LOCUS       NM_021384               3785 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus radical S-adenosyl methionine domain containing 2
            (Rsad2), mRNA.
ACCESSION   NM_021384
VERSION     NM_021384.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3785)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3785)
  AUTHORS   Wang,F. and Shang,Y.
  TITLE     Radical S-adenosyl methionine domain-containing 2, a potential
            target of D-tryptophan in asthma treatment, regulates T helper cell
            type 1/2 balance
  JOURNAL   Int Immunopharmacol 129, 111581 (2024)
   PUBMED   38310765
  REMARK    GeneRIF: Radical S-adenosyl methionine domain-containing 2, a
            potential target of D-tryptophan in asthma treatment, regulates T
            helper cell type 1/2 balance.
REFERENCE   3  (bases 1 to 3785)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3785)
  AUTHORS   Kim,J.J., Hong,S. and Seo,J.Y.
  TITLE     A Cysteine Residue of Human Cytomegalovirus vMIA Protein Plays a
            Crucial Role in Viperin Trafficking to Control Viral Infectivity
  JOURNAL   J Virol 97 (6), e0187422 (2023)
   PUBMED   37306568
  REMARK    GeneRIF: A Cysteine Residue of Human Cytomegalovirus vMIA Protein
            Plays a Crucial Role in Viperin Trafficking to Control Viral
            Infectivity.
REFERENCE   5  (bases 1 to 3785)
  AUTHORS   Zhou,X., Zhang,Z., Xu,H., Zhu,B., Zhang,L., Lie,L., Huang,Y.,
            Du,X., Liu,H., Li,Y., Huang,Y., Hu,S., Zhou,C., Wen,Q.,
            Pepplenbosch,M.P. and Ma,L.
  TITLE     Viperin impairs the innate immune response through the
            IRAK1-TRAF6-TAK1 axis to promote Mtb infection
  JOURNAL   Sci Signal 15 (754), eabe1621 (2022)
   PUBMED   36194648
  REMARK    GeneRIF: Viperin impairs the innate immune response through the
            IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
REFERENCE   6  (bases 1 to 3785)
  AUTHORS   Petri,A., Ahnfelt-Ronne,J., Frederiksen,K.S., Edwards,D.G.,
            Madsen,D., Serup,P., Fleckner,J. and Heller,R.S.
  TITLE     The effect of neurogenin3 deficiency on pancreatic gene expression
            in embryonic mice
  JOURNAL   J Mol Endocrinol 37 (2), 301-316 (2006)
   PUBMED   17032746
REFERENCE   7  (bases 1 to 3785)
  AUTHORS   Olofsson,P.S., Jatta,K., Wagsater,D., Gredmark,S., Hedin,U.,
            Paulsson-Berne,G., Soderberg-Naucler,C., Hansson,G.K. and Sirsjo,A.
  TITLE     The antiviral cytomegalovirus inducible gene 5/viperin is expressed
            in atherosclerosis and regulated by proinflammatory agents
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (7), e113-e116 (2005)
   PUBMED   15890971
  REMARK    GeneRIF: Viperin is expressed in atherosclerosis and induced in
            vascular cells by inflammatory stimuli and cytomegalovirus
            infection
REFERENCE   8  (bases 1 to 3785)
  AUTHORS   Chin,K.C. and Cresswell,P.
  TITLE     Viperin (cig5), an IFN-inducible antiviral protein directly induced
            by human cytomegalovirus
  JOURNAL   Proc Natl Acad Sci U S A 98 (26), 15125-15130 (2001)
   PUBMED   11752458
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Feb 19;99(4):2460]
REFERENCE   9  (bases 1 to 3785)
  AUTHORS   Boudinot,P., Riffault,S., Salhi,S., Carrat,C., Sedlik,C.,
            Mahmoudi,N., Charley,B. and Benmansour,A.
  TITLE     Vesicular stomatitis virus and pseudorabies virus induce a
            vig1/cig5 homologue in mouse dendritic cells via different pathways
  JOURNAL   J Gen Virol 81 (Pt 11), 2675-2682 (2000)
   PUBMED   11038379
REFERENCE   10 (bases 1 to 3785)
  AUTHORS   Boudinot,P., Massin,P., Blanco,M., Riffault,S. and Benmansour,A.
  TITLE     vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has
            a virus-induced homologue in humans and shares conserved motifs
            with the MoaA family
  JOURNAL   J Virol 73 (3), 1846-1852 (1999)
   PUBMED   9971762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK623585.1, AK151476.1 and AK153234.1.
            
            On May 14, 2009 this sequence version replaced NM_021384.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153234.1, AK151971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               CK623585.1         1-608
            609-3777            AK151476.1         591-3759
            3778-3785           AK153234.1         3759-3766
FEATURES             Location/Qualifiers
     source          1..3785
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 9.69 cM"
     gene            1..3785
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /note="radical S-adenosyl methionine domain containing 2"
                     /db_xref="GeneID:58185"
                     /db_xref="MGI:MGI:1929628"
     exon            1..382
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1122
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /note="VHSV-induced-like protein; radical S-adenosyl
                     methionine domain-containing protein 2; viral hemorrhagic
                     septicemia virus (VHSV)-induced gene 1; viperin; virus
                     inhibitory protein, endoplasmic reticulum-associated,
                     interferon-inducible"
                     /codon_start=1
                     /product="S-adenosylmethionine-dependent nucleotide
                     dehydratase RSAD2"
                     /protein_id="NP_067359.2"
                     /db_xref="CCDS:CCDS25848.1"
                     /db_xref="GeneID:58185"
                     /db_xref="MGI:MGI:1929628"
                     /translation="MGMLVPTALAARLLSLFQQQLGSLWSGLAILFCWLRIALGWLDP
                     GKEQPQVRGEPEDTQETQEDGNSTQPTTPVSVNYHFTRQCNYKCGFCFHTAKTSFVLP
                     LEEAKRGLLLLKQAGLEKINFSGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGS
                     LIRERWFKDYGEYLDILAISCDSFDEQVNALIGRGQGKKNHVENLQKLRRWCRDYKVA
                     FKINSVINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLISNEE
                     FETFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCTGGRKDPSKSILDVGVEEAI
                     KFSGFDEKMFLKRGGKYVWSKADLKLDW"
     exon            383..544
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..774
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..924
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..957
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..3785
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3755..3760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /note="hexamer: ATTAAA"
     polyA_site      3780
                     /gene="Rsad2"
                     /gene_synonym="2510004L01Rik; cig5; SAND; Vig1"
                     /note="major polyA site"
ORIGIN      
        1 cttacaggca gcagcaggtg tgtgcctatc accatgggga tgctggtgcc cactgctcta
       61 gctgctcggc tgctgagcct gttccagcag cagctgggtt ccctctggag tggcctggcc
      121 atcctgttct gctggctgag aatagcatta gggtggctag atcccgggaa ggaacagcca
      181 caggtccggg gtgagccgga ggacacccag gagacccagg aagatgggaa cagcactcag
      241 cccacaaccc ccgtgagtgt caactaccac ttcactcgtc agtgcaacta caaatgtggc
      301 ttctgcttcc acacagccaa gacatccttc gtgctgcccc tggaggaggc caagcgagga
      361 ctgcttctgc tcaaacaggc tggtttggag aagatcaact tttctggagg agaacccttc
      421 cttcaggaca ggggtgaata cttgggcaag cttgtgagat tctgcaagga ggagctagcc
      481 ctgccctctg tgagcatagt gagcaatggc agccttatcc gggagagatg gttcaaggac
      541 tatggggagt atttggacat tcttgctatc tcctgcgaca gcttcgatga gcaggttaat
      601 gctctgattg gccgtggtca aggaaaaaag aaccatgtgg aaaaccttca aaagctgagg
      661 aggtggtgca gggattacaa ggtggctttc aagatcaact ctgtcattaa tcgcttcaac
      721 gtggacgaag acatgaatga acacatcaag gccctgagcc ctgtgcgctg gaaggttttc
      781 cagtgcctcc taattgaggg tgagaactca ggagaagatg ccctgaggga agcagaaaga
      841 tttcttataa gcaatgaaga atttgaaaca ttcttggagc gtcacaaaga ggtgtcctgt
      901 ttggtgcctg aatctaacca gaagatgaaa gactcctacc ttatcctaga tgaatatatg
      961 cgctttctga actgtaccgg tggccggaag gacccttcca agtctattct ggatgttggc
     1021 gtggaagaag caataaagtt cagtggattt gatgagaaga tgtttctgaa gcgtggcgga
     1081 aagtatgtgt ggagtaaagc tgacctgaag ctggactggt gaggctgaga tgggaaggaa
     1141 actccgacca gctacaggga cattcacgcc cagctatcct tcaacaagct acatcttctg
     1201 gctatctacg gactgttgtt attagaatac agtctgttta tttttctttc agtttgactg
     1261 aactaaaaag ggagtaaaat tatgcagcag ataatcgtcc tccacaggag agagttcggt
     1321 tctcagagga gcaaggtcca gtgaccccta agaaccagca tttcatttat atttgaattt
     1381 ttgtgtggat tttactgtga atcccacatt tcctttttcc tttttgttcc ccttgagaaa
     1441 ctgggttatt ttttgctaac tatgccaatt ttgtcaacag gaaacttcac aaaacacacc
     1501 ctccaattac tgctgactat tctaatgctt ttctgctttg gaatattgga ctttttactc
     1561 aaaagtgtag aatcaaggca tatctcatag agccttaagt tagaatctta ctcttatgga
     1621 aggagttatt tcctagaaca ggctgtttgt tcatggtccc agcctctgat gctgctgctt
     1681 caagatggct gctttatact gcagcaattc cttcagggtt cttgacaaag ccaaggtaca
     1741 ctttacctcc cagggtgtgg ccatgaggat gccacttctg cagctgcaac tgccctggca
     1801 ttgaggctgc ttgagtctct catgctgaaa ggttgtcaca cttttctgaa aagctccaag
     1861 gccatgtggc acgtccagaa gagtcgtggg gggatagaca ggaaggagtc tttcaggaat
     1921 ataaaatgtg gcagctggct tggtataaat gtgcctgtgg ttccttagca tatctttcaa
     1981 gaaacactga aacttgacct agtctaggtc aacatgagaa aaacaaaaaa acaaaacaaa
     2041 acaaaacaaa aaaaaaaaaa caaaaataac aaaaacaaaa ccaaaaacag ttccttcttt
     2101 acaccaaaaa ggcaaaagac agaatgtgaa ctagccaaaa tcttcctgtg gaagcattgc
     2161 atgaggttat taagcctaga cagtgcctca ctgcttggaa aataatttcc tatcaaagag
     2221 taaagccatg gaaaattttg ttctgtccaa gaaactgaac tcccctgtag ttccactgtg
     2281 gccgctagag ggccccggga agtcagacct cattaagtat ctcagaaact ttgcttctga
     2341 gtctattttt aggacttggt ggattttggt tctgttcctt ctttgtttta tttgcttttg
     2401 tttggggttt tttttggtgc ttatattaat actaaaattt ttctaaggaa ctggaatttg
     2461 gggtatttac tcacaaaaga tgttcatact ttagttaggt cattataatt caactgagac
     2521 acactttgtc tcatgaaaaa tataggtcag ggttttctgt gttttctagt gtgtgtgtgt
     2581 gtgtgtgtgt gtgtgtttta cctatttttg cttgagtata aatataacta tgtagcccag
     2641 gctggcctgg aactcatgat acctctgccc taacctcacc ctctcaagtg ctagggattg
     2701 cacgtgtgta ttaaccaact cctatgtaga tttttctatg tgaaatttga gtcacattcc
     2761 ccctgaagat tgtgattttt ttttttagtt aagtcctgtg tgcttagttc acctgggaaa
     2821 tcccagagga catggccaga cacccacttg atcaaatgag aggaaagcaa tcatgaagct
     2881 gaggtccaac cttctgaatt gcagtatatt ttctcctggc tgagggaagc tgcatgtctc
     2941 tttccctgat taaagtagaa catgatgaga atctgcttgg gaaatgagcc accattctaa
     3001 atgtaccccc ccaccccccg ccttgtgcat gcacaggagg tgtgtgagat ctctgtgctt
     3061 aaaatattca aaaatctccc tttcctaaag gaaagaatta caatatttta ttatcacagt
     3121 aaagatcaaa cttggattag atcattcatt ggttacattt tcagtgttaa atctgggtgc
     3181 tcattttgtg aagcagatgc tctctgctgg gagaataggg gatgatctag tggacatttg
     3241 ttaagtgtta caggctgatg ccttgtgtcc catgactgat tgatgcagag tagtaatgct
     3301 gtgaaggggg ttttactcaa gaacttcaga ggctaggaca tctcacactg attttacagc
     3361 ctttggtgtc tctgttataa tgtgttcaat gataaaatca tgggctgtgt ttttgtaaga
     3421 gggacgcttc atggtgttat ttgaaaaaaa aaaaaaaggt cccaggtttc gatctgtttg
     3481 gagtttggag tctaatggtt gcatagataa acaggcgacc aatcacaccc agcagcagtt
     3541 agctccttac cgcagtaact cagctcatgg actgccctct tgatggattg atgttgtttc
     3601 ataagctatt attagacaaa gaaccatcac gcaggcctca tgtgagtatg tccagatgag
     3661 gtctaatgct cagggatata tgtatatgta tctctctgtg gaattacact gtgttctgag
     3721 gcatcgctct aatgtatggt aacatgatct gtgaattaaa atgttctata cgtggcctaa
     3781 gactc
//
