LOCUS       NM_153457               3632 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus reticulon 1 (Rtn1), transcript variant 1, mRNA.
ACCESSION   NM_153457
VERSION     NM_153457.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3632)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3632)
  AUTHORS   Zhou,J., Shi,Q., Ge,Y.Y., He,W., Hu,X., Xia,W. and Yan,R.
  TITLE     Reticulons 1 and 3 are essential for axonal growth and synaptic
            maintenance associated with intellectual development
  JOURNAL   Hum Mol Genet 32 (16), 2587-2599 (2023)
   PUBMED   37228035
  REMARK    GeneRIF: Reticulons 1 and 3 are essential for axonal growth and
            synaptic maintenance associated with intellectual development.
REFERENCE   3  (bases 1 to 3632)
  AUTHORS   Yin,Y., Haller,M.E., Chadchan,S.B., Kommagani,R. and Ma,L.
  TITLE     Signaling through retinoic acid receptors is essential for
            mammalian uterine receptivity and decidualization
  JOURNAL   JCI Insight 6 (17), e150254 (2021)
   PUBMED   34292881
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3632)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3632)
  AUTHORS   Cichon,M.A., Klas,K., Buchberger,M., Hammer,M., Sere,K., Zenke,M.,
            Tschachler,E. and Elbe-Burger,A.
  TITLE     Distinct Distribution of RTN1A in Immune Cells in Mouse Skin and
            Lymphoid Organs
  JOURNAL   Front Cell Dev Biol 8, 608876 (2021)
   PUBMED   33542915
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3632)
  AUTHORS   Oertle,T., Klinger,M., Stuermer,C.A. and Schwab,M.E.
  TITLE     A reticular rhapsody: phylogenic evolution and nomenclature of the
            RTN/Nogo gene family
  JOURNAL   FASEB J 17 (10), 1238-1247 (2003)
   PUBMED   12832288
REFERENCE   7  (bases 1 to 3632)
  AUTHORS   Hirata,T., Nomura,T., Takagi,Y., Sato,Y., Tomioka,N., Fujisawa,H.
            and Osumi,N.
  TITLE     Mosaic development of the olfactory cortex with Pax6-dependent and
            -independent components
  JOURNAL   Brain Res Dev Brain Res 136 (1), 17-26 (2002)
   PUBMED   12036513
REFERENCE   8  (bases 1 to 3632)
  AUTHORS   Schafer,G.L., Crabbe,J.C. and Wiren,K.M.
  TITLE     Ethanol-regulated gene expression of neuroendocrine specific
            protein in mice: brain region and genotype specificity
  JOURNAL   Brain Res 897 (1-2), 139-149 (2001)
   PUBMED   11282367
REFERENCE   9  (bases 1 to 3632)
  AUTHORS   Schafer,G.L., Crabbe,J.C. and Wiren,K.M.
  TITLE     Identification of neuroendocrine-specific protein as an
            ethanol-regulated gene with mRNA differential display
  JOURNAL   Mamm Genome 9 (12), 979-982 (1998)
   PUBMED   9880663
REFERENCE   10 (bases 1 to 3632)
  AUTHORS   Geisler,J.G., Stubbs,L.J., Wasserman,W.W. and Mucenski,M.L.
  TITLE     Molecular cloning of a novel mouse gene with predominant muscle and
            neural expression
  JOURNAL   Mamm Genome 9 (4), 274-282 (1998)
   PUBMED   9530622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132364.1, BC058579.1, BC027091.1 and BY615773.1.
            
            On Nov 6, 2013 this sequence version replaced NM_153457.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132364.1, BK001694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AK132364.1         1-338
            339-3105            BC058579.1         1-2767
            3106-3629           BC027091.1         905-1428
            3630-3632           BY615773.1         394-396
FEATURES             Location/Qualifiers
     source          1..3632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.2 cM"
     gene            1..3632
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /note="reticulon 1"
                     /db_xref="GeneID:104001"
                     /db_xref="MGI:MGI:1933947"
     exon            1..744
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..2846
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /note="isoform A is encoded by transcript variant 1;
                     neuroendocrine-specific protein"
                     /codon_start=1
                     /product="reticulon-1 isoform A"
                     /protein_id="NP_703187.2"
                     /db_xref="CCDS:CCDS25968.1"
                     /db_xref="GeneID:104001"
                     /db_xref="MGI:MGI:1933947"
                     /translation="MAAPPDLQDEPLSLGSPGSQWFGGRGDGEDEATAVMGARPAQQD
                     GEPAWGSGAGAGVTSSRELCSGPARSPPVAMETASTGMAAVPDALDHSPSSTLKDGEG
                     ACYTSLISDVCYPPREDSAYFTGILQKENGHITTSESPEEPETPGPSLPEVPGMEPQG
                     LLSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPQEAKGQEEQHPGLEDK
                     DLDFKDKDTEVSTKAEGVRAPNQPAPVEGKLIKDHLFEESTFAPYIDELSDEQHRVSL
                     VTAPVKITLTEIEPPLMTATQETIPEKQDLCLKPSPDTVPTVTVSEPEDDSPGSVTPP
                     SSGTEPSAAESQGKGSVSEDELIAAIKEAKGLSYETTESPRPVGQVADKPKTKTRSGL
                     PTIPSPLDQEASSAESGDSEIELVSEDPMASEDALPSGYVSFGHVSGPPPSPASPSIQ
                     YSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPGALDAIREETGSRATE
                     ERAPSHQGPVEPDPMLSFAPAAALQSRPEPSSGDGASVPEPPRSQQQKPEEEAVSSSQ
                     SPTATEIPGPLGSGLMPPLPFFNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSV
                     VSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDC
                     LQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLP
                     VVYVKHQAQVDQYLGLVRTHINTVVAKIQAKIPGAKRHAE"
     exon            745..1518
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..2280
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2488
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2627
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2697
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2744
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2803
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..3632
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3610..3615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /note="hexamer: AATAAA"
     polyA_site      3629
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /note="major polyA site"
ORIGIN      
        1 agtctggttt taacttcttg tctagtcaag ctgcagccag tacctgctgg tcctctctgt
       61 gtattcttcc ccagataaag ggtaaaacaa gtgggtttgg cacatcccct aatcagaggc
      121 tgccattaac aggcccgggg ctgacgtgca ttagggagga ctcggaccaa gcaggccatt
      181 ttcacctgcg taataacagg cttgggagta gcgaagcagc gcaggcacag caagctgcct
      241 ctggagcagg ggaggagcgc gggcggcagc cgccccgggg ccccggagga agaggagggg
      301 gagaaggagg agccgaagcg cccagaacag cagccgcggc tcggcccgag ttgcagcaaa
      361 agcagcgacg gtggcgcgga gactctgcag ccttctggag tccggagtcc cggtagggac
      421 agcagcaggg agcgtccgcg tccctagcca gcgcaccccg gccttgccaa gccacagtag
      481 cccagcctgg ggcacagcca gccatggccg caccgccgga tctgcaagat gagccgctgt
      541 ctctgggtag ccccgggtcc cagtggttcg ggggccgggg ggatggggaa gacgaagcga
      601 cggcggtgat gggggccagg ccagcgcagc aggatgggga gcccgcctgg gggtcgggcg
      661 ctggagctgg ggtaacgtcg tcgcgggaac tgtgctccgg ccccgcccgg tcgcctcccg
      721 tcgccatgga aactgcatcc acaggtatgg cagctgttcc cgatgccctc gaccactctc
      781 cctcttcaac actaaaagat ggggaagggg catgttacac atccctgatt tctgacgtct
      841 gctatccacc tcgggaggac tctgcatact ttactggaat tcttcagaag gaaaatggtc
      901 acatcaccac ttccgagagc cctgaggagc cggagacccc cggaccctcg ttaccagaag
      961 tgcccgggat ggagccacag ggcttattga gttctgattc tggaatagag atgactcctg
     1021 ctgagtccac tgaggtgaac aagatcctag ctgaccccct agaccagatg aaggcagaag
     1081 cctacaaata cattgacata accaggccac aggaggcaaa aggccaggag gagcaacacc
     1141 ctgggctaga agataaagac ttggacttta aagacaagga cactgaagtc tccacaaaag
     1201 cagaaggggt tcgagcacca aaccagccag ctcctgtgga ggggaaactc atcaaggacc
     1261 acttattcga agaatctacc tttgctcctt acatagatga gctctctgat gagcagcaca
     1321 gggtgtctct ggtcactgcc cctgtcaaga tcacactgac ggagatcgaa cctcctctta
     1381 tgactgccac acaagagaca atccccgaga agcaagacct gtgtctgaag ccaagtcctg
     1441 acacagtgcc cactgtcact gtctcagagc ctgaagatga cagcccagga tctgtcacgc
     1501 ctccatcttc tggaacagaa ccatctgctg cagagtccca ggggaaaggc agcgtctccg
     1561 aggatgagtt gattgctgcc attaaagaag caaaggggtt atcatatgaa accaccgaga
     1621 gtccaaggcc agtgggccag gtggccgaca aacccaaaac caagaccagg tctgggctgc
     1681 ccaccatccc cagtcccctc gaccaggagg ccagcagtgc cgagtccgga gactcagaaa
     1741 ttgagctggt gtcagaggac cccatggcct ctgaggatgc cctgccctct ggctatgtga
     1801 gcttcggtca tgtgtcgggc ccgcccccct ctcctgcctc tccatccatc cagtacagca
     1861 tcctgcggga ggagcgtgag gccgagctgg acagcgagct catcatcgag tcctgtgatg
     1921 cctcctcagc ctcggaggag agccccaagc gcgagcagga ctcgcccccg atgaaaccgg
     1981 gtgccctgga cgccatccgc gaggagacag gctctcgggc caccgaagaa cgagcgccca
     2041 gccaccaagg ccctgtggag cccgacccga tgctcagctt tgcccccgct gccgccctcc
     2101 aatcccgccc agagccatcg tctggagatg gagcctcggt cccggagccg cccagatcac
     2161 agcagcagaa gcctgaagag gaagctgtga gttccagtca aagtcccacg gccaccgaaa
     2221 ttcctggacc acttggttct ggcctcatgc cccctctgcc tttcttcaac aagcaaaaag
     2281 ctattgacct tctgtactgg cgggacatca agcagactgg gattgtgttc gggagcttcc
     2341 tgctgctgct cttctccctg acccagttca gcgttgtgag cgtcgttgcc tacctggccc
     2401 tggccgccct ctctgccacc atcagcttcc gcatctacaa gtccgttcta caagctgtgc
     2461 agaaaacaga tgagggtcac cctttcaagg cctacctgga gctggagatc accctgtccc
     2521 aggagcagat ccagaagtac acagactgcc tgcagctgta tgtgaacagc actctgaagg
     2581 agctacggag gcttttcctg gtccaggacc tggtggattc cttaaaattt gcagtcctca
     2641 tgtggctcct gacctacgtt ggcgcgctct tcaatggcct gaccctgctg cttatggctg
     2701 tggtttcgat gtttactcta cctgttgtgt acgttaagca ccaggcacaa gttgaccaat
     2761 atctgggact tgtgaggact cacataaaca ccgtcgtggc aaagatccag gctaaaatcc
     2821 ccggcgccaa gaggcacgct gagtagatgg tcaccccagg agaagccgga catgagtggg
     2881 ggtgtctgga gtggtaacag ctctctcctt cctcgttact gcaaattgat tgtttccctt
     2941 tcctggtacc ataatcttag aggcaaactt tgagacaggt gttttgaggc tcttcctgta
     3001 ctcttaggat atatgagccg ccccctcccc acccccgtgt caagcactaa agtatagagt
     3061 gtgttagatg tggtttttga tttcgtgttg ctaaaaaaaa aaaaagaaaa gaaaagaaaa
     3121 aaagtgcatg atggtgagag cccacgttct ccctcctccc tcgatgtcct cccctctgca
     3181 acgcttctgt agcttctact gtccctgtgg ctaggccttt cttgccaagt gcgctgacac
     3241 atagtggatc gcttatcatg tccttgggtt gctggatgga ttcatctcta ataacactat
     3301 atagaattgt aggccaatgt tttagcattt ccccacacac agagaacata aaaattaata
     3361 taaaacagtt gaccgtacat atggtgatcc attttgtata acttagaatg atcgaattaa
     3421 agaataaatc caaaatgaac gcacagtact tttctcctat gggatgcctg ggctgattta
     3481 catgtatggt aactaaaggt gccagcatgt tgactttatt acaatttgta ttacttcctc
     3541 tgtagttcct aatggactca atcacagact ctggatattt gcacttatgt acttgatact
     3601 gaatgcatca ataaatgtga ctaaatgtag ac
//
