LOCUS       NM_199223               1263 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus reticulon 4 receptor-like 2 (Rtn4rl2), mRNA.
ACCESSION   NM_199223 XM_196264
VERSION     NM_199223.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1263)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1263)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1263)
  AUTHORS   Zhao,Y., Sivaji,S., Chiang,M.C., Ali,H., Zukowski,M., Ali,S.,
            Kennedy,B., Sklyar,A., Cheng,A., Guo,Z., Reed,A.K., Kodali,R.,
            Borowski,J., Frost,G., Beukema,P. and Wills,Z.P.
  TITLE     Amyloid Beta Peptides Block New Synapse Assembly by Nogo
            Receptor-Mediated Inhibition of T-Type Calcium Channels
  JOURNAL   Neuron 96 (2), 355-372 (2017)
   PUBMED   29024660
REFERENCE   4  (bases 1 to 1263)
  AUTHORS   Yoo,S.W., Motari,M.G. and Schnaar,R.L.
  TITLE     Agenesis of the corpus callosum in Nogo receptor deficient mice
  JOURNAL   J Comp Neurol 525 (2), 291-301 (2017)
   PUBMED   27339102
REFERENCE   5  (bases 1 to 1263)
  AUTHORS   Palandri,A., Salvador,V.R., Wojnacki,J., Vivinetto,A.L.,
            Schnaar,R.L. and Lopez,P.H.
  TITLE     Myelin-associated glycoprotein modulates apoptosis of motoneurons
            during early postnatal development via NgR/p75(NTR)
            receptor-mediated activation of RhoA signaling pathways
  JOURNAL   Cell Death Dis 6 (9), e1876 (2015)
   PUBMED   26335717
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1263)
  AUTHORS   Worter,V., Schweigreiter,R., Kinzel,B., Mueller,M., Barske,C.,
            Bock,G., Frentzel,S. and Bandtlow,C.E.
  TITLE     Inhibitory activity of myelin-associated glycoprotein on sensory
            neurons is largely independent of NgR1 and NgR2 and resides within
            Ig-Like domains 4 and 5
  JOURNAL   PLoS One 4 (4), e5218 (2009)
   PUBMED   19367338
  REMARK    GeneRIF: Sensory neurons deficient for both NgR proteins displayed
            only a moderate reduction of MAG-mediated inhibition of neurite
            growth.
REFERENCE   7  (bases 1 to 1263)
  AUTHORS   Williams,G., Wood,A., Williams,E.J., Gao,Y., Mercado,M.L., Katz,A.,
            Joseph-McCarthy,D., Bates,B., Ling,H.P., Aulabaugh,A., Zaccardi,J.,
            Xie,Y., Pangalos,M.N., Walsh,F.S. and Doherty,P.
  TITLE     Ganglioside inhibition of neurite outgrowth requires Nogo receptor
            function: identification of interaction sites and development of
            novel antagonists
  JOURNAL   J Biol Chem 283 (24), 16641-16652 (2008)
   PUBMED   18411262
REFERENCE   8  (bases 1 to 1263)
  AUTHORS   Lauren,J., Airaksinen,M.S., Saarma,M. and Timmusk,T.
  TITLE     Two novel mammalian Nogo receptor homologs differentially expressed
            in the central and peripheral nervous systems
  JOURNAL   Mol Cell Neurosci 24 (3), 581-594 (2003)
   PUBMED   14664809
  REMARK    GeneRIF: predominantly expressed in the neurons of the embryonic
            and adult nervous systems
REFERENCE   9  (bases 1 to 1263)
  AUTHORS   Barton,W.A., Liu,B.P., Tzvetkova,D., Jeffrey,P.D., Fournier,A.E.,
            Sah,D., Cate,R., Strittmatter,S.M. and Nikolov,D.B.
  TITLE     Structure and axon outgrowth inhibitor binding of the Nogo-66
            receptor and related proteins
  JOURNAL   EMBO J 22 (13), 3291-3302 (2003)
   PUBMED   12839991
REFERENCE   10 (bases 1 to 1263)
  AUTHORS   Pignot,V., Hein,A.E., Barske,C., Wiessner,C., Walmsley,A.R.,
            Kaupmann,K., Mayeur,H., Sommer,B., Mir,A.K. and Frentzel,S.
  TITLE     Characterization of two novel proteins, NgRH1 and NgRH2,
            structurally and biochemically homologous to the Nogo-66 receptor
  JOURNAL   J Neurochem 85 (3), 717-728 (2003)
   PUBMED   12694398
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY250220.1.
            
            On Jan 1, 2004 this sequence version replaced XM_196264.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY250220.1, BK001303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..1263
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngr2; Ngrh1; Ngrl3"
                     /note="reticulon 4 receptor-like 2"
                     /db_xref="GeneID:269295"
                     /db_xref="MGI:MGI:2669796"
     CDS             1..1263
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngr2; Ngrh1; Ngrl3"
                     /note="nogo-66 receptor homolog 1; nogo-66
                     receptor-related protein 2; nogo receptor-like 3"
                     /codon_start=1
                     /product="reticulon-4 receptor-like 2 precursor"
                     /protein_id="NP_954693.1"
                     /db_xref="CCDS:CCDS16197.1"
                     /db_xref="GeneID:269295"
                     /db_xref="MGI:MGI:2669796"
                     /translation="MLPGLRRLLQGPASACLLLTLLALPSVTPSCPMLCTCYSSPPTV
                     SCQANNFSSVPLSLPPSTQRLFLQNNLIRSLRPGTFGPNLLTLWLFSNNLSTIHPGTF
                     RHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYL
                     YLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGV
                     HRAAFHGLSRLTILYLFNNSLASLPGEALADLPALEFLRLNANPWACDCRARPLWAWF
                     QRARVSSSDVTCATPPERQGRDLRALRDSDFQACPPPTPTRPGSRARGNSSSNHLYGV
                     AEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYGGEDQRGEQTCPGAACQA
                     PADSRGPALSAGLRTPLLCLLPLALHHL"
     exon            1..31
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngr2; Ngrh1; Ngrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            32..513
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngr2; Ngrh1; Ngrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..1263
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngr2; Ngrh1; Ngrl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgcccg ggctccggcg cctgctgcaa ggtcctgcct cagcctgcct actgctgaca
       61 ctcctggccc ttccttccgt gacccccagc tgtcctatgc tctgcacctg ctactcctcc
      121 ccgcccaccg tgagctgcca ggccaacaac ttctcctcag tgccgctgtc cttgccaccc
      181 agtacacaga gactcttctt gcagaacaac ctcatccgct cactgcggcc aggcaccttt
      241 gggcccaacc tgctcaccct gtggctcttc tccaacaacc tctccaccat ccaccctggc
      301 accttccgcc acctgcaggc cctagaagaa ctggacctcg gtgacaaccg gcacctgcgc
      361 tccctggagc ccgacacctt ccagggtctg gagaggctgc agtcactaca cctgtatcgt
      421 tgccagctca gcagcctgcc tggcaacatt ttccgaggct tggtcagcct acagtacctc
      481 tacctccagg agaacagcct gctccatcta caggatgact tgttcgcgga cctggccaac
      541 ctgagccacc tcttcctcca cgggaaccgc ctgcggctgc tcacggagca cgtgttccgc
      601 ggcttgggca gcctggaccg gctgttgctg cacgggaacc ggctgcaggg cgtgcaccgc
      661 gcggctttcc acggcctcag ccgcctcacc atcctctacc tgttcaacaa cagcctggcc
      721 tcgctgccgg gagaggcgct ggccgacctg ccggcgctcg agttcctgcg gctcaacgcc
      781 aacccctggg cgtgcgactg ccgcgctcgg ccgctctggg cttggttcca gcgcgcgcgg
      841 gtgtccagct ccgacgtgac ctgcgccacc ccgcccgagc gccagggccg ggacctgcgc
      901 gcgctgcgcg actccgattt ccaagcgtgc ccgccgccca cgcccacgcg gccgggcagc
      961 cgcgcccgcg gcaacagctc ttccaaccac ctgtacggcg tggccgaggc tggcgctccc
     1021 cccgcagacc cgtccacgct ctaccgagat ctgcccgccg aggactcgcg ggggcgccag
     1081 ggcggggacg cgcccaccga ggacgactac tgggggggct acggcggcga ggatcagcgg
     1141 ggcgagcaga cgtgtcccgg ggccgcgtgc caggcgcccg cagactcgcg tggccccgcg
     1201 ctctcggccg ggctgcgcac ccctctgctc tgcctcttgc ccctggcgct ccatcacctc
     1261 tga
//
