LOCUS       NM_028244               4809 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ribosomal RNA processing 1B (Rrp1b), transcript
            variant 1, mRNA.
ACCESSION   NM_028244 NM_183212
VERSION     NM_028244.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4809)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4809)
  AUTHORS   Lee,M., Dworkin,A.M., Gildea,D., Trivedi,N.S., Moorhead,G.B. and
            Crawford,N.P.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     RRP1B is a metastasis modifier that regulates the expression of
            alternative mRNA isoforms through interactions with SRSF1
  JOURNAL   Oncogene 33 (14), 1818-1827 (2014)
   PUBMED   23604122
  REMARK    GeneRIF: RRP1B suppresses metastatic progression by altering the
            transcriptome through its interaction with splicing regulators such
            as SRSF1
REFERENCE   3  (bases 1 to 4809)
  AUTHORS   Yu,T., Clapcote,S.J., Li,Z., Liu,C., Pao,A., Bechard,A.R.,
            Carattini-Rivera,S., Matsui,S., Roder,J.C., Baldini,A.,
            Mobley,W.C., Bradley,A. and Yu,Y.E.
  TITLE     Deficiencies in the region syntenic to human 21q22.3 cause
            cognitive deficits in mice
  JOURNAL   Mamm Genome 21 (5-6), 258-267 (2010)
   PUBMED   20512340
REFERENCE   4  (bases 1 to 4809)
  AUTHORS   Crawford,N.P., Yang,H., Mattaini,K.R. and Hunter,K.W.
  TITLE     The metastasis efficiency modifier ribosomal RNA processing 1
            homolog B (RRP1B) is a chromatin-associated factor
  JOURNAL   J Biol Chem 284 (42), 28660-28673 (2009)
   PUBMED   19710015
  REMARK    GeneRIF: RRP1B, a tumor progression and metastasis susceptibility
            candidate gene, is potentially a dynamic modulator of transcription
            and chromatin structure
REFERENCE   5  (bases 1 to 4809)
  AUTHORS   Crawford,N.P., Qian,X., Ziogas,A., Papageorge,A.G., Boersma,B.J.,
            Walker,R.C., Lukes,L., Rowe,W.L., Zhang,J., Ambs,S., Lowy,D.R.,
            Anton-Culver,H. and Hunter,K.W.
  TITLE     Rrp1b, a new candidate susceptibility gene for breast cancer
            progression and metastasis
  JOURNAL   PLoS Genet 3 (11), e214 (2007)
   PUBMED   18081427
REFERENCE   6  (bases 1 to 4809)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4809)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 4809)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 4809)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033797.5.
            
            On Jul 30, 2009 this sequence version replaced NM_028244.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016569.1, SRR9219382.133111.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               CT033797.5         92390-92832
            444-526             CT033797.5         102157-102239
            527-584             CT033797.5         103902-103959
            585-670             CT033797.5         104781-104866
            671-732             CT033797.5         105654-105715
            733-862             CT033797.5         106177-106306
            863-927             CT033797.5         107374-107438
            928-1094            CT033797.5         107911-108077
            1095-1183           CT033797.5         108967-109055
            1184-1281           CT033797.5         110085-110182
            1282-1301           CT033797.5         111333-111352
            1302-1388           CT033797.5         112139-112225
            1389-2089           CT033797.5         112784-113484
            2090-2230           CT033797.5         114752-114892
            2231-2294           CT033797.5         115502-115565
            2295-4809           CT033797.5         116576-119090
FEATURES             Location/Qualifiers
     source          1..4809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.34 cM"
     gene            1..4809
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /note="ribosomal RNA processing 1B"
                     /db_xref="GeneID:72462"
                     /db_xref="MGI:MGI:1919712"
     exon            1..443
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..2488
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribosomal RNA processing protein 1 homolog B; RRP1-like
                     protein B; ribosomal RNA processing 1 homolog B"
                     /codon_start=1
                     /product="ribosomal RNA processing protein 1 homolog B
                     isoform 1"
                     /protein_id="NP_082520.2"
                     /db_xref="CCDS:CCDS28613.1"
                     /db_xref="GeneID:72462"
                     /db_xref="MGI:MGI:1919712"
                     /translation="MALAMQSSEFQFAQRLASSEKGVRDRAVRKLRQYLSARTQSDTG
                     SFSQEELLKIWKGLFYCMWVQDEPLLQEELANIISQLIHVVNSLEAQYLFIQTFWQTM
                     NREWQGIDKLQLDKYYMLIRLVLRQSFEVLKRNAWEESQITLFLDILMKEILSPESQS
                     PNGVRTHLIDVYLEELTTVGGAELLADQNLKLIDPFCRIAAKTKDHTLVQTVARGVFE
                     VIVDQSACVPQESVEERKTKEDGSGFPTKALACRKAVSGKKAALDECLRDGVIGSRER
                     DICAALKDSGSPLQFDYKAVADRLLEIANSKSTPPFNRKRLCRLVRKFQDLCEGNGAP
                     LSSAEDNGQRRHKRKRKKLLESEKGDTVSPAAEEDSGGHIHKKKRKKRKRSHFQPDTQ
                     NLDAVAVPKVPDSESEPDTAQRQAPCGQACVTEPTAEAVSSIGENSSKPTPVMPIHNK
                     RKRPRKKKLRAHKEICKSTTLPQEDMSKNDAVSGHSQSSAAHISSSEGVQAQKRKRKL
                     GALPDSSSDLPVQKSGTPTSPVEGKDGQTTLPRCKRSQKKTASSTLDPCDPSSQKPAI
                     SKKKKKTMKLMSNGVLESNPGQIQALGSNRTLKKPLKTEDDFVKFDTRFLPKPLFFRK
                     AKNSSATRPQGPAGQLNKTPSSSKKVTFGLNRNMTAEFKKTDKSILVSPTGLSRVAFN
                     PEQRPLHGVLKTATSSPASTPLSPMRLPATTPKRRPRAADFF"
     exon            444..526
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            527..584
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            585..670
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            671..732
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            733..862
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            863..927
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1094
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1183
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1281
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1301
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1388
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2089
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2230
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2294
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..4809
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /note="hexamer: TATAAA"
     polyA_site      2552
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /note="major polyA site"
ORIGIN      
        1 gatagacctt tgttagctgt gcttagactc taaaactgca tcaaaccagc cgtaggcgtt
       61 ctgctggagg agacctgacc tccaactaac cgccctgtca atcgccctga acctgggcca
      121 ctctcaggac gcacttcaag cagcgttgct acggcgtcta cccgcacagg ggccacgcgg
      181 gctccctggg cgcgcggcga gcggcgcacc ggtgacgcca tcacccgcgc gccgcagccc
      241 atacgcagac gcagtccgga tcgcttggcg gcgagcggca cgcgcgcagc ctggggatgc
      301 tgaagcgagt gcgatggctc tcgccatgca gtcttccgag ttccagttcg cccagcggct
      361 ggcctccagt gagaagggcg tccgcgaccg cgccgtgagg aagctgcggc agtatctcag
      421 cgccaggacg cagagcgaca caggaagttt cagtcaagaa gaactcttaa aaatatggaa
      481 aggactcttc tactgcatgt gggtgcagga cgagcccctt ctgcaggagg agctagcgaa
      541 cattatttcc caactcatcc acgttgtaaa cagcttggag gctcagtacc tgtttattca
      601 gaccttctgg cagaccatga atcgagagtg gcaagggata gacaagctgc agctggacaa
      661 gtactacatg ctgatccgcc tggtcctgag gcagtccttt gaagttctca agcggaatgc
      721 ctgggaagaa agccaaatca cactgttttt ggacatcctg atgaaggaga tcctgagtcc
      781 tgagagtcag tctcccaatg gcgtgagaac ccacttgatt gatgtgtact tggaggagct
      841 taccacagtg ggaggggcgg agctcttagc ggaccagaac ctcaagttaa tcgatccatt
      901 ctgcagaatt gctgccaaga ctaaggacca cacgctggta cagactgtag cgaggggtgt
      961 ttttgaagtc attgtagatc agtctgcctg tgtacctcaa gagtctgtgg aggagcggaa
     1021 aaccaaagag gatggcagtg gcttccctac gaaggcgttg gcctgtagga aggcagtcag
     1081 tgggaagaag gctgcactag acgaatgcct cagagacgga gtcattggca gcagagaaag
     1141 agacatctgt gcagccttga aagattcagg gtcacctctc cagtttgact ataaggctgt
     1201 tgctgatcga ctcctggaaa tagccaactc aaaaagcacc ccgcctttca acaggaagcg
     1261 actctgcaga ctagtcagaa agttccagga cctctgtgaa ggcaatggtg ctccactcag
     1321 ttctgctgag gacaacggtc agagaaggca caagaggaaa agaaagaagc ttttagagag
     1381 tgagaaagga gacacggtct ctcctgctgc tgaagaggac agcggaggcc acattcacaa
     1441 gaagaaaagg aaaaagagga agaggagtca cttccagcct gacactcaga acctggacgc
     1501 tgttgccgtg cccaaagtac cggattcgga gagtgagcct gacactgccc agaggcaggc
     1561 cccgtgtggg caagcgtgtg tgactgagcc tacagcagag gctgtgtcca gcatcgggga
     1621 gaacagctcc aagcctacac ccgtcatgcc catacacaat aaaagaaaac ggccgagaaa
     1681 gaagaaactg agggcccaca aagagatctg caaatccacc actttacctc aggaggacat
     1741 gtcaaagaat gacgctgtca gtgggcattc tcagagctct gctgcccaca tttcttcctc
     1801 agaaggtgtc caagcccaga aaaggaaacg gaaactggga gctctccctg acagcagtag
     1861 tgacctacct gtacagaagt cagggacccc aacaagccca gtggagggga aggatggcca
     1921 gaccaccctg ccccggtgta agaggtcaca aaagaagaca gcatccagca cccttgaccc
     1981 ctgtgatccg tccagtcaaa aaccagcaat ctcaaaaaag aagaagaaaa ctatgaagct
     2041 gatgtcaaac ggtgtgttgg agtccaaccc tgggcagatc caagctctgg gaagcaacag
     2101 gactctgaag aagccgctga aaacggagga cgactttgtg aagtttgaca ctcggttctt
     2161 accaaagccc ctgttcttca ggaaagccaa gaacagctct gccacccgtc cccaaggtcc
     2221 tgctggccag ctgaataaaa caccctccag ttccaagaaa gtcacctttg gattgaacag
     2281 aaacatgact gcagaattta agaagacaga caagagtatc ctggtcagcc ccacaggcct
     2341 ctccagagtg gcctttaacc ctgagcagag gccactccac ggagtgctga agaccgccac
     2401 gagctccccg gccagcactc ctctgtcgcc catgaggcta ccagccacca ccccaaagag
     2461 aaggccaagg gctgcggact tcttctgaga gccagaagcc ctttctgaag cctgctttta
     2521 taccggatgt tctataaatt ataactttta aagttgggct ttttaattac tttacaaata
     2581 cccatgagtg ggacagatgt tctgaacctg gaccacaggc cttcctgcta ggcttgcagc
     2641 ccacggtgca catctgcgca caccctcact gaggactgag tgctgttggt acacggagcc
     2701 ccctcctcca tacccattgc tgcaccacca ctgtggattg cacgcctttc tgggtggctg
     2761 cagtctctgt cccttgtgaa agcatggcag cttcaggccc atctgcgggc atgtggctgt
     2821 ttttcctggg attgactcct gaaatggaat gagcaatagt gtagcttttc tacgggtgac
     2881 cagcaggagg ctagacaggt gggggggtag gggaaagcca cttttcccgg aggcttctcc
     2941 tcctctgcct ggcctgttcc tgtccctgtc ttcctacctc tatagcaagc ccaaagtgtc
     3001 ttttcaggag ggccagtagc ccccaggctg ctgcccacat tagcacagtt ttcccagggc
     3061 ctccctgact gcaccagtag ggtctggacc ccagctcttg cctgacctgg aagttggctg
     3121 cccaggagta gaagcctgtt agctgcctcc atgggtttta tacagctctt cttgcttagt
     3181 gcggaaccca gggagctgct cagacttcca ccaaagcaaa tctggctcct tctttagaga
     3241 gaagcctacg tggcgactgc tcttatttaa ggaaaccacc ttgggtctga gaggtggaga
     3301 ggccgtggga ttaagcacaa taggaggcgc agctcctgct tctaccgtta ggcgctgcag
     3361 gcttgaagtg gcaaggccct gcatctcaag cactcagagc tctgtgagct tgcctactgt
     3421 gcgcaggatc tccccaagta tgtcctactc tgtgcaccct gtgctggagc cctacttttc
     3481 accccgctgc ccctcgggag gactgcagct cgctcctgtt gggatcgcaa agctcgggta
     3541 cctgccccgg ctttgctcca cacagtcacg gggtccattt ccaagtcgtc ttttttgttt
     3601 gtttgtttgt ttgtttgttt gtttgtttgt tttttccaga caggatttct ctgtgtagcc
     3661 ctggccgtcc tggaactcac tttgtagatc aggctggcct cgaactcaga aatcggcctg
     3721 cctctgcctc ccgagtgctg ggattaaagg cgtgcgccac cacgtctggc tccatttcta
     3781 agtcttgaac caactgactc ccgaatgcca ttcccggaag gaaccaagtg gtgactttgt
     3841 cctctgcctg ctcagtcaca aagtatatca ctaggccata aaaatggaga tgatgttttg
     3901 cttgtgtcac agtaggtctt gtgcagtgtc acttgtagtt gcatggttac agcgtgctga
     3961 gtttgaccat tacattcaaa actaaaacct gtgtaggaag gttaaggtcg tggcagcaga
     4021 tgcctagctt cttatttaaa aagttgagtg cacccagcca ttttctgttt taaagatagg
     4081 ttaatatagc caagagggtc atacagccca gtggtgtaga gcaagacacc aggtagcagt
     4141 aatagaaaac aacctcacac cattttcaca atggccgccc atcctcgggg actgtgagtg
     4201 tccttgtctt agtcaaagca catctcctac caaaattgct cccaagatgg agggtgagac
     4261 ctcagtgcta ggttgacagg tgggcgtcgc catgcctgga ccaattcctg cacagcacag
     4321 gaaggctcca ctccatgaag gagtgcattt agaatggcat cctggtcctg gatgcagatt
     4381 ctcaagtaaa attgctgtta aatttcttca agtccagaga agcaaatctt agtgcgggca
     4441 gaccgagtta gtgtttgatg cgactatctc catccttagt atggatgtgg tcagttctgc
     4501 acaatttggt ttcaaactaa cttttttttc tttccttttt aaaaataata ataatgtctc
     4561 agtatgtatc ctatcccaca ctggccccac accggtggtc tccctgcctc agccaggcta
     4621 ctgctgggac acgcacagga aggagcatga gggggggttg ggaagcagtc gcctgcctgg
     4681 gaagtgggtc tgtgttttct ctaactgcca cagtgctatt tgtttaccat caaattgtat
     4741 tggtgtttcc agggcttgtt ggtacaaatc aaagccaaga ccaattaaaa gaaatgtatt
     4801 tttatcttc
//
