LOCUS       NM_194054               6165 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus reticulon 4 (Rtn4), transcript variant 1, mRNA.
ACCESSION   NM_194054
VERSION     NM_194054.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6165)
  AUTHORS   Pagella,P., Lai,C.F., Pirenne,L., Cantu,C., Schwab,M.E. and
            Mitsiadis,T.A.
  TITLE     An unexpected role of neurite outgrowth inhibitor A as regulator of
            tooth enamel formation
  JOURNAL   Int J Oral Sci 16 (1), 60 (2024)
   PUBMED   39426966
  REMARK    GeneRIF: An unexpected role of neurite outgrowth inhibitor A as
            regulator of tooth enamel formation.
            Erratum:[Int J Oral Sci. 2024 Nov 8;16(1):64. doi:
            10.1038/s41368-024-00330-y.. PMID: 39511159]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6165)
  AUTHORS   Gong,K., Xue,C., Feng,Z., Pan,R., Wang,M., Chen,S., Chen,Y.,
            Guan,Y., Dai,L., Zhang,S., Jiang,L., Li,L., Wang,B., Yin,Z., Ma,L.,
            Iwakiri,Y., Tang,J., Liao,C., Chen,H. and Duan,Y.
  TITLE     Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on
            the endoplasmic reticulum to inhibit PCSK1 cleavage
  JOURNAL   Nat Commun 15 (1), 6845 (2024)
   PUBMED   39122737
  REMARK    Erratum:[Nat Commun. 2024 Sep 10;15(1):7902. doi:
            10.1038/s41467-024-52287-5.. PMID: 39256382]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6165)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6165)
  AUTHORS   Zhang,Y., Li,J.J., Xu,R., Wang,X.P., Zhao,X.Y., Fang,Y., Chen,Y.P.,
            Ma,S., Di,X.H., Wu,W., She,G., Pang,Z.D., Wang,Y.D., Zhang,X.,
            Xie,W., Deng,X.L., Du,X.J. and Zhang,Y.
  TITLE     Nogo-B mediates endothelial oxidative stress and inflammation to
            promote coronary atherosclerosis in pressure-overloaded mouse
            hearts
  JOURNAL   Redox Biol 68, 102944 (2023)
   PUBMED   37890359
  REMARK    GeneRIF: Nogo-B mediates endothelial oxidative stress and
            inflammation to promote coronary atherosclerosis in
            pressure-overloaded mouse hearts.
REFERENCE   5  (bases 1 to 6165)
  AUTHORS   Sekine,Y., Wang,X., Kikkawa,K., Honda,S. and Strittmatter,S.M.
  TITLE     Amino-terminal proteolytic fragment of the axon growth inhibitor
            Nogo-A (Rtn4A) is upregulated by injury and promotes axon
            regeneration
  JOURNAL   J Biol Chem 299 (10), 105232 (2023)
   PUBMED   37690690
  REMARK    GeneRIF: Amino-terminal proteolytic fragment of the axon growth
            inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon
            regeneration.
REFERENCE   6  (bases 1 to 6165)
  AUTHORS   Tozaki,H., Kawasaki,T., Takagi,Y. and Hirata,T.
  TITLE     Expression of Nogo protein by growing axons in the developing
            nervous system
  JOURNAL   Brain Res Mol Brain Res 104 (2), 111-119 (2002)
   PUBMED   12225863
  REMARK    GeneRIF: expression by growing axons in the developing nervous
            system
REFERENCE   7  (bases 1 to 6165)
  AUTHORS   Fournier,A.E., GrandPre,T. and Strittmatter,S.M.
  TITLE     Identification of a receptor mediating Nogo-66 inhibition of axonal
            regeneration
  JOURNAL   Nature 409 (6818), 341-346 (2001)
   PUBMED   11201742
REFERENCE   8  (bases 1 to 6165)
  AUTHORS   Tagami,S., Eguchi,Y., Kinoshita,M., Takeda,M. and Tsujimoto,Y.
  TITLE     A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on
            endoplasmic reticulum and reduces their anti-apoptotic activity
  JOURNAL   Oncogene 19 (50), 5736-5746 (2000)
   PUBMED   11126360
REFERENCE   9  (bases 1 to 6165)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   10 (bases 1 to 6165)
  AUTHORS   GrandPre,T., Nakamura,F., Vartanian,T. and Strittmatter,S.M.
  TITLE     Identification of the Nogo inhibitor of axon regeneration as a
            Reticulon protein
  JOURNAL   Nature 403 (6768), 439-444 (2000)
   PUBMED   10667797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929371.6, BC032272.1, AK034902.1 and BU698622.1.
            
            On Dec 16, 2009 this sequence version replaced NM_194054.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056373.1, AY102284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-796               AL929371.6         94030-94825
            797-853             AL929371.6         106667-106723
            854-3214            AL929371.6         107542-109902
            3215-4667           BC032272.1         2321-3773
            4668-6006           AK034902.1         2194-3532
            6007-6165           BU698622.1         1-159               c
FEATURES             Location/Qualifiers
     source          1..6165
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 16.79 cM"
     gene            1..6165
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /note="reticulon 4"
                     /db_xref="GeneID:68585"
                     /db_xref="MGI:MGI:1915835"
     exon            1..796
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /inference="alignment:Splign:2.1.0"
     exon            797..853
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /inference="alignment:Splign:2.1.0"
     exon            854..3214
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3422
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3561
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3631
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3678
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3737
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..6165
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4017..4022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /note="hexamer: AATAAA"
     polyA_site      4036
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
     regulatory      4649..4654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /note="hexamer: AATAAA"
     polyA_site      4667
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /note="major polyA site"
     regulatory      5987..5992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /note="hexamer: AATACA"
     polyA_site      6011
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
     regulatory      6037..6042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
                     /note="hexamer: ATTAAA"
     polyA_site      6064
                     /gene="Rtn4"
                     /gene_synonym="1110020G17Rik; ASY; C130026I10Rik;
                     mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C;
                     NSP-CL"
ORIGIN      
        1 cccctgccgg gaaggtgagt cacgccaaac tgggcggaga gtctgccctc ctctctcagt
       61 tgctcatctg ggcggcggcg gctgctgcaa ctgaggacag ggcgggtggc gcatctcgag
      121 cgcggaggca ggaggagaag tcttattgtt cctggagctg tcgcctttgc gggttcctcg
      181 gcttggttcg gccagcccgg cctctgccag tcctgcccaa cccccacaac cgcccgcggc
      241 tctgaggaga agtggcccgc ggcggcagta gctgcagcat catcgccgac catggaagac
      301 atagaccagt cgtcgctggt ctcctcgtcc gcggatagcc cgccccggcc cccgcccgct
      361 ttcaagtacc agttcgtgac ggagcccgag gacgaggagg acgaggaaga cgaggaggag
      421 gaggaggacg acgaggacct ggaggaattg gaggtgctgg agaggaagcc cgcagccggg
      481 ctgtccgcgg ctccggtgcc ccccgccgcc gcaccgctgc tggacttcag cagcgactcg
      541 gtgccccccg cgccccgcgg gccgctgccg gccgcgcccc ccaccgcccc tgagaggcag
      601 ccgtcctggg aacgcagccc cgcggcgtcc gcgccatccc tgccgcccgc tgccgcagtc
      661 ctgccctcca agctcccgga ggacgacgag cctccagcgc ggcctccggc gccagccggc
      721 gcgagccccc tagcggagcc cgccgcgccc ccttccacgc cggccgcgcc caagcgcagg
      781 ggctcgggct cagtggatga gacccttttt gctcttcctg ctgcatctga gcctgtgata
      841 ccctcctctg cagaaaaaat tatggatttg aaggagcagc caggtaacac tgtttcgtct
      901 ggtcaagagg atttcccatc tgtcctgttt gaaactgctg cctctcttcc ttctctatct
      961 cctctctcaa ctgtttcttt taaagaacac ggataccttg gtaacttatc agcagtggca
     1021 tccacagaag gaactattga agaaacttta aatgaagctt ctagagaatt gccagagagg
     1081 gcaacaaatc catttgtaaa tagagagtca gcagagtttt cagtattaga atactcagaa
     1141 atgggatcat ctttcaatgg ctccccaaaa ggagagtcag ccatgttagt agaaaacact
     1201 aaggaagaag taattgtgag gagtaaagac aaagaggatt tagtttgtag tgcagccctt
     1261 cataatccac aagagtcacc tgcgaccctt actaaagtgg ttaaagaaga cggagttatg
     1321 tctccagaaa agacaatgga catttttaat gaaatgaaaa tgtcagtggt agcacctgtg
     1381 agggaagagt atgcagattt taagccattt gaacaagcat gggaagtgaa agatacttat
     1441 gagggaagta gggatgtgct ggctgctaga gctaatatgg aaagtaaagt ggacaaaaaa
     1501 tgctttgaag atagcctgga gcaaaaaggt catgggaagg atagtgaaag cagaaatgag
     1561 aatgcttctt tccccaggac cccagaactt gtgaaggacg gctccagagc gtacatcacc
     1621 tgtgattcct ttagctcagc aaccgagagt actgcagcaa acattttccc tgtgctagaa
     1681 gatcacactt cagaaaacaa aacagatgaa aaaaaaatag aagaaaggaa ggcccaaatt
     1741 ataacagaga agactagccc caaaacgtca aatcctttcc ttgtagcaat acatgattct
     1801 gaggcagatt atgtcacaac agataattta tcaaaggtga ctgaggcagt agtggcaacc
     1861 atgcctgaag gtctaacgcc agatttagtt caggaagcat gtgaaagtga actgaacgaa
     1921 gccacaggta caaagattgc ttatgaaaca aaagtggact tggtccagac atcagaagct
     1981 atacaagagt caatttaccc cacagcacag ctttgcccat catttgagga agctgaagca
     2041 actccgtcac cagttttgcc tgatattgtt atggaagcgc cattaaattc tctccttcca
     2101 agcactggtg cttctgtagc gcagcccagt gcatccccac tagaagtacc gtctccagtt
     2161 agttatgacg gtataaagct tgagcctgaa aatcccccac catatgaaga agccatgagt
     2221 gtagcactaa aaacatcgga ctcaaaggaa gaaattaaag agcctgaaag ttttaatgca
     2281 gctgctcagg aagcagaagc tccttatata tccattgcat gtgatttaat taaagaaaca
     2341 aagctctcca ctgagccaag tccagagttc tctaattatt cagaaatagc aaaatttgag
     2401 aagtcggtgc ctgatcactg tgagctcgtg gatgattcct cacccgaatc tgaaccagtt
     2461 gacttattta gtgatgattc aattcctgaa gtcccacaaa cacaagagga ggctgtgatg
     2521 ctaatgaagg agagtctcac tgaagtgtct gagacagtaa cacaacacaa acataaggag
     2581 agacttagtg cttcacctca ggaggtagga aagccatatt tagagtcttt tcagcccaat
     2641 ttacatatta caaaagatgc tgcatctaat gaaattccaa cattgaccaa aaaggagaca
     2701 atttctttgc aaatggaaga gtttaatact gcaatttatt ccaatgatga cttactttct
     2761 tctaaggaag acaaaatgaa agaaagtgaa acattttccg attcatctcc cattgagata
     2821 atagatgagt ttcccacatt tgtcagtgct aaagatgatt ctcctaagga gtacactgac
     2881 ctagaagtat ccaacaaaag tgaaattgct aatgtccaga gcggggccaa ttcgttgcct
     2941 tgctcagaat tgccctgtga cctttctttc aagaatacat atcctaaaga tgaagcacat
     3001 gtctcagatg aattctccaa aagtaggtcc agtgtatcta aggtgccctt attgcttcca
     3061 aatgtttctg ctttggaatc tcaaatagaa atgggcaaca tagttaaacc caaagtactt
     3121 acgaaagaag cagaggaaaa acttccttct gatacagaga aagaggacag atccctgaca
     3181 gctgtattgt cagcagagct gaataaaact tcagttgttg acctcctgta ctggagagac
     3241 attaagaaga ctggagtggt gtttggtgcc agcttattcc tgctgctgtc tctgacagtg
     3301 ttcagcattg tcagtgtaac ggcctacatt gccttggccc tgctctctgt gactatcagc
     3361 tttaggatat ataagggtgt gatccaagct atccagaaat cagatgaagg ccacccattc
     3421 agggcatatt tggaatctga agttgccata tcagaggaat tggttcagaa atatagtaat
     3481 tctgctcttg gtcatgtgaa cagcacaata aaagaattga ggcgtctctt cttagttgat
     3541 gatttagttg attccctgaa gtttgcagtg ttgatgtggg tatttactta cgttggtgcc
     3601 ttgttcaatg gtttgacact actgatttta gctctgatct cactcttcag tattcctgtt
     3661 atatatgaac ggcatcaggc gcagatagat cattatctag gacttgcaaa caagagcgtt
     3721 aaggatgcca tggccaaaat ccaagcaaaa atccctggat tgaagcgcaa agcagaatga
     3781 aaaggcccca aacagtagac attcatcttt aaaggggaca ctcccttggt tacggggtgg
     3841 gcgggtcagg ggtgagccct gggtggccgt gcagtttcag ttatttttag cagtgcactg
     3901 tttgaggaaa aattacctgt cttgacttcc tgtgtttatc atcttaagta ttgtaagctg
     3961 ctgtgtatgg atctcattgt agtcatactt gttttcccca gatgaggcac ttggtgaata
     4021 aaggatgctg ggaaaactgt gtgttatatt ctgttgcagg tagtctggct gtatttggaa
     4081 agttgcaaag aaggtagatt tgggggcagg aaaaacaacc cttttcacag tgtactgtgt
     4141 ttggttggtg taaaactgat gcagattttt ctgaaatgag atgtttagat gagcatacta
     4201 ctaaagcaga gtggaaaaat ctgtctttat ggtatgttct aggtgtattg tgatttactg
     4261 ttagattgcc aatataagta aatatagaca taatctatat atagtgtttc acaaagctta
     4321 gatctttaac cttgcagctg ccccacagtg cttgacctct gagtcattgg ttatacagtg
     4381 tagtcccaag cacataaact aggaagagaa tgtatttgta ggagcgctac cacctgtttt
     4441 caagagaaca tagaactcca acgtaaccgt catttcaaag atttactgta tgtatagttg
     4501 attttgtgga ctgaatttaa tgcttccaaa tgtttgcagt taccaaacat tgttatgcaa
     4561 gaaatcataa aatgaagact tataccattg tgtttaagct gtattgaatt atctgtggaa
     4621 tgcattgtga actgtaaagc aaagtatcaa taaagcttat agacttacct ttgtgtttag
     4681 tgttttagtt tcatgaatgc acagcaaaaa cacggtggta ggcttagaga gtggacacat
     4741 ggtaacatgc ttttagaaag gttttagttc atgaaacagc ttaagaacaa agaatatatt
     4801 tacatagtga gatttatttg actcataaca aaaggtttta aattatttta tactttgaaa
     4861 ataaattcat gcaccaatat tttaacagaa tacagtgcaa gatttatgaa tatacataaa
     4921 attacaccat ataaatttta caaataagac tttcaaagtc tttataacag acactattgc
     4981 tcttcaaata tatacatata tcattgatta gtcagttgtt catccacatg gttacttaat
     5041 gcaagatctg tctgaatgaa atgtcagtag tacaagacag gcagacacag tgatcactca
     5101 gcatcaccag gtacagaaaa cagaatcagg gctgcatagg gctctactga ggacccagca
     5161 acctgctagt gggttgatgt aaggcattaa taagttggcg tgtaaaatag cttaatgtgt
     5221 aatctaattc ttttagaatg ctgaagcact tctgtggtaa atgttgataa tctattcttt
     5281 aactgaaaat gcttatttca acctttctct aaaatggcaa cttcatataa ctagaaactc
     5341 aaggtctaga attttagtgc acagactgga aggactcggt ggtgtgtgta ctcacgactc
     5401 caactcccat cagccttctt aactaatagt cgtcaagtca cattctgtcc gacaactgac
     5461 tggagaaact caaatactcc ttacagtggg gaatatgttc aagaggtttt taaaaatctg
     5521 aatttaccct gcattaatca tctgaaatga gcagagccaa gccagtccta cccaagaggg
     5581 tgtaaactaa acagcaagac agctcactcg tcacactgga gctttccctg ctttccgtgt
     5641 tgctactttc tgtggagctg gactcttctt tgctgctcac cttataactg ctttcctaga
     5701 gcaggacata gtggtgaatt tgctaatccc atagccctcc tcagttttga agttttagca
     5761 ccatgtgaag gaagaagacg acatgggagg tgaggcagca gcccacacaa ctgggaactt
     5821 tgaaggcact taatggatat aaaactgcaa atgaaacttt taaaaattaa cattttaaaa
     5881 cttgtttata catggctcat ttagttttga aagctaaatg tggcaaacag ggtatttctg
     5941 tacttaagtg cttccaactt acattgtgtc cagtgaacat tcttaaaata catagaaaca
     6001 gaatagcaaa acacctttgt aaaagtctta atgcaaatta aacgctacat attggttagg
     6061 gtaattgagg atgtaaattt tatctgtggg ctacatcatc ccaattttgc cgttagtgaa
     6121 gttacaataa gtataggttt tagtctccag aacagaagca aacag
//
