LOCUS       NM_009103               3997 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus ribonucleotide reductase M1 (Rrm1), mRNA.
ACCESSION   NM_009103
VERSION     NM_009103.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3997)
  AUTHORS   Tran,P., Mishra,P., Williams,L.G., Moskalenko,R., Sharma,S.,
            Nilsson,A.K., Watt,D.L., Andersson,P., Bergh,A., Pursell,Z.F. and
            Chabes,A.
  TITLE     Altered dNTP pools accelerate tumor formation in mice
  JOURNAL   Nucleic Acids Res 52 (20), 12475-12486 (2024)
   PUBMED   39360631
REFERENCE   2  (bases 1 to 3997)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3997)
  AUTHORS   Dou,M., Li,M., Zheng,Z., Chen,Q., Wu,Y., Wang,J., Shan,H., Wang,F.,
            Dai,X., Li,Y., Yang,Z., Tan,G., Luo,F., Chen,L., Shi,Y.S., Wu,J.W.,
            Luo,X.J., Asadollahpour Nanaei,H., Niyazbekova,Z., Zhang,G.,
            Wang,W., Zhao,S., Zheng,W., Wang,X. and Jiang,Y.
  TITLE     A missense mutation in RRM1 contributes to animal tameness
  JOURNAL   Sci Adv 9 (25), eadf4068 (2023)
   PUBMED   37352351
REFERENCE   4  (bases 1 to 3997)
  AUTHORS   Carper,M.B., Troutman,S., Wagner,B.L., Byrd,K.M., Selitsky,S.R.,
            Parag-Sharma,K., Henry,E.C., Li,W., Parker,J.S., Montgomery,S.A.,
            Cleveland,J.L., Williams,S.E., Kissil,J.L., Hayes,D.N. and
            Amelio,A.L.
  TITLE     An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous
            Cell Carcinoma
  JOURNAL   Cell Rep 29 (6), 1660-1674 (2019)
   PUBMED   31693903
REFERENCE   5  (bases 1 to 3997)
  AUTHORS   Moon,S., Im,S.K., Kim,N., Youn,H., Park,U.H., Kim,J.Y., Kim,A.R.,
            An,S.J., Kim,J.H., Sun,W., Hwang,J.T., Kim,E.J. and Um,S.J.
  TITLE     Asxl1 exerts an antiproliferative effect on mouse lung maturation
            via epigenetic repression of the E2f1-Nmyc axis
  JOURNAL   Cell Death Dis 9 (11), 1118 (2018)
   PUBMED   30389914
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3997)
  AUTHORS   Albert,D.A. and Rozengurt,E.
  TITLE     Synergistic and coordinate expression of the genes encoding
            ribonucleotide reductase subunits in Swiss 3T3 cells: effect of
            multiple signal-transduction pathways
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1597-1601 (1992)
   PUBMED   1311843
REFERENCE   7  (bases 1 to 3997)
  AUTHORS   Barton,D.E., Kwon,B.S. and Francke,U.
  TITLE     Human tyrosinase gene, mapped to chromosome 11 (q14----q21),
            defines second region of homology with mouse chromosome 7
  JOURNAL   Genomics 3 (1), 17-24 (1988)
   PUBMED   3146546
REFERENCE   8  (bases 1 to 3997)
  AUTHORS   Caras,I.W. and Martin,D.W. Jr.
  TITLE     Molecular cloning of the cDNA for a mutant mouse ribonucleotide
            reductase M1 that produces a dominant mutator phenotype in
            mammalian cells
  JOURNAL   Mol Cell Biol 8 (7), 2698-2704 (1988)
   PUBMED   3043191
REFERENCE   9  (bases 1 to 3997)
  AUTHORS   Thelander,L. and Berg,P.
  TITLE     Isolation and characterization of expressible cDNA clones encoding
            the M1 and M2 subunits of mouse ribonucleotide reductase
  JOURNAL   Mol Cell Biol 6 (10), 3433-3442 (1986)
   PUBMED   3025593
REFERENCE   10 (bases 1 to 3997)
  AUTHORS   Caras,I.W., Levinson,B.B., Fabry,M., Williams,S.R. and Martin,D.W.
            Jr.
  TITLE     Cloned mouse ribonucleotide reductase subunit M1 cDNA reveals amino
            acid sequence homology with Escherichia coli and herpesvirus
            ribonucleotide reductases
  JOURNAL   J Biol Chem 260 (11), 7015-7022 (1985)
   PUBMED   2581962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102535.17 and AK168586.1.
            
            On Jul 28, 2009 this sequence version replaced NM_009103.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137075.1, AK168586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC102535.17        188552-188685       c
            135-3151            AK168586.1         2-3018
            3152-3997           AC102535.17        160609-161454       c
FEATURES             Location/Qualifiers
     source          1..3997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.72 cM"
     gene            1..3997
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /note="ribonucleotide reductase M1"
                     /db_xref="GeneID:20133"
                     /db_xref="MGI:MGI:98180"
     exon            1..349
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..2709
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /EC_number="1.17.4.1"
                     /note="ribonucleotide reductase large subunit;
                     ribonucleoside-diphosphate reductase subunit M1"
                     /codon_start=1
                     /product="ribonucleoside-diphosphate reductase large
                     subunit"
                     /protein_id="NP_033129.2"
                     /db_xref="CCDS:CCDS40049.1"
                     /db_xref="GeneID:20133"
                     /db_xref="MGI:MGI:98180"
                     /translation="MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVI
                     QGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLY
                     NYINPHNGRHSPMVASSTLDIVMANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKIN
                     GKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSC
                     FLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPML
                     RVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWI
                     PDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYA
                     IIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLA
                     LNMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGL
                     ADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCELAKEYGPYETYEGSPVSKGIL
                     QYDMWNVAPTDLWDWKPLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNI
                     YTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPDDLKQLYKT
                     VWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLR
                     TRPAANPIQFTLNKEKLKDKEKALKEEEEKERNTAAMVCSLENREECLMCGS"
     exon            350..438
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..616
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..717
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..777
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..817
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..980
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1122
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1206
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1368
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1448
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1650
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1800
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..2022
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2099
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2235
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2331
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2520
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..3997
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3134..3139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /note="hexamer: AATAAA"
     polyA_site      3152
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /note="major polyA site"
     regulatory      3327..3332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
                     /note="hexamer: CATAAA"
     polyA_site      3356
                     /gene="Rrm1"
                     /gene_synonym="RnrM1"
ORIGIN      
        1 tcaatatggc ggccaaggga ctcgtgtgct gtctgtctac tgctcagttt ccgcccattc
       61 aactcccggc gttgaaacgt caagaacgtc attcgaattc cgtccgtcgc gttgctctgc
      121 acgtcacggg tggcgggagc gggaaggagt tcgtaattcg gttagtctgc tctggtgagg
      181 aaagtgctgt ctatcgcgca gcttccatcc ctccgtccga gcagcctctc ggagtccaac
      241 ccttcacatc tgacagtcgt ctctgtccct tcttcgcctc ggagctgcta actggtctcg
      301 aacctctcag cacttcagct tctagcggcg atgcatgtga tcaagcgaga tggccgccaa
      361 gagcgagtta tgtttgacaa aattacatca cgaatccaga aactctgtta tggactcaac
      421 atggactttg ttgatcctgc tcagatcacc atgaaagtaa tccaaggcct atatagtggg
      481 gtcaccacag tggaactgga caccctggct gctgagacag ccgcgacctt gaccacgaag
      541 caccctgact atgccatcct ggcagcaagg atagccgtct ctaacttgca caaagaaaca
      601 aagaaagtgt tcagtgatgt gatggaggat ctctacaact acataaatcc gcacaacggc
      661 agacactctc ccatggtggc cagctcaaca ctcgacattg ttatggccaa taaggatcgc
      721 ctgaattctg ccattatcta tgaccgagat ttctcttata actactttgg ctttaagaca
      781 ctggaacggt catatttgtt gaagatcaat ggtaaagtgg ctgaaagacc acagcatatg
      841 ttgatgaggg tttctgtggg gattcacaaa gaagatattg atgctgcaat tgaaacctac
      901 aacctacttt ctgagaagtg gttcactcat gcctctccta ctctcttcaa tgctgggacc
      961 aaccgcccac agctgtctag ctgtttcctc ttgagtatga aagatgacag cattgaagga
     1021 atttatgata ctctgaagca gtgtgccttg atttctaagt ccgctggggg aattggtgtt
     1081 gctgtgagtt gtattcgggc cactggtagc tacatcgctg ggactaatgg caattctaat
     1141 ggccttgtgc caatgctgag agtatataac aacacagctc gctatgtgga tcaaggtgga
     1201 aacaagcgcc caggcgcgtt tgctatttac ctggagcctt ggcacttaga catctttgag
     1261 ttccttgact tgaagaagaa cacaggcaag gaagaacagc gagcacgcga tctcttcttt
     1321 gcactttgga tcccagatct cttcatgaag cgagtggaga ctaaccagga ctggtcattg
     1381 atgtgtccca atgagtgtcc tggtctggac gaggtctggg gagaggagtt tgagaagtta
     1441 tatgaaagtt acgagaagca gggtcgtgtc cgaaaagttg taaaagctca gcagctttgg
     1501 tatgccatca ttgagtccca gacggagacc ggtaccccat acatgctcta caaagattcc
     1561 tgtaaccgga agagcaacca gcagaacctg ggaaccatca aatgcagcaa cctgtgtaca
     1621 gaaatagtag agtacaccag taaagatgag gttgcagttt gtaacttggc ttctctggct
     1681 ctgaatatgt atgtcacacc ggaacatacg tatgactttg agaaactggc agaagtcact
     1741 aaagtcattg tccgaaatct gaataaaata attgatataa actactaccc tattccagag
     1801 gcacacttat caaataaacg ccatcggccc attggaattg gggtacaagg tttagcagat
     1861 gctttcatcc tgatgagata cccctttgag agcccagaag cccagttatt aaataagcag
     1921 atctttgaaa ccatttacta tggagccctg gaagccagct gtgaactagc caaggagtat
     1981 ggcccctatg aaacgtatga gggatctcca gtcagcaagg gtattcttca gtatgacatg
     2041 tggaatgttg ctcctacaga cctgtgggac tggaagcctc tcaaggagaa gattgcaaag
     2101 tatggtataa ggaacagttt acttattgcc ccaatgccta ctgcttcaac tgcccagatt
     2161 ctggggaata atgagtccat tgagccttat accagtaaca tctacactcg aagagtcttg
     2221 tcaggggaat ttcagattgt gaatcctcac ttactgaaag atcttactga gcggggcttg
     2281 tggaatgaag agatgaaaaa tcagattatt gcatgcaatg gctccattca gagcatacca
     2341 gaaattcctg atgacctgaa gcaactctat aagaccgtgt gggaaatctc tcagaagact
     2401 gttctcaaga tggcagccga gagaggtgct ttcatcgatc agagccagtc tttaaacatc
     2461 catattgctg agcccaacta cggcaaactc actagtatgc acttctacgg ttggaagcag
     2521 ggtttaaaga ctggaatgta ttacttaagg acgaggcctg ccgctaatcc aatccagttc
     2581 actctgaaca aggaaaaact gaaagataag gaaaaggcac tgaaggagga ggaggagaag
     2641 gagaggaaca cagcagccat ggtgtgctct ttggagaaca gagaggagtg cctgatgtgt
     2701 ggatcctgag aaaatcaggg cctgggagac gcagcgggct ctcctgcccg ccgaggcaga
     2761 cgatttgagc atagatagga tagtgggttt gcttggttat cagcagctct gcttggacgt
     2821 gcctgccagg acagggagcc acgacttaca gtactgtttc tacacagtgt aaatatcatt
     2881 tttaacaaac agaaaaccaa agccagcttt gatattagga atcaaagtag aggctttggg
     2941 aatactaaag agccttcctg caaattagtg aggagactta ggaagtctcg tctctccagc
     3001 tttccctgcc tggccattct cagtttgggc aaagagattt agtttgattt gactgattgc
     3061 ctagaagtaa aatcaagcaa ttactcatca gctaaagacc tttgtctaga caaacttcta
     3121 taggtcattt tgaaataaac atttctaagt gattgtgtgg tactaaactt gtcatctatt
     3181 atcatacaag acagtttagg ggaaaaaacc caaaaaccca acattttctg ttgagttcag
     3241 agagacaaac tttaaagaca tttagattgt atagatatct agtgttaaca tatgcccttt
     3301 cctgccccag gatgaaatct tgttaacata aaattgacag tttctttcat ttataatttg
     3361 attctgtggc atttagttca ttcacactgt tgtataaact gtcatccaca ccatttccaa
     3421 aacattccat cattccaaat agagactcta ctcataacca cacttcttac acctttttga
     3481 atatgtattc ctcatacaca taatgcagta tttgcacttg tatggcttgc atgatatcta
     3541 gatacatcac agtgtgatac gctgtccctc catatgtgca caccatcttg tatccatcct
     3601 gtcatctgtt catgaaactt ggttgtttcc tccctttaga tagggagaat aatggctgcc
     3661 atgaacattg gtctacaaat atctattgga ttcctgcttt taggtttggt ggttctatac
     3721 agcaaagaat tgctggacta tataattctg tttgactttg aggagctata tttgcagcac
     3781 cattatattt ctataaaagt actaaaaggc cttattctgt cttcatacct tataacactc
     3841 gattttcata tttttgataa agcccttcta tgagtgggga atttcctggt cttgtagatt
     3901 gacttgtttc gttaaacccg agttttgggg cattttctcc ctttagtcat cacatccttt
     3961 ttttccctta tgaaactcat aataaatctg ctttacg
//
