LOCUS       NM_001003934            5038 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus reticulon 3 (Rtn3), transcript variant 1, mRNA.
ACCESSION   NM_001003934
VERSION     NM_001003934.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5038)
  AUTHORS   Guo,S., Dong,Y., Du,R., Liu,Y.X., Liu,S., Wang,Q., Liu,J.S., Xu,H.,
            Jiang,Y.J., Hao,H., Fan,L.L. and Xiang,R.
  TITLE     Single-cell transcriptomic profiling reveals decreased ER protein
            Reticulon3 drives the progression of renal fibrosis
  JOURNAL   Mol Biomed 5 (1), 24 (2024)
   PUBMED   38937317
  REMARK    GeneRIF: Single-cell transcriptomic profiling reveals decreased ER
            protein Reticulon3 drives the progression of renal fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5038)
  AUTHORS   Guo,D., Zhang,M., Qi,B., Peng,T., Liu,M., Li,Z., Fu,F., Guo,Y.,
            Li,C., Wang,Y., Hu,L. and Li,Y.
  TITLE     Lipid overload-induced RTN3 activation leads to cardiac dysfunction
            by promoting lipid droplet biogenesis
  JOURNAL   Cell Death Differ 31 (3), 292-308 (2024)
   PUBMED   38017147
  REMARK    GeneRIF: Lipid overload-induced RTN3 activation leads to cardiac
            dysfunction by promoting lipid droplet biogenesis.
REFERENCE   3  (bases 1 to 5038)
  AUTHORS   Zhou,J., Shi,Q., Ge,Y.Y., He,W., Hu,X., Xia,W. and Yan,R.
  TITLE     Reticulons 1 and 3 are essential for axonal growth and synaptic
            maintenance associated with intellectual development
  JOURNAL   Hum Mol Genet 32 (16), 2587-2599 (2023)
   PUBMED   37228035
  REMARK    GeneRIF: Reticulons 1 and 3 are essential for axonal growth and
            synaptic maintenance associated with intellectual development.
REFERENCE   4  (bases 1 to 5038)
  AUTHORS   Fan,L.L., Du,R., Liu,J.S., Jin,J.Y., Wang,C.Y., Dong,Y., He,W.X.,
            Yan,R.Q. and Xiang,R.
  TITLE     Loss of RTN3 phenocopies chronic kidney disease and results in
            activation of the IGF2-JAK2 pathway in proximal tubular epithelial
            cells
  JOURNAL   Exp Mol Med 54 (5), 653-661 (2022)
   PUBMED   35596061
REFERENCE   5  (bases 1 to 5038)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   6  (bases 1 to 5038)
  AUTHORS   Cai,Y., Saiyin,H., Lin,Q., Zhang,P., Tang,L., Pan,X. and Yu,L.
  TITLE     Identification of a new RTN3 transcript, RTN3-A1, and its
            distribution in adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 138 (2), 236-243 (2005)
   PUBMED   15946766
  REMARK    GeneRIF: Since other reports have shown that RTN4-A inhibits
            neuronal outgrowth and restricts the plasticity of the central
            nervous system, we speculate that RTN3-A1 might play certain roles
            in the central nervous system.
REFERENCE   7  (bases 1 to 5038)
  AUTHORS   Di Scala,F., Dupuis,L., Gaiddon,C., De Tapia,M., Jokic,N., Gonzalez
            de Aguilar,J.L., Raul,J.S., Ludes,B. and Loeffler,J.P.
  TITLE     Tissue specificity and regulation of the N-terminal diversity of
            reticulon 3
  JOURNAL   Biochem J 385 (Pt 1), 125-134 (2005)
   PUBMED   15350194
  REMARK    GeneRIF: RTN3 isoforms may contribute, by as yet unknown
            mechanisms, to neuronal survival and plasticity
REFERENCE   8  (bases 1 to 5038)
  AUTHORS   Oertle,T., Klinger,M., Stuermer,C.A. and Schwab,M.E.
  TITLE     A reticular rhapsody: phylogenic evolution and nomenclature of the
            RTN/Nogo gene family
  JOURNAL   FASEB J 17 (10), 1238-1247 (2003)
   PUBMED   12832288
REFERENCE   9  (bases 1 to 5038)
  AUTHORS   Hamada,N., Iwahashi,J., Suzuki,K., Ogi,H., Kashiwagi,T., Hara,K.,
            Toyoda,M., Yamada,T. and Toyoda,T.
  TITLE     Molecular cloning and characterization of the mouse reticulon 3
            cDNA
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 48 (2), 163-172 (2002)
   PUBMED   11990451
  REMARK    GeneRIF: cDNA of mouse reticulon 3 (mRTN3) was cloned. The gene was
            mapped at band B of chromosome 19.
REFERENCE   10 (bases 1 to 5038)
  AUTHORS   Moreira,E.F., Jaworski,C.J. and Rodriguez,I.R.
  TITLE     Cloning of a novel member of the reticulon gene family (RTN3): gene
            structure and chromosomal localization to 11q13
  JOURNAL   Genomics 58 (1), 73-81 (1999)
   PUBMED   10331947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY295849.1, AY750849.1 and AC129188.3.
            
            On Sep 29, 2012 this sequence version replaced NM_001003934.1.
            
            Transcript Variant: This variant (1, also known as Rtn3-A1)
            represents the longest transcript and encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY750849.1, BC079882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY295849.1         1-19
            20-5032             AY750849.1         1-5013
            5033-5038           AC129188.3         139383-139388       c
FEATURES             Location/Qualifiers
     source          1..5038
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.32 cM"
     gene            1..5038
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /note="reticulon 3"
                     /db_xref="GeneID:20168"
                     /db_xref="MGI:MGI:1339970"
     exon            1..353
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..3103
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Nsp-like II"
                     /codon_start=1
                     /product="reticulon-3 isoform 1"
                     /protein_id="NP_001003934.1"
                     /db_xref="CCDS:CCDS37906.1"
                     /db_xref="GeneID:20168"
                     /db_xref="MGI:MGI:1339970"
                     /translation="MAESSAATQSPSVSSSSSGAEPSALGGGGGSPGACPALGAKSCG
                     SSCADSFVSSSSSQPVSIFSTSQAGLSSLCSDEPPSKSMTSSFLSSSEIHNPDPTTPL
                     GEKSETLGSQFVLAKGKDPLVLLDKKKLDSPQGTNKDRVDAPVSLATGIPCSHPSIPD
                     SFPEQPAFLSKEIGPAEEWVVKDQEPKNPNKVPDGEDRSALDFGQSKAEHICTYSLSP
                     SELPVASVEKDSPESPFEVIIDKATFDREFKDLYKENPNDLGGWAAHGDRESPADLLE
                     MNDKLFPLRNKEAGRYPSSVLLGRQFSHTTAALEEVSRCVNDMHNFTNEILTWDLDPQ
                     AKQQANKTSCTTESTGLDRSELRSEIPVINLKTNPQQKMPVCSFNGSTPITKSTGDWT
                     EAFTEGKPVRDYLSSTKEAGGNGVPGSSQLHSELPGSMPEKWVSGSGAATVEVTLPNL
                     RGAWPNSVMGEVTEVDSSGESDDTVIEDITEKPDSLPSAAAKTSEREIKETPSRETVR
                     SEMCENSEQPQAQPETPTQKSLEGEVASQVPNTLNEVTPEKLDMTNNPKVCSAAPPSV
                     LNETGFSLTVPASAKLESLLGKYVEDTDGSSPEDLMAVLTGAEEKGIVDKEEGDVLEA
                     VLEKIADFKNTLPVELLHESELSGSETKNIKSKYSEDSRETTGGAPTMSPDLEQEQLT
                     IRAIKELGERQAEKVQDEGISSGGKLKQTFAPQSGPQSSSDILEHTDVKTGSDLGIPK
                     NPTIIKNTRIDSISSLTKTEMVNKNVLARLLSDFPVHDLIFWRDVKKTGFVFGTTLIM
                     LLSLAAFSVISVVSYLILALLSVTISFRVYKSVIQAVQKSEEGHPFKAYLDVDITLSS
                     EAFHNYMNAAMVHVNKALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLIL
                     AELLVFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE"
     exon            354..410
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..2534
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2742
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2881
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2951
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..2998
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3057
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..5038
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3879..3884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /note="major polyA site"
     regulatory      3939..3944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /note="hexamer: TATAAA"
     polyA_site      3962
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /note="major polyA site"
     regulatory      5011..5016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /note="hexamer: AATAAA"
     polyA_site      5035
                     /gene="Rtn3"
                     /gene_synonym="RTN3-A1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgtccag gctctttgtg cgcatgcgcg ctcgcactcc ttctctccct gcggagctcg
       61 gctgagtcag tcagtctgtc ggagtcagtc ttccgaacag gcgtcgccgg gaacttcgga
      121 gagccagctg ctggattatt ctgtgtcccc tcccactctc ccgccctacg tctctcttca
      181 cccttctccc gcccttgctc gtacagccat ggcggagtcg tcagcggcca ctcagtcccc
      241 gtcagtctcc tcgtcgtcct ccggggccga gccgtcagct ctcggcggcg gcggcgggag
      301 ccctggagcc tgccccgccc tgggggcgaa gagctgcggc tcctcgtgtg cggattcctt
      361 tgtttcttcc tcttcctctc agcctgtatc tatattttcg acctcacaag cgggattgag
      421 ctctctttgc tctgatgagc caccttcaaa aagtatgact tcctcctttc tttcatcttc
      481 tgaaatacat aaccctgacc ctacaacacc gcttggagaa aagagtgaaa cattaggtag
      541 ccagtttgtt ctagctaaag gaaaagaccc cttggttctt ctagataaga aaaaactgga
      601 ctcacctcag gggaccaaca aggacagagt agacgctccg gtttctcttg caactggcat
      661 tccttgcagc cacccttcta ttccagacag tttcccagag caacctgctt ttctgtcaaa
      721 agaaattggt ccagcagaag agtgggtagt taaagaccaa gaacccaaga acccaaacaa
      781 ggttccagat ggggaggaca gaagtgcact ggattttggg cagtctaagg cagaacacat
      841 ttgtacatat tccttgtccc catctgaact tccagtagcc agtgtagaaa aagattctcc
      901 tgagtcaccg tttgaagtaa ttattgacaa agcaacattt gacagagaat ttaaagattt
      961 gtataaggaa aacccaaatg atttgggtgg ctgggcagct catggcgata gagaatcccc
     1021 cgcagacttg ttggaaatga atgacaaact ctttccactg agaaataaag aggcagggcg
     1081 ttacccatcc tctgtactgc tcggtagaca gttctcacac actacagcag cactggaaga
     1141 ggtgtctaga tgtgtgaatg atatgcataa ctttactaat gaaatactga cttgggactt
     1201 agatccccaa gcaaaacaac aggccaataa aacatcttgc accacagaaa gtacaggact
     1261 agacaggagt gaacttcgct cagaaattcc agttataaat cttaaaacaa accctcaaca
     1321 gaaaatgcct gtatgttctt ttaatgggag cactcccatt accaaatcca caggtgactg
     1381 gacagaagca tttacagaag gaaaacctgt aagagactac ctcagttcca caaaagaagc
     1441 tggtggcaac ggtgtgccag gcagttctca gcttcattct gagctgcctg gctctatgcc
     1501 tgagaaatgg gtctcaggct ctggagcagc cacagtggaa gtaactttac ctaacctgag
     1561 gggtgcctgg cctaactctg tgatggggga agtcacagag gttgatagtt ctggggaatc
     1621 tgatgacaca gtaatagagg acatcacaga aaaacctgac tcccttccaa gtgctgctgc
     1681 aaaaacaagt gaaagggaaa tcaaagagac tcccagtcgt gaaactgtga ggagtgaaat
     1741 gtgtgaaaac tctgagcagc cgcaggccca gccagaaact cctactcaga agagtctgga
     1801 aggtgaggtg gcttcacaag tacctaatac cctgaatgaa gtcacacctg aaaagcttga
     1861 tatgactaac aaccccaaag tttgctcagc agcacctcca agtgttctta atgagacagg
     1921 attctcacta actgtgccag cttctgccaa gttggaatct ttgcttggaa aatatgttga
     1981 agatacagat ggttcctccc cagaggactt gatggctgtc ctcacaggag ccgaggagaa
     2041 ggggatagtg gataaagagg aaggtgatgt tttggaagca gtgttagaga agatagcaga
     2101 ctttaaaaac actttgcctg tggaactctt gcatgaaagt gagctaagtg gttctgaaac
     2161 caaaaatatt aaaagcaaat acagtgaaga cagcagagaa acaactggag gtgcccctac
     2221 gatgtctccc gacttagagc aggagcagct caccatcaga gccattaaag aattaggaga
     2281 aaggcaagct gagaaggtgc aggatgaagg aatatcttct ggaggaaaac tcaagcaaac
     2341 ctttgctcca cagtctgggc cacagagttc atctgacatc ctagaacaca cagatgtcaa
     2401 aactggatct gatcttggaa ttcccaaaaa tcctactatc atcaaaaaca ctagaataga
     2461 ttctatttcc agccttacca agactgaaat ggttaacaag aatgttctag caagacttct
     2521 cagtgatttc ccagtgcacg atctgatttt ctggcgagat gtgaagaaga ctgggtttgt
     2581 ctttggcacc acactgatca tgctgctctc tctggcagcc ttcagtgtta tcagtgtggt
     2641 ctcttacctc atcctggctc ttctctctgt caccatcagc ttcagagtct ataagtctgt
     2701 cattcaagct gtgcagaagt cagaagaagg acatccattc aaggcctact tggatgtgga
     2761 cattaccctg tcttcagaag ctttccacaa ctacatgaat gctgcgatgg tgcatgtcaa
     2821 caaggccctc aaactcatta ttcgtctctt tctggtagaa gacttggttg actccttgaa
     2881 gctggctgtc ttcatgtggc tgatgaccta tgttggtgct gtttttaatg gaattaccct
     2941 tctgattctc gccgagctgc ttgtcttcag cgtcccaatt gtctatgaga agtataagac
     3001 acagattgac cactatgttg ggattgcccg ggatcagacc aagtcaattg ttgaaaagat
     3061 ccaagcaaag cttcctggaa tcgccaaaaa aaaggcagaa taagcacgtg aagcaagaag
     3121 tgcatcagtt actaaaacac catttaatag ttataacatc atcacttgta ctatgaagga
     3181 acttgctcag tgtcagctag agtttggttc caagttgttt gttcatttta atttggtgtt
     3241 ctctcccctc ctctcccttt accctcagta ccaagcacaa gatgtgttag actgaaaaaa
     3301 gaactgatct cttagaaccg taaagaataa agattgaatc agattactag aattaatcag
     3361 accatagtgg ggtggagctt tacatgtacc ataaaaggag aaaaagagaa gtgtctctag
     3421 ggtcctctct ccagttccaa ggactcgtat acagctccca tttataattt tgcccttatt
     3481 tttaagttag gaaataatga ttaacttatg aataaatagt atggggcaag agtgggattt
     3541 cttccgttgg gtttgtatgg ccctccagtc ccaccttcct gccttacaca taagcagcta
     3601 ctcttactgc tcctcttctt ccttaatgaa agaactctca gctctgaata acttacagaa
     3661 ctcccagaat gccacctgag aaatgggggt tggggggaca gtgggtggag cagtcagcag
     3721 gagggcagcc accaccctct ctgcggctgc tcctagggaa ggaagggctc tggggctggg
     3781 agggccgtgt acagcccttg gtctgggatc catgtgttgg ttgagaaatc attccagagt
     3841 gtgctttccc ctctccctgc ccaccttacc tcacgtttaa taaatatggt tgtacttttc
     3901 ttattatgaa ataaatgtct gtaactgctg tacactgcta taaacttgtt aaagaaaaat
     3961 aatctgcatg tgggctccca gccattgagt tattgtaatc ctatctcagt ctgtggagga
     4021 ggaggtacaa gaacatgaaa agccttcctt ctatttcttc cctgctgctt cctcctgtgc
     4081 tttgcagtgc tttagcctga ggaccaaagc cccactgact gcaagtcatg tatctgttgg
     4141 cgtccagagg cctggctgac tgaagaggtc catttctaga agcaggacat gcagctgctt
     4201 ggagtcagtg cagttctaaa aggatctcca ttttcagaca tattgatgaa atagttcata
     4261 ccatgatcca cagtgctcat ttggatcgtg ttttccagaa cttttaggtt gtgggtggcc
     4321 aagcaagacc aggtggtact gatagataca acagaactta cagtggcatc agtggagggg
     4381 tccaggatct taatttctca gaccttgcat ctctccttca gcatggaaat ccagtcagct
     4441 tgaaaactgg catccaagag tccttcattt ctcaaaccct gcctgcccta ttgtgaggaa
     4501 gtaggagctg gggatttcaa ggtatttgat ggtcacaaag ttctgtgact gtaaaagtag
     4561 gaattagtcg tctttccagt ccttttggga aacgactcac agactgcgat aggtagaatg
     4621 ccttactcca tcttctcaag ttcctttgcc cctgtacatt ttgaatcttt catttccact
     4681 gtagacaaca ctcccatcac catgctctgc cctcccagga agtgaacgca cccatggtct
     4741 atggggtctc ctaacaaggg acctcgttct gcactggaag cctccacagt ttgctctttt
     4801 ctttgttgct gctgctgtgt taaaataatt ggaaaggttt ctgtgttaca tgagagggtt
     4861 ttttcggttt tgttttttta aacaaagact cgtagagatg aaaaaattac taatgaaatt
     4921 gtgtacgtgt ctgtgcgtgc aacataaaaa cagtagtacc aagaagctct tttggtccct
     4981 gtaaaactgc aaattgatgt attaattata aataaaaaac acagtgactg tctcatca
//
