LOCUS       NM_001357328            1349 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus retbindin (Rtbdn), transcript variant 3, mRNA.
ACCESSION   NM_001357328 XM_006530865
VERSION     NM_001357328.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   Fan,J., Rajapakse,D., Peterson,K., Lerner,J., Parsa,S., Ponduri,A.,
            Sagar,V., Duncan,T., Dong,L. and Wistow,G.
  TITLE     Retbindin mediates light-damage in mouse retina while its absence
            leads to premature retinal aging
  JOURNAL   Exp Eye Res 209, 108698 (2021)
   PUBMED   34228964
  REMARK    GeneRIF: Retbindin mediates light-damage in mouse retina while its
            absence leads to premature retinal aging.
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Sinha,T., Du,J., Makia,M.S., Hurley,J.B., Naash,M.I. and
            Al-Ubaidi,M.R.
  TITLE     Absence of retbindin blocks glycolytic flux, disrupts metabolic
            homeostasis, and leads to photoreceptor degeneration
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33526685
  REMARK    GeneRIF: Absence of retbindin blocks glycolytic flux, disrupts
            metabolic homeostasis, and leads to photoreceptor degeneration.
REFERENCE   4  (bases 1 to 1349)
  AUTHORS   Genc,A.M., Makia,M.S., Sinha,T., Conley,S.M., Al-Ubaidi,M.R. and
            Naash,M.I.
  TITLE     Elimination of a Retinal Riboflavin Binding Protein Exacerbates
            Degeneration in a Model of Cone-Rod Dystrophy
  JOURNAL   Invest Ophthalmol Vis Sci 61 (6), 17 (2020)
   PUBMED   32516403
REFERENCE   5  (bases 1 to 1349)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1349)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1349)
  AUTHORS   Kelley,R.A., Al-Ubaidi,M.R., Sinha,T., Genc,A.M., Makia,M.S.,
            Ikelle,L. and Naash,M.I.
  TITLE     Ablation of the riboflavin-binding protein retbindin reduces flavin
            levels and leads to progressive and dose-dependent degeneration of
            rods and cones
  JOURNAL   J Biol Chem 292 (51), 21023-21034 (2017)
   PUBMED   29079576
  REMARK    GeneRIF: Retbindin ablation causes a retinal phenotype
            characterized by time- and dose-dependent declines in rod and cone
            photoreceptor functions as early as 120 days of age. Whereas minor
            retinal ultrastructural defects were observed at all ages examined,
            a significant decline occurred in photoreceptor nuclei at 240 days
            of age ( approximately 36.8% rods and approximately 19.9% cones).
REFERENCE   8  (bases 1 to 1349)
  AUTHORS   Kelley,R.A., Al-Ubaidi,M.R. and Naash,M.I.
  TITLE     The Potential Role of Flavins and Retbindin in Retinal Function and
            Homeostasis
  JOURNAL   Adv Exp Med Biol 854, 643-648 (2016)
   PUBMED   26427470
  REMARK    GeneRIF: Data suggest Retbindin as a possible flavin binding
            protein in the neural retina.
REFERENCE   9  (bases 1 to 1349)
  AUTHORS   Kelley,R.A., Al-Ubaidi,M.R. and Naash,M.I.
  TITLE     Retbindin is an extracellular riboflavin-binding protein found at
            the photoreceptor/retinal pigment epithelium interface
  JOURNAL   J Biol Chem 290 (8), 5041-5052 (2015)
   PUBMED   25542898
  REMARK    GeneRIF: retbindin is an excellent candidate for binding retinal
            flavins and possibly participating in their transport from the
            extracellular space to the photoreceptors.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161765.5 and AC163703.4.
            
            On Oct 25, 2017 this sequence version replaced XM_006530865.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.444863.1,
                                           SRR17784643.564630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC161765.5         215356-215500
            146-220             AC161765.5         217248-217322
            221-395             AC161765.5         217868-218042
            396-540             AC163703.4         208513-208657       c
            541-651             AC163703.4         208278-208388       c
            652-748             AC163703.4         206198-206294       c
            749-1349            AC163703.4         204695-205295       c
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.37 cM"
     gene            1..1349
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /note="retbindin"
                     /db_xref="GeneID:234542"
                     /db_xref="MGI:MGI:2443686"
     exon            1..145
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /inference="alignment:Splign:2.1.0"
     exon            146..220
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /inference="alignment:Splign:2.1.0"
     exon            221..395
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..970
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /codon_start=1
                     /product="retbindin precursor"
                     /protein_id="NP_001344257.1"
                     /db_xref="CCDS:CCDS22485.1"
                     /db_xref="GeneID:234542"
                     /db_xref="MGI:MGI:2443686"
                     /translation="MAHEGHSQHSGLVWALRPILAWIFLVACGWSHPLQTRSWGHPGL
                     AAKVRTGQLQPAGHPQSSVLPSYPRIQVPGSQTPPVPVPCCTAEIDRPESLLESCGAP
                     SPECEFFLGQLQGALRDRFHPQLFGARPVQPLCPELCQIWFTTCQADFICGPTWLQSS
                     GERGCEPSCRTYGQTFANATDLCHSVLGHVLRVAAPGSSHCLNVSISSPGARRRPRAW
                     ISNVVGSGSGSGSGDSPEPMFGFQYVSLP"
     exon            396..540
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /inference="alignment:Splign:2.1.0"
     exon            541..651
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /inference="alignment:Splign:2.1.0"
     exon            652..748
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1349
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1330..1335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /note="hexamer: AATAAA"
     polyA_site      1346
                     /gene="Rtbdn"
                     /gene_synonym="A330096I21Rik; Rtbnd"
                     /note="major polyA site"
ORIGIN      
        1 gtgagacttc tcattcatta agagcactgg ctgctcttcc agaggaccta ggtttgattg
       61 ctagaactca tgtggtggct tacaaccatt cataactcca gttccagcag atctgatatc
      121 ttcttttggc ctccttgaaa accagttgcg gctcttgact ggccttggtt cggtggttct
      181 gaggtgtctg agcatcccct agactccagc cagctaacag gtggacatgg cccacgaagg
      241 ccactctcaa cacagcggcc tggtctgggc cctgcgaccg atcctggctt ggatcttctt
      301 ggtggcctgt ggatggagtc acccactgca gactaggtcc tggggacacc ctggactggc
      361 agccaaggtg cgcacaggcc agctgcagcc ggcagggcac cctcagtcct cggttctacc
      421 atcataccca aggatccaag ttcctggctc acagacacca ccagtgccag tgccttgctg
      481 tactgcagag atagacagac cagagagcct tctagagagc tgcggggcac caagcccaga
      541 atgtgaattc ttcctgggac aacttcaagg agcccttcgc gatcgcttcc acccacagct
      601 cttcggggca cgcccagtgc agcctctctg cccagagctc tgccagattt ggttcaccac
      661 ctgccaagca gattttattt gtggcccgac ttggctgcag tcctctggag agagaggctg
      721 tgagcccagc tgccgcacct atgggcagac cttcgccaac gccacagatc tgtgtcactc
      781 tgttttgggt catgtcctgc gggtagcagc tccaggttcc agtcactgcc tcaacgtctc
      841 catctcctct ccaggagcgc gccgccgccc tcgtgcctgg atttcaaatg ttgtaggcag
      901 tggtagtggc agcggcagcg gcgacagccc cgagccaatg tttggctttc aatacgtgtc
      961 ccttccctag gccaggagcc acccagagtc atctccctct cttcctctct ccttccttcc
     1021 taaaccaggc cctcccacct gttttcctag aaatgatcta accctcactt attttgcttc
     1081 cccaaaataa agttgccagc ctagaccatg ccatacgaca tggctgctgc ttgggaaaac
     1141 acctggggag aacttggcaa caatgatagt cttagggaag aatggagact agcaacgcgg
     1201 tacacaggcc gaccctgatg atctacattc tattcccaga actcacatgg tagcaaaaga
     1261 aacaactcca acaagatggc ctctgtcctc caggtttgcc ctgacacttg tgcccccacc
     1321 cccaaaataa ataaatagat aacatagtt
//
