LOCUS       NM_130892               2982 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus reticulon 4 interacting protein 1 (Rtn4ip1),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_130892
VERSION     NM_130892.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2982)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2982)
  AUTHORS   Park,I., Kim,K.E., Kim,J., Kim,A.K., Bae,S., Jung,M., Choi,J.,
            Mishra,P.K., Kim,T.M., Kwak,C., Kang,M.G., Yoo,C.M., Mun,J.Y.,
            Liu,K.H., Lee,K.S., Kim,J.S., Suh,J.M. and Rhee,H.W.
  TITLE     Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for
            coenzyme Q synthesis
  JOURNAL   Nat Chem Biol 20 (2), 221-233 (2024)
   PUBMED   37884807
  REMARK    GeneRIF: Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase
            for coenzyme Q synthesis.
REFERENCE   3  (bases 1 to 2982)
  AUTHORS   Duan,Y., Wang,H., Mitchell-Silbaugh,K., Cai,S., Fan,F., Li,Y.,
            Tang,H., Wang,G., Fang,X., Liu,J., Jia,N., Jing,R. and Ouyang,K.
  TITLE     Heat shock protein 60 regulates yolk sac erythropoiesis in mice
  JOURNAL   Cell Death Dis 10 (10), 766 (2019)
   PUBMED   31601784
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2982)
  AUTHORS   Angebault,C., Guichet,P.O., Talmat-Amar,Y., Charif,M., Gerber,S.,
            Fares-Taie,L., Gueguen,N., Halloy,F., Moore,D., Amati-Bonneau,P.,
            Manes,G., Hebrard,M., Bocquet,B., Quiles,M., Piro-Megy,C.,
            Teigell,M., Delettre,C., Rossel,M., Meunier,I., Preising,M.,
            Lorenz,B., Carelli,V., Chinnery,P.F., Yu-Wai-Man,P., Kaplan,J.,
            Roubertie,A., Barakat,A., Bonneau,D., Reynier,P., Rozet,J.M.,
            Bomont,P., Hamel,C.P. and Lenaers,G.
  TITLE     Recessive Mutations in RTN4IP1 Cause Isolated and Syndromic Optic
            Neuropathies
  JOURNAL   Am J Hum Genet 97 (5), 754-760 (2015)
   PUBMED   26593267
  REMARK    Erratum:[Am J Hum Genet. 2015 Nov 5;97(5):769]
REFERENCE   5  (bases 1 to 2982)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2982)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 2982)
  AUTHORS   Hu,W.H., Hausmann,O.N., Yan,M.S., Walters,W.M., Wong,P.K. and
            Bethea,J.R.
  TITLE     Identification and characterization of a novel Nogo-interacting
            mitochondrial protein (NIMP)
  JOURNAL   J Neurochem 81 (1), 36-45 (2002)
   PUBMED   12067236
REFERENCE   8  (bases 1 to 2982)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153536.3, AK050324.1 and AC158637.3.
            
            On Dec 16, 2017 this sequence version replaced NM_130892.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024116.1, AK088029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC153536.3         202739-202741
            4-2979              AK050324.1         2-2977
            2980-2982           AC158637.3         189026-189028
FEATURES             Location/Qualifiers
     source          1..2982
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.12 cM"
     gene            1..2982
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /note="reticulon 4 interacting protein 1"
                     /db_xref="GeneID:170728"
                     /db_xref="MGI:MGI:2178759"
     exon            1..730
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..1647
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /note="reticulon-4-interacting protein 1, mitochondrial;
                     NOGO-interacting mitochondrial protein"
                     /codon_start=1
                     /product="reticulon-4-interacting protein 1, mitochondrial
                     precursor"
                     /protein_id="NP_570962.2"
                     /db_xref="CCDS:CCDS23823.1"
                     /db_xref="GeneID:170728"
                     /db_xref="MGI:MGI:2178759"
                     /translation="MGVLKTCVLRRSACAAACFWRRTVIPKPPFRGISTTSARSTVMP
                     AWVIDKYGKNEVLRFTQNMMLPIIHYPNEVIIKVHAASVNPIDVNMRSGYGATALNMK
                     RDPLHMKTKGEEFPLTLGRDVSGVVMECGLDVKYFQPGDEVWAAVPPWKQGTLSEFVV
                     VSGNEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLSDRNCKGKRALILGASGGVG
                     TFAIQVMKAWGAHVTAVCSKDASELVRKLGADEVIDYTLGSVEEQLKSLKLFDFILDN
                     VGGSTETWALNFLKKWSGATYVTLVTPFLLNMDRLGVADGMLQTGVTVGTKALKHLWQ
                     GVHYRWAFFMASGPYLDEIAELVDAGKIRPVIERTFPFSEVPEAFLKVERGHARGKTV
                     VNVV"
     exon            731..882
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            883..951
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1076
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1125
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1262
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1446
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1539
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..2982
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2963..2968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /note="hexamer: AATAAA"
     polyA_site      2982
                     /gene="Rtn4ip1"
                     /gene_synonym="D10Ertd690e; NIMP"
                     /note="major polyA site"
ORIGIN      
        1 gccggcgacc ggaggcgcgc ggacaggcaa ggagaccgcg gccggggtcg tgtcaggaat
       61 ccgcctgacc taggaattgc tagccttgtt tgcttgtccc tctgaggact ccctgcttgc
      121 ttgctttttt ttccttaagg ggaaggagag cgtaaggaag gaatggccag tgtactgact
      181 ggacgccaac tgggacattt ctgacgtggg gagcacagta gcaattctat tttaattccg
      241 tcgcggcttt aggttgagtt tgcttctgaa agctccccct cgcttaattg acctgtgggt
      301 ttggcagatt ttggctgaat tgaaatgtgt tagtttgacc tgcttcaggt cctttctctc
      361 caccgtcgca ccccccaccc ccgctcctcc tttctttttt ctttttcttt ttttcttttc
      421 tttttttcga ggaaacgttc tccatccctg ctcaggatgg gcgttttgaa gacctgtgta
      481 cttagaagaa gtgcttgtgc cgccgcctgc ttctggagaa ggacagttat cccaaagcca
      541 ccatttagag gcattagtac tacgtctgcg aggagcactg tcatgcccgc ttgggtgata
      601 gataaatatg gaaagaatga agtccttcga ttcacccaga acatgatgtt acctatcata
      661 cactatccaa atgaagtcat tatcaaagtc cacgctgcca gtgtaaatcc tatagatgtt
      721 aatatgagaa gtggttatgg agccacagcc ctaaatatga agcgtgatcc cctgcatatg
      781 aaaaccaaag gagaagagtt tcctctgact ctgggtcggg atgtctctgg tgtggtgatg
      841 gagtgtgggc ttgatgtgaa gtatttccag cctggagatg aggtctgggc tgcagttcct
      901 ccttggaagc aaggcactct ctcagaattt gttgtggtca gtgggaatga ggtttcacac
      961 aagcccaaat cgcttactca tactcaagct gcctctttgc catatgtggc tctcacggcc
     1021 tggtctgcca taaacaaggt tggcggcctg agtgacagga actgcaaggg gaagcgtgcc
     1081 ttaatcttgg gtgcgtcagg tggagttggt acttttgcga tacaggtaat gaaagcatgg
     1141 ggggctcatg tgacagccgt ttgctcgaaa gatgccagtg aacttgtgcg gaagcttgga
     1201 gcagatgagg tcattgatta cacgttggga agtgtggaag agcaattgaa atctctaaaa
     1261 ctgtttgact ttatccttga taacgttggt ggatctactg aaacatgggc tctaaatttt
     1321 ctcaagaagt ggtcaggagc tacctatgtg actctggtga ctcctttcct cctgaacatg
     1381 gaccgactgg gtgttgctga tggcatgttg cagacaggag tcaccgtggg tacaaaggca
     1441 ttgaagcatc tctggcaagg agtccattac agatgggcct tcttcatggc cagtggtcca
     1501 tatctagatg aaattgcaga actggtggat gcaggaaaga tccggccagt tattgagcgg
     1561 acattccctt tctctgaagt cccagaagcc ttcctgaagg tggagagagg ccacgcccga
     1621 ggaaagactg tggttaatgt agtttaaata catatatggg caagctggcg gcttgctgct
     1681 ctctcctcgc caagtgcctc ggacccagac atctagcctt caccacacat tctcccgagt
     1741 cagattttaa gtttcactat ccatgtataa acctactcct ggactggtga gagctcacag
     1801 gtaaagttgc gtggctgcct gagttcagtt cctggagccc actcgaggga gaactgattc
     1861 cagtacattg ttctctctcc ccctccccca ctatgcacac acctctacag agataaagaa
     1921 atgcataatg cttgtgtggg cacatgcgcc aagggcacga gaggacatca cagggaacct
     1981 tcgggagcca gtgctagcct ttacccacgg agtcatctca ctggcccaat gaaaaacatt
     2041 tttaaaaata tgtgttttaa aaaatacttt caaaattatt taaattgacc tagagaatag
     2101 tttcttcatg gcagtctaca tgtacgttca tgggatgtag ccttttgtgc taatcatttg
     2161 ccaatgctca gtacaaaact gtcagctcct gcacttgcct gcagtcagtg ggaagtacat
     2221 ggtgctttgt tttaatttat tttgattttg tgtcatgtgt atggatattt gcctatgtgt
     2281 atgtgcacca tatggcatgt cttgtacctg gggcgcccag aggtggttgt caggtccctt
     2341 ggaactggaa ttaacaggtg attgtgagct gccatgtagg cactgggaat tgaacctggg
     2401 tcctcaggaa gagcagccag tgttcctaaa tgcggagctg tctccagcct ctgcacagtg
     2461 tttttgtttt cataagctgt ggtttgaccc agctctgtaa atttttgtgg cctttttgta
     2521 gctcaaaccc cgccatctta tgttaatgtc tgtgagattc taaaacgggt cagaacctct
     2581 cccaaggacc ttcgtgtgca gcatcacttg tgataatact gggaggtagc agaaccttac
     2641 gtaggaccta gtgggaggaa gtggggaggc actgctggag gagataccag gacccagggc
     2701 tttcctgctt ctatgtcttg atcgcctgta ggcaggcctg aggagcattc tcttgattga
     2761 tggttggtgg atgggtccag cccactgtgg gaggtgccat ccctgggtag gtagtcatgg
     2821 ggtgtataag aaaccaaact cagtaagcta aggggaagca agccagtcag cagcactcct
     2881 ctgtggcctc tgcattagtt cctgcctccg ggttcctgca ttccttgagt ccctgccctc
     2941 tatgatgtaa tctgtgagat gtaataaacc ctttcctcct ca
//
