LOCUS       NP_780751               2226 aa            linear   ROD 28-APR-2025
DEFINITION  rotatin [Mus musculus].
ACCESSION   NP_780751
VERSION     NP_780751.2
DBSOURCE    REFSEQ: accession NM_175542.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2226)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 2226)
  AUTHORS   Chatterjee,B., Richards,K., Bucan,M. and Lo,C.
  TITLE     Nt mutation causing laterality defects associated with deletion of
            rotatin
  JOURNAL   Mamm Genome 18 (5), 310-315 (2007)
   PUBMED   17551791
  REMARK    GeneRIF: No turning (nt), a recessive lethal mutation causing
            left-right and axial patterning defects is likely elicited by
            deficiency of Rttn on chromosome 18.
REFERENCE   3  (residues 1 to 2226)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (residues 1 to 2226)
  AUTHORS   Faisst,A.M., Alvarez-Bolado,G., Treichel,D. and Gruss,P.
  TITLE     Rotatin is a novel gene required for axial rotation and left-right
            specification in mouse embryos
  JOURNAL   Mech Dev 113 (1), 15-28 (2002)
   PUBMED   11900971
  REMARK    GeneRIF: cloning and characterization of rotatin
REFERENCE   5  (residues 1 to 2226)
  AUTHORS   Stoykova,A., Chowdhury,K., Bonaldo,P., Torres,M. and Gruss,P.
  TITLE     Gene trap expression and mutational analysis for genes involved in
            the development of the mammalian nervous system
  JOURNAL   Dev Dyn 212 (2), 198-213 (1998)
   PUBMED   9626495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF265232.1 and BC023916.1.
            
            On Oct 17, 2003 this sequence version replaced NP_780751.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 58.93 cM"
     Protein         1..2226
                     /product="rotatin"
                     /calculated_mol_wt=248359
     Region          16..112
                     /region_name="RTTN_N"
                     /note="Rotatin, an armadillo repeat protein, centriole
                     functioning; pfam14726"
                     /db_xref="CDD:464283"
     Region          295..346
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4Y8.2)"
     Site            311
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86VV8; propagated from
                     UniProtKB/Swiss-Prot (Q8R4Y8.2)"
     Site            813
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q86VV8; propagated from
                     UniProtKB/Swiss-Prot (Q8R4Y8.2)"
     CDS             1..2226
                     /gene="Rttn"
                     /gene_synonym="4921538A15Rik; C530033I08Rik; D230040K24"
                     /coded_by="NM_175542.3:259..6939"
                     /db_xref="CCDS:CCDS29390.1"
                     /db_xref="GeneID:246102"
                     /db_xref="MGI:MGI:2179288"
ORIGIN      
        1 mvlaglirkl ghqlaeirer alksilckie hnlicyadli qerllflhll ewfnfpsvpm
       61 keevlnllsr lvkyspavqh lidlgavefl sklrpnvepv iqaeidgild glfilpsevp
      121 alcsssyhtd qielsqqpev ltgyfpqdks nfqqmevppg pagnqavkwl rfsvfpwlpl
      181 tttdrhvlss nesslrssnh tliwntcell kdvimqdfpa eiflqrpkiv qgllclvkla
      241 fggdgkhrla lqsvsclqql ctslrnrlnf yrdpnffssr qdtvsqnssl sycheargpy
      301 hspnpspgss ssrpsvvgrt gqrprgdgqd wdavsssgss shthvnsris vhspldvapv
      361 dlpeleaedt lelqfqqlsl pqfcistlea aapllrtgsr emiirvlell aedmlligqa
      421 isseiwddns lfainvkekl lqvlgslget mcyrktsfsm eqaeavlvhh rmafvsislf
      481 tvrllqlllp vekaseflpe smsaalffvs ldmpisleyp eihdtvvayl eqldsenysi
      541 ykrtaeavys iectcnflsd vgkegeknll elveladqal rsfsyhqhsp likeiicics
      601 kiwksaqasp llqgesqkvf lhmlshplpq vkvetyqccl eivkeclgvq nvtkpvsslc
      661 sgihfllhpk vlyeisafgi qesknevnaa akaillyllq grlmmtaltw nkfieslapv
      721 ipvlqgyadt edplgncill lskvsseage galpctarlk svlrlllvkk psvrslalkl
      781 lafhltseeg adkkrpfida gvlsrvtnlf ivkkpidlkl ddrrelvikl etvkkvcdif
      841 tsddvdlvlr ksaaeqlavi mqdikmhtvv kklclvekii ghlnefvgqd geviecliqp
      901 cltllrkvly adpvirvsls qqaslltlll rvslifhedc tvvaevgalf clllfdevsr
      961 mdtwsdtlsd kpslssvfsl pvsvfrryhl pvhvtghhav spysivlplp tecltlkpvs
     1021 dmlriawnla wyhgsdnllk qmtseakiqe fldtlqlste dilalkityt dsglkdclqs
     1081 iiqagghrdv raaitrmsfy llndklslkd digpcgvtlk slawhtvlnr flqvlpacte
     1141 dekllidiih flnklikeqr knpsiellnw ilelllrhnp splldllvlt dshageetdd
     1201 vrtavrqqlq kelisllnsl llvfmtvsdr kclelfyvfq tqlslkllqc lrvtdaphfy
     1261 glpslertla gmahltafpg wsahsplskp leicgkylsg llevitsfyv erggnamsfm
     1321 gkgvtkstgl cllhlshemi vqapgsewmp lwflplgshs eehaptqqgl awliplwvdr
     1381 dpevrftslg lgsalttiea gcvalanscq nisgglwgtv vnilldqsec slvrreaafi
     1441 lqnllvipmp seiikdytwq gpcvhdedsg lslsgkpalq allyhcrfye hlthmvkhcy
     1501 vgryifdfnf saftetseys dlnglddsfk fwrapsgtst qdhepsslst setmvaasvv
     1561 sseiqpllps tllpetaldq fvtqgqremr pvrprdslls tslnrqyvfv tpsllsavcs
     1621 lldnllavtp rdaanafqqa hliellcstv dasliemciq elktplplps avehiqaqas
     1681 ffleylssls qllkscllve pklvtqdell kplitnvirv livcpkdvld vqlvlafyrt
     1741 wthlfdllat llrkagavsl vpltsalakh weavtdtlcr cvglsfkcpa ltiaslqfls
     1801 vllaeeekrr vqdkdktneg qaptvallld gtqgslssse rlnetilqcy egispkdvlk
     1861 rvaanallsl lavsrraqrh alrsdlienc meqmkhinaq lnldllrpgk avlkkkedgf
     1921 ikelsitmql lrnclyqnee ckvaalearl vpvlhslwpw llmedslmqi alqllcvyta
     1981 nfpagcsslc wsnygqciqt ahrgtpsssl ilcilklasq mpaenttiqq lvfmflsnla
     2041 lshdckgviq ksnflqhfls ltlpkggnqh lstvailwlk lllnmsfged gqqmilrldg
     2101 cldlliemsk ykhkssphmp llifhnicfs pankpkilan ekvvtllaac lesenqtaqr
     2161 igaaslwalt ynyqkakatl knpsikrkvd eaysiakrtl snseenplns yylkclenlv
     2221 qllnys
//
