LOCUS       NM_009101                983 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus related RAS viral (r-ras) oncogene (Rras), transcript
            variant 1, mRNA.
ACCESSION   NM_009101
VERSION     NM_009101.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 983)
  AUTHORS   Herrera,J.L. and Komatsu,M.
  TITLE     Akt3 activation by R-Ras in an endothelial cell enforces quiescence
            and barrier stability of neighboring endothelial cells via Jagged1
  JOURNAL   Cell Rep 43 (3), 113837 (2024)
   PUBMED   38402584
REFERENCE   2  (bases 1 to 983)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 983)
  AUTHORS   Vahatupa,M., Nattinen,J., Aapola,U., Uusitalo-Jarvinen,H.,
            Uusitalo,H. and Jarvinen,T.A.H.
  TITLE     Proteomics Analysis of R-Ras Deficiency in Oxygen Induced
            Retinopathy
  JOURNAL   Int J Mol Sci 24 (9), 7914 (2023)
   PUBMED   37175621
  REMARK    GeneRIF: Proteomics Analysis of R-Ras Deficiency in Oxygen Induced
            Retinopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 983)
  AUTHORS   Xu,R., Hoss,C., Swiercz,J.M., Brandt,D.T., Lutz,V., Petersen,N.,
            Li,R., Zhao,D., Oleksy,A., Creigh-Pulatmen,T., Trokter,M.,
            Fedorova,M., Atzberger,A., Strandby,R.B., Olsen,A.A., Achiam,M.P.,
            Matthews,D., Huber,M., Grone,H.J., Offermanns,S. and Worzfeld,T.
  TITLE     A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin
            expression and protects against peptic ulcers
  JOURNAL   Sci Transl Med 14 (654), eabf1922 (2022)
   PUBMED   35857828
REFERENCE   5  (bases 1 to 983)
  AUTHORS   Garcia-Martin,G., Sanz-Rodriguez,M., Alcover-Sanchez,B.,
            Pereira,M.P., Wandosell,F. and Cubelos,B.
  TITLE     R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types
            of the Central Nervous System
  JOURNAL   Int J Mol Sci 23 (2), 978 (2022)
   PUBMED   35055164
  REMARK    GeneRIF: R-Ras1 and R-Ras2 Expression in Anatomical Regions and
            Cell Types of the Central Nervous System.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 983)
  AUTHORS   Szpirer,C., Molne,M., Antonacci,R., Jenkins,N.A., Finelli,P.,
            Szpirer,J., Riviere,M., Rocchi,M., Gilbert,D.J., Copeland,N.G. et
            al.
  TITLE     The genes encoding the glutamate receptor subunits KA1 and KA2
            (GRIK4 and GRIK5) are located on separate chromosomes in human,
            mouse, and rat
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11849-11853 (1994)
   PUBMED   7527545
REFERENCE   7  (bases 1 to 983)
  AUTHORS   Ahouse,J.J., Hagerman,C.L., Mittal,P., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Simister,N.E.
  TITLE     Mouse MHC class I-like Fc receptor encoded outside the MHC
  JOURNAL   J Immunol 151 (11), 6076-6088 (1993)
   PUBMED   7504013
REFERENCE   8  (bases 1 to 983)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (bases 1 to 983)
  AUTHORS   Yang-Feng,T.L., Schneider,J.W., Lindgren,V., Shull,M.M., Benz,E.J.
            Jr., Lingrel,J.B. and Francke,U.
  TITLE     Chromosomal localization of human Na+, K+-ATPase alpha- and
            beta-subunit genes
  JOURNAL   Genomics 2 (2), 128-138 (1988)
   PUBMED   2842249
REFERENCE   10 (bases 1 to 983)
  AUTHORS   Lowe,D.G., Capon,D.J., Delwart,E., Sakaguchi,A.Y., Naylor,S.L. and
            Goeddel,D.V.
  TITLE     Structure of the human and murine R-ras genes, novel genes closely
            related to ras proto-oncogenes
  JOURNAL   Cell 48 (1), 137-146 (1987)
   PUBMED   3098437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126256.4.
            
            On Mar 1, 2023 this sequence version replaced NM_009101.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009105.1, BI412492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC126256.4         62145-62341
            198-285             AC126256.4         64273-64360
            286-388             AC126256.4         64476-64578
            389-497             AC126256.4         64663-64771
            498-616             AC126256.4         65260-65378
            617-983             AC126256.4         65453-65819
FEATURES             Location/Qualifiers
     source          1..983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.08 cM"
     gene            1..983
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /note="related RAS viral (r-ras) oncogene"
                     /db_xref="GeneID:20130"
                     /db_xref="MGI:MGI:98179"
     exon            1..197
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..701
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein R-Ras; p23; Harvey rat sarcoma
                     oncogene, subgroup R"
                     /codon_start=1
                     /product="ras-related protein R-Ras isoform 1"
                     /protein_id="NP_033127.1"
                     /db_xref="CCDS:CCDS21226.1"
                     /db_xref="GeneID:20130"
                     /db_xref="MGI:MGI:98179"
                     /translation="MSSGAASGTGRGRPRGGGPGPRDPPPGETHKLVVVGGGGVGKSA
                     LTIQFIQSYFVSDYDPTIEDSYTKICTVDGIPARLDILDTAGQEEFGAMREQYMRAGN
                     GFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPIVLVGNKADLENQRQVLRSEASSF
                     SASHHMTYFEASAKLRLNVDEAFEQLVRAVRKYQEQELPPSPPSAPRKKDGGCPCVLL
                     "
     exon            198..285
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..388
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..497
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..616
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..983
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      963..968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /note="hexamer: AATAAA"
     polyA_site      983
                     /gene="Rras"
                     /gene_synonym="Rras1"
                     /note="major polyA site"
ORIGIN      
        1 gactccccct aggcggtagc ggcggcagca gcagcggtgg cgacatgagc agcggggcgg
       61 cgtccgggac tgggcggggg cggccccggg gcggggggcc gggacccagg gaccccccgc
      121 ccggcgagac tcacaagctg gtggtcgtag gcggcggcgg cgtgggcaag agcgcgctga
      181 ccatccagtt catccagtcc tactttgtgt ctgactatga tcccaccatt gaagattcct
      241 acacaaagat ctgcactgtg gacggcatcc ctgcacggct ggacatcctg gacactgcgg
      301 ggcaagagga atttggtgcc atgcgggagc agtacatgcg tgctggcaac ggcttcctgc
      361 tggtgtttgc cattaacgac aggcagagtt tcaatgaggt gggcaagctc ttcacacaga
      421 tcctcagagt caaggaccgg gatgatttcc ccattgtgtt ggttgggaac aaggcagatc
      481 tggagaacca gcgccaggtc ctccggtctg aagcctcctc tttcagtgct tcccaccaca
      541 tgacttactt tgaggcctca gccaaactgc gtctgaatgt cgatgaggca tttgagcagc
      601 tggtgcgcgc tgtccggaaa taccaggaac aagaactccc tcctagccca cctagtgctc
      661 ccaggaagaa ggatggagga tgtccctgtg tcctgctgta gccaaatagc ctcaagtgac
      721 cagcacaagc tctcgggacc agctgcctca cacttactgt gtggaccaag gctcgctcta
      781 gctgagcctc tgtttcatcc tctgggttcc ccaggacaca ctacaccctc ttacttttac
      841 ttcctggcct cctggggcta ccactgtgtg ccttctgtca atacctcctc ctttccccac
      901 aagaccctgt aggtgggggg agcatcttgt cactgctgta tataagcccc atctttcaga
      961 aaaataaata tcactgccaa caa
//
