LOCUS       NM_023544               2154 bp    mRNA    linear   ROD 29-APR-2024
DEFINITION  Mus musculus regulatory solute carrier protein, family 1, member 1
            (Rsc1a1), mRNA.
ACCESSION   NM_023544 XM_915386
VERSION     NM_023544.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Sebastiani,A., Greve,F., Golz,C., Forster,C.Y., Koepsell,H. and
            Thal,S.C.
  TITLE     RS1 (Rsc1A1) deficiency limits cerebral SGLT1 expression and delays
            brain damage after experimental traumatic brain injury
  JOURNAL   J Neurochem 147 (2), 190-203 (2018)
   PUBMED   30022488
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Errasti-Murugarren,E., Fernandez-Calotti,P., Veyhl-Wichmann,M.,
            Diepold,M., Pinilla-Macua,I., Perez-Torras,S., Kipp,H., Koepsell,H.
            and Pastor-Anglada,M.
  TITLE     Role of the transporter regulator protein (RS1) in the modulation
            of concentrative nucleoside transporters (CNTs) in epithelia
  JOURNAL   Mol Pharmacol 82 (1), 59-67 (2012)
   PUBMED   22492015
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Kroiss,M., Leyerer,M., Gorboulev,V., Kuhlkamp,T., Kipp,H. and
            Koepsell,H.
  TITLE     Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network
            and migrates into the nucleus
  JOURNAL   Am J Physiol Renal Physiol 291 (6), F1201-F1212 (2006)
   PUBMED   16788147
REFERENCE   4  (bases 1 to 2154)
  AUTHORS   Jiang,W., Prokopenko,O., Wong,L., Inouye,M. and Mirochnitchenko,O.
  TITLE     IRIP, a new ischemia/reperfusion-inducible protein that
            participates in the regulation of transporter activity
  JOURNAL   Mol Cell Biol 25 (15), 6496-6508 (2005)
   PUBMED   16024787
REFERENCE   5  (bases 1 to 2154)
  AUTHORS   Osswald,C., Baumgarten,K., Stumpel,F., Gorboulev,V., Akimjanova,M.,
            Knobeloch,K.P., Horak,I., Kluge,R., Joost,H.G. and Koepsell,H.
  TITLE     Mice without the regulator gene Rsc1A1 exhibit increased
            Na+-D-glucose cotransport in small intestine and develop obesity
  JOURNAL   Mol Cell Biol 25 (1), 78-87 (2005)
   PUBMED   15601832
  REMARK    GeneRIF: Rsc1A1 has a role in Na+-D-glucose cotransport in the
            small intestine through SGLT1 and in preventing obesity [Rsc1A1]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI854132.1 and AL671733.6.
            
            On Apr 15, 2010 this sequence version replaced NM_023544.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC150752.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               AI854132.1         48-538
            492-2154            AL671733.6         131009-132671       c
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 74.7 cM"
     gene            1..2154
                     /gene="Rsc1a1"
                     /gene_synonym="1700027M01Rik; Rs1"
                     /note="regulatory solute carrier protein, family 1, member
                     1"
                     /db_xref="GeneID:69994"
                     /db_xref="MGI:MGI:3526447"
     exon            1..2154
                     /gene="Rsc1a1"
                     /gene_synonym="1700027M01Rik; Rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1866
                     /gene="Rsc1a1"
                     /gene_synonym="1700027M01Rik; Rs1"
                     /note="transporter regulator RS1; regulatory subunit of
                     SGLT1"
                     /codon_start=1
                     /product="regulatory solute carrier protein family 1
                     member 1"
                     /protein_id="NP_076033.4"
                     /db_xref="CCDS:CCDS18879.1"
                     /db_xref="GeneID:69994"
                     /db_xref="MGI:MGI:3526447"
                     /translation="MSSLPTSDGFDHPAPSGQSPEVGSPTSLARSVSASVCAIKPGDP
                     NSIESLAMEATKASAEFQTNSKKTDPPPLQVLPDLASSAEQSLAMPFHKSSKEAVVAG
                     NLEKSVEKGTQGLRVYLHTRQDASLTLTTTGMREPQIFAEEKSWHPENQTPSPVNGLQ
                     QHRETGSVQREAGQQSVPQDQGCLCDAEDLELHEEVVSLEALRKGELQRHAHLPSAEK
                     GLPASGLCSCPCSEALMEVDTAEQSLVAMCSSTGRQDAVIKSPSVAHLASDNPTMEVE
                     TLQSNPSCEPVEHSILTRELQLPEDNVDMSTMDNKDDNSSSLLSGHGQPSVESAEEFC
                     SSVTVALKELHELLVISCKPASEESPEHVTCQSEIGAESQPSVSDLSGRRVQSVHLTP
                     SDQYSQGSCHQATSESGKTEIVGTAPCAAVEDEASTSFEGLGDGLSPDREDVRRSTES
                     ARKSCSVAITSAKLSEQLPCTSGVEIAPELAASEGAHSQPSEHVHNPGPDRPETSSVC
                     PGAGLPRSGLDQPPTQSLSTPSVLPPFIFPAADVDRILGAGFTLQEALGALHRVGGNA
                     DLALLVLLAKNIVVPT"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rsc1a1"
                     /gene_synonym="1700027M01Rik; Rs1"
                     /note="hexamer: AATAAA"
     polyA_site      2153
                     /gene="Rsc1a1"
                     /gene_synonym="1700027M01Rik; Rs1"
                     /note="major polyA site"
ORIGIN      
        1 ggcctgcttt tattctattg aggattcaac tctgataagt tagtggtctg ctagctaatc
       61 tttttctctt ttctctttat tacagagaaa agcagtaaag aatctacctc actgggaatg
      121 tcatcattgc cgacttcaga tgggtttgac catccagctc cttcagggca gagtcctgag
      181 gttggtagcc cgacgagtct cgctcgctct gtttctgctt ccgtctgcgc catcaagccc
      241 ggtgacccca atagcattga atctctagct atggaggcta cgaaggcttc agctgaattc
      301 cagacaaact ctaagaaaac agaccctcct cctctgcagg ttcttcctga ccttgcttcc
      361 tcagcagagc agagtctagc catgcctttc cataagtcat caaaagaagc cgttgttgca
      421 ggtaatctgg agaaatctgt tgagaaagga acccagggcc tcagagtgta tctccacaca
      481 agacaggacg ctagtttaac tctcacaact actgggatgc gggagccaca gatatttgcg
      541 gaggaaaaga gttggcatcc agaaaatcag accccaagtc ccgtgaacgg ccttcagcag
      601 cacagagaaa cagggagtgt acagcgagag gctggacagc agagtgttcc acaggaccag
      661 ggctgtcttt gtgacgcaga agaccttgag cttcatgaag aagttgtcag tttggaagct
      721 ctgaggaaag gtgagctaca aagacacgct catcttccca gtgcagagaa gggtcttcca
      781 gcttcaggac tctgtagctg tccatgctca gaagccctga tggaagtaga tacagctgaa
      841 cagtctctgg ttgctatgtg cagctcaaca ggcaggcagg atgccgtcat caagagccct
      901 agtgtagcac atctcgcttc agataatccc actatggaag tggagacatt acagtctaac
      961 ccgtcctgtg agcctgtgga acattccatc ttgactcggg aattgcagct cccagaagat
     1021 aatgttgaca tgtctacaat ggataacaaa gatgacaatt cctcttccct tctaagtggc
     1081 cacggtcagc cctctgtgga atcagcagaa gaattttgtt catctgtcac agtggccttg
     1141 aaagaactcc atgagctttt ggtcattagc tgtaagccag cttcagaaga gtcacctgag
     1201 catgttacct gtcagtcaga gataggagct gagagccaac caagtgtttc agacctttca
     1261 ggaagaaggg tccaaagtgt gcatttgacc cctagtgacc agtactcaca aggctcctgt
     1321 caccaggcca cctctgaatc aggaaagaca gaaatcgtag gaactgcccc ttgtgctgcg
     1381 gtagaagatg aagcatccac tagctttgaa ggtctgggtg atggcttgtc acctgaccga
     1441 gaagatgtcc gcagatcaac agagtcagcc aggaagagct gttctgtcgc cataacctca
     1501 gctaaactgt ctgagcagtt gccctgcacc tcaggggtag aaatagcacc tgaacttgca
     1561 gcaagtgagg gtgcccacag tcagccttca gagcatgtgc ataatccagg cccagacagg
     1621 ccggagacca gcagtgtctg ccctggagct gggttgcccc gtagtggatt ggaccaacct
     1681 cccacacagt ccttgtccac cccctccgtt cttccaccgt tcatctttcc tgctgcagat
     1741 gttgacagga ttcttggtgc cggcttcact ctgcaggaag cgctcggggc tctgcatcga
     1801 gttggtggga atgcagacct tgcccttctt gttttgttag caaagaacat tgtagtccca
     1861 acataattgt gggaagtggg ctaggccaca cgtcattcct tttgaaaaag cccttttcac
     1921 acaaatatac tacacacaca cacacacaat gtgtagaaaa tctgcaagca aaatgttgag
     1981 ccagattttt tttttgccgg ccaaagtaat ttatgatctt ttgtctgaat ttgtctattc
     2041 tacttgttaa catttgggcc ttttaaatgt attggcagtg tgtgcataca aagcttttta
     2101 ttctcatgac gatgatgtat tctggaataa agcagatggt tttgtgtata gcat
//
