LOCUS       NM_001177869            8756 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus ras responsive element binding protein 1 (Rreb1),
            transcript variant 6, mRNA.
ACCESSION   NM_001177869 XM_006516750
VERSION     NM_001177869.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8756)
  AUTHORS   Han,G., Cui,M., Lu,P., Zhang,T., Yin,R., Hu,J., Chai,J., Wang,J.,
            Gao,K., Liu,W., Yao,S., Cao,Z., Zheng,Y., Tian,W., Guo,R., Shen,M.,
            Liu,Z., Li,W., Zhao,S., Lin,X., Zhang,Y., Song,K., Sun,Y., Zhou,F.
            and Zhang,H.
  TITLE     Selective translation of nuclear mitochondrial respiratory proteins
            reprograms succinate metabolism in AML development and
            chemoresistance
  JOURNAL   Cell Stem Cell 31 (12), 1777-1793 (2024)
   PUBMED   39357516
REFERENCE   2  (bases 1 to 8756)
  AUTHORS   Wu,Z., Chen,X., Yan,T., Yu,L., Zhang,L., Zheng,M. and Zhu,H.
  TITLE     Rreb1 is a key transcription factor in Sertoli cell maturation and
            function and spermatogenesis in mouse
  JOURNAL   Zygote 32 (2), 130-138 (2024)
   PUBMED   38248872
  REMARK    GeneRIF: Rreb1 is a key transcription factor in Sertoli cell
            maturation and function and spermatogenesis in mouse.
REFERENCE   3  (bases 1 to 8756)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 8756)
  AUTHORS   Griffin,E.N., Jucius,T., Sim,S.E., Harris,B.S., Heinz,S. and
            Ackerman,S.L.
  TITLE     RREB1 regulates neuronal proteostasis and the microtubule network
  JOURNAL   Sci Adv 10 (2), eadh3929 (2024)
   PUBMED   38198538
  REMARK    GeneRIF: RREB1 regulates neuronal proteostasis and the microtubule
            network.
REFERENCE   5  (bases 1 to 8756)
  AUTHORS   Cazzaro,S., Woo,J.A., Wang,X., Liu,T., Rego,S., Kee,T.R., Koh,Y.,
            Vazquez-Rosa,E., Pieper,A.A. and Kang,D.E.
  TITLE     Slingshot homolog-1-mediated Nrf2 sequestration tips the balance
            from neuroprotection to neurodegeneration in Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 120 (30), e2217128120 (2023)
   PUBMED   37463212
REFERENCE   6  (bases 1 to 8756)
  AUTHORS   Yamane,T., Suzui,S., Kitaura,H., Takahashi-Niki,K.,
            Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Transcriptional activation of the cholecystokinin gene by DJ-1
            through interaction of DJ-1 with RREB1 and the effect of DJ-1 on
            the cholecystokinin level in mice
  JOURNAL   PLoS One 8 (11), e78374 (2013)
   PUBMED   24348900
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8756)
  AUTHORS   Kent,O.A., Chivukula,R.R., Mullendore,M., Wentzel,E.A.,
            Feldmann,G., Lee,K.H., Liu,S., Leach,S.D., Maitra,A. and
            Mendell,J.T.
  TITLE     Repression of the miR-143/145 cluster by oncogenic Ras initiates a
            tumor-promoting feed-forward pathway
  JOURNAL   Genes Dev 24 (24), 2754-2759 (2010)
   PUBMED   21159816
REFERENCE   8  (bases 1 to 8756)
  AUTHORS   Chen,R.L., Chou,Y.C., Lan,Y.J., Huang,T.S. and Shen,C.K.
  TITLE     Developmental silencing of human zeta-globin gene expression is
            mediated by the transcriptional repressor RREB1
  JOURNAL   J Biol Chem 285 (14), 10189-10197 (2010)
   PUBMED   20133935
REFERENCE   9  (bases 1 to 8756)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   10 (bases 1 to 8756)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022682.16 and CT010477.16.
            
            On or before Apr 14, 2022 this sequence version replaced
            XM_006516750.3, NM_001177869.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.2787074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               AC022682.16        31096-31445         c
            351-452             CT010477.16        151318-151419       c
            453-559             CT010477.16        147632-147738       c
            560-772             CT010477.16        146306-146518       c
            773-862             CT010477.16        141789-141878       c
            863-1026            CT010477.16        140503-140666       c
            1027-1165           CT010477.16        124130-124268       c
            1166-1302           CT010477.16        123695-123831       c
            1303-1492           CT010477.16        111978-112167       c
            1493-4424           CT010477.16        107801-110732       c
            4425-4586           CT010477.16        98586-98747         c
            4587-5393           CT010477.16        92627-93433         c
            5394-8756           CT010477.16        88285-91647         c
FEATURES             Location/Qualifiers
     source          1..8756
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..8756
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /note="ras responsive element binding protein 1"
                     /db_xref="GeneID:68750"
                     /db_xref="MGI:MGI:2443664"
     exon            1..350
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            351..452
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            453..559
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            560..772
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     CDS             602..5866
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /note="isoform 2 is encoded by transcript variant 6;
                     RAS-responsive zinc finger transcription factor RREB"
                     /codon_start=1
                     /product="ras-responsive element-binding protein 1 isoform
                     2"
                     /protein_id="NP_001171340.1"
                     /db_xref="CCDS:CCDS49238.1"
                     /db_xref="GeneID:68750"
                     /db_xref="MGI:MGI:2443664"
                     /translation="MTSNSPIGLEGSDLSSINTMMSAVMSVASVTENGGSPQGIKSPM
                     KPPGPNRIGRRNQETKEEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADHACSIC
                     GKSLSSASSLDRHMLVHSGERPYKCTVCGQSFTTNGNMHRHMKIHEKDTNSTTAAAPP
                     SPLKRRRLSSKRKLSHDAESEDPGPAKKMVEDGQSGDLDKMSDEIFHCPVCFKEFVCK
                     YELETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIP
                     AGFHDLGFTDFSCRKFPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLSSLILHRQ
                     SHIPADQGREKLQTKTLAAESLEQKAFLALLGLQHTKDVKPAPAEELLPDDNQAIQLQ
                     TLKYQLPQEPGCPTVLSVSPLDAASLGGSLTVLPATKENMKHLSLQPFQKGFIIQPDS
                     SIVVKPISGESAIELADIQQILKMAASAPPQISLPPLSKAPATPLQAIFKHMPPLKPK
                     PLVTPRTVVAASTPPPLINAQQASPGCISPSLPPQSLKFLKGSVEAVSNVHLLQSKSG
                     IQPSTTTQLFLQQAGVELPGQPEMKTQLEQESIIEALLPLNMEAKIKQEITEGDLKAI
                     MTGPSGKKTPAMRKVLYPCRFCNQVFAFSGVLRAHVRSHLGISPYQCNICDYIAADKA
                     ALIRHIRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSPTA
                     ELVDAFCAPETVCRLCGEDLKHYRALRIHMRTHCSRGLGGCHKGRKPFECKECNAPFV
                     AKRNCIHHILKQHLHVPEKDIESYVLATNSGLGPADTPTDAASRGEEGSCVTFAECKP
                     LATFLEPQNGFLHSSPTQPLPSHISVKLEPASSFAMDFNEPLDFSQKGLALVQVKQEN
                     VSSLLTSSSSSALYDCSMEPIDLSIPKSVKKGDKDTVVPSDAKKPEPEAGQAEPLSPR
                     PPPCPTLSVTVEPKGSLETPTGTVVAVTTAAKLEPHTQPLQGSVQLAVPIYSPALVSN
                     TPLLGNSAALLNNPALLRPLRPKPPLLLPKPSMTEELPPLASIAQIISSVSSAPTLLK
                     TKVADPGPSITSSNTVATDSPGSSIPKAAATPTDTTSSKESSEPPPAASSPEEALPTE
                     QGPAATSSSRKRGRKRGLRNRPLPNSSAVDLDSSGEFASIEKMLATTDTNKFSPFLQT
                     AEDDTQEEVAGAPADQHGPADEEQGSPAEDRLLRAKRNSYANCLQKINCPHCPRVFPW
                     ASSLQRHMLTHTGQKPFPCQKCDAFFSTKSNCERHQLRKHGVTTCSLRRNGLIPPKES
                     DVGSHDSTDSQSDTDTLTTPGEVLDLTAQAKEQPPAEGASEISPASQDLAIKEAKAAA
                     APSEEEEEKETEENPEPEEECRVEESTGAADAPEEDTASNQSLDLDFATKLMDFKLAE
                     SEAGSVDSQGPAQQEPKHACDTCGKNFKFLGTLSRHKKAHSCQEPKEEEAAAPSLENE
                     GVGRAVEGPSPSPEPEEKPAESLAIDPTPGTREASVAKQNEETEGPTDGEGTAEKRGD
                     GDKRPKTDSPKSMASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERT
                     FTLKHSLVRHQRIHQKARHSKHHGKDSDKDERAEEDSEDESTHSATNPASENEAESAP
                     STSNHVAVTRSRKESLSTSGKECSPEERAAAEQAAEPSAPKEQASPGETDPQSPAAIV
                     QDLLELCGKRPAPILAATDGASQLLGME"
     exon            773..862
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1026
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1165
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1302
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1492
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..4424
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            4425..4586
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            4587..5393
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     exon            5394..8756
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8730..8735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /note="hexamer: AATAAA"
     polyA_site      8756
                     /gene="Rreb1"
                     /gene_synonym="1110037N09Rik; B930013M22Rik; sao"
                     /note="major polyA site"
ORIGIN      
        1 ctccgctcct ttccccttcc cgagctgccg gctctgccaa ccagctccca gcgcgagccg
       61 ccgcagcgcc ccgccagcag gacctgatgc gcatccatat tagccgtccg agcgcaggaa
      121 tccggcccga cccgcgccgc cgagtttatt tttaaccagc cctgccggga ctcggatggt
      181 gcgcgcaccg cgggccagaa acatcttccc agcgctgctc tccatcttcc gccctctctc
      241 ccccgacatc ctccccccca tgtgggaggg gaaacttttc tcctacatac tttctagtcc
      301 ctctcgggtc gggaagcacg gagatgacgg agccagcccg ccgccgcaag gttgttgcaa
      361 tcctgtgctc cagaagtggt ggctttgagg tgtgaccctg cccacatttg ggcccagtcc
      421 tcaccagctc ctcggcagaa cgaagaaaac agcataaagg agtgatatcc agagaataaa
      481 agggctcccc agagtcattt cctactccat gtggatgaca gcaggagcaa gggactatca
      541 tttggggcag aaaatggagt tctatagcag agacttctta gaagcataaa accctgtccc
      601 gatgacgtcg aattcgccca ttggtttaga aggctcagac ctgtcttcca tcaacaccat
      661 gatgtcagca gtaatgagcg tagcgagtgt cacagagaat ggtgggagcc cccagggcat
      721 caagtccccc atgaaacctc caggaccaaa tcggattggc agaaggaacc aggaaacgaa
      781 agaggagaag tcttcctaca actgtcccct atgtgaaaag atttgcacca cccagcacca
      841 gctgaccatg cacatccgtc agcacaacac agacacggga ggagctgacc acgcatgcag
      901 tatctgtggg aagtcgctga gctcggccag ctccctggat cgtcacatgc tggtgcactc
      961 tggcgagagg ccttacaagt gtacagtgtg tggccagtct ttcaccacca atgggaacat
     1021 gcacagacat atgaagattc atgagaagga taccaacagt actacagctg cagcccctcc
     1081 atcccctctg aagcgcaggc ggttgtcctc caaaaggaag ctgagtcacg atgccgagtc
     1141 agaagaccca ggaccagcta aaaagatggt agaagacggg cagtcaggcg atttggacaa
     1201 gatgagcgat gaaatctttc actgcccagt gtgtttcaag gagtttgttt gcaagtatga
     1261 actggagacc cacatggaga cccactcaga taacccacta agatgtgaca tttgctgcgt
     1321 caccttccgc acacatcgag gactgctgcg ccacaatgca cttgtccaca agcagcttcc
     1381 cagagatgcc atgggaagac cttttatcca gaacaaccct tcgattcctg ctggcttcca
     1441 tgatttaggg tttactgact tctcctgtag gaagtttcct cgaatctctc aggcctggtg
     1501 tgagacaaac ctacggcggt gcatcagcga gcagcaccgg tttgtgtgtg acacctgcga
     1561 caaggcgttc cccatgctgt cgtcactcat cctgcacagg cagagccaca tccctgccga
     1621 tcagggacgg gagaagctcc agaccaagac cctggctgcc gagtccttgg aacagaaggc
     1681 cttcctggcc ttgctgggcc tgcagcacac caaagacgtc aagcctgccc cggcggagga
     1741 gctcctgccg gacgacaacc aagcaataca gctccagaca cttaagtacc agctacctca
     1801 ggagcctggc tgccccaccg tgctgagtgt gtctcctctt gacgctgctt ctttaggtgg
     1861 ctctctgaca gtcctcccag ctaccaagga gaatatgaag catctgtccc tgcagccctt
     1921 ccagaagggc ttcatcatcc agccagacag tagcattgtg gttaagccta tttcaggaga
     1981 gtcggccatt gagctggcag atatccaaca gattctaaag atggcagctt ccgctcctcc
     2041 gcagatcagt cttccgccac tttccaaggc ccctgccacc ccgctgcagg cgattttcaa
     2101 gcacatgcct cctttgaagc caaagccctt ggtcacaccc cggacagtgg tagccgcctc
     2161 cacgccccca cctctcatca acgcccagca ggcatctccc ggttgtatca gccccagcct
     2221 tcctccacag tccctgaagt tcctcaaggg gtcggtggag gcagtgtcca atgttcatct
     2281 gcttcagtcc aagtctggga tccagccaag caccaccaca cagctcttcc tgcagcaagc
     2341 tggagtggag ttgccgggcc agcccgagat gaagacacag ctggaacaag agagtatcat
     2401 tgaggccctg ctgcccctca acatggaggc gaagatcaag caggagataa cagaaggtga
     2461 cctcaaggcc atcatgacag gccccagtgg caagaagacc cccgccatgc gcaaggtgct
     2521 ctacccctgc cgcttttgca accaggtgtt tgctttctct ggagtcctgc gagcccacgt
     2581 tcgctcccac ctgggcatct caccctacca atgcaacatc tgtgactata ttgctgcaga
     2641 caaagccgcc ctgatccgtc acatccgcac acacagcggg gaacggcctt acatctgcaa
     2701 gatctgccac tacccattca cggtcaaagc caactgtgag cggcacctgc gcaagaagca
     2761 cctcaaggcc accaggaagg acattgagaa gaacatagag tacgtgagca gccccaccgc
     2821 agagctggtg gacgccttct gcgccccaga gaccgtgtgc agactgtgcg gggaggatct
     2881 gaagcactac cgagctctac gcatccacat gcgcacacac tgcagccggg gcctgggcgg
     2941 ctgccacaaa ggccggaaac ccttcgagtg caaggaatgc aacgctccct tcgtggccaa
     3001 gcgcaactgc atccatcaca tcctcaagca gcacctgcac gtgcccgaga aggacatcga
     3061 gagctacgtg cttgccacca acagtggcct cggccccgcg gacacgccca cggatgccgc
     3121 ttccagagga gaagagggca gctgtgtcac tttcgcggag tgcaagcccc tcgccacttt
     3181 cctggagccc caaaatggct ttcttcactc gagccccacc cagcccctgc cttcccacat
     3241 ctctgtcaag ctggagccag ccagcagctt tgccatggac ttcaacgaac cccttgactt
     3301 ttcgcagaaa ggcctggcac tggtccaagt gaagcaggaa aatgtttcct ccttgctgac
     3361 gtcttcctcc tcctctgccc tctatgactg ctccatggag cccattgacc tgtccatccc
     3421 caagagcgtc aagaaaggag acaaggacac agttgttccc agtgacgcca agaaaccgga
     3481 accggaagct gggcaagccg agccgctctc accccgccca ccaccctgcc ctaccttgtc
     3541 agtgactgtg gagcccaagg ggagcctgga aacccccaca ggcacggtgg tggccgtcac
     3601 cacagctgcc aagctagagc cccacactca gcccctccag ggctccgtgc agctggctgt
     3661 ccccatctac tcccccgcgc tcgtcagcaa tactcccctc ttgggcaatt ctgctgccct
     3721 cttgaacaac ccagccttgc ttcggccctt acggccaaag ccccccctcc tcttgccaaa
     3781 gccctcgatg acagaggagc tgccgccact ggcctccatc gcccagatca tttcttccgt
     3841 gtcctcggcc cctactctgc tgaaaacgaa ggtagctgac cctggaccat cgatcaccag
     3901 cagtaacact gtggccacag acagcccagg aagctccatc cccaaagctg ccgccacccc
     3961 cactgacacc acaagctcta aagaatccag tgagccaccc cctgcagcca gcagccctga
     4021 ggaagccttg cctactgaac aagggccggc tgccacttcc tcgtcgagga agaggggcag
     4081 gaaaagggga ctgagaaacc ggcccctccc caacagcagt gctgtggacc tggactccag
     4141 tggggagttt gctagcatcg agaagatgct ggccaccaca gataccaaca agttcagtcc
     4201 ctttctgcag actgcagagg atgacactca ggaagaggtg gctggagccc ctgccgacca
     4261 gcatgggccc gctgatgagg agcaaggtag ccccgcagaa gacaggctgc tgagagcaaa
     4321 gcggaactcc tatgccaact gcctgcaaaa gatcaactgt ccccactgtc cccgggtctt
     4381 cccttgggcc agctccctgc agcggcacat gcttacacac actggtcaga aacccttccc
     4441 ttgtcaaaaa tgcgatgcct tcttttctac caaatctaac tgtgagcggc accagttgcg
     4501 caaacacgga gttaccacct gctccctgag aagaaacggg cttattcccc caaaagagag
     4561 tgatgttgga tcccatgata gcacagacag ccagtcagac acagacacgt tgaccacccc
     4621 aggtgaggtg ctggatctca cagcacaggc taaagagcag ccgccagcag agggagccag
     4681 tgagatcagt ccggcttcac aggaccttgc tatcaaagag gccaaagcag cagcagctcc
     4741 ctctgaggag gaggaagaaa aggagacaga ggagaaccca gagccagagg aagagtgtcg
     4801 tgtggaagag agcactgggg ctgcagatgc ccccgaggaa gacacagcca gcaaccagag
     4861 cctggatctt gacttcgcca ccaagctgat ggacttcaag ctggcagaga gtgaggcagg
     4921 ctctgtggac agccaaggcc cagcccagca ggagccaaag catgcctgcg atacctgtgg
     4981 aaagaacttc aagttcctgg gcaccctgag tcgccacaag aaggcacaca gctgccagga
     5041 gccgaaggag gaggaagcag cggcaccttc gctggagaat gagggcgttg gcagagcggt
     5101 tgaggggccc tcgccttccc ctgagcctga agagaaacca gccgaatccc tagcaatcga
     5161 tccaacacca ggaaccaggg aggcctcagt ggcgaaacag aatgaagaaa cagagggtcc
     5221 cactgatggg gaaggtacgg ctgagaagag gggtgacggt gacaaaagac caaagacaga
     5281 ctcccccaaa agcatggcca gtaaggcaga caagaggaag aaggtttgca gtgtatgcaa
     5341 caagcggttc tggtccctgc aggacctcac ccggcacatg aggtcacaca caggagaaag
     5401 gccatacaag tgtcagacct gtgagcgaac cttcacctta aagcacagcc tggttcgaca
     5461 ccagaggatc caccagaaag ccaggcacag caagcaccac gggaaagaca gcgacaagga
     5521 tgagcgggct gaggaggaca gtgaggacga gtccacccac agtgctacca accctgcctc
     5581 tgagaatgag gccgagtcag ctcccagcac cagcaaccac gtagctgtca ccaggagccg
     5641 gaaagagagc ttgtccactt ctgggaagga atgtagccca gaggagagag ccgcagctga
     5701 gcaggcagct gagcccagtg cccccaaaga gcaggcgtct ccaggtgaaa cagaccccca
     5761 gagcccggca gccatcgtgc aagacttgct ggagctgtgc ggcaagaggc ctgccccaat
     5821 cctggcggcc accgacgggg cctcacagct cctgggcatg gagtgacagc ccgccctgtc
     5881 tccatcagct cagagacaaa gctagcggag catcccaaat gtagatttta caaggttttc
     5941 tcagcttcct tcagttgtct ggagagagag gaaaaagagg gcaagagaga gacaagcaag
     6001 cctgtggcca accagctcgt gccatagcct tacccagtac acatgcaccc ggccccagta
     6061 cagccggctt cagtgcctta actacttatg ggtcctccca tgtcgttgtg ggtgtccccc
     6121 ttccaaaaaa aaaagacatt ttaacaaaac aaatatttta atgaattttt cggaggacct
     6181 tttcatttaa gcattaacat taccttttgt atttgtgtgt ttgagcttgt ttttgtgagt
     6241 ctgtgatagt actgtttttg ttctgtgagc tggaagcaga aaaccttccc cttggatcct
     6301 gtagccaata actggaagaa aatgatgtga atttcatgta catgacccga gggaagaggg
     6361 tgtgaggcta atttctaagc tagacctgta ttctctggtt cacgtcgggg aggagccgcg
     6421 gcctggcctc tgtcattagt agatgtggtt gacgcagggt tcctgtgtgg tgtgagccaa
     6481 agccaggaaa gagtctagct tcaacctcgc gagtgtttcc accctctccg tgttagaaat
     6541 ggctagtgtt cccattctta atttacagag aaaagtggcc tccccagcac cctagcctac
     6601 agaggacacg gctggaggtc atatagccac tttcccttct tcccattcgg tatatgttat
     6661 taatattatt attattattt ttatttttac ttcttcagtt cgctgggctc tgcattcagc
     6721 agaaacaaat gggcaatatt tgtcctgggt gacctgtact gctccctggt ccccccttat
     6781 tgtgtgcctg aagcttctgg tggcacgcca gtgatggctc ttctactgta ctcagacaaa
     6841 cctttcttcc atgactgtag aatccagcag gggccaggag tggtcctcca agcgtggcca
     6901 aggagtggct cagaggggag agcaaggatg cacaagtggt ggggagcagg catccgagac
     6961 accaggccat acctggggca cctcagagtc agtttgcaag gcaccccagt cttcctgcta
     7021 agctgggtca gcgccttccc ccagccgtgc tactaccgtc atttgggaag cattgagata
     7081 ctactgccag tgatgaactg aagtgcatgc gcaaggtcta gatgcgagag ttgtcttcac
     7141 ctttctgcag tgtggggttg ctgcttggag agaggagtgc ttttaaatcc ctaactggcc
     7201 caagcccctg gtgcacagag acagggttcc tttagttcct gggtgttctg tacaaacagt
     7261 agacctcgct catcagcaaa aagaaactct tcctactgta gctgagctcg gttcagcacc
     7321 ctgtccttta gccgagaccc gaggatgcct gagccacact gctactagag ccctgtttgt
     7381 cccttgcctt cagggcctca agatttcccc aagagaggcc ctccactgct tcaccccctc
     7441 ccttatcctg tggctctata tgctcctccg caaagatgtg caacccgagg cgtgcgtacc
     7501 cctttgtcca ccagtatcta gtggctaaaa tccaaccacc ctgacttcaa tggaagatag
     7561 atattctaga gataatgaaa agtgatatat gtatgaaaaa aacattgagg tatatatgat
     7621 ttttaattgt attagggatg tgtggaccca tttaaagttg agattttatt tactgtagag
     7681 agagaaaaat cagaaccatt gatcccatga tcttctaagt caaacccagc tcctacatcc
     7741 cttaggtgtt tttattatta ttattattat tattattatt acaattgtta ttgttttcat
     7801 tgttattatt tggggtttct tgtgttttgg ttttctttgc aactctccac actaaactca
     7861 tgatactgtg gggagaggcc atgactgaac cctacgctgc ggtaagatgt agcaggggtt
     7921 gctcccagca gcggccgccg ccagggctgc aactggcaat aatcactatt gatttaaagc
     7981 tttatttagt ctcatctgtt ccttcatagt taataaggtc ttgccacatt ttattagtga
     8041 gattgagaga tgaattattt gtctgttgtc ctccccgcct tccctccccc aatattaaac
     8101 tgtgaagttt gtgattttgt ttaaacgctg ggtgaatcat agtgttagtt tgcatgtcca
     8161 gctaatttgt ttctatacat tttgtttgat tctctttctc ctcagggctt ttacaaatat
     8221 atatatatta tatatgtata tatatatgga tcttctgaaa aaaattgagg tgcaaatttt
     8281 ctcttttttg ttgttttttg ttttctcttt aatggacaca atgctgatat tcaatcacta
     8341 cataaaatat ctggctgtga aacaaaccag agaggcccca cggggcgtta tccaagcagc
     8401 tctgcagaag ctccgtgaat cggataccga tttcagacag atcatcctgc gttcgtctct
     8461 ttcctctctt ctctttcttc aagaaaaaaa agttgatcct aatgatttca gcccatgcat
     8521 taaacagaaa acaataataa ctgtagaatt catatttttc taaagggaac ttaaaaactg
     8581 ctgctacatg tatgtacaaa actggtctct gctacatgaa cagaatcaca ggtttggttt
     8641 tggtactttt gtttctcttt gtactcagtt gtgtagaact tccaaattca gagtgaaaag
     8701 aaagctgttc tgcatcaaac catctaagca ataaatgtta tatttaaaaa acggca
//
