LOCUS       NM_001013769            2599 bp    mRNA    linear   ROD 01-JUL-2022
DEFINITION  Mus musculus regulator of sex limited protein 1 (Rsl1), mRNA.
ACCESSION   NM_001013769 XM_354760
VERSION     NM_001013769.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2599)
  AUTHORS   Krebs CJ, Zhang D, Yin L and Robins DM.
  TITLE     The KRAB zinc finger protein RSL1 modulates sex-biased gene
            expression in liver and adipose tissue to maintain metabolic
            homeostasis
  JOURNAL   Mol Cell Biol 34 (2), 221-232 (2014)
   PUBMED   24190968
  REMARK    GeneRIF: RSL1 balances metabolism via liver-to-adipose-tissue
            communication.
REFERENCE   2  (bases 1 to 2599)
  AUTHORS   Krebs CJ, Schultz DC and Robins DM.
  TITLE     The KRAB zinc finger protein RSL1 regulates sex- and
            tissue-specific promoter methylation and dynamic hormone-responsive
            chromatin configuration
  JOURNAL   Mol Cell Biol 32 (18), 3732-3742 (2012)
   PUBMED   22801370
  REMARK    GeneRIF: experiments demonstrate a surprisingly dynamic interplay
            between a hormonal activator, STAT5b, and a KRAB-ZFP repressor,
            RSL1, and provide unique insights into KRAB-ZFP epigenetic
            mechanisms
REFERENCE   3  (bases 1 to 2599)
  AUTHORS   Krebs CJ and Robins DM.
  TITLE     A pair of mouse KRAB zinc finger proteins modulates multiple
            indicators of female reproduction
  JOURNAL   Biol Reprod 82 (4), 662-668 (2010)
   PUBMED   20042539
  REMARK    GeneRIF: Transcriptional repression by RSL in liver modifies female
            mouse reproduction via targets that likely impact both hormonal and
            pheromonal cues.
REFERENCE   4  (bases 1 to 2599)
  AUTHORS   Krebs CJ, Larkins LK, Khan SM and Robins DM.
  TITLE     Expansion and diversification of KRAB zinc-finger genes within a
            cluster including Regulator of sex-limitation 1 and 2
  JOURNAL   Genomics 85 (6), 752-761 (2005)
   PUBMED   15885501
REFERENCE   5  (bases 1 to 2599)
  AUTHORS   Krebs CJ, Larkins LK, Price R, Tullis KM, Miller RD and Robins DM.
  TITLE     Regulator of sex-limitation (Rsl) encodes a pair of KRAB
            zinc-finger genes that control sexually dimorphic liver gene
            expression
  JOURNAL   Genes Dev 17 (21), 2664-2674 (2003)
   PUBMED   14563677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC187103.3 and AC163667.3.
            
            On Jul 1, 2022 this sequence version replaced NM_001013769.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001622.1, BC103788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC187103.3         183114-183193
            81-207              AC187103.3         186388-186514
            208-303             AC187103.3         187005-187100
            304-633             AC187103.3         191689-192018
            634-2599            AC163667.3         140643-142608
FEATURES             Location/Qualifiers
     source          1..2599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.54 cM"
     gene            1..2599
                     /gene="Rsl1"
                     /gene_synonym="rslcan-9"
                     /note="regulator of sex limited protein 1"
                     /db_xref="GeneID:380855"
                     /db_xref="MGI:MGI:3044162"
     exon            1..80
                     /gene="Rsl1"
                     /gene_synonym="rslcan-9"
                     /inference="alignment:Splign:2.1.0"
     exon            81..207
                     /gene="Rsl1"
                     /gene_synonym="rslcan-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1502
                     /gene="Rsl1"
                     /gene_synonym="rslcan-9"
                     /note="regulator of sex-limitation 1; regulator of sex
                     limited protein-Slp 1"
                     /codon_start=1
                     /product="regulator of sex limited protein 1"
                     /protein_id="NP_001013791.2"
                     /db_xref="CCDS:CCDS26613.1"
                     /db_xref="GeneID:380855"
                     /db_xref="MGI:MGI:3044162"
                     /translation="MLSFWDVAIDFSPEEWECLEPAQWDLYRDVMLENFSHLVFLGLA
                     VSKPFLVTFLEQIQGPWDMKRQGTAPVYPGIIPNDPNNCSKLTNCKSLLITQRRNHIG
                     EKPYKCGECGKALSSHKTLSIHQRLHTGDKPYKCEECHKAFSTRSSLFIHMKNHTDEK
                     IYKCEDCGRTFYYLSMLKQHQRIHSGEKPYKCEECGKSFSFPSFLKQHQRLHCRKNAF
                     KHEQCVNRFPPPLPLQEHEQIRTEEKPYKCGECYKTFRYHSALRIHKAVHTGERPYKC
                     EECGKCFSSSSCLKKHQILHSEDNPYKCEECYKAFRNHSALRIHKTVHTGERPYKCQE
                     CGKCYSSPSCLKRHQILHSKYNPYKCEECGKCLSSSSCLKTHQTLHSEDKPYKCEDCS
                     RCFCSSSSLRRHQKFHSEGNPYKCEKCDKRFSCSAGLQDHQTIHTGEKPYRCENCHKA
                     FCYRSSLRKHKTVHTREKSTHM"
     exon            208..303
                     /gene="Rsl1"
                     /gene_synonym="rslcan-9"
                     /inference="alignment:Splign:2.1.0"
     exon            304..2599
                     /gene="Rsl1"
                     /gene_synonym="rslcan-9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtctgtac tcgtgcgtct ttcttaaggt tgggcggaaa tcgtatgcgg ctatctattc
       61 cagttgtctc tgacaagaag gaaatgttgt ccttctggga tgtagccatt gatttctctc
      121 cagaagagtg ggaatgcctg gagcctgctc agtgggacct gtacagggat gtgatgctgg
      181 agaatttcag ccaccttgtg ttcctgggtc ttgctgtctc taagccattc ctggtgacat
      241 ttctggagca aatacaaggg ccttgggaca tgaagagaca aggaacggcc cctgtgtacc
      301 caggaataat acccaatgat cctaacaatt gcagcaaact gactaattgt aaatcactcc
      361 ttattacaca aagaagaaat catatagggg agaaacccta caagtgtgga gaatgtggta
      421 aggcccttag ttctcataaa acactttcta tacatcagag acttcacact ggagacaaac
      481 cttacaagtg tgaagagtgt cataaggcct tcagtactcg ctcatcactt tttatacaca
      541 tgaaaaatca tactgatgaa aaaatctaca agtgtgaaga ctgtggcaga acattttact
      601 atctttcaat gctgaagcaa catcagagaa ttcattctgg agagaaaccc tacaagtgtg
      661 aagaatgtgg gaaaagcttt agctttccct cgttccttaa gcaacatcaa agacttcatt
      721 gtagaaaaaa tgccttcaag catgaacaat gtgtcaacag atttccccct cctctacccc
      781 ttcaggaaca tgagcaaatc cgtactgaag agaaacccta caagtgtgga gaatgttata
      841 aaacctttcg ttatcactca gcccttagga tacacaaggc agttcatact ggagagagac
      901 cttacaagtg tgaagagtgt ggcaaatgtt tttcctcatc ttcctgcctt aaaaaacatc
      961 aaatacttca ctctgaagac aacccctaca agtgtgaaga atgttataaa gcctttcgta
     1021 atcactcagc ccttaggatt cacaagacag ttcatacggg agagagacct tacaaatgtc
     1081 aggagtgtgg caaatgctat tcctcacctt cctgccttaa aagacatcaa atacttcact
     1141 ctaaatacaa cccctacaag tgtgaagagt gtggcaaatg tctttcctca tcttcctgcc
     1201 ttaaaacaca tcaaaccctt cactctgaag acaaacccta caagtgtgaa gactgctcca
     1261 gatgtttctg ctcatcttca tctcttaggc gacatcaaaa attccattct gaaggcaatc
     1321 cctataagtg tgaaaaatgt gacaaaagat tttcatgttc tgcaggtctt caggaccatc
     1381 aaacaattca tactggggag aaaccatata ggtgtgaaaa ttgtcacaaa gccttttgtt
     1441 atcgctcatc ccttaggaaa cataagacag ttcataccag agagaaatcc acacacatgt
     1501 gacaagtgtc ctaggggctt ttcctcatcc tcctgccttg tacaacatca agctcttcac
     1561 tctgaagaca atccacacaa gtgtgtagaa tgtaggcaaa gcctttgtta atgtttatag
     1621 ccagattcga cccatgacag ttcatgctgg agagaaatcc tataaagatc tcttagcatt
     1681 atcaattggt tctgaaatta ttgtatggtc atctggtaaa tttagaattt attaatacat
     1741 aaatctgatt ggttttttta taagcttcta gagtcttgtt cctaccaggc aaatggatgt
     1801 tgttatggct gaccatagag tggatagtca tgtggtggtg gtggtgggga tggaggcagg
     1861 ggctagccag agagttgcca gtggcaggag agtgggatgc ctattcttcc agtccttgac
     1921 agagagttgg caggcagaga gcacctggag cacagagagt tggcagtttc ttttttaata
     1981 tttttctcaa cagtctttaa aagtttatac ttcttcagtc cttaaaagac atcaactaat
     2041 tcatactgaa taaaaccttg tatggtgtgc ggtaaaaacc attcctaatc cttcaaaccg
     2101 tatccaactc aaatcaatcc ctagggtaga ctattaagtg aattagtttg aaatgtcaac
     2161 accaccatct tactcccagc agcacaaatg ttgagaatgt catcagagaa cagtagagac
     2221 ttctctttac tataacctcc caaccaatgt gttctatagt gtgcttgaat atggcatggg
     2281 ttgttgcatt tctttcttct gtagctacag acataaaaca aaactgttat tatttcataa
     2341 tgtgggtctt agatctgggc tattgtatag ttactgttgt tttcctcact ggggtcaccc
     2401 aagctccccc agtaatgttt ctcttgagca tgtaaaaagc tcgataaact cagatgtctc
     2461 actttttgta aaatgatctg cactggttct aacctaggtt gaatgggcgt tagtgtttct
     2521 ctctccaaga aattctaaca gaacacactg aagtcatatt tagttccaga ataaaggatc
     2581 tttattcact ttgattaca
//
