actgaggaaa
     5521 gctggtgctg tctcccttgt tcctcttacc tcagctcttg ccaagcattg ggaggcagtg
     5581 actgatacac tgtgtagatg tgtgggcctc tcattcaagt gccctgccct gactattgcc
     5641 agcctccagt tcctgtctgt tctcttggct gaggaagaaa agaggcgtgt ccaggacaag
     5701 gacaaaacaa atgagggcca ggccccaaca gtggccttac ttcttgatgg aactcaggga
     5761 agccttagct cttcagagcg acttaatgaa acaattcttc agtgctatga aggaatatcc
     5821 cccaaagatg tcctgaaaag agttgctgca aatgccctgt tgtcacttct ggctgttagc
     5881 agaagagcgc agaggcatgc tttgagatct gatctcatag aaaactgtat ggagcagatg
     5941 aagcacatca atgcacaact gaacttagat ttgctgagac ctgggaaagc agtactgaaa
     6001 aaaaaggagg atggcttcat taaagaatta agcatcacca tgcagctcct aagaaactgc
     6061 ctttatcaaa atgaagaatg taaagtggca gctcttgaag cacgtcttgt gcctgtattg
     6121 cactctctct ggccttggct tttgatggaa gattcattga tgcaaattgc cttgcagttg
     6181 ctttgtgtct atactgcaaa ttttccagct ggctgcagtt ccctttgttg gtcaaattat
     6241 ggacagtgta ttcaaactgc acacagaggc acccccagta gctccctgat actgtgtatc
     6301 ctgaaactgg cttctcagat gcctgcagag aacaccacca ttcagcagtt ggtttttatg
     6361 tttctttcaa acttggcctt atctcatgac tgcaagggag taattcaaaa gagcaacttt
     6421 ctacagcact tcttgtccct gacattgcct aaaggaggaa accaacatct cagcactgtg
     6481 gccattctgt ggttgaagtt gctcctgaat atgtcatttg gagaagatgg acagcaaatg
     6541 atcctgaggc tagatggctg cttagactta ctcatagaga tgagcaagta caagcacaag
     6601 agcagccctc acatgcctct gctgatcttt cataacattt gcttcagtcc tgctaataag
     6661 cctaaaatcc tggctaatga aaaagttgtt actcttctgg ctgcctgttt agaaagtgag
     6721 aatcaaactg cccagaggat tggagcagct tcactttggg ctctaactta caattaccaa
     6781 aaggcaaaag caactttgaa aaatccatca ataaaaagaa aagtagatga agcatattcc
     6841 atagcaaaga gaactctctc aaactcagaa gaaaaccctc tgaattccta ctatttgaaa
     6901 tgccttgaaa atctagtaca actgcttaac tattcctgac ccatgaaata ctctactcca
     6961 aacctgaccg ccgtccacag gagatctgga tcagctttgt atagcagctg ctccctgaat
     7021 aatgctaact ctgcagtatc agtgcctgcc ttccctgtga gacagcagcc gccaaactga
     7081 aaggagtaga actggtgact tctcaggctg tttgttcctg gcagtcttcc agaagtgaag
     7141 actcgctgac ccaagatgct gcaaagacag aattctgaca atataaacat ttttatactt
     7201 ttctatgcaa tgtattttgt aaaaatatct atttcatagt tatttaataa ataatatttt
     7261 tagaaactaa aaaaaaaaaa
//
