LOCUS       NM_001001882            4451 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus regulator of telomere elongation helicase 1 (Rtel1),
            transcript variant 1, mRNA.
ACCESSION   NM_001001882 XM_194070
VERSION     NM_001001882.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4451)
  AUTHORS   Xu,H.P., Niu,H., Wang,H., Lin,J. and Yao,J.J.
  TITLE     Knockdown of RTEL1 Alleviates Chronic Obstructive Pulmonary Disease
            by Modulating M1, M2 Macrophage Polarization and Inflammation
  JOURNAL   COPD 21 (1), 2316607 (2024)
   PUBMED   38420994
  REMARK    GeneRIF: Knockdown of RTEL1 Alleviates Chronic Obstructive
            Pulmonary Disease by Modulating M1, M2 Macrophage Polarization and
            Inflammation.
REFERENCE   2  (bases 1 to 4451)
  AUTHORS   Smoom,R., May,C.L., Ortiz,V., Tigue,M., Kolev,H.M., Rowe,M.,
            Reizel,Y., Morgan,A., Egyes,N., Lichtental,D., Skordalakes,E.,
            Kaestner,K.H. and Tzfati,Y.
  TITLE     Telomouse-a mouse model with human-length telomeres generated by a
            single amino acid change in RTEL1
  JOURNAL   Nat Commun 14 (1), 6708 (2023)
   PUBMED   37872177
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4451)
  AUTHORS   Kotsantis,P., Segura-Bayona,S., Margalef,P., Marzec,P., Ruis,P.,
            Hewitt,G., Bellelli,R., Patel,H., Goldstone,R., Poetsch,A.R. and
            Boulton,S.J.
  TITLE     RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription
            Collisions
  JOURNAL   Cell Rep 33 (12), 108546 (2020)
   PUBMED   33357438
  REMARK    GeneRIF: RTEL1 Regulates G4/R-Loops to Avert
            Replication-Transcription Collisions.
REFERENCE   4  (bases 1 to 4451)
  AUTHORS   Bellelli,R., Youds,J., Borel,V., Svendsen,J.,
            Pavicic-Kaltenbrunner,V. and Boulton,S.J.
  TITLE     Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in
            Metazoan DNA Replication
  JOURNAL   Cell Rep 31 (8), 107675 (2020)
   PUBMED   32460026
REFERENCE   5  (bases 1 to 4451)
  AUTHORS   Seshadri,N., Sandhu,S., Wu,X., Liu,W. and Ding,H.
  TITLE     Generation of an Rtel1-CreERT2 knock-in mouse model for lineage
            tracing RTEL1+ stem cells during development
  JOURNAL   Transgenic Res 27 (6), 571-578 (2018)
   PUBMED   30196476
REFERENCE   6  (bases 1 to 4451)
  AUTHORS   Wu,X., Sandhu,S., Patel,N., Triggs-Raine,B. and Ding,H.
  TITLE     EMG1 is essential for mouse pre-implantation embryo development
  JOURNAL   BMC Dev Biol 10, 99 (2010)
   PUBMED   20858271
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4451)
  AUTHORS   Wu,X., Sandhu,S. and Ding,H.
  TITLE     Establishment of conditional knockout alleles for the gene encoding
            the regulator of telomere length (RTEL)
  JOURNAL   Genesis 45 (12), 788-792 (2007)
   PUBMED   18064678
REFERENCE   8  (bases 1 to 4451)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 4451)
  AUTHORS   Ding,H., Schertzer,M., Wu,X., Gertsenstein,M., Selig,S.,
            Kammori,M., Pourvali,R., Poon,S., Vulto,I., Chavez,E., Tam,P.P.,
            Nagy,A. and Lansdorp,P.M.
  TITLE     Regulation of murine telomere length by Rtel: an essential gene
            encoding a helicase-like protein
  JOURNAL   Cell 117 (7), 873-886 (2004)
   PUBMED   15210109
REFERENCE   10 (bases 1 to 4451)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY023099.1 and AK173097.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001001882.4.
            
            On Oct 31, 2009 this sequence version replaced NM_001001882.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173097.1, AY481619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY023099.1         1-38
            39-4451             AK173097.1         1-4413
FEATURES             Location/Qualifiers
     source          1..4451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.63 cM"
     gene            1..4451
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /note="regulator of telomere elongation helicase 1"
                     /db_xref="GeneID:269400"
                     /db_xref="MGI:MGI:2139369"
     exon            1..133
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            134..385
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..3913
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulator of telomere length; DEAH helicase"
                     /codon_start=1
                     /product="regulator of telomere elongation helicase 1
                     isoform 1"
                     /protein_id="NP_001001882.3"
                     /db_xref="CCDS:CCDS17208.1"
                     /db_xref="GeneID:269400"
                     /db_xref="MGI:MGI:2139369"
                     /translation="MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPT
                     GTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIEC
                     YTDIPKIIYASRTHSQLTQVIRELRNTAYRPKVCVLGSREQLCIHPEVKKQESNHMQI
                     SLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQ
                     ADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGL
                     EIINQVLEEQARVTQQGELQQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQL
                     PGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKL
                     MDIIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRKQG
                     KVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDK
                     NQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVM
                     EKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCR
                     GKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEW
                     YQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAQLPSWVRPYLKVYDNFGH
                     VIRDVAQFFRVAQKTMPLPVPQAVTSSVSEGEIALKDATLSSYSLSTRKAMSLDVHVP
                     SLRQKPIGLPAAGDSESSLCGEYEQQTFSAQQRPMGLLAALEYNEQKAGASEEQALGS
                     STPSLRCEKRLSTEQKGGRKKVRLVNHPEEPMAGTQAGRAKMFMVAVKQALSQANFDT
                     FTQALQHYKSSDDFEALVASLTCLFAEDPKKHTLLKGFYQFVRPHHKQQFEDICFQLT
                     GQRCGYQPGKRELESKLTLSEGVDRQLDPGQHLNQGQPHLSAHPTSKAHFSKPGHTSH
                     CTKVGCAVEKPGQPAVSDYLSDVHKALGSASCNQLTAALRAYKQDDDLDKVVAVVAAL
                     TTAKPEHLPLLQRFGMFVRRHHKPQFLQTCADLMGLPTTGKDLELEGPRDESPTVPPE
                     LTHEDLKPGPSMSKKPEKTQSKISSFFRQRPDESVRSDDTTPKPMQLPPRLPHELMKP
                     HRSKQ"
     exon            386..584
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            585..678
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            679..760
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            761..821
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            822..897
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            898..982
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1048
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1202
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1241
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1320
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1418
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1474
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1549
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1631
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1764
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1878
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1919
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2005
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2083
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2161
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2308
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2424
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2548
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2699
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2839
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2935
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3134
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3224
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3341
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3584
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3746
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..4439
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4419..4424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /note="hexamer: AATAAA"
     polyA_site      4439
                     /gene="Rtel1"
                     /gene_synonym="Rtel"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgtag catttaggcg tggctacacg gatctgcccg cgaagttcca atcagcggac
       61 tgcggagcac gcgggatccg tgtctttaca gttgtttgat accggacttt gaaaggcagc
      121 cctaccgaga caaggaattc ttacagaggg aaacctgatg ccacatgctg ccaacactta
      181 cctggagtgg ctgaaacact gagatgatca gaggggtttg tctcacagac ccagacagcc
      241 tgcatcttgg cctaccaccg tgtcttcctc agtataggct gatatgccca gggtagtcct
      301 gaatggtgtg acagtggatt ttcctttcca gccctaccca tgccaacagg aatatatgac
      361 caaggtgcta gaatgtctcc agaagaaagt gaatggcatc ctggagagcc ccacaggcac
      421 tgggaagacg ctgtgcctcc tctgttccac cttggcctgg caacaacatc tccgagatgc
      481 agtttcttcc ctaaagattg ctgagagagt tcaaggggaa ctctttgcca gtcggacctt
      541 gtcatcctgg gggagtgctg ctgccgccag cggagactca atagagtgct acacagatat
      601 cccaaagatc atctatgctt ctagaacgca ctcccagcta actcaggtca tccgtgagct
      661 tcggaatacc gcctaccggc ccaaggtatg tgtgctgggc tcccgggagc agctgtgtat
      721 tcatcctgaa gtgaagaagc aggagagtaa tcacatgcag atcagtttgt gccgcaagaa
      781 ggtagcaagt cgctcctgtc atttctacaa caatgtggaa gcgaaattcc tggagcaaga
      841 tttggctacc cccatcctgg atattgagga ccttgtcaag aatggaagca aacaaaaaat
      901 gtgcccatac tacctttctc gaaacatgaa acagcaagcg gacatcatct ttatgccata
      961 caattacctg ttggatgcta agagtcgtaa ggcgcacagc attgacctga agggaacagt
     1021 tgtgatcttt gatgaagctc acaatgtgga gaagatatgt gaggagtcag cctcctttga
     1081 cttgactccc cgtgatgtgg cttcaggact ggagattatc aaccaggttt tggaggaaca
     1141 agcccgggtg actcagcagg gtgaactcca acaggagttc attgtagaca cgtccagctc
     1201 aggactcaac atggagctgg aagacatcgc aaagctaaag atgatcctgc ttcgcctgga
     1261 ggaggctatt gatgccgttc agctgcctgg ggatgacaga ggcgtcacca aacctggaag
     1321 ctatatcttc gagctgtttg ctgaagctca aataacattt caaaccaaag gctgcatttt
     1381 ggaatcactg gaccagataa tccagcacct ggcaggccgt actggtgtgt tcaccaacac
     1441 ggctgggttg cagaagctta tggacattat ccagattgtg ttcagcgtgg accctccgga
     1501 aggcagccct ggttctctgg tggggctggg tatctcacat tcctataagg tacacataca
     1561 ccctgaaacc agccaccgga gagcagctaa gcggtcagat gcctggagta ccactgcatc
     1621 caggaaacaa gggaaggtgc tgagctattg gtgcttcagt cccagccaga gtatgcggga
     1681 actggtctgc caaggagttc gtacccttat cctcaccagc ggtaccctgg ctccactgtc
     1741 ttcctttgct ctggagatgc agattccatt cccagtctgt ctggagaatc cacacatcat
     1801 tgacaagaac cagctctggg tggggattgt ccccagaggc cctgatggtg ttcagctaag
     1861 ctctgcctat gacaaaaggt tttctgaaga gtgtttatct tccctgggga aggctctgag
     1921 caacattgct cgcgtggtgc cccatgggct tctggtcttc ttcccttcct accctgtcat
     1981 ggagaaaagc ctggagttct ggcaggtaca aggattggcc aggaaggtag aggcactaaa
     2041 gcctctgttc gtggaaccca ggaacaaagg cagcttctca gaggtcattg atgcctacta
     2101 ccaacaagtt gcctcccctg cgtctaatgg ggccaccttc ttagcagtgt gtcggggaaa
     2161 ggccagcgaa gggctggact tctcagacat gaatggtcgt ggtgtgattg tcacgggcct
     2221 cccatatcct ccacgcatgg atccccgtgt tgtcctcaag atgcagttct tggatgagat
     2281 gagaggccgg agtggggttg gaggccagtg cctctctggg caggaatggt accagcagca
     2341 agcatccagg gctgtgaacc aggctattgg gagggttatt cgacaccgcc atgactatgg
     2401 ggccatcttc ctgtgtgacc acaggttcgc ctatgctgat gccagggccc agctgccctc
     2461 ctgggtgcgc ccctacctta aggtgtatga caactttggc catgtcatcc gagatgtggc
     2521 ccagttcttc cgtgttgctc agaaaactat gcctttgcca gttcctcagg ctgtgacctc
     2581 aagtgtgagt gagggagaaa ttgctctcaa ggatgctaca ttgtccagct actccctctc
     2641 taccaggaaa gccatgagtt tggatgtgca tgtgcccagc ctgaggcaga agcccatagg
     2701 attaccagct gctggagact ctgagagcag cctgtgtggg gagtatgagc agcagacatt
     2761 ttctgcccag cagagaccta tgggactgct agctgcctta gaatacaacg agcagaaggc
     2821 tggggcatct gaggagcagg cactgggctc ctccacccca tctctccggt gcgagaagag
     2881 gctgtctact gagcaaaaag gaggaaggaa gaaagtcagg ctggtcaacc atccggagga
     2941 accaatggct ggcacacagg caggcagagc caagatgttc atggtggctg tgaagcaagc
     3001 actgagccaa gctaactttg acacctttac ccaggccctg cagcactata agagttctga
     3061 tgactttgaa gccctagtgg cctctctcac ctgtctcttt gctgaagacc ccaagaaaca
     3121 caccctgctt aaaggtttct accagtttgt tcgaccccac cacaagcagc agtttgagga
     3181 catctgcttc cagctaacag gccaacgatg tggctaccag ccaggaaaga gagagctgga
     3241 gtctaaactg accttgtctg aaggtgtaga caggcagctg gatcctggac agcacctgaa
     3301 ccaggggcag cctcacctgt ctgcccatcc aacctccaaa gctcattttt ccaaaccagg
     3361 acacaccagc cattgtacaa aagtgggatg tgcagtagaa aaacctggcc agcctgctgt
     3421 gagtgactac ctatctgatg tccacaaggc tctgggatct gcaagctgca accagcttac
     3481 ggcagctctg agggcataca aacaggatga tgacctggac aaggtggtgg ctgtggtggc
     3541 agcactgacc actgcaaaac ctgaacactt acccttgcta cagagatttg gcatgtttgt
     3601 gcgtcggcat cataagcctc agttcctaca gacctgtgca gacctaatgg gcctgcctac
     3661 cacaggcaag gacttggagc tcgaaggtcc cagagatgag agcccaactg tgcctcctga
     3721 gcttacccat gaggacctga aaccagggcc ctcgatgtcc aagaaacctg agaagaccca
     3781 gagtaagatc tcatccttct ttagacagag gccagatgag agtgtgaggt ctgatgatac
     3841 caccccaaag cccatgcaac ttcctcctag actaccccat gagcttatga agcctcatcg
     3901 gagtaagcaa taggggctac agtgaatgtt ggttatggta gggcactgaa cagtgtgctc
     3961 acttagacct cctgcaacag aatttgtatg cccggcctgt gcaactgagg atacagtgct
     4021 tttccagtgc ccctcctgtg acttctaccg ctgttgggcc tgttggaaac ttcaactcca
     4081 ggttggggtc taaccctctc cagcccatca ggcatctctc caggtggtgg gggctaaggg
     4141 agcaatgcca agcttcagtg cctagcaggt atctccacag gcctctagac tgtgtccggc
     4201 ttgtggtgct gttaacagga agcagagcat tacacaggtc atctggccga agccccagtg
     4261 aagacagatg gagccctttg cttgccctga tgtggttaaa cccactgcag gtctcatgct
     4321 tggctgtcca atgagatctg aatctacttg tgaagttctg aaacctcaaa tagcctatat
     4381 tggcattgca catgtaccac tgaaggtgta ggctgtccaa taaaactaag ttatcaggaa
     4441 aaaaaaaaaa a
//
