LOCUS       NM_199476               4543 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ribonucleotide reductase M2 B (TP53 inducible)
            (Rrm2b), transcript variant 1, mRNA.
ACCESSION   NM_199476 XM_356784
VERSION     NM_199476.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4543)
  AUTHORS   Chatterji,A., Holmgren,A. and Sengupta,R.
  TITLE     Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and
            p53R2 subunits of mammalian class I ribonucleotide reductase
            protein
  JOURNAL   Mol Biol Rep 48 (11), 7621-7626 (2021)
   PUBMED   34599703
  REMARK    GeneRIF: Ribonucleotide reductase: In-vitro S-glutathionylation of
            R2 and p53R2 subunits of mammalian class I ribonucleotide reductase
            protein.
REFERENCE   2  (bases 1 to 4543)
  AUTHORS   Molina-Jijon,E., Gambut,S., Mace,C., Avila-Casado,C. and
            Clement,L.C.
  TITLE     Secretion of the epithelial sodium channel chaperone PCSK9 from the
            cortical collecting duct links sodium retention with
            hypercholesterolemia in nephrotic syndrome
  JOURNAL   Kidney Int 98 (6), 1449-1460 (2020)
   PUBMED   32750454
REFERENCE   3  (bases 1 to 4543)
  AUTHORS   Loupe,J.M., Pinto,R.M., Kim,K.H., Gillis,T., Mysore,J.S.,
            Andrew,M.A., Kovalenko,M., Murtha,R., Seong,I., Gusella,J.F.,
            Kwak,S., Howland,D., Lee,R., Lee,J.M., Wheeler,V.C. and
            MacDonald,M.E.
  TITLE     Promotion of somatic CAG repeat expansion by Fan1 knock-out in
            Huntington's disease knock-in mice is blocked by Mlh1 knock-out
  JOURNAL   Hum Mol Genet 29 (18), 3044-3053 (2020)
   PUBMED   32876667
  REMARK    GeneRIF: Promotion of somatic CAG repeat expansion by Fan1
            knock-out in Huntington's disease knock-in mice is blocked by Mlh1
            knock-out.
REFERENCE   4  (bases 1 to 4543)
  AUTHORS   Chen,Y.F., Lin,I.H., Guo,Y.R., Chiu,W.J., Wu,M.S., Jia,W. and
            Yen,Y.
  TITLE     Rrm2b deletion causes mitochondrial metabolic defects in renal
            tubules
  JOURNAL   Sci Rep 9 (1), 13238 (2019)
   PUBMED   31519977
  REMARK    GeneRIF: Rrm2b deletion causes mitochondrial metabolic defects in
            renal tubules.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4543)
  AUTHORS   Xue,L., Liu,X., Wang,Q., Liu,C.Q., Chen,Y., Jia,W., Hsie,R.,
            Chen,Y., Luh,F., Zheng,S. and Yen,Y.
  TITLE     Ribonucleotide reductase subunit M2B deficiency leads to
            mitochondrial permeability transition pore opening and is
            associated with aggressive clinicopathologic manifestations of
            breast cancer
  JOURNAL   Am J Transl Res 10 (11), 3635-3649 (2018)
   PUBMED   30662615
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4543)
  AUTHORS   Strand,K.R., Karlsen,S., Kolberg,M., Rohr,A.K., Gorbitz,C.H. and
            Andersson,K.K.
  TITLE     Crystal structural studies of changes in the native dinuclear iron
            center of ribonucleotide reductase protein R2 from mouse
  JOURNAL   J Biol Chem 279 (45), 46794-46801 (2004)
   PUBMED   15322079
REFERENCE   7  (bases 1 to 4543)
  AUTHORS   Kimura,T., Takeda,S., Sagiya,Y., Gotoh,M., Nakamura,Y. and
            Arakawa,H.
  TITLE     Impaired function of p53R2 in Rrm2b-null mice causes severe renal
            failure through attenuation of dNTP pools
  JOURNAL   Nat Genet 34 (4), 440-445 (2003)
   PUBMED   12858174
  REMARK    GeneRIF: Rrm2b deficiency caused higher rates of spontaneous
            mutation in the kidneys of Rrm2b-/- mice. p53R2 has a pivotal role
            in maintaining dNTP levels for repair of DNA in resting cells.
REFERENCE   8  (bases 1 to 4543)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4543)
  AUTHORS   Guittet,O., Hakansson,P., Voevodskaya,N., Fridd,S., Graslund,A.,
            Arakawa,H., Nakamura,Y. and Thelander,L.
  TITLE     Mammalian p53R2 protein forms an active ribonucleotide reductase in
            vitro with the R1 protein, which is expressed both in resting cells
            in response to DNA damage and in proliferating cells
  JOURNAL   J Biol Chem 276 (44), 40647-40651 (2001)
   PUBMED   11517226
REFERENCE   10 (bases 1 to 4543)
  AUTHORS   Tanaka,H., Arakawa,H., Yamaguchi,T., Shiraishi,K., Fukuda,S.,
            Matsui,K., Takei,Y. and Nakamura,Y.
  TITLE     A ribonucleotide reductase gene involved in a p53-dependent
            cell-cycle checkpoint for DNA damage
  JOURNAL   Nature 404 (6773), 42-49 (2000)
   PUBMED   10716435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122291.4.
            
            On Feb 8, 2023 this sequence version replaced NM_199476.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058103.1, SRR7652917.958953.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AC122291.4         103125-103366       c
            243-398             AC122291.4         95880-96035         c
            399-515             AC122291.4         89016-89132         c
            516-649             AC122291.4         87320-87453         c
            650-744             AC122291.4         86779-86873         c
            745-878             AC122291.4         79497-79630         c
            879-983             AC122291.4         73883-73987         c
            984-1097            AC122291.4         71319-71432         c
            1098-4543           AC122291.4         66233-69678         c
FEATURES             Location/Qualifiers
     source          1..4543
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.1 cM"
     gene            1..4543
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /note="ribonucleotide reductase M2 B (TP53 inducible)"
                     /db_xref="GeneID:382985"
                     /db_xref="MGI:MGI:2155865"
     exon            1..242
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1250
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /EC_number="1.17.4.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribonucleoside-diphosphate reductase subunit M2 B;
                     TP53-inducible ribonucleotide reductase M2 B;
                     p53-inducible ribonucleotide reductase small subunit
                     2-like protein"
                     /codon_start=1
                     /product="ribonucleoside-diphosphate reductase subunit M2
                     B isoform 1"
                     /protein_id="NP_955770.1"
                     /db_xref="CCDS:CCDS27437.1"
                     /db_xref="GeneID:382985"
                     /db_xref="MGI:MGI:2155865"
                     /translation="MGDPERPEAARPEKGEQLCSETEENVVRSNEEPLLRKSSRRFVI
                     FPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGI
                     VNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIE
                     TMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLT
                     FSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIG
                     MNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRF
                     AVMAETTDNVFTLDADF"
     exon            243..398
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..515
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..649
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..744
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..878
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /inference="alignment:Splign:2.1.0"
     exon            879..983
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1097
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..4543
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4523..4528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /note="hexamer: AATAAA"
     polyA_site      4543
                     /gene="Rrm2b"
                     /gene_synonym="p53R2"
                     /note="major polyA site"
ORIGIN      
        1 aggcgccgag agtagcgtgc ctgggcggag ccaccgcaga gaaggcccct caatgggccg
       61 gctagaaccc aggaccggcg cggcaaggcg tgcccggagc aggaggaggt tcgcacagga
      121 cgatctgatc ctactaggat ttggtcggcc gcgctcagtt cctcagctcg ggtggctctg
      181 gtggagtctg cgcgatgggc gacccggaaa ggccggaagc ggccaggccg gagaagggtg
      241 agcaattgtg ttcggagaca gaagaaaatg tggtgaggtc aaatgaagag ccactcctaa
      301 gaaagagttc ccgacggttc gtcatctttc caatccagta tcctgatatc tggagaatgt
      361 acaagcaagc acaggcatct ttctggacag cagaggaggt tgacttgtca aaggacctcc
      421 ctcactggaa caagcttaaa tccgacgaga agtattttat ctcccacatc ttagcctttt
      481 ttgcagccag tgatggaatt gtaaatgaaa acttggtgga gcgttttagt caggaggtgc
      541 aggttccaga ggctcgctgc ttctatggct ttcagattct catcgagaat gttcactcag
      601 agatgtacag tttactaata gacacttaca tcagagatcc aaagaaaagg gaatttttat
      661 ttaatgcaat tgaaacaatg ccatatgtta agaaaaaagc ggactgggct ctgcgctgga
      721 tagcagatag gaaatctact tttggggaaa gagtggtggc ctttgctgct gtggaaggaa
      781 ttttcttctc tggatcattt gctgcaatat tctggctaaa gaagagaggc ctcatgcctg
      841 gactgacttt ttcaaatgaa ctgatcagca gggatgaagg acttcactgt gactttgcct
      901 gcctgatgtt tcagtacttg gtaaacaagc cttcagaaga tagagtgagg gaaatcattg
      961 ctgatgctgt tcaaatcgag caggagtttt taacagaagc cttgcctgtt ggcctcattg
     1021 gaatgaactg tgttttgatg aaacagtaca ttgagtttgt agctgacaga ttacttggag
     1081 aacttggatt ctcaaagatt tttcaggcag aaaatccctt tgattttatg gagaacattt
     1141 cattagaagg gaaaacaaat ttctttgaga aacgagtttc tgagtatcag cgatttgcag
     1201 tcatggccga aaccacagat aatgtcttca ccttggatgc agatttctaa agccctcctc
     1261 atttaaaaaa aaaaatctat agaattcggc tgtggtagta catgccttag tccagtcctc
     1321 agaggaagct gagggcacgt ggatctctgg gtttgaggat gatcagggat acatactgag
     1381 atctatctca aaagcaacag aacagcgaaa acaaacaaaa cacatggaaa cctgttgttg
     1441 gtaaatagca atctattttt gtctttttga aactttcagt atctcattta agggaatgag
     1501 aatttgaata gaaggaaata taaaactaaa ttctaaatga tttaatttta tctaaatgta
     1561 cttcagttta tttatacaat gaaagtgtga ccaatatgtc tttttttttt cctttttgtc
     1621 ataagcactt aagatggcat taagagcata gatttaggag tcaggtatga gcttgatatt
     1681 ctggcttact ccttgatgtg accttggcaa gtcagttagt cactgtaaac gtcaggatat
     1741 ttatctgtaa aatttgtata atagtaagtc ccaagttcat ggaggtgacc agagggctaa
     1801 tatacagaaa tagtttgttt atctaatact tttatctcca ctgcctcacc tgctaattaa
     1861 tattagtgag aagatcaagt acagtggcgt tgtgatgcag tccactcctc gccagagagt
     1921 gactgagggg tggattgaga taaagaattc attgaatctt tgtggtttta atgtttgcag
     1981 gaggaatata agggtctcct tagagagatc ataattcttg tcaactgctt tgaattcatt
     2041 aatctgcagt aaagaaataa tatatagctc ttaattgctt atcgtgggag gcttatggag
     2101 tagtagactc caggttacca tggttgtggt tcttgtaagc aaagtgattc ttctttagga
     2161 attaaaagga taactgttgc cagggacagc ccaggggtgt ttagaacctg gattgatggg
     2221 catttctcaa agttgtcttc tcaaacctgg tagatcttca gagttcttgt gatggaaaaa
     2281 gagatgcagt cagtgggctt ggggaaggct gagcattcca tccctgccta gaatgcagtc
     2341 tgcaaagcag ctgcccacat gtacacaaca caaggctgtc agcacctccc acagctactg
     2401 agtgcactgg ggaaagctgt cctagaatca tttatacaca ctggaaatgg agaaaagaag
     2461 ggaggtggga gggactagtg aaccattttg gatttgtgcc aatctgagaa agtgatttaa
     2521 ggttgacgtc atctttatat ccttatactc ttaagtctct acactgttat aaaggaatgt
     2581 tcttttaatg gactgtctat aagggagatg gaagtctttc taagaaagat gcagagaggc
     2641 caggagccag gacacctggg caatgtgccc ttcctcattt tcaggaaagt atcaagagga
     2701 agcctaaacc ccatcaaacc cggtccctgg ctcagtaaag ttcctgctac tcaagtgtga
     2761 ggtcctgaat ccagatccct agcatagcac acacgcacac acgtacacat gcacacacgc
     2821 acacaccacc tgtacatgca cacatatgca cacacacaga gtacaaataa aatgatggca
     2881 gctgaaattc agaggtttat ctctgttgaa gtttttattc tatttgctct acaactatct
     2941 gatcaaaact cggaatccta aatgaatgca agccatactt ccattgttaa agggagcacc
     3001 agaaatgaaa catggctctg tgcttcccat ttgtcatgtt atcacccagt agccctctaa
     3061 gcacgacaga gtagctatta ctaaaacatg gagagaggaa ggaaggcatc agagaagctg
     3121 aaaaacttaa ctttacaggc actgtcctat aatatgttga gactgttaca tcctttaaac
     3181 ttcatccatc atgatttatt ttgtctattc tttcattaat taaactattg catactacta
     3241 taacagagta tcaaaatatc atagaactcg gggtatgtgg gtagtatatt ccaaggtatt
     3301 catccactat tatacaaaaa cagctaaaac ttaaattacc acagactgaa agaaaacagt
     3361 tttaaaggtg tacattctca aagttttaaa cccggttctt cataagtagt gacaggaacc
     3421 tttatgtgat acatgttaat agtagcaata agcaaaactg tatttgaaag aagtcttaat
     3481 tctgaaaaac tgaattctta gtacactgtt acattactac tctcagtatt ctgtatccct
     3541 tcagtgcctc caggttgcac atttatttat tatgtttagt attttggttc ttagatatgg
     3601 aaaaatcaag ttataaaata tctttttaat atctcacaga taacaaaaaa atcaaggtaa
     3661 tgccatctct ctctctctct ctctctctct cttttttttt acagtacatg cgtttcaaag
     3721 aagtgcaatt tgtcctagag ttatgttttt atatttcaag atgataaaca gctttgttat
     3781 gaccatagtt taaataaatg tttcaacacc tagaatcatg atgtagagga actttggatg
     3841 aattttttgc agggctgagt ttcaataatt aagagttatt tttgtggata gatcactccc
     3901 agccatatct tattatttga acctgttaca gttgtttcat ttaaaaatct ccagattcta
     3961 tttatgtagc tactttatta tgtttatttt ccttctttta gttggtgtct catgtggtct
     4021 ggcctggatc tcacacataa ccctcttgct tcagcctccc agtccctggg gttattggtg
     4081 tgtgatgcca tgcccagcta ccactttatg ttctgtgcat gaagaaatgt agtgttcata
     4141 tttaaaaata atttaatatt caaaattttg tattttatat ttaaatgtta ttatgtcatt
     4201 ttcaaagact ccagattttt ttcacaatta agcaaagact ccaatgtcac ttcattgata
     4261 tggaaactct tgatgggcta cattcaggac aaattagttc taaagtcaaa aatcatgttt
     4321 tgaattcact gagggagttg tcacccagct cagacagaac ttggggctgg taatgatcat
     4381 ttaactaaat tactaattat ttaaacaagt ttattagaca tggtgttcct aaatatattt
     4441 tgttaaaata cattatggta gtaaaaccaa ttctgcatgt agagtttgag gtttttttgc
     4501 tctgaaaaat tatgactttt aaaataaagt ttactgaaat aaa
//
