LOCUS       NM_001040689            2371 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus R-spondin 4 (Rspo4), mRNA.
ACCESSION   NM_001040689 NM_175468
VERSION     NM_001040689.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Watanabe,K., Horie,M., Hayatsu,M., Mikami,Y. and Sato,N.
  TITLE     Spatiotemporal expression patterns of R-spondins and their
            receptors, Lgrs, in the developing mouse telencephalon
  JOURNAL   Gene Expr Patterns 49, 119333 (2023)
   PUBMED   37651925
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   Dasgupta,K., Cesario,J.M., Ha,S., Asam,K., Deacon,L.J., Song,A.H.,
            Kim,J., Cobb,J., Yoon,J.K. and Jeong,J.
  TITLE     R-Spondin 3 Regulates Mammalian Dental and Craniofacial Development
  JOURNAL   J Dev Biol 9 (3), 31 (2021)
   PUBMED   34449628
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Liu,S., Gao,Y., Zhang,L., Yin,Y. and Zhang,W.
  TITLE     Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis
            through the AMPKalpha-SREBP2 pathway
  JOURNAL   FASEB J 34 (11), 14946-14959 (2020)
   PUBMED   32926477
  REMARK    GeneRIF: Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol
            synthesis through the AMPKalpha-SREBP2 pathway.
REFERENCE   6  (bases 1 to 2371)
  AUTHORS   Coulpier,F., Le Crom,S., Maro,G.S., Manent,J., Giovannini,M.,
            Maciorowski,Z., Fischer,A., Gessler,M., Charnay,P. and Topilko,P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
REFERENCE   7  (bases 1 to 2371)
  AUTHORS   Ishii,Y., Wajid,M., Bazzi,H., Fantauzzo,K.A., Barber,A.G.,
            Blaydon,D.C., Nam,J.S., Yoon,J.K., Kelsell,D.P. and Christiano,A.M.
  TITLE     Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia
  JOURNAL   J Invest Dermatol 128 (4), 867-870 (2008)
   PUBMED   17805348
REFERENCE   8  (bases 1 to 2371)
  AUTHORS   Nakamura,M. and Ishikawa,O.
  TITLE     The localization of label-retaining cells in mouse nails
  JOURNAL   J Invest Dermatol 128 (3), 728-730 (2008)
   PUBMED   17914453
REFERENCE   9  (bases 1 to 2371)
  AUTHORS   Nam,J.S., Turcotte,T.J. and Yoon,J.K.
  TITLE     Dynamic expression of R-spondin family genes in mouse development
  JOURNAL   Gene Expr Patterns 7 (3), 306-312 (2007)
   PUBMED   17035101
REFERENCE   10 (bases 1 to 2371)
  AUTHORS   Blaydon,D.C., Ishii,Y., O'Toole,E.A., Unsworth,H.C., Teh,M.T.,
            Ruschendorf,F., Sinclair,C., Hopsu-Havu,V.K., Tidman,N., Moss,C.,
            Watson,R., de Berker,D., Wajid,M., Christiano,A.M. and Kelsell,D.P.
  TITLE     The gene encoding R-spondin 4 (RSPO4), a secreted protein
            implicated in Wnt signaling, is mutated in inherited anonychia
  JOURNAL   Nat Genet 38 (11), 1245-1247 (2006)
   PUBMED   17041604
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845480.12.
            
            On Aug 3, 2006 this sequence version replaced NM_175468.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043484.1, AK020904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AL845480.12        89785-90010
            227-415             AL845480.12        114614-114802
            416-556             AL845480.12        115429-115569
            557-742             AL845480.12        116627-116812
            743-2371            AL845480.12        119898-121526
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..2371
                     /gene="Rspo4"
                     /gene_synonym="A730099F22; A930029K19Rik"
                     /note="R-spondin 4"
                     /db_xref="GeneID:228770"
                     /db_xref="MGI:MGI:1924467"
     exon            1..226
                     /gene="Rspo4"
                     /gene_synonym="A730099F22; A930029K19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..834
                     /gene="Rspo4"
                     /gene_synonym="A730099F22; A930029K19Rik"
                     /note="R-spondin family, member 4; R-spondin-like protein;
                     cristin-4; mCristin-4; roof plate-specific spondin-4;
                     cysteine-rich and single thrombospondin domain-containing
                     protein 4"
                     /codon_start=1
                     /product="R-spondin-4 precursor"
                     /protein_id="NP_001035779.1"
                     /db_xref="CCDS:CCDS38272.1"
                     /db_xref="GeneID:228770"
                     /db_xref="MGI:MGI:1924467"
                     /translation="MRAPLCLLLLLAHAVDMLALYRRKKQAGTGLGGNCTGCVICSEE
                     NGCSTCQQRLFLFIRREGIRQYGKCVHDCPLGFFGIRGQEANRCKKCGATCESCFSQD
                     FCIRCKRRFHLYKGKCLPSCPPGTLTHQSTRECQEECEPSPWGSWSPCIHNGKTCGSG
                     WGLETRVREAGPAKQEETASCRVLSESRKCPIKRLCPGERNPRQKNRKDRRQRKDRKL
                     ERRPHQRGSQ"
     exon            227..415
                     /gene="Rspo4"
                     /gene_synonym="A730099F22; A930029K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            416..556
                     /gene="Rspo4"
                     /gene_synonym="A730099F22; A930029K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            557..742
                     /gene="Rspo4"
                     /gene_synonym="A730099F22; A930029K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..2371
                     /gene="Rspo4"
                     /gene_synonym="A730099F22; A930029K19Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1184
                     /gene="Rspo4"
                     /gene_synonym="A730099F22; A930029K19Rik"
                     /note="major polyA site"
ORIGIN      
        1 actcgaccca ccgcgccctg ggcgcaccgg cgggtccctg gtggccgtag cgaccagcga
       61 cccgcggatg ctcaacgcgc gccacaggct gtcccccgca cagaggctgc cgggccgtcg
      121 gggagccagg agcaccaggc tgcccagatg cgggctccac tctgcctgct gctgctcctc
      181 gcccacgcag tggacatgct cgccctgtac cgaaggaaga agcaagcagg cactggtctg
      241 gggggcaact gcacgggctg tgtcatatgc tcggaggaga atggctgttc cacctgccag
      301 cagaggctct tcctcttcat ccgccgtgaa ggcatccgtc agtacggcaa gtgtgtgcac
      361 gactgtcccc ttggcttctt tgggatccgt ggccaggagg ccaacaggtg caagaaatgt
      421 ggggccacgt gcgagagctg tttcagccag gacttctgta tccgctgcaa aaggcggttt
      481 cacctataca aagggaagtg cctgccctcc tgtccaccgg gcaccttgac ccaccagagt
      541 acccgggagt gccaggaaga gtgtgagccg agcccttggg gcagctggag tccctgcata
      601 cacaatggga agacctgtgg ctcaggctgg ggcctagaaa cccgggtccg ggaggctggc
      661 ccggccaagc aggaagagac ggcgagttgc cgagtgttat ctgagtccag gaagtgtcct
      721 ataaagagac tctgcccagg agaaagaaat cccaggcaga agaacaggaa ggatcggcgc
      781 cagcgtaagg acaggaagtt ggagcgcagg ccacaccagc gtggctcaca gtgaccatct
      841 ccagctctgg cctctgcctt ccgctcgccg cacttccaca gtgggctcct cgcttctccc
      901 ctgtccagct ctttctccac attcttcact ctttctacct ttcccgtctg tctgctcttt
      961 cctttagatt ttatccgtct cccttttcct cttgccctca ccttcttctt cctgtccttc
     1021 tttgaaactt tccttctccc cgtgtaccct tctcttcatt cccttctgtt ttcctttctg
     1081 atcttcaccg tccaccccgc acacggagac agacataaga gagagattaa gcttgtatcc
     1141 tccatgtggc tctctgcacc ccaaagcaaa cttttttttc tagatctttc tgtgactctg
     1201 tcctgactcc atctttgcaa agttacaatt ttataggaat aggtttgggt gcaacttgac
     1261 aagtcctgag agctctgctt ctagctagag agaccctgca gccggagtta tatgaaccat
     1321 tcacctggcc agtccctcaa ggccgattct acagcactca gccattgcct ctgcgatgag
     1381 gccaccaggg acaaactctg ggacctccga aggcccagcc tgaacctctt atccaggatg
     1441 gtggtatagg agccctttag ctaggggccc tttagctaga cagtggtcca ggcccatgag
     1501 cacatcccct tggaagtgcc tgtaacacac cctctggtca tcctcccacc tctccaccct
     1561 cacctcctac cccaccccta tccccatccc actctggtct ccctttcata gtgcccatga
     1621 cccttctcca gctgaccacc ctcccaaggc ctttggagac ccatgcacag gatcaggtgg
     1681 ggctgtgatc tcttatgaaa taatcccaaa ggctactgaa gctaaatgga gcttagacat
     1741 ggtcccaccc gctccattca ccgctctgct acccgaggcc catcgtaccc atagagactg
     1801 atgtctaagg aagtgatggg cactctactc tgtctttgga ccgcacatca catctatgaa
     1861 gaagctccag tgtgtttaga gaagtataga aaattgccag gttagcagtt ggggtggcct
     1921 ctcacatgga taacctgagt gttttctttc actgtgatac cctcaactgc aggtgggagg
     1981 gatattggga ggagccttca ggtaaaacaa accaaatggc aagtctgtct taacctctgc
     2041 catttggcct aggagctgcc attgtttctg ggagctccga gtcagggcat tagggcccaa
     2101 agatagctgg ggaaggatgt ggtataggca ggagagaaac gccatgagaa gtaatgtcac
     2161 tcagacaggg accttcacag tcacactacg cttgacagat gggggtcccc agcaccactc
     2221 ctgaccctgt agctgtgttc ctccatgatg ccccactgag aacagctggg acccctgctt
     2281 gccaggccag gggcccagct tctctgcaga agttcacacc tctgaaatgc tttcttattt
     2341 caagactccc agctactttt caaagaaaga t
//
