LOCUS       NM_001409853            1555 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus retinal pigment epithelium derived rhodopsin homolog
            (Rrh), transcript variant 1, mRNA.
ACCESSION   NM_001409853
VERSION     NM_001409853.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Cook,J.D., Ng,S.Y., Lloyd,M., Eddington,S., Sun,H., Nathans,J.,
            Bok,D., Radu,R.A. and Travis,G.H.
  TITLE     Peropsin modulates transit of vitamin A from retina to retinal
            pigment epithelium
  JOURNAL   J Biol Chem 292 (52), 21407-21416 (2017)
   PUBMED   29109151
  REMARK    GeneRIF: mice with a null mutation in the peropsin gene (Rrh)
            exhibited normal retinal histology, normal morphology of outer
            segments and RPE cells, and no evidence of photoreceptor
            degeneration. Biochemically, Rrh-/- mice had approximately 2-fold
            higher vitamin A (all-trans-retinol) in the neural retina following
            a photobleach.
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Tarttelin,E.E., Bellingham,J., Bibb,L.C., Foster,R.G.,
            Hankins,M.W., Gregory-Evans,K., Gregory-Evans,C.Y., Wells,D.J. and
            Lucas,R.J.
  TITLE     Expression of opsin genes early in ocular development of humans and
            mice
  JOURNAL   Exp Eye Res 76 (3), 393-396 (2003)
   PUBMED   12573668
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Sun,H., Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Peropsin, a novel visual pigment-like protein located in the apical
            microvilli of the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9893-9898 (1997)
   PUBMED   9275222
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111097.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046288.1, SRR9219381.8562.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849384 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC111097.10        71884-72047
            165-355             AC111097.10        78674-78864
            356-481             AC111097.10        79058-79183
            482-581             AC111097.10        81075-81174
            582-735             AC111097.10        81663-81816
            736-904             AC111097.10        82645-82813
            905-1083            AC111097.10        83720-83898
            1084-1555           AC111097.10        85378-85849
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 59.09 cM"
     gene            1..1555
                     /gene="Rrh"
                     /note="retinal pigment epithelium derived rhodopsin
                     homolog"
                     /db_xref="GeneID:20132"
                     /db_xref="MGI:MGI:1097709"
     exon            1..164
                     /gene="Rrh"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1198
                     /gene="Rrh"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peropsin; visual pigment-like receptor peropsin"
                     /codon_start=1
                     /product="visual pigment-like receptor peropsin isoform 1"
                     /protein_id="NP_001396782.1"
                     /db_xref="GeneID:20132"
                     /db_xref="MGI:MGI:1097709"
                     /translation="MLSEASDFNSSGSRSEGSVFSRTEHSVIAAYLIVAGITSILSNV
                     VVLGIFIKYKELRTPTNAVIINLAFTDIGVSSIGYPMSAASDLHGSWKFGHAGCQFQG
                     RNDRQVTGCLYTCLVPHVCNAGGAKRRAVDLLKLTLQMDIYAGLNIFFGMVSIGLLTV
                     VAMDRYLTISCPDVGRRMTTNTYLSMILGAWINGLFWALMPIIGWASYAPDPTGATCT
                     INWRNNDTSFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLRLYAASDCTAHLHRDWAD
                     QADVTKMSVIMILMFLLAWSPYSIVCLWACFGNPKKIPPSMAIIAPLFAKSSTFYNPC
                     IYVAAHKKFRKAMLAMFKCQPHLAVPEPSTLPMDMPQSSLAPVRI"
     exon            165..355
                     /gene="Rrh"
                     /inference="alignment:Splign:2.1.0"
     exon            356..481
                     /gene="Rrh"
                     /inference="alignment:Splign:2.1.0"
     exon            482..581
                     /gene="Rrh"
                     /inference="alignment:Splign:2.1.0"
     exon            582..735
                     /gene="Rrh"
                     /inference="alignment:Splign:2.1.0"
     exon            736..904
                     /gene="Rrh"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1083
                     /gene="Rrh"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1555
                     /gene="Rrh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rrh"
                     /note="hexamer: AATAAA"
     polyA_site      1555
                     /gene="Rrh"
                     /note="major polyA site"
ORIGIN      
        1 attcttgacc gatcaccatt gctgagggct gcttcaaagg tggtcttgac tttccaaaat
       61 gctgagtgag gcttcggatt ttaacagctc gggctctagg agcgaaggtt ctgtcttttc
      121 aaggactgag cacagcgtca tagcggctta cctgattgtg gcaggtatca cgagcattct
      181 cagcaacgta gtagtcctgg gtatcttcat caagtacaag gagctgcgga cacccaccaa
      241 tgcagtgatt atcaacctgg ctttcacgga tataggggtc agtagcatcg gctatcccat
      301 gtctgcggct tcagatctgc atggaagttg gaaatttgga catgcaggct gtcagttcca
      361 gggaagaaac gacaggcagg tgactgggtg cctgtataca tgtcttgtac cgcatgtatg
      421 caatgctggt ggagccaaga ggagggcagt ggatctccta aagctgactc tacagatgga
      481 tatttatgca ggactgaata tcttctttgg gatggtgagc attggcttac tcacggttgt
      541 agctatggat cggtacctga ccatcagttg ccctgatgta ggacgaagaa tgaccaccaa
      601 cacttacctc agcatgatcc tgggcgcctg gatcaatggc ctgttttggg ctttgatgcc
      661 catcataggg tgggctagtt atgccccgga tcctacaggg gccacgtgta ccataaactg
      721 gcggaataat gatacctcgt tcgtgtctta caccatgatg gttatcgtgg tgaacttcat
      781 tgtgcccttg acagtgatgt tttactgtta ctaccacgtc agtcggtccc tgagactcta
      841 cgccgctagt gactgcactg cacacctcca cagagactgg gcagaccagg cagatgtaac
      901 aaagatgtct gtgataatga tactgatgtt tctgctggca tggtcccctt attccatcgt
      961 gtgcttgtgg gcttgttttg gaaaccccaa aaagattcct ccttcaatgg ctatcatagc
     1021 tccactgttt gcaaaatcct ctacgttcta caacccctgt atttacgtgg ctgcgcataa
     1081 gaagtttcgg aaggccatgt tggccatgtt taaatgccaa cctcacctag cagtgcctga
     1141 gccaagtact ctaccaatgg atatgcctca gagctcattg gctcctgtga ggatctgaac
     1201 tgcaagaaaa gaatatacca ccaaacattt gatttgctta ttttttgaca atacactaac
     1261 tttgatttaa atatggatcc atttgaacca agtgcagaca tagcctattg ccttactgga
     1321 tggtaggttc ctcccactca gccagcccaa ctctgcttga agagttgttg ccgtagagcc
     1381 ttcactatgt cctcaaggat aattaagcag gcacacaaaa ctacagtctc ttttctttct
     1441 tcttaaaagg cacacattat agtatattaa tgacctgtaa cttgactaag ttttccatta
     1501 gactagaaac agctatcaga ataccagaat attttaataa aattataatc ctcaa
//
