LOCUS       NM_022982               1938 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus reticulon 4 receptor (Rtn4r), mRNA.
ACCESSION   NM_022982 XM_192796
VERSION     NM_022982.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Eom,T.Y., Schmitt,J.E., Li,Y., Davenport,C.M., Steinberg,J.,
            Bonnan,A., Alam,S., Ryu,Y.S., Paul,L., Hansen,B.S., Khairy,K.,
            Pelletier,S., Pruett-Miller,S.M., Roalf,D.R., Gur,R.E.,
            Emanuel,B.S., McDonald-McGinn,D.M., Smith,J.N., Li,C.,
            Christie,J.M., Northcott,P.A. and Zakharenko,S.S.
  TITLE     Tbx1 haploinsufficiency leads to local skull deformity,
            paraflocculus and flocculus dysplasia, and motor-learning deficit
            in 22q11.2 deletion syndrome
  JOURNAL   Nat Commun 15 (1), 10510 (2024)
   PUBMED   39638997
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Dos Santos Natividade,R., Dumitru,A.C., Nicoli,A., Strebl,M.,
            Sutherland,D.M., Welsh,O.L., Ghulam,M., Stehle,T., Dermody,T.S., Di
            Pizio,A., Koehler,M. and Alsteens,D.
  TITLE     Viral capsid structural assembly governs the reovirus binding
            interface to NgR1
  JOURNAL   Nanoscale Horiz 9 (11), 1925-1937 (2024)
   PUBMED   39347978
  REMARK    GeneRIF: Viral capsid structural assembly governs the reovirus
            binding interface to NgR1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1938)
  AUTHORS   Pagella,P., Lai,C.F., Pirenne,L., Cantu,C., Schwab,M.E. and
            Mitsiadis,T.A.
  TITLE     An unexpected role of neurite outgrowth inhibitor A as regulator of
            tooth enamel formation
  JOURNAL   Int J Oral Sci 16 (1), 60 (2024)
   PUBMED   39426966
  REMARK    Erratum:[Int J Oral Sci. 2024 Nov 8;16(1):64. doi:
            10.1038/s41368-024-00330-y. PMID: 39511159]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1938)
  AUTHORS   Kurihara,Y., Kawaguchi,Y., Ohta,Y., Kawasaki,N., Fujita,Y. and
            Takei,K.
  TITLE     Nogo Receptor Antagonist LOTUS Promotes Neurite Outgrowth through
            Its Interaction with Teneurin-4
  JOURNAL   Cells 13 (16), 1369 (2024)
   PUBMED   39195260
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1938)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1938)
  AUTHORS   Liu,B.P., Fournier,A., GrandPre,T. and Strittmatter,S.M.
  TITLE     Myelin-associated glycoprotein as a functional ligand for the
            Nogo-66 receptor
  JOURNAL   Science 297 (5584), 1190-1193 (2002)
   PUBMED   12089450
  REMARK    GeneRIF: Myelin-associated glycoprotein(MAG) binds directly, with
            high affinity, to NgR; MAG and Nogo-66 activate NgR independently
            and serve as redundant NgR ligands that may limit axonal
            regeneration after CNS injury
REFERENCE   7  (bases 1 to 1938)
  AUTHORS   Wang,X., Chun,S.J., Treloar,H., Vartanian,T., Greer,C.A. and
            Strittmatter,S.M.
  TITLE     Localization of Nogo-A and Nogo-66 receptor proteins at sites of
            axon-myelin and synaptic contact
  JOURNAL   J Neurosci 22 (13), 5505-5515 (2002)
   PUBMED   12097502
  REMARK    GeneRIF: Localization of Nogo-66 receptor at sites of axon-myelin
            and synaptic contact
REFERENCE   8  (bases 1 to 1938)
  AUTHORS   Nakanishi,A., Imajoh-Ohmi,S. and Hanaoka,F.
  TITLE     Characterization of the interaction between DNA gyrase inhibitor
            and DNA gyrase of Escherichia coli
  JOURNAL   J Biol Chem 277 (11), 8949-8954 (2002)
   PUBMED   11777918
REFERENCE   9  (bases 1 to 1938)
  AUTHORS   Ng,C.E. and Tang,B.L.
  TITLE     Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron
            regeneration
  JOURNAL   J Neurosci Res 67 (5), 559-565 (2002)
   PUBMED   11891768
  REMARK    GeneRIF: Nogo-66 retards neurite outgrowth and induces growth cone
            collapse by its interaction with NgR and as yet unidentified
            transmembrane coreceptors.
            Review article
REFERENCE   10 (bases 1 to 1938)
  AUTHORS   Fournier,A.E., GrandPre,T. and Strittmatter,S.M.
  TITLE     Identification of a receptor mediating Nogo-66 inhibition of axonal
            regeneration
  JOURNAL   Nature 409 (6818), 341-346 (2001)
   PUBMED   11201742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087064.27 and AC118542.20.
            
            On Apr 20, 2018 this sequence version replaced NM_022982.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058381.1, AF283462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC087064.27        7417-7677           c
            262-1938            AC118542.20        73255-74931         c
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.23 cM"
     gene            1..1938
                     /gene="Rtn4r"
                     /gene_synonym="NgR; NgR1; NOGOR"
                     /note="reticulon 4 receptor"
                     /db_xref="GeneID:65079"
                     /db_xref="MGI:MGI:2136886"
     exon            1..261
                     /gene="Rtn4r"
                     /gene_synonym="NgR; NgR1; NOGOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1661
                     /gene="Rtn4r"
                     /gene_synonym="NgR; NgR1; NOGOR"
                     /note="nogo66 receptor-1"
                     /codon_start=1
                     /product="reticulon-4 receptor precursor"
                     /protein_id="NP_075358.1"
                     /db_xref="CCDS:CCDS37279.1"
                     /db_xref="GeneID:65079"
                     /db_xref="MGI:MGI:2136886"
                     /translation="MKRASSGGSRLLAWVLWLQAWRVATPCPGACVCYNEPKVTTSCP
                     QQGLQAVPTGIPASSQRIFLHGNRISHVPAASFQSCRNLTILWLHSNALARIDAAAFT
                     GLTLLEQLDLSDNAQLHVVDPTTFHGLGHLHTLHLDRCGLRELGPGLFRGLAALQYLY
                     LQDNNLQALPDNTFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVH
                     PHAFRDLGRLMTLYLFANNLSMLPAEVLMPLRSLQYLRLNDNPWVCDCRARPLWAWLQ
                     KFRGSSSEVPCNLPQRLADRDLKRLAASDLEGCAVASGPFRPIQTSQLTDEELLSLPK
                     CCQPDAADKASVLEPGRPASAGNALKGRVPPGDTPPGNGSGPRHINDSPFGTLPSSAE
                     PPLTALRPGGSEPPGLPTTGPRRRPGCSRKNRTRSHCRLGQAGSGASGTGDAEGSGAL
                     PALACSLAPLGLALVLWTVLGPC"
     exon            262..1938
                     /gene="Rtn4r"
                     /gene_synonym="NgR; NgR1; NOGOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn4r"
                     /gene_synonym="NgR; NgR1; NOGOR"
                     /note="hexamer: AATAAA"
     polyA_site      1938
                     /gene="Rtn4r"
                     /gene_synonym="NgR; NgR1; NOGOR"
                     /note="major polyA site"
ORIGIN      
        1 atcctctcct ggcccgcgct gcgagcgccc cgccagtccg cgccgccgcc ctcaccctgt
       61 gcgcccgcag cccgcgagcc cagcccggcc cggtagagcg gagcgccgga gcctcgtccc
      121 gcggccgggc cgggaccggg ccggagcagc ggcgcctgga tgcggacccg gccgcgcgca
      181 gacgggcgcc cgccccgaag ccgcttccag tgcccgacgc gccccgctcg accccgaaga
      241 tgaagagggc gtcctccgga ggaagcaggc tgctggcatg ggtgttatgg ctacaggcct
      301 ggagggtagc aacaccatgc cctggtgctt gtgtgtgcta caatgagccc aaggtaacaa
      361 caagctgccc ccagcagggt ctgcaggctg tgcccactgg catcccagcc tctagccagc
      421 gaatcttcct gcatggcaac cgaatctctc acgtgccagc tgcgagcttc cagtcatgcc
      481 gaaatctcac tatcctgtgg ctgcactcta atgcgctggc tcggatcgat gctgctgcct
      541 tcactggtct gaccctcctg gagcaactag atcttagtga taatgcacag cttcatgtcg
      601 tggaccctac cacgttccac ggcctgggcc acctgcacac actgcaccta gaccgatgtg
      661 gcctgcggga gctgggtccc ggcctattcc gtggactagc agctctgcag tacctctacc
      721 tacaagacaa caatctgcag gcactccctg acaacacctt tcgagacctg ggcaacctca
      781 cgcatctctt tctgcatggc aaccgtatcc ccagtgtgcc tgagcacgct ttccgtggcc
      841 tgcacagtct tgaccgcctc ctcttgcacc agaaccatgt ggctcgtgtg cacccacatg
      901 ccttccggga ccttggccgc ctcatgaccc tctacctgtt tgccaacaac ctctccatgc
      961 tgcctgcaga ggtcctaatg cccctgaggt ctctgcagta cctgcgactc aatgacaacc
     1021 cctgggtgtg tgactgccgg gcacgtccac tctgggcctg gctgcagaag ttccgaggtt
     1081 cctcatcaga ggtgccctgc aacctgcccc aacgcctggc agaccgtgat cttaagcgcc
     1141 tcgctgccag tgacctagag ggctgtgctg tggcttcagg acccttccgt cccatccaga
     1201 ccagtcagct cactgatgag gagctgctga gcctccccaa gtgctgccag ccagatgctg
     1261 cagacaaagc ctcagtactg gaacccggga ggccagcttc tgccggaaac gccctcaagg
     1321 gacgtgtgcc tcccggtgac actccaccag gcaatggctc aggccctcgg cacatcaatg
     1381 actctccatt tggaactttg cccagctctg cagagccccc actgactgcc ctgcggcctg
     1441 ggggttccga gccaccagga cttcccacca ctggtccccg caggaggcca ggttgttccc
     1501 ggaagaatcg cacccgcagc cactgccgtc tgggccaggc gggaagtggg gccagtggaa
     1561 caggggacgc agagggttca ggggctctgc ctgctctggc ctgcagcctt gctcctctgg
     1621 gccttgcact ggtactttgg acagtgcttg ggccctgctg accagccacc agccaccagg
     1681 tgtgtgtaca tatggggtct ccctccacgc cgccagccag agccagggac aggctctgag
     1741 gggcaggcca ggccctccct gacagatgcc tccccaccag cccaccccca tctccacccc
     1801 atcatgttta cagggttccg ggggtggcgt ttgttccaga acgccacctc ccacccggat
     1861 cgcggtatat agagatatga attttatttt acttgtgtaa aatatcggat gacgtggaat
     1921 aaagagctct tttcttaa
//
