LOCUS       NM_001404800            3248 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus ribosomal protein S6 kinase related (Rskr), transcript
            variant 1, mRNA.
ACCESSION   NM_001404800 XM_006532965
VERSION     NM_001404800.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3248)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3248)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591070.19.
            
            On Apr 14, 2022 this sequence version replaced XM_006532965.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.1353322.1,
                                           SRR17784651.768116.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AL591070.19        59051-59149         c
            100-348             AL591070.19        58321-58569         c
            349-432             AL591070.19        58152-58235         c
            433-501             AL591070.19        57960-58028         c
            502-571             AL591070.19        57516-57585         c
            572-676             AL591070.19        57192-57296         c
            677-717             AL591070.19        56996-57036         c
            718-745             AL591070.19        56579-56606         c
            746-835             AL591070.19        56372-56461         c
            836-924             AL591070.19        56026-56114         c
            925-1035            AL591070.19        55818-55928         c
            1036-3248           AL591070.19        53185-55397         c
FEATURES             Location/Qualifiers
     source          1..3248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..3248
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /note="ribosomal protein S6 kinase related"
                     /db_xref="GeneID:216976"
                     /db_xref="MGI:MGI:2652869"
     exon            1..99
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1263
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; sugen
                     kinase 494; ribosomal protein S6 kinase-related protein"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase-related protein
                     isoform 1"
                     /protein_id="NP_001391729.1"
                     /db_xref="GeneID:216976"
                     /db_xref="MGI:MGI:2652869"
                     /translation="MGAVSCRQGQHTRVSAPQKQGDNIQGHWVQGWKSLWCGMGTIRS
                     GLEELWGLQRHQCLHQELLQPAPLLLEKPQSEWPVPQFISLFLPEFPVRPVREQQELK
                     ILGLVAKGSFGTVLKVLDCAQKAVFAVKVVPKVKVLQRDTLRQCKEEVSIQRQINHPF
                     VHSLGDSWQGKQHLFIMCSYCSMDLYSLWSTVGWFPEDSIRLFAAELVLVLCYLHDLG
                     IIHRDVKMENILLDERGHLKVTDFGLSRHLSQGARAYTICGTLQYMAPEVLSGGPYNH
                     TADWWSLGVLLFSLATGKFPVAAERDHVAMLASVAHCESEIPASINQELSLLLHELLC
                     QNPLHRLRYLHHFQVHPFFRGVAFDPELLQKQPVNFVMEKQDTWPSPLESMSFEDFDY
                     DLESLVHSISIDSY"
     exon            100..348
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            349..432
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            433..501
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            502..571
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            572..676
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            677..717
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            718..745
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            746..835
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            836..924
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1035
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..3248
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1759..1764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /note="hexamer: ATTAAA"
     polyA_site      1790
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /note="major polyA site"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /note="hexamer: ATTAAA"
     polyA_site      2467
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
     regulatory      3230..3235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
                     /note="hexamer: AATAAA"
     polyA_site      3248
                     /gene="Rskr"
                     /gene_synonym="Sgk494"
ORIGIN      
        1 ggacaacaga tttagcagcg cgaaaagagg cagaggctgg aaatgggagc agtaagctgt
       61 cggcagggac aacacacccg ggtgtctgct cctcagaagc agggtgacaa catccagggt
      121 cactgggtcc aaggctggaa gagcctctgg tgtggtatgg ggaccatcag gtcaggtctg
      181 gaagaactat ggggactaca gaggcatcag tgcctacatc aggagctgct ccagccagcc
      241 ccactgctac tagagaagcc tcagtctgag tggccagtgc ctcagttcat cagcctcttt
      301 ctaccagagt ttcccgtgag gcctgttagg gagcagcagg agctgaagat tttaggcctt
      361 gtggctaaag gttcgtttgg aactgtcctg aaagtgctag attgtgccca gaaagctgta
      421 tttgcagtga aggtggtgcc caaagtaaaa gttctacagc gggatacgct gaggcagtgc
      481 aaagaagagg ttagcatcca gcgacagatc aaccatcctt ttgtacacag tttgggggac
      541 agctggcagg ggaaacaaca cctctttatt atgtgtagct actgcagcat ggatctctac
      601 tccctgtggt ctactgttgg ttggtttcca gaggattcta tccgtctctt tgcagctgaa
      661 ctggtccttg tactgtgcta tctccacgac ttgggtatca tccaccgtga tgtaaagatg
      721 gagaatatcc tgctggatga acgaggccat ctgaaagtga cagactttgg tctgtctcgc
      781 cacctatccc agggagcacg agcctacact atctgcggca ctcttcaata catggcccca
      841 gaggtcctga gtggtgggcc ttacaaccac actgctgact ggtggtccct gggtgtgttg
      901 cttttctctc tggcaactgg taagtttcca gtggctgcag agagagatca tgtggctatg
      961 ttggcaagtg tggcccactg tgaatctgag atcccagcgt ctattaatca ggagctctca
     1021 ctcctgctcc atgagctctt atgccagaac cctctgcatc gtctacgata cctgcatcac
     1081 ttccaggtcc acccgttctt tcggggtgta gcctttgacc ctgagctcct acagaagcag
     1141 ccagtgaact ttgtcatgga gaaacaagat acctggccta gtccactgga gtccatgtcc
     1201 ttcgaggact ttgactatga tctggagtcc ttggtccact ccatctctat tgattcctat
     1261 tgattctcta gtgtggatag gcactcagcc agaaaccact cagtaccacc attataatga
     1321 tccagttttt actttgttgt tctattgtag gtactgggct agagtttaat ctttggcatt
     1381 ctgcagctga tagccaaaac tgcccctacg ctttcctatc atacaacccc tctcagttcg
     1441 ggtcaaggca atggccttca cttctccagt actttcactt gagctgccaa acaaaggctt
     1501 cttgaacttg accttattca tgtttttcta ccatactttt ttgggcaata atgaaactct
     1561 ggggacttcc aaggtgctat ttagatgttt taacaagtta atcagatgcc aggtggtgcc
     1621 aggtggcact tgtccctgca ttgaggacac agaggcaggt agatctctga gtttgaggcc
     1681 agcctggtct acagagttcc aggatactca ggaatacaca aagaaaccct gtctcaggaa
     1741 aaaaaaatta caaggattat taaattgatt gtttcttcca tacaacccaa gatttagagt
     1801 tggttttgtt ttttttccgc ttttgaactg gaccagcaga ggatcagggg atcagaaaat
     1861 gaagaaggaa agtataggat caggtcttgc ccaagctata tcttatgcca caccaagcag
     1921 gcttatttta ttaagtacag catcgcatat acaggaaaaa ggggaaaaag ggatagaatc
     1981 atcaaaaaac tgacttagag tggactgaag tcagcaggaa gctaatcagg caatgttgaa
     2041 tgaagggaaa caaatgcatc acagaggagc acatcgcagc cttggggcta atagccttgt
     2101 agggggaaag agttcatttc tcatatataa agcagcagct cccccagggt cctgacccca
     2161 gaccgttatt ggctttgcta agcatagtcc ttagtttaga caaggaactt cattcctcca
     2221 cacatcaggc ctcagggaaa accttaggtt agatcagcct ggctccccat cccaacacct
     2281 ttagttttaa gatccaggga tgttgtgttg ttactgttta attttgtgat cctagggacc
     2341 acaccgaggg cctttatata ctaggtatct acttagtcac attcccagtg aacgttcatc
     2401 caggttcctt ctccccgaga catctcttta aatgccaaag ctggaatatt aaacttaccc
     2461 aggcagacct tgcttgtgat cttcctgctt tgatcttcca aatggctgag attataggcc
     2521 tgtaccacaa ggcctatgct aagattgggt tttgatgaac aaatgaaagg attgagggcc
     2581 atggcattaa atttagcatt tagagttata gatgtatctc gagaatattc tcctcttgta
     2641 aggaaaatca tccaggcctt ttatgtaact tctggtcttt tttcattttc ctcaattctc
     2701 aaaagttcca tttttgttgt gatctttttt agggttttta aaatgtttat gtgtatgagt
     2761 aattttacct gcaagtatgt actctccagc ccctttgttc tgacatttaa ggaaaagtgt
     2821 gctttaatct agattattat tttccagtta tgtctgatct cttttcaggc caaaaactat
     2881 ctgaagacta ccctgtatcc tcctggttac tctccctggg ttagaccagg tctcccatct
     2941 tagtggcctc tgtagaacgg ttttgttctt tgtgctttgg cagtccgtat gagtctcaat
     3001 gaatttgatg ctctaattgt gtgttatggg gctggagaga cagctcagtg gctaagagca
     3061 cttgttgctc ttgcagagga cctgggtttg attcccagca cccacatggc agctcactgc
     3121 catctgtaac tccagttcca ggggatctga cgctctttcc tgacctctgc tgtctagcac
     3181 actaatacta cgtgtacaca tgcaagcaat tcactcatac atgtcaaata ataaaagtgt
     3241 taagggtg
//
