LOCUS       NM_145422               1979 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus RNA 2',3'-cyclic phosphate and 5'-OH ligase (Rtcb),
            mRNA.
ACCESSION   NM_145422
VERSION     NM_145422.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1979)
  AUTHORS   Liu,P., Zhang,R., Song,X., Tian,X., Guan,Y., Li,L., He,M., He,C.
            and Ding,N.
  TITLE     RTCB deficiency triggers colitis in mice by influencing the
            NF-kappaB and Wnt/beta-catenin signaling pathways
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (3), 405-413 (2024)
   PUBMED   38425245
  REMARK    GeneRIF: RTCB deficiency triggers colitis in mice by influencing
            the NF-kappaB and Wnt/beta-catenin signaling pathways.
REFERENCE   2  (bases 1 to 1979)
  AUTHORS   Zhang,H., Jiang,J.C., Wu,Y.W., Yu,Y.S., Wang,H.N., Ding,N.Z. and
            Fan,H.Y.
  TITLE     The RNA ligase RNA terminal phosphate cyclase B regulates mRNA
            alternative splicing and is required for mouse oocyte development
            and maintenance
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36178098
  REMARK    GeneRIF: The RNA ligase RNA terminal phosphate cyclase B regulates
            mRNA alternative splicing and is required for mouse oocyte
            development and maintenance.
REFERENCE   3  (bases 1 to 1979)
  AUTHORS   Li,R., Song,X.T., Guo,S.W., Zhao,N., He,M., He,C.Q. and Ding,N.Z.
  TITLE     YY1 and RTCB in mouse uterine decidualization and embryo
            implantation
  JOURNAL   Reproduction 162 (6), 461-472 (2021)
   PUBMED   34591784
  REMARK    GeneRIF: YY1 and RTCB in mouse uterine decidualization and embryo
            implantation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1979)
  AUTHORS   Zhang,T., Wilson,A.F., Mahmood Ali,A., Namekawa,S.H.,
            Andreassen,P.R., Ruhikanta Meetei,A. and Pang,Q.
  TITLE     Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell
            Depletion in Mice Under Genotoxic Stress
  JOURNAL   Stem Cells 33 (7), 2320-2330 (2015)
   PUBMED   25917546
  REMARK    GeneRIF: This novel Faap20 mouse model may be valuable in studying
            the regulation of the FA pathway during bone marrow failure
            progress in FA patients.
REFERENCE   5  (bases 1 to 1979)
  AUTHORS   Jurkin,J., Henkel,T., Nielsen,A.F., Minnich,M., Popow,J.,
            Kaufmann,T., Heindl,K., Hoffmann,T., Busslinger,M. and Martinez,J.
  TITLE     The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA
            and controls antibody secretion in plasma cells
  JOURNAL   EMBO J 33 (24), 2922-2936 (2014)
   PUBMED   25378478
REFERENCE   6  (bases 1 to 1979)
  AUTHORS   Ding,N.Z., He,M., He,C.Q., Hu,J.S., Teng,J.L. and Chen,J.
  TITLE     Yin yang-1 regulates the characterized murine focal
            adhesion-associated protein promoter
  JOURNAL   DNA Cell Biol 31 (4), 496-503 (2012)
   PUBMED   21977911
REFERENCE   7  (bases 1 to 1979)
  AUTHORS   Zhao,J., Ju,X., Zhang,L., An,Y., Zhang,Z., Sun,Z., Ding,N. and
            Teng,C.B.
  TITLE     Spatiotemporal expression of D10Wsu52e in the developing mouse
            pancreas
  JOURNAL   Front Biosci (Elite Ed) 3 (1), 355-363 (2011)
   PUBMED   21196315
  REMARK    GeneRIF: D10Wsu52e may be related to the acinar development,
            adhesion and migration of progenitors and endocrine precursors.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1979)
  AUTHORS   Ding,N.Z., He,M., He,C.Q., Hu,J.S., Teng,J. and Chen,J.
  TITLE     Expression and regulation of FAAP in the mouse epididymis
  JOURNAL   Endocrine 38 (2), 188-193 (2010)
   PUBMED   21046479
  REMARK    GeneRIF: FAAP (D10Wsu52e) mRNA and protein expression are highly
            regionalized in the mouse epididymis with predominant enrichment in
            the initial segment; during sexual maturation, FAAP mRNA is always
            expressed in the caput epididymides
REFERENCE   9  (bases 1 to 1979)
  AUTHORS   Wang,Y., Hai,T., Liu,Z., Zhou,S., Lv,Z., Ding,C., Liu,L., Niu,Y.,
            Zhao,X., Tong,M., Wang,L., Jouneau,A., Zhang,X., Ji,W. and Zhou,Q.
  TITLE     HSPC117 deficiency in cloned embryos causes placental abnormality
            and fetal death
  JOURNAL   Biochem Biophys Res Commun 397 (3), 407-412 (2010)
   PUBMED   20510672
  REMARK    GeneRIF: defects in HSPC117 expression may be an important
            contributing factor to loss of cloned nuclear transfer embryos in
            vivo.
REFERENCE   10 (bases 1 to 1979)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC122919.3 and
            AC151901.3.
            
            On Oct 19, 2007 this sequence version replaced NM_145422.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003288.1, AK145891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC122919.3         140245-140423
            180-258             AC122919.3         142241-142319
            259-326             AC151901.3         1914-1981
            327-426             AC151901.3         3964-4063
            427-583             AC151901.3         5796-5952
            584-740             AC151901.3         8085-8241
            741-900             AC151901.3         9068-9227
            901-1076            AC151901.3         11428-11603
            1077-1265           AC151901.3         12021-12209
            1266-1376           AC151901.3         12820-12930
            1377-1496           AC151901.3         13400-13519
            1497-1979           AC151901.3         16299-16781
FEATURES             Location/Qualifiers
     source          1..1979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.81 cM"
     gene            1..1979
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /note="RNA 2',3'-cyclic phosphate and 5'-OH ligase"
                     /db_xref="GeneID:28088"
                     /db_xref="MGI:MGI:106379"
     exon            1..179
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1604
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /EC_number="6.5.1.8"
                     /note="tRNA-splicing ligase RtcB homolog; focal
                     adhesion-associated protein; 3'-phosphate/5'-hydroxy
                     nucleic acid ligase"
                     /codon_start=1
                     /product="RNA-splicing ligase RtcB homolog"
                     /protein_id="NP_663397.1"
                     /db_xref="CCDS:CCDS24094.1"
                     /db_xref="GeneID:28088"
                     /db_xref="MGI:MGI:106379"
                     /translation="MSRNYNDELQFLDKINKNCWRIKKGFVPNMQVEGVFYVNDALEK
                     LMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAF
                     DMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGV
                     IPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSPRAKKRGLPQ
                     LGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVA
                     MEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAK
                     VFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDY
                     QLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLD
                     KLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG"
     exon            180..258
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            259..326
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            327..426
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            427..583
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            584..740
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            741..900
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1076
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1265
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1376
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1496
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1979
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1958..1963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /note="hexamer: ATTAAA"
     polyA_site      1979
                     /gene="Rtcb"
                     /gene_synonym="D10Wsu52e; FAAP; HSPC117"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcgct gcgtggagcg ggtggactgc ggggtggttt ctctttctaa gcgtagccag
       61 gagctatcgc tggcctcgcc gccaccatga gtcgtaacta caacgatgag ctacagttct
      121 tggacaagat caataaaaac tgctggagga tcaagaaggg ctttgtgccc aacatgcagg
      181 ttgaaggagt gttttatgtg aatgatgctc tggaaaaact aatgtttgag gaattaagga
      241 acgcctgtcg aggtggtggt gttggtggct ttctgccagc catgaagcag attggcaatg
      301 tggcagccct gcctggaata gttcatcggt ctatcgggct tcctgatgtc cattcaggct
      361 atgggtttgc catagggaac atggctgcct ttgatatgaa tgaccctgag gccgttgtat
      421 ccccaggtgg tgtcggattt gatattaact gtggtgtccg cttgctaaga accaatttag
      481 atgagagcga tgtacagcct gtgaaggaac aacttgccca agctatgttt gaccacatcc
      541 ctgttggggt gggatcaaaa ggtgtcattc caatgaatgc caaagacttg gaggaggcat
      601 tggagatggg ggtggactgg tccctgaggg aaggctatgc ctgggctgaa gacaaggagc
      661 actgtgagga gtatggaagg atgctgcaag ccgaccccaa taaggtctca cccagggcaa
      721 agaaaagggg ccttcctcag ttggggaccc tgggagcagg caaccattat gcagaaatcc
      781 aggttgtaga tgagattttc aatgagtatg ccgccaagaa gatgggcatc gaccataagg
      841 gacaggtgtg tgtgatgatc cacagtggaa gcagaggctt gggccaccaa gtagctacag
      901 atgcactggt agctatggaa aaggccatga agagagacaa gattatagtc aatgaccggc
      961 agttggcttg tgctcggatt gcatccccag agggacaaga ctatctaaag ggaatggctg
     1021 cagctggaaa ctacgcctgg gttaaccgct cctctatgac cttcttaacc cgtcaggctt
     1081 ttgccaaagt cttcaacaca acccctgatg acctggacct gcatgtgatc tatgatgtgt
     1141 cgcacaatat cgccaaagtg gagcagcacg tggtggatgg gaaggaacgg acgctgctgg
     1201 tgcacaggaa gggatccacc cgtgctttcc cgcctcacca ccccctcatt gctgtggatt
     1261 atcaactcac aggacaacca gtgcttattg gtggcaccat ggggacctgt agttacgttc
     1321 tgactggcac tgaacaaggc atgactgaga cctttggaac aacctgtcat ggagcgggcc
     1381 gtgctttgtc cagagcaaaa tcacgtcgta acttagattt ccaagatgtc ttagacaaac
     1441 tggcagacat gggaattgca atccgggttg cttcccccaa gctggttatg gaagaggcac
     1501 cagagtccta taagaatgtg acagacgtcg tgaacacctg ccatgatgct gggatcagca
     1561 agaaggccat taaactgaga ccaattgctg ttattaaagg gtagatccaa gactatcaga
     1621 gcgtctgagg tgcccatgga ctgaaattcc taagacatga gactcaaggc ctgacaagat
     1681 ccgaattgca gagctgttgc tgtgcgtgcc accatggctg gtggagaggc tgctgtcaca
     1741 gggttggaaa atagccttcc aggagatgtg tctctgatgg gagcagggca aatgagcctc
     1801 ttcttccttt gtcccacagg ggtttgtgac tgtcaattgg ggtgtgggaa ggggcccaga
     1861 aatgccctgt ttggtcatac aagtctgtaa tcaccagagt gggcttcttt atcccaggcc
     1921 ctgtttgtag cccagaaggt atcatggaga acatgctatt aaataggttt ttgaatgtt
//
