LOCUS       NM_025846               2289 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus related RAS viral (r-ras) oncogene 2 (Rras2), mRNA.
ACCESSION   NM_025846
VERSION     NM_025846.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Fernandez-Pisonero,I., Clavain,L., Robles-Valero,J.,
            Lorenzo-Martin,L.F., Caloto,R., Nieto,B., Garcia-Macias,C.,
            Oeste,C.L., Sanchez-Martin,M., Abad,A., Hortal,A., Caballero,D.,
            Gonzalez,M., Dosil,M., Alarcon,B. and Bustelo,X.R.
  TITLE     A hotspot mutation targeting the R-RAS2 GTPase acts as a potent
            oncogenic driver in a wide spectrum of tumors
  JOURNAL   Cell Rep 38 (11), 110522 (2022)
   PUBMED   35294890
  REMARK    GeneRIF: A hotspot mutation targeting the R-RAS2 GTPase acts as a
            potent oncogenic driver in a wide spectrum of tumors.
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Hortal,A.M., Oeste,C.L., Cifuentes,C., Alcoceba,M.,
            Fernandez-Pisonero,I., Clavain,L., Tercero,R., Mendoza,P.,
            Dominguez,V., Garcia-Flores,M., Pintado,B., Abia,D.,
            Garcia-Macias,C., Navarro-Bailon,A., Bustelo,X.R., Gonzalez,M. and
            Alarcon,B.
  TITLE     Overexpression of wild type RRAS2, without oncogenic mutations,
            drives chronic lymphocytic leukemia
  JOURNAL   Mol Cancer 21 (1), 35 (2022)
   PUBMED   35120522
  REMARK    GeneRIF: Overexpression of wild type RRAS2, without oncogenic
            mutations, drives chronic lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Garcia-Martin,G., Sanz-Rodriguez,M., Alcover-Sanchez,B.,
            Pereira,M.P., Wandosell,F. and Cubelos,B.
  TITLE     R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types
            of the Central Nervous System
  JOURNAL   Int J Mol Sci 23 (2), 978 (2022)
   PUBMED   35055164
  REMARK    GeneRIF: R-Ras1 and R-Ras2 Expression in Anatomical Regions and
            Cell Types of the Central Nervous System.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   Alcover-Sanchez,B., Garcia-Martin,G., Escudero-Ramirez,J.,
            Gonzalez-Riano,C., Lorenzo,P., Gimenez-Cassina,A., Formentini,L.,
            de la Villa-Polo,P., Pereira,M.P., Wandosell,F. and Cubelos,B.
  TITLE     Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that
            trigger axonal degeneration in a hypomyelinating disease model
  JOURNAL   Glia 69 (3), 619-637 (2021)
   PUBMED   33010069
REFERENCE   6  (bases 1 to 2289)
  AUTHORS   Nunez Rodriguez,N., Lee,I.N., Banno,A., Qiao,H.F., Qiao,R.F.,
            Yao,Z., Hoang,T., Kimmelman,A.C. and Chan,A.M.
  TITLE     Characterization of R-ras3/m-ras null mice reveals a potential role
            in trophic factor signaling
  JOURNAL   Mol Cell Biol 26 (19), 7145-7154 (2006)
   PUBMED   16980617
REFERENCE   7  (bases 1 to 2289)
  AUTHORS   Pozzi,A., Coffa,S., Bulus,N., Zhu,W., Chen,D., Chen,X.,
            Mernaugh,G., Su,Y., Cai,S., Singh,A., Brissova,M. and Zent,R.
  TITLE     H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell
            branching morphogenesis
  JOURNAL   Mol Biol Cell 17 (4), 2046-2056 (2006)
   PUBMED   16467383
  REMARK    GeneRIF: Data suggest that R-Ras and TC-21 play a role in
            facilitating branching and growth in early ureteric bud
            development, whereas H-Ras might favor cell migration and
            elongation of tubules, events that occur later in development.
REFERENCE   8  (bases 1 to 2289)
  AUTHORS   Huang,Y., Rangwala,F., Fulkerson,P.C., Ling,B., Reed,E., Cox,A.D.,
            Kamholz,J. and Ratner,N.
  TITLE     Role of TC21/R-Ras2 in enhanced migration of
            neurofibromin-deficient Schwann cells
  JOURNAL   Oncogene 23 (2), 368-378 (2004)
   PUBMED   14724565
  REMARK    GeneRIF: role of TC21/R-Ras2 activation in the migration of
            neurofibromin-deficient Schwann cells
REFERENCE   9  (bases 1 to 2289)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2289)
  AUTHORS   Murphy,G.A., Graham,S.M., Morita,S., Reks,S.E., Rogers-Graham,K.,
            Vojtek,A., Kelley,G.G. and Der,C.J.
  TITLE     Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in
            TC21/R-Ras2-mediated transformation
  JOURNAL   J Biol Chem 277 (12), 9966-9975 (2002)
   PUBMED   11788587
  REMARK    GeneRIF: PI3K, but not RalGDS, is an important mediator of cell
            proliferation by TC21.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078870.1, AK011419.1, AK003733.1 and BX524069.1.
            
            On Jan 19, 2008 this sequence version replaced NM_025846.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011419.1, SRR1660811.89655.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AK078870.1         2-289
            289-564             AK011419.1         289-564
            565-1485            AK078870.1         566-1486
            1486-2269           AK003733.1         872-1655
            2270-2289           BX524069.1         281-300
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.29 cM"
     gene            1..2289
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /note="related RAS viral (r-ras) oncogene 2"
                     /db_xref="GeneID:66922"
                     /db_xref="MGI:MGI:1914172"
     exon            1..386
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            387..474
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            475..577
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            578..686
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            687..805
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            806..2275
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1469..1474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /note="hexamer: ATTAAA"
     polyA_site      1487
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /note="major polyA site"
     regulatory      2250..2255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /note="hexamer: ATTAAA"
     polyA_site      2275
                     /gene="Rras2"
                     /gene_synonym="2610016H24Rik; TC21"
                     /note="major polyA site"
ORIGIN      
        1 agacggccat ttgtagcggt gccgaaggct gcgttcggct gcgctgcaga tccgcgaaga
       61 agagcgcgct ccctggccgc tgcgtcctct gccctggagc cttcccggct ctccagcgtc
      121 tcgggcaact cccagccggt ccgagggata gcgctccgcg gccctccagg ccactcacgg
      181 accccgcgcg ctctaccgcc tgtaacccag ccggccgcac tcgtccccgg agccgggcct
      241 agggcgcgcg gcggccgggc tgggctcggg gcgtcccgat ggccgcggcc ggctggcgcg
      301 acggctccgg ccaggagaag taccggctcg tggtggtcgg cggtggcggc gtgggcaagt
      361 cggcgctcac catccagttc atccagtcct attttgtgac ggactatgat ccaaccattg
      421 aagactcata cacaaagcaa tgtgtgatcg atgaccgagc tgcccggctg gacattttgg
      481 atacagccgg acaagaggag tttggagcca tgagagagca atacatgagg acaggcgagg
      541 gcttcctgtt ggtcttctca gtcacggata gaggcagttt tgaagaaatc tataagtttc
      601 aaagacagat tctcagagta aaggaccgtg atgagtttcc catgatttta attggcaata
      661 aagctgacct ggaccatcag agacaggtaa cacaggaaga agggcagcag ttagcaaggc
      721 agctcaaggt cacatatatg gaggcatcgg caaagatcag gatgaatgta gaccaagctt
      781 tccacgaact tgtccgggtt ataaggaaat ttcaagagca agaatgccct ccttcaccag
      841 aaccaacccg gaaagaaaaa gacaagaaag gctgccattg tgtcattttc taagagtccc
      901 ttgaggttta gctaacaact gccagggaag ccctcatctc tgctaccgtt tacatcatcc
      961 ggtacctttg tagccttaga ccgatgatca ccgtgttagc cttacaccaa gaagctggca
     1021 aatcctttat gtgaagctaa tgtaacggtc ttacccagac ttgtgtaaag gaaacactaa
     1081 ggctgcttca gacgttatct gattccttta aaacacatgt ctacacacac agatgcagtc
     1141 ttcaagggct tttaatagag gtaaaccaag tttggagcct gagctgtttg ctaagctgaa
     1201 gtcataggtt ggaaagtaat ttttaacttc tggaatcatg ttgcctactg ttactctaaa
     1261 tagaaatata gggaaggttt tttttttgtt gttgttgttt ttttaaatgt gaatttttgc
     1321 ctatctttaa aactttggtt gtcaactttc attaacctta aatacactga atggaatcaa
     1381 cacaagtgag acatctcaga cctttcctga tgctacggct tttgtttttc cagtggccaa
     1441 aataccaaaa tgcctgttgt atttatggat taaaaactgc tgattaagcc tttgttatca
     1501 tgcttccttc aagatgacaa tattctctgt ggccaaatgt ttggactggt tctgcacttg
     1561 ggtgttttgg tgaactcgct atcttttcac agccgtggta agggtaagag tggatggttc
     1621 ctgtcttgtc ttccttctca agtattcctg gttaagggat taaaaaagaa aacccacaca
     1681 agctaaagct gtttttgttt gatgtaatat aaaatatgga attgatcttt ccaaagtcag
     1741 agatgattaa tgtttttgct atatactttt atacgttatt ttcttatcaa actagttaac
     1801 aagtattttt atatgtttgt aagcggatat gcttccacct tgtgtatatg taaagatgag
     1861 tatttaagtc tcactgttca ctgttaactg acaaagagac catggctttt gcttgctggc
     1921 ttggtccttt ttacatccac tggtggccaa taatcagaaa accttcccaa cagaacgcaa
     1981 caggacgaga gtgcgaagtc acgttcagtg tccccgctag atattgactg ttatatcaag
     2041 tattacgtgt aaaacctcta cttgacaatt agtgtaactg tggatggctt ctgactttgt
     2101 ttttaactct gtggattgtg tttaagcaat tcgaagtgcg ctcctgattt tgagactcag
     2161 tggtattgca cagtggtcac tttattgaat gtgtacaaca gccccatgaa gtttataaag
     2221 tggacccttg tatagcttca ggtgctagaa ttaaagttga tctgttgtca ccagaaaaaa
     2281 aaaaaaaaa
//
