LOCUS       NM_001004151            3120 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus receptor transporter protein 1 (Rtp1), mRNA.
ACCESSION   NM_001004151 XM_155893
VERSION     NM_001004151.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3120)
  AUTHORS   Orecchioni,M., Kobiyama,K., Winkels,H., Ghosheh,Y., McArdle,S.,
            Mikulski,Z., Kiosses,W.B., Fan,Z., Wen,L., Jung,Y., Roy,P.,
            Ali,A.J., Miyamoto,Y., Mangan,M., Makings,J., Wang,Z., Denn,A.,
            Vallejo,J., Owens,M., Durant,C.P., Braumann,S., Mader,N., Li,L.,
            Matsunami,H., Eckmann,L., Latz,E., Wang,Z., Hazen,S.L. and Ley,K.
  TITLE     Olfactory receptor 2 in vascular macrophages drives atherosclerosis
            by NLRP3-dependent IL-1 production
  JOURNAL   Science 375 (6577), 214-221 (2022)
   PUBMED   35025664
REFERENCE   2  (bases 1 to 3120)
  AUTHORS   Fukutani,Y., Tamaki,R., Inoue,R., Koshizawa,T., Sakashita,S.,
            Ikegami,K., Ohsawa,I., Matsunami,H. and Yohda,M.
  TITLE     The N-terminal region of RTP1S plays important roles in dimer
            formation and odorant receptor-trafficking
  JOURNAL   J Biol Chem 294 (40), 14661-14673 (2019)
   PUBMED   31395660
  REMARK    GeneRIF: using recombinant proteins and split luciferase assays in
            mammalian cells, we provided evidence for the dimer formation of
            RTP1S. Furthermore, we determined that the 2nd Cys residue is
            required for the efficient dimerization of RTP1S. Altogether, these
            findings provide insights into the mechanism for plasma membrane
            transport of odorant receptors (ORs) by RTP1S.
REFERENCE   3  (bases 1 to 3120)
  AUTHORS   Sharma,R., Ishimaru,Y., Davison,I., Ikegami,K., Chien,M.S., You,H.,
            Chi,Q., Kubota,M., Yohda,M., Ehlers,M. and Matsunami,H.
  TITLE     Olfactory receptor accessory proteins play crucial roles in
            receptor function and gene choice
  JOURNAL   Elife 6, e21895 (2017)
   PUBMED   28262096
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3120)
  AUTHORS   Garaffo,G., Provero,P., Molineris,I., Pinciroli,P., Peano,C.,
            Battaglia,C., Tomaiuolo,D., Etzion,T., Gothilf,Y., Santoro,M. and
            Merlo,G.R.
  TITLE     Profiling, Bioinformatic, and Functional Data on the Developing
            Olfactory/GnRH System Reveal Cellular and Molecular Pathways
            Essential for This Process and Potentially Relevant for the
            Kallmann Syndrome
  JOURNAL   Front Endocrinol (Lausanne) 4, 203 (2013)
   PUBMED   24427155
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3120)
  AUTHORS   Wang,S.Z., Ou,J., Zhu,L.J. and Green,M.R.
  TITLE     Transcription factor ATF5 is required for terminal differentiation
            and survival of olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 109 (45), 18589-18594 (2012)
   PUBMED   23090999
REFERENCE   6  (bases 1 to 3120)
  AUTHORS   Zhuang,H. and Matsunami,H.
  TITLE     Synergism of accessory factors in functional expression of
            mammalian odorant receptors
  JOURNAL   J Biol Chem 282 (20), 15284-15293 (2007)
   PUBMED   17387175
REFERENCE   7  (bases 1 to 3120)
  AUTHORS   Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
  TITLE     RTP family members induce functional expression of mammalian
            odorant receptors
  JOURNAL   Cell 119 (5), 679-691 (2004)
   PUBMED   15550249
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK047543.1.
            
            On Apr 6, 2007 this sequence version replaced NM_001004151.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047543.1, SRR1660819.31239.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3120              AK047543.1         2-3121
FEATURES             Location/Qualifiers
     source          1..3120
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 14.21 cM"
     gene            1..3120
                     /gene="Rtp1"
                     /gene_synonym="Gm1766; Gm604"
                     /note="receptor transporter protein 1"
                     /db_xref="GeneID:239766"
                     /db_xref="MGI:MGI:2685450"
     exon            1..318
                     /gene="Rtp1"
                     /gene_synonym="Gm1766; Gm604"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..838
                     /gene="Rtp1"
                     /gene_synonym="Gm1766; Gm604"
                     /codon_start=1
                     /product="receptor-transporting protein 1"
                     /protein_id="NP_001004151.1"
                     /db_xref="CCDS:CCDS28078.1"
                     /db_xref="GeneID:239766"
                     /db_xref="MGI:MGI:2685450"
                     /translation="MRIFRPWRLRCPALHLPSFPTFSIKCSLPPLPTDEDMCKSVTTG
                     EWKKVFYEKMEEVKPADSWDFIIDPNLKHNVLAPGWKQYLELHASGRFHCSWCWHTWQ
                     SPHVVILFHMYLDKAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIESLVDNLITS
                     LREQCYGERGGHYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFS
                     RAPSPTKPQAETGSGCNFCSIPWCLFWATVLMLIIYLQFSFRTSV"
     exon            319..3120
                     /gene="Rtp1"
                     /gene_synonym="Gm1766; Gm604"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggacaaag gagggagctg ggtcctgctt cctcctgatc ctgccgatga ggatttttag
       61 accgtggaga ctgcgctgcc ctgccttaca cttaccctct ttccccacgt tctctataaa
      121 gtgtagtttg cctcctcttc ccactgacga agacatgtgt aagagtgtga ccacaggtga
      181 gtggaagaag gtcttctacg agaagatgga ggaggtgaag ccagcggaca gctgggactt
      241 catcatagac cccaacctca agcacaatgt gttggcccct ggctggaagc agtacctgga
      301 acttcatgcc tcaggcaggt tccactgttc ctggtgctgg cacacctggc agtcacccca
      361 tgtagtcatc ctcttccaca tgtacctgga caaggctcag cgcgctggtt cggtgcgcat
      421 gcgtgtgttc aagcagctct gctacgagtg cggtacagca cggctggatg agtccagcat
      481 gctggaggag aacatcgaaa gcctggtgga caacctcatc accagtttgc gagagcagtg
      541 ctacggggag cgtggtggcc actaccgcat ccatgtggcc agccggcagg acaaccggcg
      601 acaccgcgga gagttctgcg aggcctgcca ggaaggcatc gtgcactgga agcccagtga
      661 gaagctgctg gaggaggagg cgaccaccta caccttctcc cgtgctccca gccccaccaa
      721 accgcaggct gaaacaggct caggctgcaa cttctgctcc attccctggt gcttattttg
      781 ggccacggtt ttgatgctca tcatctacct gcaattctcc ttccgtactt ctgtctaagc
      841 ttggggtggg gagtcagttg gtgggaaggg gtgaggtgag acctggcttg ggaatgggtc
      901 acattttaat gtgatgcagt tattgatttg gtgggaactc tgaatattta tccatttttc
      961 cccctatctg tagaattaag tgtctgggct ggatggttga tttctcaaaa gaaatccagg
     1021 gttccgaagt ccttctaggt acctcaggaa tgtatgattt gggaagtagt caatgagtga
     1081 gttgctttct cctaacccaa tatcggcccc caccctcaac ttctgccttt tcccttgctg
     1141 taatcagaag agaactactt tccatggtgt tccatgtagg acttttatat atacatatat
     1201 acaatatatg tgtatatata aacacaatat atatatgtac atatatacat atgtatgtat
     1261 atatacaagc ttgcatacac tatatgcata tatatatgct taaaaagaaa acaagcttgg
     1321 aaattatagg actaggttat ctctaaagat cttaaagcca aggaacttac ttgactttgc
     1381 tctcttggta ttttcaccct gtcctcatta ttaaccatag catctagctg gagctttaaa
     1441 gaacctcttt gccttcaata tgagcctgcc tcaggcacac acagaagttt ctcctgaagg
     1501 taaagaggta gggccactgg gtcgctggct ccactgcagt gtgcatgtgt tccccagact
     1561 tgaagcttct ggtatcttgt ccttcgggtg gatcccaagg tctgtctgct tgacaaaggg
     1621 gtggcagttg aggtagagtc acagggtgag gcctcacact cagtgcttgt gaagtggcat
     1681 aatttagaga ggtttgggag gaaaccacat agaataatga ctccccgtta tagtggagag
     1741 ctttcagggt tcagggtact tgtgtctcga ataggggaac aggggcctgg tcgcctatga
     1801 tttttgctga aagggtagaa gactggtttt ccacattggc tttctacctg gaccacagtg
     1861 atagaggatg cattaaatat acaaataact tgttggtaga gagtgcctag aagctcacat
     1921 cctttcaaaa tggggtacat tacggtttgc agccacagga ttggagacac cctgataaca
     1981 gagagtaagg ctggtgggga aaggtgaagg gccgggaata ggatgctccc caccctgagc
     2041 tctcgaggcc attgttcact gtctgagtta gtaaccaact tcctgtcctc cagccaggtc
     2101 tatagaaagt cacaatgcct gtagtgtggg agataggaaa gctacttaca taaagacctt
     2161 cagggtgtca ttaatgcacc attgagattc cccacatggt ccttgatgtc cattgggcca
     2221 ttagtgtccc ctctcagtat cctgtcttct ttcttactga gactctgtct agccattgtg
     2281 ctgggccaag aaaatcagca caaggcaagt gtcaccatga cagtagcaac cagctgtgac
     2341 ttcttccttc gcagtattaa tttctttagt cagccacaca tcctgggcac cactctctag
     2401 taagttctga tctgggtcca tacagtaggc accttgagcc aggttgagac tgtcagagtc
     2461 atctgctcat ttcagggctt ctcagccttg gctctatgtt aggaaccctg ggagctttta
     2521 aagcaatatt aatgacctaa acatccgagt tagagcaaac ctctgctgcc tggtgtaata
     2581 cgtcaatgaa aggggcagct tcatttgcat ccagtttata aacaatgcct ggcaatctcc
     2641 tctgatgaat ctccctggct ttctcagaaa tctagggctc actttccctc ctcagttgcc
     2701 ttccctctca tcccgttacc tgggagtaca gtcctccttc tcctttccca ccatggagat
     2761 ccgttgtgac aagggtgtta ccctgctctc tggtctccat tactgagact ttcttgcctt
     2821 gctagaatgc ctacacatct gacccgctgt aatctcttag tatcggagat actcccgatt
     2881 agaatgtaaa ttccagccag cacagtctcc ctggattgtc ttttacctct attgagcaca
     2941 gaacaagagc tcaggaagat tttgttgaac gactaagtga atcaatagct aggctatcgc
     3001 cagcctcatc tttgcttctg tgtactgttt gtttgtgaga atatgtatag tccccttttc
     3061 ataggaccac ctaatttcct agatcttcta cccatcaacc ccaaataaac tatttaaacc
//
