LOCUS       NM_009104               2199 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus ribonucleotide reductase M2 (Rrm2), mRNA.
ACCESSION   NM_009104
VERSION     NM_009104.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2199)
  AUTHORS   Wu,L.F., Zhou,Z.J., Zeng,Y.H., Yang,S.L. and Zhang,Q.Y.
  TITLE     Circular RNA RRM2 alleviates metabolic dysfunction-associated
            steatotic liver disease by targeting miR-142-5p to increase NRG1
            expression
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 327 (4), G485-G498 (2024)
   PUBMED   39259911
  REMARK    GeneRIF: Circular RNA RRM2 alleviates metabolic
            dysfunction-associated steatotic liver disease by targeting
            miR-142-5p to increase NRG1 expression.
REFERENCE   2  (bases 1 to 2199)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2199)
  AUTHORS   He,S., He,Y., Deng,L., Guo,Y., Wang,X., Wang,Q., Luo,L. and Liu,Q.
  TITLE     Identification of RRM2 as a key ferroptosis-related gene in sepsis
  JOURNAL   Inflamm Res 73 (3), 459-473 (2024)
   PUBMED   38286859
  REMARK    GeneRIF: Identification of RRM2 as a key ferroptosis-related gene
            in sepsis.
REFERENCE   4  (bases 1 to 2199)
  AUTHORS   Giang,L.H., Wu,K.S., Lee,W.C., Chu,S.S., Do,A.D., Changou,C.A.,
            Tran,H.M., Hsieh,T.H., Chen,H.H., Hsieh,C.L., Sung,S.Y., Yu,A.L.,
            Yen,Y., Wong,T.T. and Chang,C.C.
  TITLE     Targeting of RRM2 suppresses DNA damage response and activates
            apoptosis in atypical teratoid rhabdoid tumor
  JOURNAL   J Exp Clin Cancer Res 42 (1), 346 (2023)
   PUBMED   38124207
  REMARK    GeneRIF: Targeting of RRM2 suppresses DNA damage response and
            activates apoptosis in atypical teratoid rhabdoid tumor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2199)
  AUTHORS   Corrales-Guerrero,S., Cui,T., Castro-Aceituno,V., Yang,L., Nair,S.,
            Feng,H., Venere,M., Yoon,S., DeWees,T., Shen,C. and Williams,T.M.
  TITLE     Inhibition of RRM2 radiosensitizes glioblastoma and uncovers
            synthetic lethality in combination with targeting CHK1
  JOURNAL   Cancer Lett 570, 216308 (2023)
   PUBMED   37482342
  REMARK    GeneRIF: Inhibition of RRM2 radiosensitizes glioblastoma and
            uncovers synthetic lethality in combination with targeting CHK1.
REFERENCE   6  (bases 1 to 2199)
  AUTHORS   Fisher,A., Laub,P.B. and Cooperman,B.S.
  TITLE     NMR structure of an inhibitory R2 C-terminal peptide bound to mouse
            ribonucleotide reductase R1 subunit
  JOURNAL   Nat Struct Biol 2 (11), 951-955 (1995)
   PUBMED   7583667
REFERENCE   7  (bases 1 to 2199)
  AUTHORS   MacLaren,D.C., O'Connor,C.M., Xia,Y.R., Mehrabian,M., Klisak,I.,
            Sparkes,R.S., Clarke,S. and Lusis,A.J.
  TITLE     The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1)
            maps to human chromosome 6q22.3-6q24 and the syntenic region of
            mouse chromosome 10
  JOURNAL   Genomics 14 (4), 852-856 (1992)
   PUBMED   1478665
REFERENCE   8  (bases 1 to 2199)
  AUTHORS   Thelander,M. and Thelander,L.
  TITLE     Molecular cloning and expression of the functional gene encoding
            the M2 subunit of mouse ribonucleotide reductase: a new dominant
            marker gene
  JOURNAL   EMBO J 8 (9), 2475-2479 (1989)
   PUBMED   2684652
REFERENCE   9  (bases 1 to 2199)
  AUTHORS   Yang-Feng,T.L., Barton,D.E., Thelander,L., Lewis,W.H.,
            Srinivasan,P.R. and Francke,U.
  TITLE     Ribonucleotide reductase M2 subunit sequences mapped to four
            different chromosomal sites in humans and mice: functional locus
            identified by its amplification in hydroxyurea-resistant cell lines
  JOURNAL   Genomics 1 (1), 77-86 (1987)
   PUBMED   3311968
REFERENCE   10 (bases 1 to 2199)
  AUTHORS   Thelander,L. and Berg,P.
  TITLE     Isolation and characterization of expressible cDNA clones encoding
            the M1 and M2 subunits of mouse ribonucleotide reductase
  JOURNAL   Mol Cell Biol 6 (10), 3433-3442 (1986)
   PUBMED   3025593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085136.1 and BF468116.2.
            
            On May 14, 2009 this sequence version replaced NM_009104.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085136.1, AK147111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2142              BC085136.1         1-2142
            2143-2199           BF468116.2         24-80               c
FEATURES             Location/Qualifiers
     source          1..2199
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.5 cM"
     gene            1..2199
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /note="ribonucleotide reductase M2"
                     /db_xref="GeneID:20135"
                     /db_xref="MGI:MGI:98181"
     exon            1..192
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1266
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /EC_number="1.17.4.1"
                     /note="ribonucleotide reductase small chain;
                     ribonucleoside-diphosphate reductase M2 chain;
                     ribonucleotide reductase small subunit"
                     /codon_start=1
                     /product="ribonucleoside-diphosphate reductase subunit M2"
                     /protein_id="NP_033130.1"
                     /db_xref="CCDS:CCDS25844.1"
                     /db_xref="GeneID:20135"
                     /db_xref="MGI:MGI:98181"
                     /translation="MLSVRTPLATIADQQQLQLSPLKRLTLADKENTPPTLSSTRVLA
                     SKAARRIFQDSAELESKAPTNPSVEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASF
                     WTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEAR
                     CFYGFQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVKKKADWALRWIGDK
                     EATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACL
                     MFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLML
                     ELGFNKIFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSTENSFTLDADF"
     exon            193..267
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..414
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..531
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..665
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..760
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..894
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..999
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1113
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..2180
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1314..1319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /note="hexamer: AAGAAA"
     polyA_site      1332
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /note="major polyA site"
     regulatory      2104..2109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /note="hexamer: AATAAA"
     polyA_site      2131
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /note="major polyA site"
     regulatory      2150..2155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rrm2"
                     /gene_synonym="R2"
                     /note="hexamer: ATTAAA"
     polyA_site      2169
                     /gene="Rrm2"
                     /gene_synonym="R2"
ORIGIN      
        1 tttaaagggc gcgggcgctg gcagtcggcg gtgcaccgga ttccagctgt tttcgcctgc
       61 tcctcgccgt ctccgccgct gccctcgttc gccatgctct ccgtccgcac cccgctcgcc
      121 accatcgctg accagcagca gctgcagttg tcgccgctga agcgactcac cctggctgac
      181 aaggagaaca cgcccccgac tctcagcagc acccgcgtcc tggccagcaa agctgcgagg
      241 agaatcttcc aggactccgc cgagctggaa agtaaagcgc ctactaaccc cagcgttgag
      301 gatgagccgt tactgagaga aaacccccgc cgcttcgttg tctttcccat cgagtaccat
      361 gatatctggc agatgtacaa gaaagccgag gcctcctttt ggactgccga ggaggtggac
      421 ctttccaagg atattcagca ctgggaagct ctgaaacccg atgagagaca ttttatatct
      481 cacgttctgg ctttctttgc agcgagtgat ggcatagtca atgagaactt ggtggagcga
      541 tttagccaag aagttcaagt tacagaggcc cgctgtttct atggcttcca aattgccatg
      601 gaaaacatac actctgaaat gtacagtctc cttattgaca cttacattaa agatcccaag
      661 gaaagagaat atctcttcaa tgctattgaa acaatgcctt gtgtgaagaa gaaggctgac
      721 tgggccttgc gctggattgg ggacaaagag gctacgtatg gagaacgcgt tgtggccttt
      781 gccgccgtag aaggaatctt cttttccggt tcttttgcat cgatattctg gctcaagaaa
      841 cgggggctga tgccgggcct tacattttcc aatgagctta ttagcagaga cgagggttta
      901 cactgtgact ttgcctgcct gatgttcaag cacctggtac acaagccagc agagcagagg
      961 gtccgagaga taatcaccaa cgccgttagg atagagcagg agttcctcac ggaggccttg
     1021 cccgtgaagc tcatcgggat gaactgcact ttgatgaagc agtacattga gtttgtggcc
     1081 gacaggctta tgctggagct gggttttaac aagattttca gagtagaaaa tccgtttgac
     1141 ttcatggaaa atatctcact agaaggaaag acaaacttct ttgagaagcg agtaggcgag
     1201 tatcagagga tgggagtcat gtcgaattcg acagagaact cttttacctt ggatgctgac
     1261 ttctaagtaa ctgatcgtgt gttcttcgct gatttttgtc cccttgccat taaaagaaac
     1321 cagcaaaaac aaccaactgg ctacaccatg aattgtcatt aaatttgcta aacaggtgtc
     1381 taaaaagctg tgtagctacc tcagtcctgt ttgccaggct ggtcactaga agaaagtata
     1441 cttcaaacaa tgggtacttg gatccttagg gagatcctgt ccttggcttt tacaagtagt
     1501 gtggtcacct ttgacctcat caaagtacta acagcactgg gccaggtttt aggagcagtg
     1561 accatcaagc aagcaggttt aaacatttag atgctgttta gggctgttta aagatgtcgg
     1621 actgcttcct gcaggcatgc agggtctact taacaagttt gtaaataaaa ttggcacttt
     1681 gcacacacac acacatagtg ctgtcaggcg attaaactat acattttatg aggtagtacc
     1741 tctatgcttt tttttttttt ttttaatgct cagtattatc ttgaagtttg caaatgctat
     1801 gatggtacag taaattctga catttgccct aatagtgtca cttttttttt ttcttcgaga
     1861 cagagtttct ctgtatagcc ctggctgtac ggaattcaca agtgagtttg agcccagtgg
     1921 tgggtacacc cgtgggactc ttacaaacca aaacaggaaa agcaagtgtt ccctgaggta
     1981 gtttactgtg atctagcttc ctcatgaact gacataaccc tgatcagttt ccttgattat
     2041 tgtatagatg tttttgtaat atgaaaagcc tttgtacctt ttaaattatt gttacttaaa
     2101 attaataaac tcttgaatta acagtcttga actttcatgg catacaagta ttaaatgatt
     2161 taactaaaac cttaatgtca aaaaaaaaaa aaaaaaaaa
//
