LOCUS       NM_138683               1834 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus R-spondin 1 (Rspo1), mRNA.
ACCESSION   NM_138683 XM_908508
VERSION     NM_138683.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Cao,J., El Mansouri,F., Reynoso,S., Liu,Z., Zhu,J. and Taketo,T.
  TITLE     Inefficient Sox9 upregulation and absence of Rspo1 repression lead
            to sex reversal in the B6.XYTIR mouse gonaddagger
  JOURNAL   Biol Reprod 110 (5), 985-999 (2024)
   PUBMED   38376238
  REMARK    GeneRIF: Inefficient Sox9 upregulation and absence of Rspo1
            repression lead to sex reversal in the B6.XYTIR mouse gonaddagger.
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   Makela,O.J.M. and Mikkola,M.L.
  TITLE     Mesenchyme governs hair follicle induction
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37982496
REFERENCE   5  (bases 1 to 1834)
  AUTHORS   Gregoire,E.P., De Cian,M.C., Migale,R., Perea-Gomez,A., Schaub,S.,
            Bellido-Carreras,N., Stevant,I., Mayere,C., Neirijnck,Y.,
            Loubat,A., Rivaud,P., Sopena,M.L., Lachambre,S., Linssen,M.M.,
            Hohenstein,P., Lovell-Badge,R., Nef,S., Chalmel,F., Schedl,A. and
            Chaboissier,M.C.
  TITLE     The -KTS splice variant of WT1 is essential for ovarian
            determination in mice
  JOURNAL   Science 382 (6670), 600-606 (2023)
   PUBMED   37917714
REFERENCE   6  (bases 1 to 1834)
  AUTHORS   Zhang,D., Stumpo,D.J., Graves,J.P., DeGraff,L.M., Grissom,S.F.,
            Collins,J.B., Li,L., Zeldin,D.C. and Blackshear,P.J.
  TITLE     Identification of potential target genes for RFX4_v3, a
            transcription factor critical for brain development
  JOURNAL   J Neurochem 98 (3), 860-875 (2006)
   PUBMED   16893423
REFERENCE   7  (bases 1 to 1834)
  AUTHORS   Nam,J.S., Turcotte,T.J., Smith,P.F., Choi,S. and Yoon,J.K.
  TITLE     Mouse cristin/R-spondin family proteins are novel ligands for the
            Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent
            gene expression
  JOURNAL   J Biol Chem 281 (19), 13247-13257 (2006)
   PUBMED   16543246
REFERENCE   8  (bases 1 to 1834)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   9  (bases 1 to 1834)
  AUTHORS   Kazanskaya,O., Glinka,A., del Barco Barrantes,I., Stannek,P.,
            Niehrs,C. and Wu,W.
  TITLE     R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling
            and is required for Xenopus myogenesis
  JOURNAL   Dev Cell 7 (4), 525-534 (2004)
   PUBMED   15469841
REFERENCE   10 (bases 1 to 1834)
  AUTHORS   Kamata,T., Katsube,K., Michikawa,M., Yamada,M., Takada,S. and
            Mizusawa,H.
  TITLE     R-spondin, a novel gene with thrombospondin type 1 domain, was
            expressed in the dorsal neural tube and affected in Wnts mutants
  JOURNAL   Biochim Biophys Acta 1676 (1), 51-62 (2004)
   PUBMED   14732490
  REMARK    GeneRIF: R-spondin might be a novel marker of the boundary between
            the roof plate and neuroepithelium and may contribute to the
            development of dorsal neural tube under the regulation of Wnts.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB016768.1 and AK132277.1.
            
            On Apr 24, 2009 this sequence version replaced NM_138683.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016768.1, AK132277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-831               AB016768.1         1-831
            832-1190            AK132277.1         779-1137
            1191-1834           AB016768.1         1191-1834
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.96 cM"
     gene            1..1834
                     /gene="Rspo1"
                     /gene_synonym="R-spondin; Rspondin"
                     /note="R-spondin 1"
                     /db_xref="GeneID:192199"
                     /db_xref="MGI:MGI:2183426"
     exon            1..242
                     /gene="Rspo1"
                     /gene_synonym="R-spondin; Rspondin"
                     /inference="alignment:Splign:2.1.0"
     exon            243..576
                     /gene="Rspo1"
                     /gene_synonym="R-spondin; Rspondin"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1280
                     /gene="Rspo1"
                     /gene_synonym="R-spondin; Rspondin"
                     /note="thrombospondin type 1 domain containing gene
                     Rspondin; cristin-3; mCristin-3; roof plate-specific
                     spondin-1; cysteine-rich and single thrombospondin
                     domain-containing protein 3; R-spondin homolog"
                     /codon_start=1
                     /product="R-spondin-1 precursor"
                     /protein_id="NP_619624.2"
                     /db_xref="CCDS:CCDS18633.1"
                     /db_xref="GeneID:192199"
                     /db_xref="MGI:MGI:2183426"
                     /translation="MRLGLCVVALVLSWTHIAVGSRGIKGKRQRRISAEGSQACAKGC
                     ELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHC
                     EACFSHNFCTKCQEGLYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCS
                     KKRKLCGFRKGSEERTRRVLHAPGGDHTTCSDTKETRKCTVRRTPCPEGQKRRKGGQG
                     RRENANRHPARKNSKEPGSNSRRHKGQQQPQPGTTGPLTSVGPTWAQ"
     exon            577..768
                     /gene="Rspo1"
                     /gene_synonym="R-spondin; Rspondin"
                     /inference="alignment:Splign:2.1.0"
     exon            769..918
                     /gene="Rspo1"
                     /gene_synonym="R-spondin; Rspondin"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1107
                     /gene="Rspo1"
                     /gene_synonym="R-spondin; Rspondin"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1834
                     /gene="Rspo1"
                     /gene_synonym="R-spondin; Rspondin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggattccctc cctcgtgcga gccggggacc ggcccctctc cgggcgcggg gcgcagagcc
       61 cgggcggcgc actgcggggc ccgcgcgggc cgccccagca ccaatgcacc gggcggggcg
      121 ctggcggccg agaaggcatt gagcaactgg gcggcgggcg gagcgcgggg ccgacggcaa
      181 cgcgggaccc agtggccgcg ccctcgcccc tccgggctgc cccgccacgg ccgctgcgcc
      241 aggtctatct tgggggtggt tctctgctgg cgtgagaaga cttctcatgt gaccctctga
      301 ggtggattca agcaggacag gacctccctt tggaccaatg gagaagccgg ctccaaaccc
      361 tctcggatcc cagctaaggt tatggtggat ccgggcctgg ctctcctgcc actgacccag
      421 cctcagagcc ttttagcaag agaccacccc tcctgccagg ggcccggggc tggccagtga
      481 ctatgcggct tgggctgtgc gtggtggccc tggttctgag ctggacacac atcgccgtgg
      541 gcagccgggg gatcaagggc aagagacaga ggcggatcag tgctgagggg agccaagcct
      601 gcgccaaggg ctgtgagctc tgttcagaag tcaacggttg cctcaagtgc tcgcccaagc
      661 tcttcattct gctggagagg aacgacatcc gccaggtggg cgtctgcctg ccgtcctgcc
      721 cacctggata ctttgatgcc cgcaaccccg acatgaacaa atgcatcaaa tgcaagatcg
      781 agcactgtga ggcctgcttc agccacaact tctgcaccaa gtgtcaggag ggcttgtact
      841 tacacaaggg ccgctgctat ccagcctgcc ctgagggctc tacagccgct aacagcacca
      901 tggagtgcgg cagtcctgca caatgtgaaa tgagcgagtg gtccccgtgg ggaccctgct
      961 ccaagaagag gaagctgtgc ggtttccgga agggatcgga agagcggaca cgcagagtgc
     1021 tccatgctcc cgggggagac cacaccacct gctccgacac caaagagacc cgcaagtgta
     1081 ccgtgcgcag gacgccctgc ccagaggggc agaagaggag gaaggggggc cagggccgga
     1141 gggagaatgc caacaggcat ccggccagga agaacagcaa ggagccgggc tccaactctc
     1201 ggagacacaa agggcaacag cagccacagc cagggacaac agggccactc acatcagtag
     1261 gacctacctg ggcacagtga ccggtctcca gatacctgtg gaagagtaca gtgctgtact
     1321 gtataatgag aactttccag aactggagca tctgggagag tccacacata ccccatccac
     1381 ccacccatcc aactatccat ccatccatcc atgcacacat atggccacat ctgaaaacgt
     1441 caacacacac acacacacac acacacacac acacacacat tcttgaggtc actgaagaca
     1501 cttctattct gtggcccagc tgtatattca gtctttaatg ctcttggaag acatatctga
     1561 gagaaccttt cccagcatct gaaactaagg agtggaacct tctggaggaa cttctgggac
     1621 agcatctgac agatggatgg cagattggag ccaaagctgg agcagctgcc gagagggaga
     1681 gagagggaaa gcgctttccc ggcttgagag gcactcccag ctgtgagact tgattgtcgg
     1741 agatgagaat tattacacat ccgtggtaca cgtcacggat gacctgactt ggaaactgct
     1801 taaaggttta tttcaaatta aaaaagagaa aaac
//
