LOCUS       NM_177630               4426 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus retrotransposon Gag like 6 (Rtl6), mRNA.
ACCESSION   NM_177630
VERSION     NM_177630.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4426)
  AUTHORS   Ishino,F., Itoh,J., Irie,M., Matsuzawa,A., Naruse,M., Suzuki,T.,
            Hiraoka,Y. and Kaneko-Ishino,T.
  TITLE     Retrovirus-Derived RTL9 Plays an Important Role in Innate
            Antifungal Immunity in the Eutherian Brain
  JOURNAL   Int J Mol Sci 24 (19), 14884 (2023)
   PUBMED   37834332
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4426)
  AUTHORS   Irie,M., Itoh,J., Matsuzawa,A., Ikawa,M., Kiyonari,H., Kihara,M.,
            Suzuki,T., Hiraoka,Y., Ishino,F. and Kaneko-Ishino,T.
  TITLE     Retrovirus-derived RTL5 and RTL6 genes are novel constituents of
            the innate immune system in the eutherian brain
  JOURNAL   Development 149 (18) (2022)
   PUBMED   36162816
REFERENCE   3  (bases 1 to 4426)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4426)
  AUTHORS   Youngson,N.A., Kocialkowski,S., Peel,N. and Ferguson-Smith,A.C.
  TITLE     A small family of sushi-class retrotransposon-derived genes in
            mammals and their relation to genomic imprinting
  JOURNAL   J Mol Evol 61 (4), 481-490 (2005)
   PUBMED   16155747
REFERENCE   5  (bases 1 to 4426)
  AUTHORS   Brandt,J., Schrauth,S., Veith,A.M., Froschauer,A., Haneke,T.,
            Schultheis,C., Gessler,M., Leimeister,C. and Volff,J.N.
  TITLE     Transposable elements as a source of genetic innovation: expression
            and evolution of a family of retrotransposon-derived neogenes in
            mammals
  JOURNAL   Gene 345 (1), 101-111 (2005)
   PUBMED   15716091
REFERENCE   6  (bases 1 to 4426)
  AUTHORS   Brandt,J., Veith,A.M. and Volff,J.N.
  TITLE     A family of neofunctionalized Ty3/gypsy retrotransposon genes in
            mammalian genomes
  JOURNAL   Cytogenet Genome Res 110 (1-4), 307-317 (2005)
   PUBMED   16093683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611986.15.
            
            On Jan 23, 2019 this sequence version replaced NM_177630.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC094559.1, AK083881.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4426              AL611986.15        71612-76037         c
FEATURES             Location/Qualifiers
     source          1..4426
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.88 cM"
     gene            1..4426
                     /gene="Rtl6"
                     /gene_synonym="Ldoc1l; Mar6; Mart6"
                     /note="retrotransposon Gag like 6"
                     /db_xref="GeneID:223732"
                     /db_xref="MGI:MGI:2675858"
     exon            1..4426
                     /gene="Rtl6"
                     /gene_synonym="Ldoc1l; Mar6; Mart6"
                     /inference="alignment:Splign:2.1.0"
     CDS             631..1362
                     /gene="Rtl6"
                     /gene_synonym="Ldoc1l; Mar6; Mart6"
                     /note="protein LDOC1L; gag-like protein; mammalian
                     retrotransposon-derived protein 6; leucine zipper,
                     down-regulated in cancer 1-like"
                     /codon_start=1
                     /product="retrotransposon Gag-like protein 6"
                     /protein_id="NP_808298.2"
                     /db_xref="CCDS:CCDS37168.1"
                     /db_xref="GeneID:223732"
                     /db_xref="MGI:MGI:2675858"
                     /translation="MVQPRTSKTESPASAPGASAQMDDVVDTLTSLRLTNSALRREAS
                     TLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAITSNGTRPMTTPPTSLP
                     EPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDS
                     PLRNNYQGFLAELRRTYKSPLRHSRRAQIRKTSASNRAVRERERERQMLCRQLAAAGT
                     GSCPVHPASNGTNPAPALPSRGRNL"
     regulatory      4408..4413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtl6"
                     /gene_synonym="Ldoc1l; Mar6; Mart6"
                     /note="hexamer: ATTAAA"
     polyA_site      4426
                     /gene="Rtl6"
                     /gene_synonym="Ldoc1l; Mar6; Mart6"
                     /note="major polyA site"
ORIGIN      
        1 gcggtctcta tggcaaccag caggccctgg cccagttgcc aggttcccag cggccgtcta
       61 gctggccgcg cctgcacaaa gaccgcgcgg tgaccgcgca gcgcagcgcc gggaccaggt
      121 caagccagcc ccgcaggaat tgccaccccc gccgccgctg cccggaaagc agttccggcg
      181 gcctccgtga cgtacaggcc gggcgcggcc tcgaccctcg ggccatcttg gcagcggagg
      241 gagcagcgga gcgacaggta catacgccgc ccagcctggg ccagcccagg tgccgacgcc
      301 tttgttcacg cgcgggtggt cgcatggcac cggtggtcag tgcctgcatc cgcagcccga
      361 gctccggcag gtgcatcctg caaagtctgg caggtccgcg catctcgtaa ggcctgggca
      421 gatccagcct atgcattcta caagggctat ccagctcgag catccttcag ggcctgggca
      481 ggtccagcca gcgacccaca ctttgatcct gcgaagcttg cagaaaggaa ctgcatccag
      541 gacaggacca gcgtcctcag gcttgcttca gcatccaagg ccttgcgctc tggttctcca
      601 ggtacctgtg gcttaacttt ggccgccagc atggtccaac ctcggacctc caaaactgaa
      661 agcccagcct ctgcccctgg tgccagcgct cagatggatg acgtagttga caccctgacc
      721 tctctgcgcc tcaccaactc cgcgctgagg cgcgaggcct ccacactgag ggcggagaag
      781 gccaacctca ccaacatgct ggagagtgtg atggccgaac taactctgct gcgcacccga
      841 gcgcgcatcc ctggcgctct acagattact ccacctatct ctgccatcac ctccaatggg
      901 acccgaccca tgaccacgcc acccacctca ctgcctgaac ccttctcagg agaccctgga
      961 cagttggcag ggttcctgat gcagatggac aggttcatga tttttcaagc ctcccgcttc
     1021 cccggtgaag ccgagagagt ggccttcctg gtatcccgtc tgactgggga ggcggagaag
     1081 tgggccatcc cccacatgca accagacagc cctttgcgaa acaattacca ggggtttctg
     1141 gctgagctcc gcagaaccta caagtccccg ctgaggcact caaggcgagc acaaatccgg
     1201 aagacatccg cgtccaatag ggctgtgcgg gagcgagagc gggagcgcca gatgttgtgt
     1261 cgccaactgg ccgcagctgg cacaggatcc tgcccggtgc atccagcctc caacgggacc
     1321 aatcccgcac cagccttgcc ctctcgtggc cggaaccttt aaggacttgc caccaccctg
     1381 gtagtctgtg tccacccagg tagctagact ccgttgttga gagttgtcaa ttcagtagct
     1441 ttgccctgtt tgaggcaccc ttcacgcctc tctggtctac gggagaccat cctgtcatcg
     1501 gcattggtca cccaccccgc tgtgcggcgt gtatttgttt tgttagcgtt acccgcgact
     1561 cagtgcatgc tccccctttc tgttgcttgc aatcccagct tctccagcaa tcacaacaca
     1621 gccccttggg catgtgcctg cccaggaacc atttaggctg accacctctg cgagctcagc
     1681 tcacggatac tcagctcctg gaacactccc tacagctctt gctgccccag gctgaagaac
     1741 tggcgaggag tggccaactg cttcgggtct catgtggaca catgttccag tcccaaggag
     1801 cagagcctca caggaggatg acctctcaat cagactcagc caagcctctg gaccatgaca
     1861 tcatctgtca tttcaatgcc aaatgaactg tgtttacata cctacctggc ccctttgggg
     1921 agatgggtta cctctcctgg gttttcctgc cctcctctgc atggtcttgg cttgaccaca
     1981 agaaaaccaa caacaacaac aaaaccgcct ctgaacccac ggaaagacat ctctctcctc
     2041 tcaggagccc agaggctggg gcctagaacc cggcctcttc cagagacttt ctccgtcatt
     2101 gggaaaagtg actgactaac cagcacagcc acctttgcaa gaccaggaca ggagtcttcg
     2161 ctgctcgctg ggctcccggc ccatagccac ctgcttcttg ttaactctgt tagcctagca
     2221 gcctcactga acagccaggg caccctgctg gcactatggt gctataagca ggtggaagac
     2281 tcctggggtt ccactgagag tactcaccta tccccagcag ctgagtctca tgcatgacct
     2341 ttcggtggag gggtccccag gtgaagctac agctgcacca gaaaaaatgg gggataggga
     2401 ggaggtgtat gtggaggcag gtgacaactg gaaggtttct ttgtggcttt ccacgttgtt
     2461 gtcgaggccc atccaccggg gaggcaggtc acctgccctg gctcctcgga ccaatgggtg
     2521 ctggctgtat ttgcattagg ttttgcttca gagccattca ggctgcctgt ctccaggtgt
     2581 ggcttcatta ccttctgctg catctggtct gacccacctg ggccactctg cctcagtggc
     2641 tccgtcccta cctctgctct ggtggtggtg gcttggcaat ggttttgttt cttgatgcat
     2701 gtatttagga ccgacatctc aatagctctc tgtggcttgg agcctggagc acacaagaga
     2761 gggttgaggc ttgccctctg cgtcggacct ggaagagaca cttgggattg gttgctgagg
     2821 ggcccatggt ggctctcgtc ggggccgtgg tttgtcccca gccaagacga tgaggtgcaa
     2881 ggcccatgta gctccagagg gagactgtga taactggacc taaagctgag caagaggggg
     2941 aggctttgta catatcttaa ggttctagtt gcttgagctc agaagagaac agggagaggg
     3001 gaatggggga gttggtctat gaaggagttg tgtcactcca cattgacagt cgcggcggta
     3061 ctgtgcccgc tctccagact ctgtgacacc catccggtag gtggggcttc actgtactca
     3121 gcgtctaatg gacaggggga cctggcattt gggtgacttc ccagcccaat gtttactgtg
     3181 atcttggaat tatctccatg tcccaaagca ttcagtgact ttgaggaaac agcaaagatc
     3241 catctcctta tccctggcta aatccatgac agggtgcgca tgctctgtat gacagggtgc
     3301 gcatgctctg tgttagggca tctgggcggg cctgagatag atgcctgttg ctgcagagga
     3361 cagagccact tctggatgtg catgccctgg gcttcagctt gcaggggagt gaatggcagt
     3421 ggagaagttg gcataggcat agcgtgactt agggagcaag cctggggctt agctggaaca
     3481 cactggggac agggtgttgg gtggcaaatg ctcggctgcg tagcctgagt gctaaggcca
     3541 tcctgtggcc ctttgcctgg gagatgtccg tcaggagctt tgctaggaca ccgtgaaatg
     3601 aggctcgggt tagggagtga gatctggagc ttggacaggc aggcaagctt gcagtgtctg
     3661 ggaggtcctc gcctttggca tctctctagg acctcatgtt ggactcggtg gcagccagtg
     3721 gagctaaaga gaggcgtccc cacccagtgc catcaacatg tggaccaggg cttcccattc
     3781 tctacagcag cagaccagga attctggggg accagggagg ggaaaggaaa atggtaaaat
     3841 tcaatgtttt gatgtttcct tcctgtccct ggcctggaat ttctttgcct cttatacagc
     3901 catggtgctg cctgtggacc cctactgtgt acatatgaca acactgtttc catgtgccac
     3961 ccaccttacc ctgagtgact gtgaaccctc ccctcaggca aaggaacagt gctggtactg
     4021 tcagatactg acaatgtgtc aggttttcct ccaagaaagg agccaaagtt gcttcctcgg
     4081 gattcgttct ctaaggtagg attattggat tagtgaacat ggggccctct gagactttta
     4141 ctacctacag acaaaacggt ttccagaagt ttcagtgtcc attgcacggc ccccatcgag
     4201 gggaagtgtc ctggttgagg gtcttctccc aggcccgagg actccctgac ttggcgaggt
     4261 cagccgcacc atgttttagt tgcatctttc gatcctagct caccgtgagt cgtttcacac
     4321 caagtgactg catttcctct tttgcagact gccgctgtcc tttgccccac tgacgggcct
     4381 gaccagtttg taagagctcc atatgtaatt aaagatacta acctgg
//
