LOCUS       NM_021511               2058 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ribosome biogenesis regulator 1 (Rrs1), mRNA.
ACCESSION   NM_021511
VERSION     NM_021511.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2058)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2058)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2058)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   4  (bases 1 to 2058)
  AUTHORS   Carnemolla,A., Fossale,E., Agostoni,E., Michelazzi,S.,
            Calligaris,R., De Maso,L., Del Sal,G., MacDonald,M.E. and
            Persichetti,F.
  TITLE     Rrs1 is involved in endoplasmic reticulum stress response in
            Huntington disease
  JOURNAL   J Biol Chem 284 (27), 18167-18173 (2009)
   PUBMED   19433866
  REMARK    GeneRIF: mammalian Rrs1 is localized both in the nucleolus as well
            as in the endoplasmic reticulum (ER) of neurons
REFERENCE   5  (bases 1 to 2058)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   6  (bases 1 to 2058)
  AUTHORS   Fossale,E., Wheeler,V.C., Vrbanac,V., Lebel,L.A., Teed,A.,
            Mysore,J.S., Gusella,J.F., MacDonald,M.E. and Persichetti,F.
  TITLE     Identification of a presymptomatic molecular phenotype in Hdh CAG
            knock-in mice
  JOURNAL   Hum Mol Genet 11 (19), 2233-2241 (2002)
   PUBMED   12217951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142041.1.
            
            On Apr 28, 2009 this sequence version replaced NM_021511.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK142041.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2058              AK142041.1         2-2059
FEATURES             Location/Qualifiers
     source          1..2058
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.08 cM"
     gene            1..2058
                     /gene="Rrs1"
                     /gene_synonym="5730466A07Rik; D1Ertd701e; Rrr"
                     /note="ribosome biogenesis regulator 1"
                     /db_xref="GeneID:59014"
                     /db_xref="MGI:MGI:1929721"
     exon            1..2048
                     /gene="Rrs1"
                     /gene_synonym="5730466A07Rik; D1Ertd701e; Rrr"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1214
                     /gene="Rrs1"
                     /gene_synonym="5730466A07Rik; D1Ertd701e; Rrr"
                     /note="RRS1 ribosome biogenesis regulator homolog;
                     regulator for ribosome resistance homolog"
                     /codon_start=1
                     /product="ribosome biogenesis regulatory protein homolog"
                     /protein_id="NP_067486.2"
                     /db_xref="CCDS:CCDS14811.1"
                     /db_xref="GeneID:59014"
                     /db_xref="MGI:MGI:1929721"
                     /translation="MEGQRVEELLAKAEQEEAEKLQRITVHKELELEFDLGNLLASDR
                     NPPTVLRQAGPSPEAELRALARDNTQLLINQLWRLPTERVEEAVVARLPEPATRLPRE
                     KPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEASGQWRRRWGYKRARDDTKEWLIEV
                     PGSADPMEDQFAKRTQAKKERVAKNELNRLRNLARAHKMQMPSSAGLHPTGHQSKEEL
                     GRAMQVAKVSTASVGRFQERLPKEKAPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMN
                     SKKPRLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPSGKRKGGPPGQGEKR
                     KGGLGSKKHSWPSALAGKKKGVPPQGGKRRK"
     regulatory      2025..2030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rrs1"
                     /gene_synonym="5730466A07Rik; D1Ertd701e; Rrr"
                     /note="hexamer: AATAAA"
     polyA_site      2045
                     /gene="Rrs1"
                     /gene_synonym="5730466A07Rik; D1Ertd701e; Rrr"
                     /note="major polyA site"
ORIGIN      
        1 tcttccggat tacgggtccg gacgtccgca cgtggttgcc ggtttagggt gctgctgtag
       61 tggcgatacg tcccgccgct gtcccgaagt gagggatccg agccgcagcg agagccatgg
      121 agggccagcg cgtggaggag ctgctggcca aggcagagca ggaggaggcg gagaagctgc
      181 agcgcatcac ggtgcacaag gagctggagc tggagttcga cctgggcaac ctgctggctt
      241 cggaccgcaa ccccccgacc gtgctgcgcc aggccgggcc gtcgccggag gccgagctgc
      301 gggccctggc gcgggacaac acgcagctgc tcatcaacca gctgtggcgg ctgccgaccg
      361 agcgcgtgga ggaggcggtg gtcgcgcgct tgccggagcc cgccactcgc ctgccccgcg
      421 agaagccgct gccccgacca cggccgctca cccgctggca gcagttcgcg cgccttaagg
      481 gaatccgtcc caagaagaag accaacctcg tgtgggacga ggcgagtggc cagtggcggc
      541 gccgttgggg ctacaagcgc gcccgggatg acactaaaga atggctgatc gaggtgcctg
      601 ggagcgccga ccccatggaa gaccagttcg ccaagaggac tcaggccaag aaagaacgcg
      661 tggccaagaa tgagctgaac cgtctgcgga acctggctcg cgcgcacaag atgcagatgc
      721 ccagctcagc cggcctgcac cctactggac accagagtaa ggaagagctg ggccgcgcca
      781 tgcaagtggc caaggtttcc accgcttcgg tgggacgctt ccaggagcgc cttcccaagg
      841 agaaagctcc ccggggctcc ggcaagaaga ggaagtttca gcccctcttt ggggacttcg
      901 cagccgagaa aaagaaccag ttggagctac ttcgagtcat gaacagcaag aaacctcggc
      961 tggacgtgac gagggccacc aacaagcaga tgagggaaga ggaccaggag gaggctgcca
     1021 agaggaggaa aatgagccag aaaggcaaga ggaaaggggg ccggcaagga ccttcgggca
     1081 agagaaaggg cggcccgccg ggtcagggag aaaagaggaa aggaggcttg ggaagcaaaa
     1141 agcattcctg gccttctgct ttagctggca agaagaaagg agtgccgccc caaggtggga
     1201 agaggaggaa gtagcgttct cccctcggga ccagttctga aaagctggga ctgtactaaa
     1261 agttaacttg ggcggtatag gtggccgctg ccctcagtga catttgacat taaaaggacg
     1321 ggtttgcctt ccctcgagtc agtgctggac gagttaatag agacactgac tggaaattgg
     1381 tgtattttga gaattataga aatgatatag ccagaaccag gaataagtta aggcctgcct
     1441 ttttatcttg actttggata ctgcgttaca gtagattggt ttcaacattt ttgcattatt
     1501 tttataacaa agcttgtgta tttatcaaag cggggagggc gggggaaaat tatatctacc
     1561 tgtgatttgc aagtattgta aatggatgca ggtacctggt gttgctttta acttttactg
     1621 tcggtagagg ttgcatgtga agccagtaac ctgggcacca atatggagtg tgcttgagaa
     1681 aaacaaagta gttacagtgg ttctaaaaaa gaccccttgt tttaggaaaa ctttggccct
     1741 aactataata ttaaaagtat agtgcttttt ggtgttggtt caggtggtgc atttggccaa
     1801 tggattgctt taagtccaga aatagttgtc attttgtttg taaccggtgg cttttgttta
     1861 attggcttgg gttttagata ttgtcaaaat atctggcatt cactatggaa ccaaggctgc
     1921 cctggaactc agggccaagt gctgagatta taatcgagca gcagatttca tgtttatttc
     1981 tgtcctagat gtttttccct gtttcattgt cttattttgt tcttaataaa cttatctttg
     2041 cataattaaa aaaaaaaa
//
