LOCUS       NM_028351               2411 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus R-spondin 3 (Rspo3), mRNA.
ACCESSION   NM_028351 XM_125588
VERSION     NM_028351.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Ferrena,A., Zhang,X., Shrestha,R., Zheng,D. and Liu,W.
  TITLE     Six3 and Six6 jointly control diverse target genes in multiple cell
            populations over developmental trajectories of mouse embryonic
            retinal progenitor cells
  JOURNAL   PLoS One 19 (10), e0308839 (2024)
   PUBMED   39446806
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Ishii,Y., Wajid,M., Bazzi,H., Fantauzzo,K.A., Barber,A.G.,
            Blaydon,D.C., Nam,J.S., Yoon,J.K., Kelsell,D.P. and Christiano,A.M.
  TITLE     Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia
  JOURNAL   J Invest Dermatol 128 (4), 867-870 (2008)
   PUBMED   17805348
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Aoki,M., Mieda,M., Ikeda,T., Hamada,Y., Nakamura,H. and Okamoto,H.
  TITLE     R-spondin3 is required for mouse placental development
  JOURNAL   Dev Biol 301 (1), 218-226 (2007)
   PUBMED   16963017
  REMARK    GeneRIF: suggest a critical role for Rspo3 in the interaction
            between chorion and allantois in labyrinthine development
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Nam,J.S., Turcotte,T.J. and Yoon,J.K.
  TITLE     Dynamic expression of R-spondin family genes in mouse development
  JOURNAL   Gene Expr Patterns 7 (3), 306-312 (2007)
   PUBMED   17035101
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Nam,J.S., Turcotte,T.J., Smith,P.F., Choi,S. and Yoon,J.K.
  TITLE     Mouse cristin/R-spondin family proteins are novel ligands for the
            Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent
            gene expression
  JOURNAL   J Biol Chem 281 (19), 13247-13257 (2006)
   PUBMED   16543246
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Kazanskaya,O., Glinka,A., del Barco Barrantes,I., Stannek,P.,
            Niehrs,C. and Wu,W.
  TITLE     R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling
            and is required for Xenopus myogenesis
  JOURNAL   Dev Cell 7 (4), 525-534 (2004)
   PUBMED   15469841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133916.1 and BC103794.1.
            
            On Nov 28, 2009 this sequence version replaced NM_028351.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103794.1, AB055811.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849382,
                                           SAMN01164131 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-928               AK133916.1         2-929
            929-2411            BC103794.1         863-2345
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 16.64 cM"
     gene            1..2411
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /note="R-spondin 3"
                     /db_xref="GeneID:72780"
                     /db_xref="MGI:MGI:1920030"
     exon            1..636
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             540..1373
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /note="thrombospondin, type I, domain 2; cabriolet;
                     cristin 1; nucleopondin; roof plate-specific spondin-3;
                     cysteine-rich and single thrombospondin domain-containing
                     protein 1; R-spondin 3 homolog"
                     /codon_start=1
                     /product="R-spondin-3 precursor"
                     /protein_id="NP_082627.3"
                     /db_xref="CCDS:CCDS23761.1"
                     /db_xref="GeneID:72780"
                     /db_xref="MGI:MGI:1920030"
                     /translation="MHLRLISCFFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGG
                     CATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKVDC
                     DTCFNKNFCTKCKSGFYLHLGKCLDSCPEGLEANNHTMECVSIVHCEASEWSPWSPCM
                     KKGKTCGFKRGTETRVRDILQHPSAKGNLCPPTSETRTCIVQRKKCSKGERGKKGRER
                     KRKKLNKEERKETSSSSDSKGLESSIETPDQQENKERQQQQKRRARDKQQKSVSVSTV
                     H"
     exon            637..828
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..975
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1173
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..2397
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2369..2374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /note="hexamer: AATAAA"
     regulatory      2373..2378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /note="hexamer: AATATA"
     polyA_site      2391
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /note="major polyA site"
     polyA_site      2397
                     /gene="Rspo3"
                     /gene_synonym="2810459H04Rik; Cristin1; Thsd2"
                     /note="major polyA site"
ORIGIN      
        1 atggggtgct cctagcccgg cccaacactg gagcggctcc tgctcagaac gccagaagca
       61 gctcgggtct ctccagcgcc ccttgaccat ggctgcggta cccacggcgt ccgcttccct
      121 gcgctcccgg ggtccctgcc acagccgcag ccgctgcagc ctctgagccc caggggccac
      181 tgctcgcctg gattccgccc gcagccgccg ctgctgtgca accgaggcta acctgcggcc
      241 agccaggagg ctcctgcaac cttcgctcgc ggcgatgaca gccaccccag agcagccggc
      301 tgtgttcgga caatttgaga atgcaattgt tggtttcccg gtccacccgt cccgcttcgc
      361 ttgccatcac agcacgcctg ttggatctca gtggagaagt cccgctgctc tggtttttct
      421 actcttcgta tagactcgcc taacacctac atacatattt ttctttaaaa aaaaacatta
      481 aatataacta acagtgaaaa gaaaaaggag agaaaaaagg gaaacattac agggttacta
      541 tgcacttgcg actgatttct tgttttttta tcattttgaa ctttatggaa tacattggca
      601 gccaaaacgc ctcccgagga aggcgccagc gaagaatgca tcctaatgtc agtcaaggct
      661 gccaaggagg ctgtgcaacg tgttcagatt acaatggctg tttgtcatgt aagcccagac
      721 tgttttttgt tctggaaagg attggcatga agcagatagg agtgtgtctc tcttcgtgtc
      781 caagtggata ttacggaact cgatatccag atataaataa atgtacaaaa tgcaaagttg
      841 actgtgatac ctgtttcaac aaaaatttct gcacaaagtg taaaagtgga ttttacttac
      901 accttggaaa gtgccttgac agttgcccag aagggttaga agccaacaat catactatgg
      961 aatgtgtcag tattgtacac tgtgaggcca gtgaatggag tccatggagt ccatgtatga
     1021 agaaaggaaa aacatgtggc ttcaaaaggg ggactgaaac acgggtccga gatatactac
     1081 agcatccttc agccaagggt aacctgtgcc ccccaaccag cgagacaaga acttgtatag
     1141 tacaaagaaa gaagtgttca aagggagagc gaggaaaaaa gggaagagag agaaaacgaa
     1201 aaaaactgaa taaagaagaa agaaaggaaa caagctcctc ctctgacagc aaaggtttgg
     1261 agtccagcat tgagacccca gaccagcagg aaaacaaaga gaggcagcag cagcagaaga
     1321 gaagagcccg agacaagcaa cagaaatcgg tatcagtcag cactgtacac tagagggtcc
     1381 tgcgaggtta ctgtagactc atgatgctgc tatctcaacc agatgtccag gacaggtgtt
     1441 ctagccatta gaaccacaaa tggacaacac atcagttacc actctgtcta aacaacattc
     1501 ctaatagttg ctatattctt catacaaaca tagtaaacag caaagagcca aatgttcaaa
     1561 gaagggatac tttcagatgg ttatcttatg tgcttctgtg tatttttaaa agatgagaaa
     1621 atttgtacat aattatcaat aagctataag atatcctcaa tgtaatgacg acagctggag
     1681 aagaatcatc ttttctttat aaaaaaatta ttcttcgaat aattgtcttt aagaagcaaa
     1741 aggtaattct gcaacttcaa aaatgcagtg tccctcaaaa ccaagatttg tcaggggaga
     1801 gaatcatggc tccatgtaca gggtggattt gtcccggaga actagtgaat gctcagaatt
     1861 agggcctggc attttgaatc ctagagttaa tcatcacaga agcaagtggt ttaggattgc
     1921 ttcggttgcc ctcctctgca agaaactgaa catgcataat agagttaaat atattgtgtg
     1981 gagttggaat aaggcaagct gtggaagaaa tcatagagct ggagaccatc ttgtgctttc
     2041 cagaaccgtg aggggttttg gtcacctgga acagggctcc aatctatatt agcactgtgt
     2101 ggttgatctt ccactactcc ttggtttata taagtctgta aacatgtacc tgtacctttc
     2161 ttccaaaagt aaaaccatac ttactagaag aaaattctaa ctttatggaa aacaaaagtg
     2221 taagaagaat gtgacatgtt tgcaaagttg agtgttttct ttctgaaatg aggggaaaac
     2281 tattttatta cctgcctatg ggtccacctg gaactaaagg gatactactt tctaacaagg
     2341 tgtatctagt aggagagaaa gccaccacaa taaatatatt tgttaatagt ttttaaaaaa
     2401 aaaaaaaaaa a
//
