LOCUS       NM_001278534            4354 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus retrotransposon Gag like 5 (Rtl5), mRNA.
ACCESSION   NM_001278534 NR_028404
VERSION     NM_001278534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4354)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4354)
  AUTHORS   Ishino,F., Itoh,J., Irie,M., Matsuzawa,A., Naruse,M., Suzuki,T.,
            Hiraoka,Y. and Kaneko-Ishino,T.
  TITLE     Retrovirus-Derived RTL9 Plays an Important Role in Innate
            Antifungal Immunity in the Eutherian Brain
  JOURNAL   Int J Mol Sci 24 (19), 14884 (2023)
   PUBMED   37834332
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4354)
  AUTHORS   Irie,M., Itoh,J., Matsuzawa,A., Ikawa,M., Kiyonari,H., Kihara,M.,
            Suzuki,T., Hiraoka,Y., Ishino,F. and Kaneko-Ishino,T.
  TITLE     Retrovirus-derived RTL5 and RTL6 genes are novel constituents of
            the innate immune system in the eutherian brain
  JOURNAL   Development 149 (18) (2022)
   PUBMED   36162816
REFERENCE   4  (bases 1 to 4354)
  AUTHORS   Shen,Z., Asa,S.L. and Ezzat,S.
  TITLE     The retrotransposon gag domain containing protein Rgag4 is an
            Ikaros target in the pituitary
  JOURNAL   Mol Cell Endocrinol 461, 188-193 (2018)
   PUBMED   28919299
  REMARK    GeneRIF: The results introduce Rgag4 to the repertoire of effectors
            serving to couple the chromatin remodeler Ikaros with the hormonal
            stress response.
REFERENCE   5  (bases 1 to 4354)
  AUTHORS   Youngson,N.A., Kocialkowski,S., Peel,N. and Ferguson-Smith,A.C.
  TITLE     A small family of sushi-class retrotransposon-derived genes in
            mammals and their relation to genomic imprinting
  JOURNAL   J Mol Evol 61 (4), 481-490 (2005)
   PUBMED   16155747
REFERENCE   6  (bases 1 to 4354)
  AUTHORS   Brandt,J., Schrauth,S., Veith,A.M., Froschauer,A., Haneke,T.,
            Schultheis,C., Gessler,M., Leimeister,C. and Volff,J.N.
  TITLE     Transposable elements as a source of genetic innovation: expression
            and evolution of a family of retrotransposon-derived neogenes in
            mammals
  JOURNAL   Gene 345 (1), 101-111 (2005)
   PUBMED   15716091
REFERENCE   7  (bases 1 to 4354)
  AUTHORS   Brandt,J., Veith,A.M. and Volff,J.N.
  TITLE     A family of neofunctionalized Ty3/gypsy retrotransposon genes in
            mammalian genomes
  JOURNAL   Cytogenet Genome Res 110 (1-4), 307-317 (2005)
   PUBMED   16093683
REFERENCE   8  (bases 1 to 4354)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807784.11.
            
            On Feb 4, 2022 this sequence version replaced NM_001278534.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220436.1, BC137795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3783              AL807784.11        12430-16212         c
            3784-4354           AL807784.11        11423-11993         c
FEATURES             Location/Qualifiers
     source          1..4354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 45.06 cM"
     gene            1..4354
                     /gene="Rtl5"
                     /gene_synonym="6430402L03Rik; Mar5; Mart5; mKIAA2001;
                     Rgag4"
                     /note="retrotransposon Gag like 5"
                     /db_xref="GeneID:331474"
                     /db_xref="MGI:MGI:3045324"
     exon            1..3783
                     /gene="Rtl5"
                     /gene_synonym="6430402L03Rik; Mar5; Mart5; mKIAA2001;
                     Rgag4"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..4354
                     /gene="Rtl5"
                     /gene_synonym="6430402L03Rik; Mar5; Mart5; mKIAA2001;
                     Rgag4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4338..4343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtl5"
                     /gene_synonym="6430402L03Rik; Mar5; Mart5; mKIAA2001;
                     Rgag4"
                     /note="hexamer: AATAAA"
     polyA_site      4354
                     /gene="Rtl5"
                     /gene_synonym="6430402L03Rik; Mar5; Mart5; mKIAA2001;
                     Rgag4"
                     /note="major polyA site"
ORIGIN      
        1 gagttagctg cagctaggga aggagagagt gagtgagagc gcagccgcgg gagccagtgg
       61 gctccctcgg ttcccgaagg cccgcccctg cggggggcgc gcgtagctga gcttaaaagg
      121 cgagagggat cgctgtctgc aagatttttc ctcgacagat cctgccgcag tcccttccct
      181 cctactctgc ctgcctctgt tggcgtcacc tctgccagcg tctcgtctgt ctcctgcgcc
      241 tgccgcctcc aggtcccgag ctgctgcctg ctctctctcc gacccctgcc acgaggtaac
      301 gcgtcccgga ccgagcccct gtgggtgtgg cccgggctcg cttgcgccgg gtcgccctgt
      361 cgccgcacgt tggtctcctc ccacgcccac ctcctcattt ctgcctcctc ctgcactccc
      421 cataactccc tacccccaag tgcccagcac tcaaagcccc aggaacttgt cacaatgtct
      481 gaagcggcgg gaaatctcaa tagcctccgc ttggcgaatg tggccctgcg agaggagtta
      541 aatgcccttc gaggagagaa tgtccagctg ggcctgcagc tcggaagagc cttggccgag
      601 gttaattcct tgcggggcaa tgtctcgagc tacatccgct ggcccatgcc catagtaccg
      661 gtccttgccg aggagaactt tgagttcctg ctcaatgaga ctgatcccac tcctgaggag
      721 gaggaagagg aggaggagga ggtgcctttc ctgtgctggc ctcctccacg cacagatccc
      781 gagtacgtct cagatgatct tttgattaat gtggtccagg actataccaa ccccgacggg
      841 tccagtgacc ctcctctgtc acccagcccg tcccagccgg aactgcactc ccccatgtta
      901 aaggagccaa cctttgagtt ccttttgcca ccgctggagc ggccagacat agaacccttt
      961 tcaggcgacc cagtgtacct ggctgaattt ctgatgcagc tagagacttt catagcagat
     1021 cacgaggatc acttccctgg gggcgcggaa cgggtggcat ttctcatctc ctttttcaca
     1081 ggggaagcga gagactgggc tatctcagtc actcaggaag gaagctcctt gcatgccaac
     1141 ttcccgcgct tcctggatga aatccgtaag gaattctgtg gccccatccc ctcacgcgtg
     1201 gctaaaaagg ccatacgcaa gctcaagcag ggaaactgta ccctgggcag ctatgcagat
     1261 gcttttcagt tcttggccca gttcttgtct tgggatgact gtcgcctcca aaaccaattt
     1321 ctcaaaggct tgtcagaaat ttttcgaaag gaactcttat ggtcaactga agtggccgac
     1381 ctggatgagc tgattcttga gtgtgtcaag atagaaagga aagtgcgtgt ccccaagaca
     1441 gcctcgctca ctggagttca aaatagctgc tgcccctttg cactaattcc taatgaggat
     1501 gaaaatgaag gtgtggagtt ctacagtgaa aatgagggtg agggtgaaga ggcaggcggg
     1561 tacaggcttt atctgaagga tcagaggcag cacatgacag ctttcccaca agagatgagg
     1621 gaggaagagg aggagatgag gaaagaggaa gacgagatgg aggatgagga ggatgaggac
     1681 gaggatgagg attatgaatt tgaggaggag gatgaagacg acgacgacga ggaggaagag
     1741 gaggaggaag aggaggagga agacaaggag gaggagatga agaatgagga tagcgatgag
     1801 aataagtatg aagaagaaga tgaagttatc gttagggtcc tggagccaga gcaggagcaa
     1861 gagagggagg agatagagca cgagcatgtg tatgtgcacg agcacataca cgcccatgtg
     1921 cacacacttg ctgcccacca ccacggccta catggagagc tcatggtgat ggacgaacct
     1981 gtccttgttg acacgtcaac ccagaccatt agctccgcca taggctacca tgctgaaaat
     2041 tacctggggg tatccccttc tgtaatgcat tctagcagac agaggagcca gaatcgagtc
     2101 ccacttctgg agggccttcc cgggaccaat tcatccttct acagcccgcc accactgatg
     2161 cgccatgcag gtcgcttggg gcaacgccaa atgcgaagat gtccctcagt gctcttctgc
     2221 ctcactccta ggcagggggg ccaccgagct actcaaggtc gaattcgagt gtgaacactg
     2281 ggggtgagtt ggccacgggg aacacaccct tcccctgctt cccttgcctc tgctattgct
     2341 gctgtacgtg ccccatctac tgaccagtcc gtacgaaagc cccagactgg aggaagaccc
     2401 caaagaagac ctgcagaatt ccagattgtt tcgcaaccac aaccagaaga gtgaaaagtg
     2461 cccaaccagg gccatccagg aaaggagagg tcaggactca acagtcctct tgctgtgtac
     2521 tcggctcagt cctcgcacaa agttgcaaag caagtctctt ggcctgttct tgtaaatggc
     2581 actggtcacc tttgtctcca actctagttg tccccaatct tcgcctctcc tgtgcttctt
     2641 tgccctgtgt tctacagtgt tatcctgact ttaccccaat gcctgagtga tctgccccaa
     2701 ccaatgatct aaaggcatta gatctaaact cttaatgctc tgaggccact tactagacaa
     2761 cgagcaggat gacaccaaga aatatgtact cgccatattt ccagcagaag ggcctgaaag
     2821 gggaacctac acctagagca gcgagaacct gcaaagccat gagtgcaatg gacaacttga
     2881 ctgaggttta ctctctttgg gggcgggagg ggggatggcg ggcaaacaga cctcactttg
     2941 agtgctgggg tttaccttcc cctcagactc ctgcctcagg acctctgcac agactttggc
     3001 taattcggcc ttcatgttgc ctacaggact ggcattaggg ggaggaggag gcagaggtgg
     3061 ctggagcacc atagttcagt ttgacatcct aaggagtgaa tcttgcttta ggaacagggc
     3121 cctcttctgg ctaggcttta agactgcagt cccagccaga ggcctctgag gagactgtgt
     3181 cctctaggtt gtgggggtag ccctgctggc ccactcttta agcccctctg actctaagga
     3241 gtccttagaa ctgaaaggag aaaacagggc tggctctgca gagactggac tcattgcagc
     3301 attgctggcc aacaccccta tggttctcac gtgaggggca aacctctcct aggcctgttg
     3361 ttgaacttca gttaaccagt gtggcttaag aggcgactgc ctcctgcaca ctcctggggc
     3421 ttcttgggca ccaactcagg tgcccctagt caaagacctg ctgttcactt ttgggtccag
     3481 gaaaatactg ctgctgcagt gggaagtaca catgtattat gtccattctg gccacaaaat
     3541 ggcagcctgg ttcactgctg gcccaagttg ttcctggaca ttgaacttgc tgcacggtgc
     3601 ctagcagctg ggcaaagtgg agcccaagtt gtccgtggtc agcaggaaga aagcagcaaa
     3661 tggtgtctct tcctcattgg agtctgaaga tgagaaccca gccctagagt ttgaacttaa
     3721 gaccagagaa ggaacttgag gaagaggagt cctagacaga cctagtcctc agactggtta
     3781 acgcttattt cctcaagcga gaattccaga agggaaaact ctattccttg aagctatgga
     3841 ccctgtctgc tgatgccaac atactggtca cgctgcctgt gtccttgtgg agaagcgcaa
     3901 gaagcaggtg tcttgtacct cagattccag agatccccct tggcacacac aggctttgcc
     3961 tgtcttcacg gtgcttctta gtctgaatgc ttgtggccct gaccagggag accaagcaca
     4021 tgagcactaa actggcctgt gggcctctgg gggcagaggg gccttgaact tcctttaacc
     4081 ttttcccttc tttcccagtt cttcaatatt tgttgtgatg tgacagctac aggagctgtc
     4141 cgaagctctg agtgcctcct tgggttgagg ggggtggggg tgggggtggg gatgcatgca
     4201 gggtacaagg gtgatccaaa gacacccgga ggctccagag aaacaaatgt gttactgttt
     4261 ttactgttac tgttgtatta ttgtgctgtg aagataaatt gttctgtatg ctaaagcttt
     4321 ctctcctcaa taaaacaaat aaagggtgtg taaa
//
