LOCUS       NM_025517               1576 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus RNA 3'-terminal phosphate cyclase (Rtca), mRNA.
ACCESSION   NM_025517
VERSION     NM_025517.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1576)
  AUTHORS   Vargas,E.J.M., Matamoros,A.J., Qiu,J., Jan,C.H., Wang,Q.,
            Gorczyca,D., Han,T.W., Weissman,J.S., Jan,Y.N., Banerjee,S. and
            Song,Y.
  TITLE     The microtubule regulator ringer functions downstream from the RNA
            repair/splicing pathway to promote axon regeneration
  JOURNAL   Genes Dev 34 (3-4), 194-208 (2020)
   PUBMED   31919191
REFERENCE   2  (bases 1 to 1576)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   3  (bases 1 to 1576)
  AUTHORS   Song,Y., Sretavan,D., Salegio,E.A., Berg,J., Huang,X., Cheng,T.,
            Xiong,X., Meltzer,S., Han,C., Nguyen,T.T., Bresnahan,J.C.,
            Beattie,M.S., Jan,L.Y. and Jan,Y.N.
  TITLE     Regulation of axon regeneration by the RNA repair and splicing
            pathway
  JOURNAL   Nat Neurosci 18 (6), 817-825 (2015)
   PUBMED   25961792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152129.1, AK159961.1 and BM899781.1.
            
            On Jul 23, 2009 this sequence version replaced NM_025517.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090403.1, AK152129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AK152129.1         2-111
            111-1558            AK159961.1         1-1448
            1559-1576           BM899781.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1576
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 50.35 cM"
     gene            1..1576
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /note="RNA 3'-terminal phosphate cyclase"
                     /db_xref="GeneID:66368"
                     /db_xref="MGI:MGI:1913618"
     exon            1..231
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1287
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /EC_number="6.5.1.4"
                     /note="RNA cyclase; RNA-3'-phosphate cyclase; RNA terminal
                     phosphate cyclase domain 1; RNA terminal phosphate cyclase
                     domain-containing protein 1"
                     /codon_start=1
                     /product="RNA 3'-terminal phosphate cyclase"
                     /protein_id="NP_079793.2"
                     /db_xref="CCDS:CCDS17786.1"
                     /db_xref="GeneID:66368"
                     /db_xref="MGI:MGI:1913618"
                     /translation="MEGQRVEVDGGIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRS
                     TPGLRPQHLSGLEMVRDLCGGHLEGAEIGSTEITFTPEKIRGGVHTADTKTAGSVCLL
                     MQVSMPCVLFAASPSELRLKGGTNAEMAPQIDYTMMVFKPIAEKFGFTFNCDIKTRGY
                     YPKGGGEVIVRVSPVKRLDPINLTDRGSVTKIYGRAFVAGVLPLKVAKDMAAAAVRCI
                     RKEIRDLYVSIQPVQEARDQAFGNGSGIIIVAETSTGCLFAGSSLGKRGVNADKVGIE
                     AAEMLLANLRHGGTVDEYLQDQLIIFMALANGISRIKTGSVTLHTQTAIHFAEQLAKA
                     KFTVKKSEEEEDATKDTYVIECEGIGMANPHL"
     exon            232..332
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..476
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..600
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            601..659
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..801
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..926
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..985
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1080
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1185
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1561
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1537..1542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /note="hexamer: AATAAA"
     polyA_site      1561
                     /gene="Rtca"
                     /gene_synonym="2310009A18Rik; RPC; Rtcd1"
                     /note="major polyA site"
ORIGIN      
        1 gccggcaggg tcccctgggg aattcgtttc cacagcaaca gtttcccggg aggcgcgggt
       61 tctttctcct tccggcgagc tcggcccgga agcgcactat caggcctgcg ggcttgcggg
      121 cgcctcgtct tttgccggtt gcagcaggga cgtggtcgct gccggccggg ctcagaggcg
      181 cccgccatgg agggccagcg ggtggaggtg gacggtggga tcatggaagg gggcggccag
      241 atcctcaggg tctccaccgc cctgagctgc ctcctgggcc tacccttgcg cgtgcagaag
      301 atccgcgcgg gccgcagcac gccgggcctc aggcctcagc atttatctgg actggaaatg
      361 gttcgtgatt tgtgtggcgg gcacctggag ggagcagaaa tcggctcaac agagataacc
      421 tttacccccg agaagatcag aggtggagtc cacacggcag ataccaagac agcagggagt
      481 gtgtgcctct tgatgcaggt ttcaatgccc tgtgtcctgt ttgcggcttc cccgtcggag
      541 ctccgtctga aaggcggcac caatgcggag atggccccgc agatcgatta caccatgatg
      601 gttttcaagc caattgctga gaagtttggt ttcacattta attgtgacat taaaacgagg
      661 ggctattacc ccaaaggggg tggtgaagtg attgtccgag tgtccccagt taaacgattg
      721 gacccaataa atctgactga tcgaggctct gtgaccaaga tttatgggag agcttttgtt
      781 gccggtgttt tgccactaaa agtagcaaaa gatatggcgg cggcggctgt gcggtgcatc
      841 cggaaggaga tccgggatct gtacgtcagc atccagcccg tgcaggaggc cagggaccaa
      901 gccttcggca atgggagtgg aatcatcatt gttgctgaga catccactgg ctgcttgttt
      961 gctggatcat cacttggcaa aagaggtgtg aatgcagaca aggttgggat tgaagctgct
     1021 gaaatgctat tagcgaacct tagacacggt ggcactgtgg atgagtatct acaagaccag
     1081 ctgattattt tcatggcgct agccaatgga atttccagaa taaaaacagg atcagtcaca
     1141 ctccacacgc agactgctat acattttgct gaacagctag caaaggccaa atttaccgtg
     1201 aagaaatcag aagaggaaga agatgccact aaggacactt acgtcatcga gtgtgaagga
     1261 attgggatgg caaatccaca cctctagggt gttcacgtac gctctacctc cttgttgcac
     1321 tgacttagcc catgcatgct gcaacacagt gagtgagacg tcagctacca caggacttga
     1381 gtctttggag atggaggttg gcactgtcag ttgctgagaa tgctccatca tgttaagctc
     1441 gtgggatatc tccccagata tagacagtga acgatcaaac gtaatgaata tgtgtaatag
     1501 tcaacttcaa tattaacatc ataccctaac gttataaata aattgttgtt cataccctaa
     1561 aaaaaaaaaa aaaaaa
//
