LOCUS       NM_011302               5855 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus retinoschisis (X-linked, juvenile) 1 (human) (Rs1),
            mRNA.
ACCESSION   NM_011302
VERSION     NM_011302.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5855)
  AUTHORS   Liu,X., Zhang,D., Li,D., Chen,Y., Xie,B., Li,X., Zhou,J., Li,J.,
            Gu,F. and Xu,T.
  TITLE     Retinoschisin Is Required for Pineal Gland Calcification and
            Cellular Communication in Pinealocytes of Rats and Mice
  JOURNAL   Lab Invest 104 (7), 102086 (2024)
   PUBMED   38797343
  REMARK    GeneRIF: Retinoschisin Is Required for Pineal Gland Calcification
            and Cellular Communication in Pinealocytes of Rats and Mice.
REFERENCE   2  (bases 1 to 5855)
  AUTHORS   Hassan,S., Hsu,Y., Mayer,S.K., Thomas,J., Kothapalli,A., Helms,M.,
            Baker,S.A., Laird,J.G., Bhattarai,S. and Drack,A.V.
  TITLE     A visually guided swim assay for mouse models of human retinal
            disease recapitulates the multi-luminance mobility test in humans
  JOURNAL   Saudi J Ophthalmol 37 (4), 313-320 (2023)
   PUBMED   38155679
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5855)
  AUTHORS   Vijayasarathy,C., Zeng,Y., Marangoni,D., Dong,L., Pan,Z.H.,
            Simpson,E.M., Fariss,R.N. and Sieving,P.A.
  TITLE     Targeted Expression of Retinoschisin by Retinal Bipolar Cells in
            XLRS Promotes Resolution of Retinoschisis Cysts Sans RS1 From
            Photoreceptors
  JOURNAL   Invest Ophthalmol Vis Sci 63 (11), 8 (2022)
   PUBMED   36227606
  REMARK    GeneRIF: Targeted Expression of Retinoschisin by Retinal Bipolar
            Cells in XLRS Promotes Resolution of Retinoschisis Cysts Sans RS1
            From Photoreceptors.
REFERENCE   4  (bases 1 to 5855)
  AUTHORS   Jin,X., Zhang,X., Liu,J., Wang,W., Liu,M., Yang,L., Liu,G., Qiu,R.,
            Yang,M., Yao,S. and Lei,B.
  TITLE     Retinal Proteomic Alterations and Combined Transcriptomic-Proteomic
            Analysis in the Early Stages of Progression of a Mouse Model of
            X-Linked Retinoschisis
  JOURNAL   Cells 11 (14), 2150 (2022)
   PUBMED   35883593
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5855)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5855)
  AUTHORS   Weber,B.H., Schrewe,H., Molday,L.L., Gehrig,A., White,K.L.,
            Seeliger,M.W., Jaissle,G.B., Friedburg,C., Tamm,E. and Molday,R.S.
  TITLE     Inactivation of the murine X-linked juvenile retinoschisis gene,
            Rs1h, suggests a role of retinoschisin in retinal cell layer
            organization and synaptic structure
  JOURNAL   Proc Natl Acad Sci U S A 99 (9), 6222-6227 (2002)
   PUBMED   11983912
  REMARK    GeneRIF: Inactivation of Rs1h suggests a role of retinoschisin in
            retinal cell layer organization and synaptic structure
REFERENCE   7  (bases 1 to 5855)
  AUTHORS   Bibb,L.C., Holt,J.K., Tarttelin,E.E., Hodges,M.D.,
            Gregory-Evans,K., Rutherford,A., Lucas,R.J., Sowden,J.C. and
            Gregory-Evans,C.Y.
  TITLE     Temporal and spatial expression patterns of the CRX transcription
            factor and its downstream targets. Critical differences during
            human and mouse eye development
  JOURNAL   Hum Mol Genet 10 (15), 1571-1579 (2001)
   PUBMED   11468275
REFERENCE   8  (bases 1 to 5855)
  AUTHORS   Brunner,B., Todt,T., Lenzner,S., Stout,K., Schulz,U., Ropers,H.H.
            and Kalscheuer,V.M.
  TITLE     Genomic structure and comparative analysis of nine Fugu genes:
            conservation of synteny with human chromosome Xp22.2-p22.1
  JOURNAL   Genome Res 9 (5), 437-448 (1999)
   PUBMED   10330123
REFERENCE   9  (bases 1 to 5855)
  AUTHORS   Gehrig,A.E., Warneke-Wittstock,R., Sauer,C.G. and Weber,B.H.
  TITLE     Isolation and characterization of the murine X-linked juvenile
            retinoschisis (Rs1h) gene
  JOURNAL   Mamm Genome 10 (3), 303-307 (1999)
   PUBMED   10051329
REFERENCE   10 (bases 1 to 5855)
  AUTHORS   Reid,S.N., Akhmedov,N.B., Piriev,N.I., Kozak,C.A., Danciger,M. and
            Farber,D.B.
  TITLE     The mouse X-linked juvenile retinoschisis cDNA: expression in
            photoreceptors
  JOURNAL   Gene 227 (2), 257-266 (1999)
   PUBMED   10023077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC046422.1.
            
            On Feb 9, 2004 this sequence version replaced NM_011302.2.
            
            Sequence Note: An in-frame AUG is located 26 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it would disrupt the signal peptide on
            NP_035432.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046422.1, AF073780.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849390,
                                           SAMN01164131 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..5855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 73.95 cM"
     gene            1..5855
                     /gene="Rs1"
                     /gene_synonym="Rs1h; tmgc1; Xlrs1"
                     /note="retinoschisis (X-linked, juvenile) 1 (human)"
                     /db_xref="GeneID:20147"
                     /db_xref="MGI:MGI:1336189"
     exon            1..225
                     /gene="Rs1"
                     /gene_synonym="Rs1h; tmgc1; Xlrs1"
                     /inference="alignment:Splign:2.1.0"
     exon            226..251
                     /gene="Rs1"
                     /gene_synonym="Rs1h; tmgc1; Xlrs1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..357
                     /gene="Rs1"
                     /gene_synonym="Rs1h; tmgc1; Xlrs1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..499
                     /gene="Rs1"
                     /gene_synonym="Rs1h; tmgc1; Xlrs1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..695
                     /gene="Rs1"
                     /gene_synonym="Rs1h; tmgc1; Xlrs1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..5840
                     /gene="Rs1"
                     /gene_synonym="Rs1h; tmgc1; Xlrs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacaatacct ccccagactg cttgttgagg caggggacta tgtggcttaa ttggatgggg
       61 gctgagtgaa agacctaaga actaaatgaa ataagatgct taagttaatc gcctgctcct
      121 atgccagctc tccacttcac ttagatcttg ctgtgaccaa ggacaaggag aaaatgccac
      181 acaagattga aggcttcttc ttgttacttc tctttggcta tgaagccaca ttgggattgt
      241 catcgacaga ggatgagggt gaggacccct ggtaccagaa agcatgcaag tgtgattgcc
      301 aggtaggagc caatgctctg tggtctgctg gagctacctc cttagactgt attccagaat
      361 gcccatatca caagcccctg ggtttcgagt caggggaggt cacgccagat cagatcactt
      421 gctccaaccc agagcagtat gtgggctggt attcctcatg gacagcaaac aaggcccgac
      481 tcaacagtca aggttttggg tgtgcttggc tttccaagta tcaggacagc agccagtggt
      541 tacagataga tttgaaggag atcaaggtga tttcggggat cctgacccaa ggacgctgtg
      601 acatagacga gtgggtgacc aagtacagtg tgcagtatag gactgatgag cgcctgaact
      661 ggatctacta taaggatcag accggaaaca atcgggtctt ctatggaaac tcagaccgga
      721 gttctacagt tcagaactta ctcaggcccc ccatcatttc ccgcttcatc cgactgatcc
      781 ctctaggctg gcatgtccga attgccatcc ggatggagct gcttgagtgt gccagcaagt
      841 gtgcctgatg tctatttcag ctcagttctg tcacttgcag ggagagcttt ggggggaggg
      901 caccctgaaa taccactggg atgaatgggg ctatatctta taagcacttt acaatgtaga
      961 tctgggtaga gaatatttca ctttttaaaa gatagtttca aatttcaaag ggagagagag
     1021 agagagagag agagagagag agagagagag agaagctttt aagcttttct tcaactcagg
     1081 gccaaagaaa ataagaacaa agaaagtatc tctcaaacca attttcttac acaaacccaa
     1141 atagcagggg taatttgctg ctctggctcc ccatcttttt ctctttgtct cagtgacacc
     1201 gtcaaaggtg caggcccagg ggaacacaaa gcagctctga taatttgaaa attctttttg
     1261 gctcttagca cattcagaag aggagcgtac tctttggcaa agcctcacat gaacacttgc
     1321 atgaaatcct cactatagag gcctggtgac aagtacatag gtgtgaagaa agcagaagga
     1381 agcctggcgt atggcccacg agtctggagc cagtaaccaa ccaaccaact aaccaactaa
     1441 ccaaccagtc aaggcttccc cctccctgga attgcttttg cctggaaggg gtggagctcc
     1501 ttgtgcagaa actccattct acagcccttt tggcaatgtg tccttctgtg attgcctgga
     1561 gatgaatgca aggggcaggc tatatgtgtg tgtggatagt gaggtttccc ttaaactgag
     1621 gaagcccaaa taactagaat acatcacacc ttctttatcc atggctacag tttcccagaa
     1681 attgaacagg cttagaaaac agctgagata aaccatatct ctatctactg ggaagagatc
     1741 atgctttggg ggaaggggtt aggactccta tcatagagga ctgtacacag atgatctgtc
     1801 agtaaagggc ttgctgtaca gcataggaac ttgagattat atttctagaa tgcatgtaaa
     1861 aagctaggta tggacaggta tggtggaaca tgccattagt cttagtattt ggaagacaga
     1921 ggcaagcaga tctgagttca gggccagcct ggtctacata gcagttccaa gctagccaag
     1981 gctacacagt aaggccctgt ttcaagaaaa aaagaccagg catggagggg cacacctgca
     2041 aatccaggac taggaggcag gcagagacag gatgatgcct agagcttgtc tgccaatcag
     2101 tacactccag gttcatggtc agaccctgtc tcaaaactaa agtgaagagc tattgaggaa
     2161 gataccagat gtcaacctct gtccaacatg cacacataca catacactgg taggtttcaa
     2221 acctggggca aatggcagag gtgcctagtt aaggttctcc cagcatctct cagcccctac
     2281 caggtcctcc tagttggcat accccgcccc ctaccccgaa actcttcagc ccagggggtt
     2341 gggcttcttc cctatataat ccaactattt tggtcaccct ttctctttgt acctttgggc
     2401 ctcctggttg ctgcatctgg ttcctctgtt ctcccttatc tcttttcctc cctcctctcc
     2461 tcacaaggcc cagcttagag tgttcatgtc tattctggac tctctcccgg atgcccctgc
     2521 ctctggctat gctctcccac atatctacca taaactctct cctctaccat acctaggaca
     2581 agtcatgttc ctttcctttt cctttttgtt tcccattcaa acatgtaaat aggaaaaaca
     2641 aaatacaaca acaacaaaca aaaataaaac cacaaaagcc ttctctccga gcggcttcct
     2701 cccgtcctgc ccacccaaac atgcttactc agacatgaca tttgaaactt ctttcggtag
     2761 tcattctctg gcaggaatag ctcatttaat caggagcttt ggagcctgag agaatgacta
     2821 ctggtctcta gctcatttcc atctgtagct caagctgggt ttgaggctct tctctgggag
     2881 aggctgttaa ctggagtgag ggtcaaaaag gcatgcgggg agaagctgag aatgagaact
     2941 gcccagagac aaggtcttgg cctcacacac acacaataca gccttggtta gtacttttct
     3001 ctgagctatt ttctatttcc aggtattaaa ggagattaca tggattcaca ccaaaataac
     3061 tttggatggc cagacatggt atcttccatc tttaatccta gcactgggaa aacacagaca
     3121 ggtggatctc tgtgagttca aggccaggtt tgcatagcaa gctccagacc agccaaggct
     3181 atgtagtgag actgtctcaa aaatcaatcc atcaatcaaa tgatcttgga tgtcacattc
     3241 ttctcagtga atagaacaac attttaatag catcaaattt cctacctagt attttggagt
     3301 tccacaggtg tgtgtgtatg tgtggcaatg tacaacaata ttcctggtat gactacatat
     3361 gtacaaattc attttggata atattcctga cagcagacct ttatttggaa aattgagtta
     3421 cctttctcac cacactgagt aattgttaga gaaaaatggc aataacttaa gaatactgat
     3481 cagggagaaa aaaacccaaa tggtacaagg catgggtaaa tagtcatcaa attaaaaaat
     3541 catgccataa atttgttttc taatagtttc attaacttca cataaacagt cctaattcat
     3601 ttaaggtgtg taattcaata tagtatattc aaacttgaac aatcatcact acaagtaact
     3661 ttagactatt cttatcaccc ccaagagaat cctctaacaa tgggccatca gccaccacag
     3721 ctctagatta ctcgtcatcc attttctatt tgtgtgtgga ttttttttcc attctgggca
     3781 tttctccaca caaatggaat cttagaatat atagtagttt atgacttgtt tcttgtactt
     3841 atcatagtgt ttttaaagtc catgtgttgg agaagtacat cctccttttt tgttattaac
     3901 attctgtgta gggtattgta ttattattta tccatgcatt tgggtggggc tagtatgaat
     3961 aatgctgctt catgaaaatt tatatgtaag ttattgcgtg gacatgtttt atcttgggca
     4021 tactcacact gagaatagag aattgttggg tctcttggga actatttctc caggtggctg
     4081 taccatcttc tgttcccacc agcaatgtct aatgcttcca gcctctcatc tttagcaatg
     4141 cttcttgtat ttcattagat ctgtcctagt atgtatgaag tagcattcga tgatgaattt
     4201 gatttgcatt tctctaataa ccaatgtttt ttgagcatct tttcaagtca ccagtgacat
     4261 atttttggag aaagttctat tcagaccctt gcccatataa agatttcatt tcacggattc
     4321 attaagagtt ctttgggtgt tctacataca attctcttat gcaaacattt cttccatcct
     4381 gtttttcttc ttgtcattgt cttggtttag ttttgcacca ggatttcact atgtagctca
     4441 ggctggcctg gaacttgcaa agatccttct gtctctgcct cccaggttct gagattctgg
     4501 gtatttgcca ccacacctgg cctttctctg aagcacaaca aataccaaat tttaatgaag
     4561 tccaaccttc cggtttcctt ttttggtgta ttatctgaga aactactgtc aaaccatggt
     4621 caagaagatt cactcttgtg ttttcttcta aatgttttga aaaaaaattt ttaaaaagtt
     4681 ttaaagtttt aactcttact ttgtgaacag ttataaagta agggtgtaat ttcattcttt
     4741 ggatatcaat atgcagctgt cttggtagct tgtgttgtct tcaccacagt caatggtctt
     4801 tattcttcca aaaacaactg accaagaata ttagagtata tgctaggcct cataattcta
     4861 ttaccacata gtcttcatta ctgtagcatt gtagtgagtt gtggaattag gacatataaa
     4921 tcttccaatt ctggttatgt ttcaagactg aactaactat tctgggttcc ttaaacttct
     4981 aagtaagtat atctgtaaat aagccagcca ggggtctcac aatggaaaat gttttcaatt
     5041 tcaaaattaa ataaacaatg agatattaag atctgcaaga tatttatctg tagttaattt
     5101 tctttcaata gttaatgaaa atgttagcat tttcttcctt ttgtgttagg atatatatat
     5161 aaaagaaacc ctattattaa agtaaacctg aaaaagaatc ttcctattaa acaaaaaata
     5221 tgtttgcaat attatttctt ttagggggca actaattcaa taaagattat ataatggagg
     5281 aaagtcattc ctatcttaac acattttgtt tatttttacc actagacttt gggttattaa
     5341 ggattttatt ttttatggtt ttgaggacat aacccaggtt tttcatacat ggtaggcaaa
     5401 tactcttcaa ttgagttctc tctgcagcct gcagatcaaa acaaaacaaa acattatggt
     5461 aaagcataac aatttacata cttttagtta actgtgaagc attaaataat gatattaaga
     5521 aaaaaatgga agtaatcctg gtagttgatg tgggaggtta tatagtgtgg tggtttggat
     5581 atgcttggcc tattaggagg tgtggctttg ttggagtagg tgtggccttg ttggaagaag
     5641 tacatcattg tgggagtggg ctttgacacc ctcctcctcg ctgcccgaaa gacagtattc
     5701 tggctacctt tggatcaaga tatagaactc ttggctcctt ctccagcacc atgtctgcct
     5761 gcatgctgtt ggctaggatg ataattgact aaacatctga aactgtaagc cagccccaat
     5821 taaatgttgt ctttctaaga aaaaaaaaaa aaaaa
//
