LOCUS       NP_082520                724 aa            linear   ROD 28-APR-2025
DEFINITION  ribosomal RNA processing protein 1 homolog B isoform 1 [Mus
            musculus].
ACCESSION   NP_082520 NP_899035
VERSION     NP_082520.2
DBSOURCE    REFSEQ: accession NM_028244.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 724)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 724)
  AUTHORS   Lee,M., Dworkin,A.M., Gildea,D., Trivedi,N.S., Moorhead,G.B. and
            Crawford,N.P.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     RRP1B is a metastasis modifier that regulates the expression of
            alternative mRNA isoforms through interactions with SRSF1
  JOURNAL   Oncogene 33 (14), 1818-1827 (2014)
   PUBMED   23604122
  REMARK    GeneRIF: RRP1B suppresses metastatic progression by altering the
            transcriptome through its interaction with splicing regulators such
            as SRSF1
REFERENCE   3  (residues 1 to 724)
  AUTHORS   Yu,T., Clapcote,S.J., Li,Z., Liu,C., Pao,A., Bechard,A.R.,
            Carattini-Rivera,S., Matsui,S., Roder,J.C., Baldini,A.,
            Mobley,W.C., Bradley,A. and Yu,Y.E.
  TITLE     Deficiencies in the region syntenic to human 21q22.3 cause
            cognitive deficits in mice
  JOURNAL   Mamm Genome 21 (5-6), 258-267 (2010)
   PUBMED   20512340
REFERENCE   4  (residues 1 to 724)
  AUTHORS   Crawford,N.P., Yang,H., Mattaini,K.R. and Hunter,K.W.
  TITLE     The metastasis efficiency modifier ribosomal RNA processing 1
            homolog B (RRP1B) is a chromatin-associated factor
  JOURNAL   J Biol Chem 284 (42), 28660-28673 (2009)
   PUBMED   19710015
  REMARK    GeneRIF: RRP1B, a tumor progression and metastasis susceptibility
            candidate gene, is potentially a dynamic modulator of transcription
            and chromatin structure
REFERENCE   5  (residues 1 to 724)
  AUTHORS   Crawford,N.P., Qian,X., Ziogas,A., Papageorge,A.G., Boersma,B.J.,
            Walker,R.C., Lukes,L., Rowe,W.L., Zhang,J., Ambs,S., Lowy,D.R.,
            Anton-Culver,H. and Hunter,K.W.
  TITLE     Rrp1b, a new candidate susceptibility gene for breast cancer
            progression and metastasis
  JOURNAL   PLoS Genet 3 (11), e214 (2007)
   PUBMED   18081427
REFERENCE   6  (residues 1 to 724)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (residues 1 to 724)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (residues 1 to 724)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (residues 1 to 724)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033797.5.
            
            On Jul 30, 2009 this sequence version replaced NP_082520.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016569.1, SRR9219382.133111.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.34 cM"
     Protein         1..724
                     /product="ribosomal RNA processing protein 1 homolog B
                     isoform 1"
                     /note="ribosomal RNA processing protein 1 homolog B;
                     RRP1-like protein B; ribosomal RNA processing 1 homolog B"
                     /calculated_mol_wt=80451
     Region          11..218
                     /region_name="Nop52"
                     /note="Nucleolar protein,Nop52; pfam05997"
                     /db_xref="CDD:461800"
     Region          331..576
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            370
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            432
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            438
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            494
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            618
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Region          625..649
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            668
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            672
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Region          687..724
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            694
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            698
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     Site            701
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14684; propagated from
                     UniProtKB/Swiss-Prot (Q91YK2.2)"
     CDS             1..724
                     /gene="Rrp1b"
                     /gene_synonym="2600005C20Rik; D030064A17; Kiaa0179;
                     mKIAA0179"
                     /coded_by="NM_028244.2:314..2488"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28613.1"
                     /db_xref="GeneID:72462"
                     /db_xref="MGI:MGI:1919712"
ORIGIN      
        1 malamqssef qfaqrlasse kgvrdravrk lrqylsartq sdtgsfsqee llkiwkglfy
       61 cmwvqdepll qeelaniisq lihvvnslea qylfiqtfwq tmnrewqgid klqldkyyml
      121 irlvlrqsfe vlkrnawees qitlfldilm keilspesqs pngvrthlid vyleelttvg
      181 gaelladqnl klidpfcria aktkdhtlvq tvargvfevi vdqsacvpqe sveerktked
      241 gsgfptkala crkavsgkka aldeclrdgv igsrerdica alkdsgsplq fdykavadrl
      301 leianskstp pfnrkrlcrl vrkfqdlceg ngaplssaed ngqrrhkrkr kkllesekgd
      361 tvspaaeeds gghihkkkrk krkrshfqpd tqnldavavp kvpdsesepd taqrqapcgq
      421 acvteptaea vssigenssk ptpvmpihnk rkrprkkklr ahkeickstt lpqedmsknd
      481 avsghsqssa ahisssegvq aqkrkrklga lpdsssdlpv qksgtptspv egkdgqttlp
      541 rckrsqkkta sstldpcdps sqkpaiskkk kktmklmsng vlesnpgqiq algsnrtlkk
      601 plkteddfvk fdtrflpkpl ffrkaknssa trpqgpagql nktpssskkv tfglnrnmta
      661 efkktdksil vsptglsrva fnpeqrplhg vlktatsspa stplspmrlp attpkrrpra
      721 adff
//
