LOCUS       NM_177708               3308 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus reticulon 4 receptor-like 1 (Rtn4rl1), mRNA.
ACCESSION   NM_177708
VERSION     NM_177708.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3308)
  AUTHORS   Bakhuraysah,M.M., Theotokis,P., Lee,J.Y., Alrehaili,A.A., Aui,P.M.,
            Figgett,W.A., Azari,M.F., Abou-Afech,J.P., Mackay,F., Siatskas,C.,
            Alderuccio,F., Strittmatter,S.M., Grigoriadis,N. and Petratos,S.
  TITLE     B-cells expressing NgR1 and NgR3 are localized to EAE-induced
            inflammatory infiltrates and are stimulated by BAFF
  JOURNAL   Sci Rep 11 (1), 2890 (2021)
   PUBMED   33536561
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3308)
  AUTHORS   Zhao,Y., Sivaji,S., Chiang,M.C., Ali,H., Zukowski,M., Ali,S.,
            Kennedy,B., Sklyar,A., Cheng,A., Guo,Z., Reed,A.K., Kodali,R.,
            Borowski,J., Frost,G., Beukema,P. and Wills,Z.P.
  TITLE     Amyloid Beta Peptides Block New Synapse Assembly by Nogo
            Receptor-Mediated Inhibition of T-Type Calcium Channels
  JOURNAL   Neuron 96 (2), 355-372 (2017)
   PUBMED   29024660
REFERENCE   3  (bases 1 to 3308)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3308)
  AUTHORS   Yoo,S.W., Motari,M.G. and Schnaar,R.L.
  TITLE     Agenesis of the corpus callosum in Nogo receptor deficient mice
  JOURNAL   J Comp Neurol 525 (2), 291-301 (2017)
   PUBMED   27339102
REFERENCE   5  (bases 1 to 3308)
  AUTHORS   Palandri,A., Salvador,V.R., Wojnacki,J., Vivinetto,A.L.,
            Schnaar,R.L. and Lopez,P.H.
  TITLE     Myelin-associated glycoprotein modulates apoptosis of motoneurons
            during early postnatal development via NgR/p75(NTR)
            receptor-mediated activation of RhoA signaling pathways
  JOURNAL   Cell Death Dis 6 (9), e1876 (2015)
   PUBMED   26335717
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3308)
  AUTHORS   Wills,Z.P., Mandel-Brehm,C., Mardinly,A.R., McCord,A.E., Giger,R.J.
            and Greenberg,M.E.
  TITLE     The nogo receptor family restricts synapse number in the developing
            hippocampus
  JOURNAL   Neuron 73 (3), 466-481 (2012)
   PUBMED   22325200
REFERENCE   7  (bases 1 to 3308)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   8  (bases 1 to 3308)
  AUTHORS   Lauren,J., Airaksinen,M.S., Saarma,M. and Timmusk,T.
  TITLE     Two novel mammalian Nogo receptor homologs differentially expressed
            in the central and peripheral nervous systems
  JOURNAL   Mol Cell Neurosci 24 (3), 581-594 (2003)
   PUBMED   14664809
  REMARK    GeneRIF: predominantly expressed in the neurons of the embryonic
            and adult nervous systems
REFERENCE   9  (bases 1 to 3308)
  AUTHORS   Barton,W.A., Liu,B.P., Tzvetkova,D., Jeffrey,P.D., Fournier,A.E.,
            Sah,D., Cate,R., Strittmatter,S.M. and Nikolov,D.B.
  TITLE     Structure and axon outgrowth inhibitor binding of the Nogo-66
            receptor and related proteins
  JOURNAL   EMBO J 22 (13), 3291-3302 (2003)
   PUBMED   12839991
REFERENCE   10 (bases 1 to 3308)
  AUTHORS   Pignot,V., Hein,A.E., Barske,C., Wiessner,C., Walmsley,A.R.,
            Kaupmann,K., Mayeur,H., Sommer,B., Mir,A.K. and Frentzel,S.
  TITLE     Characterization of two novel proteins, NgRH1 and NgRH2,
            structurally and biochemically homologous to the Nogo-66 receptor
  JOURNAL   J Neurochem 85 (3), 717-728 (2003)
   PUBMED   12694398
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK140456.1.
            
            On Apr 6, 2007 this sequence version replaced NM_177708.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140456.1, SRR1660815.244358.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3308              AK140456.1         2-3309
FEATURES             Location/Qualifiers
     source          1..3308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.76 cM"
     gene            1..3308
                     /gene="Rtn4rl1"
                     /gene_synonym="Ngr3; Ngrh2; Ngrl2"
                     /note="reticulon 4 receptor-like 1"
                     /db_xref="GeneID:237847"
                     /db_xref="MGI:MGI:2661375"
     exon            1..302
                     /gene="Rtn4rl1"
                     /gene_synonym="Ngr3; Ngrh2; Ngrl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1627
                     /gene="Rtn4rl1"
                     /gene_synonym="Ngr3; Ngrh2; Ngrl2"
                     /note="nogo-66 receptor homolog 2; nogo receptor-like 2;
                     nogo-66 receptor-related protein 3"
                     /codon_start=1
                     /product="reticulon-4 receptor-like 1 precursor"
                     /protein_id="NP_808376.1"
                     /db_xref="CCDS:CCDS25043.1"
                     /db_xref="GeneID:237847"
                     /db_xref="MGI:MGI:2661375"
                     /translation="MLRKGCCVELLLLLLAGELPLGGGCPRDCVCYPAPMTVSCQAHN
                     FAAIPEGIPEDSERIFLQNNRITFLQQGHFSPAMVTLWIYSNNITFIAPNTFEGFVHL
                     EELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGIFGGLHSLQYLYLQDNH
                     IEYLQDDIFVDLVNLSHLFLHGNKLWSLGQGIFRGLVNLDRLLLHENQLQWVHHKAFH
                     DLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGNAWDCGCRARSLWEWLRRFRGS
                     SSAVPCATPELRQGQDLKLLRVEDFRNCTGPVSPHQIKSHTLTTSDRAARKEHHPSHG
                     ASRDKGHPHGHPPGSRSGYKKAGKNCTSHRNRNQISKVSSGKELTELQDYAPDYQHKF
                     SFDIMPTARPKRKGKCARRTPIRAPSGVQQASSGTALGAPLLAWILGLAVTLR"
     exon            303..3308
                     /gene="Rtn4rl1"
                     /gene_synonym="Ngr3; Ngrh2; Ngrl2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3308
                     /gene="Rtn4rl1"
                     /gene_synonym="Ngr3; Ngrh2; Ngrl2"
                     /note="putative"
ORIGIN      
        1 ggcagaatca ggccgccggc tcggcggagc aagccactcg cccggggctg agcgagcgca
       61 ccgcgttggt tggcagcgcc gcggttgcta gcaggcgccg gtgccctgag caccgggttt
      121 gggctcacca tgcccctgcg ggaccgggcc gccgggcaca agcggattcc cggcttgccc
      181 ccgcctcgac gcgctcggat tagctgcagc tggcgcccag ggatttgaat ctggacccca
      241 ggagggagcg cgcctaggcc gacctcggag cggcggcccc gcggccaaca tgcttcgcaa
      301 agggtgctgt gtggaattgc tgctgttgct gctcgctgga gagctacctc tgggtggtgg
      361 ttgtcctcga gactgtgtgt gctaccctgc gcccatgact gtcagctgcc aggcacacaa
      421 ctttgctgcc atcccggagg gcatcccaga ggacagtgag cgcatcttcc tgcagaacaa
      481 tcgcatcacc ttcctccagc agggccactt cagccccgcc atggtcaccc tctggatcta
      541 ctccaacaac atcactttca ttgctcccaa caccttcgag ggctttgtgc atctggagga
      601 gctagacctt ggagacaacc gacagctgcg aacgctggca cccgagacct tccaaggcct
      661 ggtgaagctt cacgccctct acctctataa gtgtggactg agcgccctgc ccgcaggcat
      721 ctttggtggc ctgcacagcc tgcagtatct ctacttgcag gacaaccata tcgagtacct
      781 ccaagatgac atctttgtgg acctggtcaa tctcagtcac ttgtttctcc atggtaacaa
      841 gctatggagc ctgggccaag gcatcttccg gggcctggtg aacctggacc ggttgctgct
      901 gcatgagaac cagctacagt gggttcacca caaggctttc catgacctcc acaggctaac
      961 caccctcttt ctcttcaaca acagcctcac tgagctgcag ggtgactgtc tggcccccct
     1021 ggtggccttg gagttccttc gcctcaatgg gaatgcttgg gactgtggct gccgggcacg
     1081 ttccctgtgg gaatggctgc gaaggttccg tggctctagc tctgctgtcc cctgcgcgac
     1141 ccccgagctg cggcaaggcc aggatctgaa gctgctgagg gtggaggact tccggaactg
     1201 cacaggacca gtgtctcctc accagatcaa gtctcacacg cttaccacct ctgacagggc
     1261 tgcccgcaag gagcaccatc cgtcccatgg ggcctccagg gacaaaggcc acccacatgg
     1321 ccatccgcct ggctccaggt caggttacaa gaaggcaggc aagaactgca ccagccacag
     1381 gaaccggaac cagatctcta aggtgagctc tgggaaagag cttaccgaac tgcaggacta
     1441 tgcccccgac tatcagcaca agttcagctt tgacatcatg cccaccgcac gacccaagag
     1501 gaagggcaag tgtgctcgca ggacccccat ccgtgccccc agtggggtgc agcaggcatc
     1561 ctcaggcacg gcccttgggg ccccactcct ggcctggata ctggggctgg cagtcactct
     1621 ccgctgagga cccagggctc cgtcacccag cactgccaca tgtccagcaa ggaacagaat
     1681 ttttttcttc ttttctttct ttctttcttt tttttttcct aagtggaaga tctgctgggt
     1741 ttcaggaaaa ggctgctgaa gccttcagcc accgtctgga cccttcctgg tggattataa
     1801 gcccaaaatg tacagccgta gacgggaagg gtatcacgtc tcactcggct gtcctgaccg
     1861 agcgcctctg gaccgtatcc actccagcac agtggtcaaa ggcacgcaaa gtgagtcatt
     1921 agtggtgtcg ggacatgcgc cccttgaaga agctgggctc tgcggaagcc tggtcatttg
     1981 gagagaaggg ctgaaggacc ctgctggttt tggaaggagc aggactcaga acaaggctct
     2041 cccagagcca gctggggcaa ccagcaatct cagagcactc ttggctcttg tctgagatca
     2101 cttagttaac ctgccctgtc caaccctatg ccaccctcag tccctatcca tgggggtaat
     2161 gcctctcatt cctgacgtct caggcagccc ccggcagacc tgctggggtc caagaaccaa
     2221 tcaccaaagg agagatcgcc agtggatgac atttagaact gtactcgcaa tgagagtcac
     2281 acagaaggtg cagttttata cctatgtcca cttatatata tcctcactct gcccacacac
     2341 ccacataata tatatatata tataaatata taaatgcaca ggtcccccaa cccactcctt
     2401 accaaactgt atgtcttatc atgtttataa actatacggg aacctatatt tgctcaatta
     2461 aggactgtat cggtaacttc tagcaagaaa aaaaaaaaca aaaaactgcg gcaattttgt
     2521 tcagaacccc agccagcaac aatagtccct gggcttgctg ggggcaaagg tgtcagtggg
     2581 aagagtcggg aaggaagaga agcagcaaga atcacttcag gggaccaaca ttcttagata
     2641 cttagaacat cacctcgttt ttatatgcaa cacacgcctg tctggcaccc cggagcaccc
     2701 cgtcacccct actgtagaag ctgcagacat tagcgagaga agtggatgtc agggtgctgg
     2761 aggcaagcta ggcggagctg gggaagaggt ttctggggtt ttcaagctgg cagacaaggc
     2821 agcgtctaca gtgttagtcc aatgggttgg atggacaatg tccttcttag cactttgtgc
     2881 aggccaggga ggctctgagc tctggcctca ggagaggctt tagctgcagt tttaacatct
     2941 aggctctttg gccagtgacc tactgagggc cctgagtagt ctggcagtgg gaaaaaaatc
     3001 tagtggcctt agcagatgag ggtgtttcag tagccatctc aggaaccctg tatcacagtg
     3061 gtcctgctcc tcctggatga ccccaggacg ggcagaggtc agagggccag actcaggggt
     3121 cagcccagaa ggcagcctgc aggcaagccc agtcagggaa tagggctgtt ggcccaaggg
     3181 tttctggcaa gcacagtctc ttgtgctctg catagacaga cctgaattcc ctaccagaga
     3241 ggatacctga ggagtaagaa atgctgaatc caattaagag agaaaaataa taataaaaat
     3301 tctcttgg
//
